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Clinical significance and prognostic value of tumor necrosis factor-α and dickkopf related protein-1 in ankylosing spondylitis

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World Journal of Clinical Cases 2020年第7期8卷 1213-1222页

作者： jun-hui xiong Jian Liu Jian Chen Department of Rheumatology Lishui People’s HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Ankylosing spondylitis(AS)frequently occurs in people aged 30-45 years,and its prevalence is generally believed to be between 0.1%and 1.4%*** present,the“gold standard”for diagnosis of AS requires the provision of pelvic X-rays,which makes it more difficult to perform in population-based epidemiological ***,the identification of serological indicators related to the diagnosis,treatment,and prognosis of AS patients is of great *** To analyze the therapeutic,diagnostic significance and prognostic value of dickkopf-related protein-1(DKK-1)and tumor necrosis factor-α(TNF-α)in *** A total of 113 patients with active AS were selected as the research group,and 100 healthy subjects who underwent physical examination were selected as the control *** levels of DKK-1 and TNF-α in peripheral blood in the two groups were *** diagnostic and predictive values of DKK-1 and TNF-α for AS were analyzed with ROC curves,and the factors influencing AS recurrence were analyzed with COX *** Before treatment,the research group showed lower DKK-1 levels but higher TNF-αlevels than the control group(both aP<0.05).In the research group,DKK-1 was up-regulated and TNF-αwas down-regulated after 12 wk of treatment(aP<0.05).The area under the curve,sensitivity and specificity of DKK-1 combined with TNF-αfor diagnosing AS were 0.934,82.30%and 97.00%,*** treatment,the area under the curve,cutoff value,sensitivity and specificity of DKK-1 for predicting the curative effect were 0.825,68.42 pg/mL,73.68%and 80.00%,respectively,and those of TNF-αwere 0.863,32.79 ng/L,92.11%and 77.33%,***-1 and TNF-αlevels after treatment were closely related to the curative effect(aP<0.05).C-reactive protein,the Bath Ankylosing Spondylitis Disease Activity Index,DKK-1,and TNF-αwere risk factors for AS recurrence(aP<0.05).CONCLUSION DKK-1 and TNF-αare effective in the diagnosis and treatment of AS and are risk f

关键词： Dickkopf-related protein-1 Tumor necrosis factor-α Ankylosing spondylitis Diagnosis Prognosis Peripheral blood

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Predicting overlapping protein complexes in weighted interactome networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第10期14卷 756-765页

作者： Wen-yin NI hui-jun xiong Bi-hai ZHAO Sai HU Department of Information and Computing Science Changsha University

Protein complexes play important roles in integrating individual gene products to perform useful cellular *** increasing mount of protein–protein interaction(PPI)data has enabled us to predict protein *** spite of the advances in these computational approaches and experimental techniques,it is impossible to construct an absolutely reliable PPI *** into account the reliability of interactions in the PPI network,we have constructed a weighted protein–protein interaction(WPPI)network,in which the reliability of each interaction is represented as a weight using the topology of the PPI *** overlaps are likely to have biological importance,we proposed a novel method named WN-PC(weighted network-based method for predicting protein complexes)to predict overlapping protein complexes on the WPPI *** proposed algorithm predicts neighborhood graphs with an aggregation coefficient over a threshold as candidate complexes,and binds attachment proteins to candidate ***,we have filtered redundant complexes which overlap other complexes to a very high extent in comparison to their density and size.A comprehensive comparison between competitive algorithms and our WN-PC method has been made in terms of the F-measure,coverage rate,and *** have applied WN-PC to two different yeast PPI data sets,one of which is a huge PPI network consisting of over 6000 proteins and 200000 *** results show that WN-PC outperforms the state-of-the-art *** think that our research may be helpful for other applications in PPI networks.

关键词： Protein–protein interaction Weighted network Overlap

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AKINβ1 is Involved in the Regulation of Nitrogen Metabolism and Sugar Signaling in Arabidopsis

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Journal of Integrative Plant Biology 2009年第5期51卷 513-520页

作者： Xiao-Fang Li Yu-Ju Li Ying-hui An Li-jun xiong Xing-Hua Shao Yang Wang Yue Sun School of Life Sciences East China Normal University Shanghai 200062 China

Sucrose non-fermenting-l-related protein kinase 1 （SnRK1） has been located at the heart of the control of metabolism and development in plants. The active SnRK1 form is usually a heterotrimeric complex. Subcellular localization and specific target of the SnRK1 kinase are regulated by specific beta subunits. In Arabidopsis, there are at least seven genes encoding beta subunits, of which the regulatory functions are not yet clear. Here, we tried to study the function of one beta subunit, AKINβ1. It showed that AKINβ1 expression was dramatically induced by ammonia nitrate but not potassium nitrate, and the investigation of AKINβ1 transgenic Arabidopsis and T-DNA insertion lines showed that AKINβ1 negatively regulated the activity of nitrate ruductase and was positively involved in sugar repression in early seedling development. Meanwhile AKIN/β1 expression was reduced upon sugar treatment （including mannitol） and did not affect the activity of sucrose phosphate synthase. The results indicate that AKIN/β1 is involved in the regulation of nitrogen metabolism and sugar signaling.

