Overlap maximum matching ratio （OMMR）： a new measure to evaluate overlaps of essential modules

作     者：Xiao-xia ZHANG Qiang-hua XIAO Bin LI Sai HU Hui-jun XIONG Bi-hai ZHAO 

作者机构：Department of Mathematics and Computer Science Changsha University Changsha 410003 China School of lnformation Science and Engineering Central South University Changsha 410083 China 

出 版 物：《Frontiers of Information Technology & Electronic Engineering》 (信息与电子工程前沿（英文版）)

年 卷 期：2015年第16卷第4期

页      面：293-300页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0835[工学-软件工程] 081202[工学-计算机软件与理论] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：Project supported by the National Scientific Research Foundation of Hunan Province  China (Nos. 14C0096  10C0408  and 10B010)  the Natural Science Foundation of Hunan Province  China (Nos. 13JJ4106 and 14J J3138)  and the Science and Technology Plan Project of Hunan Province  China (No. 2010FJ3044) 

主　　题：Protein-protein interaction network Essential protein modules Overlap Overlap maximum matching ratio 

摘      要：Protein complexes are the basic units of macro-molecular organizations and help us to understand the cell s *** development of the yeast two-hybrid,tandem affinity purification,and mass spectrometry high-throughput proteomic techniques supplies a large amount of protein-protein interaction data,which make it possible to predict overlapping complexes through computational *** shows that overlapping complexes can contribute to identifying essential proteins,which are necessary for the organism to survive and reproduce,and for life s *** pay more attention to the evaluation of protein ***,few of them focus on predicted *** this paper,an evaluation criterion called overlap maximum matching ratio(OMMR) is proposed to analyze the similarity between the identified overlaps and the benchmark overlap *** of essential proteins and gene ontology(GO) analysis are also used to assess the quality of *** perform a comprehensive comparison of serveral overlapping complexes prediction approaches,using three yeast protein-protein interaction(PPI) *** focus on the analysis of overlaps identified by these *** results indicate the important of overlaps and reveal the relationship between overlaps and identification of essential proteins.