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Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion

Neural Regeneration Research 2019年第11期14卷 1977-1985页

作者： guo-Qian He Wen-Ming Xu hui-juan Liao Chuan Jiang Chang-Qing Li Wei Zhang Department of Pediatrics Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University)Ministry of EducationWest China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina Joint Laboratory of Reproductive Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University)Ministry of EducationWest China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Neurology The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Medical Oncology Sichuan Cancer Hospital & InstituteSichuan Cancer CenterCancer Hospital Affiliated to School of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina

HECT, UBA and WWE domain-containing 1(Huwe1), an E3 ubiquitin ligase involved in the ubiquitin-proteasome system, is widely expressed in brain tissue. Huwe1 is involved in the turnover of numerous substrates, including p53, Mcl-1, Cdc6 and N-myc, thereby playing a critical role in apoptosis and neurogenesis. However, the role of Huwe1 in brain ischemia and reperfusion injury remains unclear. Therefore, in this study, we investigated the role of Huwe1 in an in vitro model of ischemia and reperfusion injury. At 3 days in vitro, primary cortical neurons were transduced with a control or shRNA-Huwe1 lentiviral vector to silence expression of Huwe1. At 7 days in vitro, the cells were exposed to oxygen-glucose deprivation for 3 hours and reperfusion for 24 hours. To examine the role of the c-Jun N-terminal kinase(JNK)/p38 pathway, cortical neurons were pretreated with a JNK inhibitor(SP600125) or a p38 MAPK inhibitor(SB203508) for 30 minutes at 7 days in vitro, followed by ischemia and reperfusion. Neuronal apoptosis was assessed by TUNEL assay. Protein expression levels of JNK and p38 MAPK and of apoptosis-related proteins(p53, Gadd45 a, cleaved caspase-3, Bax and Bcl-2) were measured by western blot assay. Immunofluorescence labeling for cleaved caspase-3 was performed. We observed a significant increase in neuronal apoptosis and Huwe1 expression after ischemia and reperfusion. Treatment with the shRNA-Huwe1 lentiviral vector markedly decreased Huwe1 levels, and significantly decreased the number of TUNEL-positive cells after ischemia and reperfusion. The silencing vector also downregulated the pro-apoptotic proteins Bax and cleaved caspase-3, and upregulated the anti-apoptotic proteins Gadd45 a and Bcl-2. Silencing Huwe1 also significantly reduced p-JNK levels and increased p-p38 levels. Our findings show that downregulating Huwe1 affects the JNK and p38 MAPK signaling pathways as well as the expression of apoptosis-related genes to provide neuroprotection during ische

关键词： nerve regeneration ischemic stroke oxygen-glucose deprivation and reperfusion ischemia/reperfusion cortical neuron ubiquitin proteasome system Huwe1 apoptosis therapeutic targets cell culture cell death neural regeneration

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Quantum Discord Behavior about Two-Qubit Heisenberg XYZ Model with Decoherence

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Chinese Physics Letters 2014年第3期31卷 18-22页

作者： SONG Le YANG guo-hui School of Physics and Information Engineering Shanxi Normal University Linfen 041004

We investigate the properties of quantum discord dynamics of a two-qubit Heisenberg XYZ system which is influenced by the environmental decoherence under an external nonuniform magnetic field. It shows that the influence of the parameters on the system heavily rely on the selection of the initial states. One point shows that the environmental decoherence cannot entirely destroy the quantum correlation, and properly controlling the parameters can inhibit the decoherence. Moreover, it presents that the inhomogeneous magnetic field cannot affect the steady quantum discord （QD）, while the uniform magnetic field and the anisotropy coupling constant will change the steady QD. These investigations imply that one can obtain larger steady QD values by reasonably adjusting parameters on quantum correlation in solid state systems.

关键词： QUBITS RESEARCH DECOHERENCE (Quantum mechanics) QUANTUM mechanics MAGNETIC fields PHYSICS research

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Preparation of microsized crosslinked microspheres by dispersion copolymerization of polystyrene/polyethylene glycol 200-dimethacrylae

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Journal of University of Science and Technology Beijing 2006年第4期13卷 380-384页

作者： Wenli guo juan Wang Tongxiang Liang Institute of Nuclear Energy Technology Tsinghua University Beijing 100084 China

Dispersion copolymerization of styrene with polyethylene glycol 200-dimethacrylae as the cross-linking agent was completed by using poly（N-vinyl pyrrolidone） and 2,2-azo-bisisobutyronitrile as the steric stabilizer and initiator, respectively. Crosslinked copolymeric microspheres were prepared directly by the one-step method of dispersion copolymerization. The effects of the content of polyethylene glycol 200-dimethacrylae on the particle morphology and the copolymerization rate were investigated. It shows that the crosslinking agent plays an important role in the particle morphology and the system stability. When the content of crosslinking reached 2.5wt%, the floriated particles were obtained.

关键词： polystyrene microsphere dispersion polymerization crosslinking agent

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Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

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Rare Metals 2024年第4期43卷 1610-1621页

作者： Bing-Bing Liu Yi-hui Liu You-Bin Zhang Zhen-guo Qi guo-hui Qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

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Architectural Design of a Cloud Robotic System for Upper-Limb Rehabilitation with Multimodal Interaction

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Journal of Computer Science & Technology 2017年第2期32卷 258-268页

作者： hui-Jun Li Ai-guo Song School of Instrument Science and Engineering Southeast University Nanjing 210096 China

The rise in the cases of motor impairing therapy. Due to the current situation that the service illnesses demands the research for improvements in rehabilitation of the professional therapists cannot meet the need of the motorimpaired subjects, a cloud robotic system is proposed to provide an Internet-based process for upper-limb rehabilitation with multimodal interaction. In this system, therapists and subjects are connected through the Internet using client/server architecture. At the client site, gradual virtual games are introduced so that the subjects can control and interact with virtual objects through the interaction devices such as robot arms. Computer graphics show the geometric results and interaction haptic/force is fed back during exercising. Both video/audio information and kinematical/physiological data axe transferred to the therapist for monitoring and analysis. In this way, patients can be diagnosed and directed and therapists can manage therapy sessions remotely. The rehabilitation process can be monitored through the Internet. Expert libraries on the central server can serve as a supervisor and give advice based on the training data and the physiological data. The proposed solution is a convenient application that has several features taking advantage of the extensive technological utilization in the area of physical rehabilitation and multimodal interaction.

