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A circular single-stranded DNA mycovirus infects plants and confers broad-spectrum fungal resistance

Molecular Plant 2024年第6期17卷 955-971页

作者： Xianhong Wang Ioly Kotta-Loizou Robert H.A.Coutts huifang deng Zhenhao Han Ni Hong Karim Shafik Liping Wang Yashuang Guo Mengmeng Yang Wenxing Xu Guoping Wang National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops Wuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Lab of Plant Pathology of Hubei Province Wuhan 430070China Department of Life Sciences Faculty of Natural SciencesImperial College LondonLondon SW72AZUK Department of Clinical Pharmaceutical and Biological ScienceSchool of Life and Medical SciencesUniversity of HertfordshireHatfield AL109ABUK Department of Plant Pathology Faculty of AgricultureAlexandria UniversityAlexandria 21526Egypt

Circular single-stranded DNA(ssDNA)viruses have been rarely found in fungi,and the evolutionary and ecological relationships among ssDNA viruses infecting fungi and other organisms remain *** this study,a novel circular ssDNA virus,tentatively named Diaporthe sojae circular DNA virus 1(DsCDV1),was identified in the phytopathogenic fungus Diaporthe sojae isolated from pear ***1 has a monopartite genome(3185 nt in size)encapsidated in isometric virions(21-26 nm in diameter).The genome comprises seven putative open reading frames encoding a discrete replicase(Rep)split by an intergenic region,a putative capsid protein(CP),several proteins of unknown function(P1-P4),and a long intergenic ***,the two split parts of DsCDV1 Rep share high identities with the Reps of Geminiviridae and Genomoviridae,respectively,indicating an evolutionary linkage with both *** analysis based on Rep or CP sequences placed DsCDV1 in a unique cluster,supporting the establishment of a new family,tentatively named Gegemycoviridae,intermediate to both ***1 significantly attenuates fungal growth and nearly erases fungal virulence when transfected into the host ***,DsCDV1 can systematically infect tobacco and pear seedlings,providing broad-spectrum resistance to fungal *** localization analysis revealed that DsCDV1 P3 is systematically localized in the plasmodesmata,while its expression in trans-complementation experiments could restore systematic infection of a movement-deficient plant virus,suggesting that P3 is a movement ***1 exhibits unique molecular and biological traits not observed in other ssDNA viruses,serving as a link between fungal and plant ssDNA viruses and presenting an evolutionary connection between ssDNA viruses and *** findings contribute to expanding our understanding of ssDNA virus diversity and evolution,offering potential biocontrol applications for managing crucial plant d

关键词： circular single-stranded DNA virus mycovirus virus evolution Genomoviridae Gegemycoviridae Diaporthe sojae circular DNA virus 1

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Improving sentence simplification model with ordered neurons network

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CAAI Transactions on Intelligence Technology 2022年第2期7卷 268-277页

作者： Chunhui deng Lemin Zhang huifang deng School of Computer Engineering Guangzhou College of South China University of TechnologyGuangzhouChina School of Computer Science and Engineering South China University of TechnologyGuangzhouChina

Sentence simplification is an essential task in natural language processing and aims to simplify complex sentences while retaining their primary *** date,the main research works on sentence simplification models have been based on sequence-to-sequence(Seq2Seq)***,these Seq2Seq models are incapable of analysing the hierarchical structure of sentences,which is of great significance for sentence *** problem can be addressed with an ON-MULTI-STAGE model constructed based on the improved MULTI-STAGE encoder *** this model,an ordered neurons network is introduced and can provide sentence-level structural infor-mation for the encoder and decoder.A weak attention connection method is then employed to make the decoder use the sentence-level structural *** results on two open data sets demonstrated that the constructed model outperforms the state-of-the-art baseline models in sentence simplification.