关键词： AKIN/β1 metabolism nitrate reductase sucrose phosphate synthase sugar signaling

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Overlap maximum matching ratio （OMMR）： a new measure to evaluate overlaps of essential modules

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Frontiers of Information Technology & Electronic Engineering 2015年第4期16卷 293-300页

作者： Xiao-xia ZHANG Qiang-hua XIAO Bin LI Sai HU hui-jun xiong Bi-hai ZHAO Department of Mathematics and Computer Science Changsha University Changsha 410003 China School of lnformation Science and Engineering Central South University Changsha 410083 China

Protein complexes are the basic units of macro-molecular organizations and help us to understand the cell's *** development of the yeast two-hybrid,tandem affinity purification,and mass spectrometry high-throughput proteomic techniques supplies a large amount of protein-protein interaction data,which make it possible to predict overlapping complexes through computational *** shows that overlapping complexes can contribute to identifying essential proteins,which are necessary for the organism to survive and reproduce,and for life's *** pay more attention to the evaluation of protein ***,few of them focus on predicted *** this paper,an evaluation criterion called overlap maximum matching ratio(OMMR) is proposed to analyze the similarity between the identified overlaps and the benchmark overlap *** of essential proteins and gene ontology(GO) analysis are also used to assess the quality of *** perform a comprehensive comparison of serveral overlapping complexes prediction approaches,using three yeast protein-protein interaction(PPI) *** focus on the analysis of overlaps identified by these *** results indicate the important of overlaps and reveal the relationship between overlaps and identification of essential proteins.

关键词： Protein-protein interaction network Essential protein modules Overlap Overlap maximum matching ratio

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[Research advances in the transplacental transfer efficiencies of environmental pollutants]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 13-21页

作者： Ke-Yu Yuan jun xiong Bi-Feng Yuan School of Public Health Wuhan University Wuhan 430071 China.

Industrialization has led to significant increases in the types and quantities of pollutants, with environmental pollutants widely present in various media, including the air, food, and everyday items. These pollutants can enter the human body via multiple pathways, including ingestion through food and absorption through the skin; this intrusion can disrupt the production, release, and circulation of hormones in the body, resulting in a range of illnesses that affect the reproductive, endocrine, and nervous systems. Consequently, these pollutants pose substantial risks to human health. In particular, fetuses are highly sensitive to environmental pollutants during critical stages of development, and exposure during periods of growth and development can result in more-obvious and severe health hazards that can lead to preterm birth, low birth weight, and fetal malformations. The placenta acts as a barrier between the mother and fetus, and selectively filters certain pollutants. While some pollutants remain in the maternal bloodstream, others cross the placental barrier into the fetal umbilical blood through passive diffusion, placental transport proteins, or endocytosis. The transplacental transfer efficiency (TTE) is the ratio of the level of the pollutant in the umbilical blood to that in the maternal blood, and is a valuable metric for evaluating the ability of a pollutant to breach the placental barrier. A higher TTE implies that a larger proportion of pollutants are transferred from the mother to the fetus, thereby amplifying the potential risks to the fetus. Mass spectrometry-based detection methods are extensively used in the chemical and environmental sciences because they are exceptionally sensitive and highly resolving. This analytical technique involves ionizing compounds within a sample and identifying them based on their distinct mass-to-charge ratios; it enables both qualitative and quantitative analyses of various environmental pollutants. Current metho

关键词： chromatography-mass spectrometry environmental pollutants organochlorine pesticides (OCPs) per- and polyfluoroalkyl substances (PFASs) polybrominated diphenyl ethers (PBDEs) polychlorinated biphenyls (PCBs) review transplacental transfer efficiency (TTE)

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Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei xiong Xuan Ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan xiong Xin Wang junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

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Adaptive-basis decomposition-based low-rank network for efficient non-uniform motion deblurring

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Optoelectronics Letters 2025年第1期21卷 43-50页

作者： CHEN Lei xiong Qingbo ZHANG Wei LI Runde School of Software Henan University School of Applied Technology China University of Labor Relations

In this study, we present a unified sparsity-driven framework that significantly enhances motion deblurring performance by integrating two key components: a custom-designed dataset and a low-rank module(LRM). This framework leverages the inherent sparsity of per-pixel blur kernels to bolster both deblurring accuracy and model interpretability. Firstly, we propose an adaptive-basis decomposition-based deblurring(ADD) approach, which constructs a tailored training dataset to enhance the generalization capacity of the deblurring network. The ADD framework adaptively decomposes motion blur into sparse basis elements, effectively addressing the intricacies associated with non-uniform blurs. Secondly, an LRM is proposed to improve the interpretability of deblurring models as a plug-and-play module, primarily designed to identify and harness the intrinsic sparse features in sharp images. A series of ablation studies have been conducted to substantiate the synergistic advantages of combining the proposed ADD with the LRM for overall improvement in deblurring efficacy. Subsequently, we empirically demonstrate through rigorous experimentation that incorporating the LRM into an existing Uformer network leads to substantial enhancement in reconstruction performance. This integration yields a sparsity-guided low-rank network(SGLRN). Operating under the overarching principle of sparsity, SGLRN consistently outperforms state-of-the-art methods across multiple standard deblurring benchmarks. Comprehensive experimental results, assessed through quantitative metrics and qualitative visual evaluations, provide compelling evidence of its effectiveness. The overall deblurring results are available at Google Drive.

关键词： Image enhancement

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-hui Chen Peng Zhao Wen-Bo Deng Ji xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi xiong Qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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