关键词： ordered network while

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Improving word vector model with part-of-speech and dependency grammar information

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CAAI Transactions on Intelligence Technology 2020年第4期5卷 276-282页

作者： Chunhui deng Gangming Lai huifang deng School of Computer Engineering Guangzhou College of South China University of TechnologyNo.1 Xue Fu RoadHuaduGuangzhou 510800People’s Republic of China School of Computer Science and Engineering South China University of TechnologyUniversity TownPanyuGuanghzou 510006People’s Republic of China

Part-of-speech(POS)and dependency grammar(DG)are the basic components of natural language ***,current word vector models have not made full use of both POS information and DG information,and hence the models’performances are limited to some *** authors first put forward the concept of POS vector,and then,based on continuous bag-of-words(CBOW),constructed four models:CBOW+P,CBOW+PW,CBOW+G,and CBOW+G+P to incorporate POS information and DG information into word *** CBOW+P and CBOW+PW models are based on POS tagging,the CBOW+G model is based on DG parsing,and the CBOW+G+P model is based on POS tagging and DG *** information is integrated into the training process of word vectors through the POS vector to solve the problem of the POS similarity being difficult to *** POS vector correlation coefficient and distance weighting function are used to train the POS vector as well as the word *** information is used to correct the information loss caused by fixed context *** relations weight is used to measure the difference of dependency *** demonstrated the superior performance of their models while the time complexity is still kept the same as the base model of CBOW.

关键词： vector hence similarity

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《伤寒杂病论》“将息”释义

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中华中医药杂志 2024年第2期39卷 979-981页

作者：王海晓徐爽邓慧芳钟相根北京中医药大学中医学院北京100029 北京同有三和中医药发展基金会北京100102 道地药材品质保障与资源持续利用全国重点实验室北京100700

《伤寒杂病论》“将息”一词共记载10次,后世学者视其为一双音节词组,并释义为“养息、调养”,为服药后护理之法。然汉代张仲景记载之“将息”为两个单音节词连用,并非为一词组。历版教材径将“将息”注解为调养之意是所处时代的语言背... 详细信息

《伤寒杂病论》“将息”一词共记载10次,后世学者视其为一双音节词组,并释义为“养息、调养”,为服药后护理之法。然汉代张仲景记载之“将息”为两个单音节词连用,并非为一词组。历版教材径将“将息”注解为调养之意是所处时代的语言背景限制,未考虑到仲景时期的用词习惯。文章梳理“将息”的词意变化,通过考证相关秦汉非医典籍中“将”“息”的含义,结合《伤寒杂病论》原文阐释仲景“将息”之原意。认为“将”,行也;“息”,止也。凡服药之法,病瘥则不终一剂则止,不愈则服至二三剂。“将息”强调了服药进退之法度,是临床诊疗的重要环节之一,理应高度重视并落实于诊疗实践中。

关键词：《伤寒论》《金匮要略》将息仲景原意服药方法

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连续脑电图监测在抗N-甲基-D-天冬氨酸受体脑炎中的临床应用价值

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国际神经病学神经外科学杂志 2024年第4期51卷 65-68页

作者：邓会芳王博孙婧王钦鹏梁成兰州大学第二医院神经内科ICU 甘肃兰州730000

抗N-甲基-D-天冬氨酸(NMDA)受体脑炎是一种罕见且严重的自身免疫性脑炎,主要依靠血清及脑脊液中检查到抗NMDA受体抗体确诊,但对其治疗效果和预后判断仍缺乏有效的监测指标。连续脑电图是一种临床上常用的监测大脑电活动的检查手段,易于... 详细信息

抗N-甲基-D-天冬氨酸(NMDA)受体脑炎是一种罕见且严重的自身免疫性脑炎,主要依靠血清及脑脊液中检查到抗NMDA受体抗体确诊,但对其治疗效果和预后判断仍缺乏有效的监测指标。连续脑电图是一种临床上常用的监测大脑电活动的检查手段,易于操作且成本较低,在辅助抗NMDA受体脑炎患者的诊断、指导治疗及判断预后方面均有较高价值。

关键词：连续脑电图抗N-甲基-D-天冬氨酸受体脑炎诊断治疗预后

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仲景原文“烦疼”“疼烦”症考释

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浙江中医药大学学报 2024年第6期48卷 738-740,751页

作者：任沁怡徐爽邓慧芳钟相根北京中医药大学中医学院北京100029 北京同有三和中医药发展基金会道地药材品质保障与资源持续利用全国重点实验室

[目的]考证《伤寒论》《金匮要略》中“烦疼”“疼烦”的含义。[方法]从历代注家注疏入手,对不同观点进行归纳、分析,同时通过文字学考证,参考秦汉医学与非医文献,探明“烦”字字义,并结合张仲景原文分析二症含义。[结果]历代注家将二... 详细信息

[目的]考证《伤寒论》《金匮要略》中“烦疼”“疼烦”的含义。[方法]从历代注家注疏入手,对不同观点进行归纳、分析,同时通过文字学考证,参考秦汉医学与非医文献,探明“烦”字字义,并结合张仲景原文分析二症含义。[结果]历代注家将二症释为疼痛剧烈、疼痛并烦扰、热疼不妥。文字学考证可见,“烦”字除了表示心神的不适感之外,还有繁多、频繁之意。在张仲景原文中二症与具体身体部位连用,见于湿病、疟病、少阳病等,表示疼痛频繁、反复。[结论]张仲景原文中“烦疼”“疼烦”实为“疼痛频繁”之意。

关键词：张仲景烦疼疼烦烦频繁湿病《伤寒论》《金匮要略》

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基于临床用药特点的补骨脂斑马鱼肝毒性确证与机制探讨

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中国药物警戒 2024年第6期21卷 611-616页

作者：敖婷王宁宁周磊邓慧芳杨兴鑫周维沈磐高月云南中医药大学中药学院云南昆明650500 军事科学院军事医学研究院辐射医学研究所北京100850

目的遵循补骨脂临床用药特点,基于蛋白质组学探究其对于斑马鱼肝脏影响及其潜在肝毒性机制。方法以低、中、高浓度补骨脂水煎液(0.025、0.050、0.100 mg·mL-1)连续对成年斑马鱼给药21 d,比较斑马鱼体重变化、肝脏病理切片及酶联免疫吸... 详细信息

目的遵循补骨脂临床用药特点,基于蛋白质组学探究其对于斑马鱼肝脏影响及其潜在肝毒性机制。方法以低、中、高浓度补骨脂水煎液(0.025、0.050、0.100 mg·mL-1)连续对成年斑马鱼给药21 d,比较斑马鱼体重变化、肝脏病理切片及酶联免疫吸附试验(ELISA)测定血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)的含量变化;基于鉴定的肝脏蛋白质组学,通过聚类分析和通路富集分析研究潜在肝毒性机制,并结合分子对接探究补骨脂主要肝毒性成分的潜在毒性靶点。结果补骨脂水煎液给药组斑马鱼与空白组相比,给药组斑马鱼体重明显下降,且随着给药浓度的增加体重下降更加明显。补骨脂给药组的ALT、AST含量升高,差异具有统计学意义(P<0.05),且具有明显的剂量依赖性。苏木精一伊红(HE)染色结果显示,补骨脂给药组的肝脏组织与对照组相比肝细胞排列混乱、间隙增加,伴有脂肪变性、免疫细胞侵润等现象,且病变程度随着给药剂量的升高肝脏病变越发严重。基于蛋白质组学的聚类和功能富集分析表明,补骨脂影响斑马鱼肝脏中脂质和能量代谢相关的蛋白质乙酰辅酶A乙酰转移酶1(acat1)、3-羟基酰基辅酶A脱氢酶(ehhadh)、琥珀酸脱氢酶(sdha与sdhb)的表达,且分子对接发现补骨脂中主要肝毒性成分具有与此类蛋白结合的潜能。结论长时间补骨脂给药造成肝脏脂质代谢紊乱,最终产生以脂肪变性为代表的肝毒性,其潜在毒性机制为补骨脂主要肝毒性成分介导的脂质和能量代谢相关蛋白的表达异常。

关键词：补骨脂肝毒性脂肪变性蛋白质组学脂质能量代谢分子对接斑马鱼

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Inosine:A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation

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Journal of Pharmaceutical Analysis 2023年第1期13卷 11-23页

作者： Ningning Wang Entao Li huifang deng Lanxin Yue Lei Zhou Rina Su Baokun He Chengcai Lai Gaofu Li Yuwei Gao Wei Zhou Yue Gao Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing100850China Tianjin University of Traditional Chinese Medicine Tianjin301617China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun130122China College of Veterinary Medicine Jilin Agricultural UniversityChangchun130022China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced cytokine storms constitute the primary cause of coronavirus disease 19(COVID-19)progression,severity,criticality,and *** and anti-cytokine therapies are frequently administered to treat COVID-19,but have limited clinical efficacy in severe and critical ***,the weaknesses of these treatment modalities have prompted the development of anti-inflammatory therapy against this *** found that the broad-spectrum anti-inflammatory agent inosine downregulated proinflammatory interleukin(IL)-6,upregulated anti-inflammatory IL-10,and ameliorated acute inflammatory lung injury caused by multiple infectious *** significantly improved survival in mice infected with *** indirectly impeded TANK-binding kinase 1(TBK1)phosphorylation by binding stimulator of interferon genes(STING)and glycogen synthase kinase-3β(GSK3β),inhibited the activation and nuclear translocation of the downstream transcription factors interferon regulatory factor(IRF3)and nuclear factor kappa B(NF-κB),and downregulated IL-6 in the sera and lung tissues of mice infected with lipopolysaccharide(LPS),H1N1,or ***,inosine administration is feasible for clinical anti-inflammatory therapy against severe and critical ***,targeting TBK1 is a promising strategy for inhibiting cytokine storms and mitigating acute inflammatory lung injury induced by SARS-CoV-2 and other infectious agents.

关键词： Cytokine stormInterleukin 6 (IL-6)InosineSARS-CoV-2TANK-binding kinase 1 (TBK1)

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毛竹扩张对南亚热带常绿阔叶林土壤跳虫群落特征的影响

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中南林业调查规划 2024年第1期43卷 51-57,70页

作者：佟富春吴智华林瑞雪吴晓君邓惠方黄子峻李仁杰栾军伟华南农业大学林学与风景园林学院广东广州510642 国际竹藤中心竹藤资源与环境研究所北京100102

以广州市流溪河国家森林公园内的毛竹林、竹阔混交林和常绿阔叶林为研究对象,探讨2018—2019年的旱、雨季,毛竹扩张对土壤理化性质的影响,及其引起的土壤跳虫群落特征的改变。研究结果显示:①共捕获土壤跳虫4455头,隶属于12科27属,其中... 详细信息

以广州市流溪河国家森林公园内的毛竹林、竹阔混交林和常绿阔叶林为研究对象,探讨2018—2019年的旱、雨季,毛竹扩张对土壤理化性质的影响,及其引起的土壤跳虫群落特征的改变。研究结果显示:①共捕获土壤跳虫4455头,隶属于12科27属,其中,符跳属、拟裸长角跳属和小圆跳属为优势属。②3种类型样地中土壤跳虫的个体密度和类群数均为雨季高于旱季。旱季所有指标在不同林分类型之间无显著差异。雨季土壤跳虫的个体密度、类群数、Shannon⁃Weiner多样性指数、Simpson优势度指数和Margalef丰富度指数均表现为毛竹林>竹阔混交林>常绿阔叶林,Pielou均匀度指数为竹阔混交林>毛竹林>常绿阔叶林。③随着毛竹扩张,凋落物层的β-葡糖苷酶、酸性磷酸酶、β-乙酰葡糖胺糖苷酶和土壤有机碳显著降低,导致土壤跳虫的个体密度、类群数显著增加,多样性亦增加,但扩张中过渡类型的竹阔混交林跳虫多样性减少。毛竹扩张不同阶段中土壤跳虫的大部分优势属和常见属相同,表明土壤跳虫群落在毛竹扩张过程中具有一定的稳定性。

关键词：毛竹扩张土壤跳虫群落结构常绿阔叶林广州市流溪河国家森林公园

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Joint Toxicity Determination of Clopyralid,Picloram and Benazolin Mixtures on Broad-leaved Weed Lapsana apogonoides *** Rape Fields

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Agricultural Biotechnology 2021年第5期10卷 56-57,97页

作者： Xiong LI Jingbo LI huifang deng Yunyun ZHOU Kaifa GUO Xiongmei ZHU Chenzhong JIN Guiying LIU Key Laboratory of Harmless Application of Pesticide in Hunan Higher Education Hunan University of HumanitiesScience and TechnologyLoudi 417000China Collaborative Innovation Center for Field Weeds Control Hunan University of HumanitiesScience and TechnologyLoudi 417000China

[Objectives]This study was conducted to investigate the compounding of three herbicides:clopyralid,picloram and benazolin,so as to improve the effectiveness of herbicides.[Methods]With Lapsana apogonoides *** the target and clopyralid,picloram and benazolin as the test agents,seven gradient concentrations were set up to determine the joint toxicity of the three agents.[Results]When the compounding ratio of picloram,clopyralid and benazolin was 2∶1∶6,the maximum co-toxicity coefficient was 290.0.[Conclusions]The compounding of picloram,clopyralid and benazolin has a significant synergistic effect on ***,which reduces production costs and environmental pressure,providing technical support for the effective control of broad-leaved weeds such as ***.

关键词： Clopyralid Picloram Benazolin Rape Weeds Joint toxicity

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