关键词： cloud robot multimodal interaction motor rehabilitation haptic/force feedback

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ON NODAL LINE OF THE SECOND EIGENFUNCTION OF THE LAPLACIAN OVER CONCAVE DOMAINS IN R^2

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Journal of Systems Science & Complexity 2013年第3期26卷 483-488页

作者： YANG Dong-hui guo Bao-Zhu Department of Mathematics Central South University Academy of Mathematics and Systems Science Academia Sinica

In this note,the Payne's conjecture from convex domains to concave domains is *** is shown that the nodal line N of the second eigenfunction of the Laplacian over some simply connected concave domain Ω in R^2 must in... 详细信息

关键词： Eigenfunction eigenvalue Laplacian.

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A new method in highway route design:joining circular arcs by a single C-Bézier curve with shape parameter

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第4期10卷 562-569页

作者： Hua-hui CAI guo-jin WANG Institute of Computer Graphics and Image Processing State Key Lab of CAD & CG Zhejiang University Hangzhou 310027 China

We constructed a single C-Bezier curve with a shape parameter for G^2 joining two circular arcs. It was shown that an S-shaped transition curve, which is able to manage a broader scope about two circle radii than the Bezier curves, has no curvature extrema, while a C-shaped transition curve has a single curvature extremum. Regarding the two kinds of curves, specific algorithms were presented in detail, strict mathematical proofs were given, and the effectiveness of the method was shown by examples This method has the following three advantages：（1） the pattern is unified; （2） the parameter able to adjust the shape of the transition curve is available; （3） the transition curve is only a single segment, and the algorithm can be formulated as a low order equation to be solved for its positive root. These advantages make the method simple and easy to implement.

关键词： Transition curve C-Bezier curve Monotone curvature Shape parameter

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A NEW WELL TEST MODEL FOR A TWO-ZONE LINEAR COMPOSITE RESERVOIR WITH VARIED THICKNESSES

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Journal of Hydrodynamics 2010年第6期22卷 804-809页

作者： ZHANG Lie-hui guo Jing-jing LIU Qi-guo State Key Laboratory of Reservoir Geology and Exploitation Southwest Petroleum University Chengdu 610500China

This article presents a new well test model for two-zone linear composite reservoirs, where the rock and fluid properties as well as the formation thicknesses on both sides of the discontinuity are distinctly different. An analytical solution of pressure-transient behavior for a line-source, constant-rate well in this type of reservoir configuration is obtained with Fourier space transformation and Laplace transformation. By applying Duhamel principle, the wellbore storage and skins effects can easily be included. A set of type curves are generated and the sensitivities of the relevant parameters are discussed. A new correlating parameter MhDl√ηD is proposed to identify the pressure response in the pressure derivative curve. The model as well as the corresponding type curves are quite general that they are useful in predicting the production performance or analyzing the production data from this type of well-reservoir systems.

关键词： non-uniform thickness linear composite well test model type curve

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Experimental study of a highway bridge with shape memory alloy restrainers focusing on the mitigation of unseating and pounding

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Earthquake Engineering and Engineering Vibration 2012年第2期11卷 195-204页

作者： guo, Anxin Zhao, Qingjie Li, hui School of Civil Engineering Harbin Institute of Technology Harbin 150090 China School of Civil Engineering the 2nd Campus Harbin Institute of Technology P.O. Box 2537 Harbin 150090 China

This paper presents an experimental study to investigate the performance of shape memory alloy(SMA) restrainers for mitigating the pounding and unseating of highway bridges when subjected to seismic *** property tests of the SMA wire used in the restrainers are conducted first to understand the pseudo-elastic characteristics of the ***,a series of shaking table tests are carried out on a highway bridge *** structural responses of the highway bridge model equipped with SMA restrainers,installed in the form of deck-deck and deck-pile connections,are analyzed and compared with the uncontrolled *** test results of this study indicate that the SMA restrainers are not only effective in preventing unseating but also in suppressing the seismic-induced pounding of the highway bridge model used in this study.

关键词： shape memory alloy restrainer unseating pounding highway bridge

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Dynamically switchable porphyrin-based molecular tweezer for on-off fullerene recognition

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Chinese Chemical Letters 2024年第6期35卷 283-287页

作者： Zhimin Sun Xin-hui guo Yue Zhao Qing-Yu Meng Li-juan Xing He-Lue Sun College of Chemistry and Materials Science Hebei Key Laboratory of Organic Functional MoleculesHebei Normal UniversityShijiazhuang 050024China

Herein,a novel molecular tweezer based on 2,2'-bipyridine-bridged porphyrin subunits was constructed for efficient fullerenes *** syn conformation of the molecule,which was obtained by Zn(Ⅱ)coordination,gives rise to a proper cavity to interact with fullerene guests to form a stable 1:1 complex in toluene *** exhibits distinct binding selectivity towards C_(60)over C_(70).Moreover,the fullerene recognition capacity can be adequately suppressed by importing H_(2)PO_(4)^(-)to competitively capture Zn(Ⅱ)along with syn-anti conformational ***,the molecular tweezer regenerated to bind the fullerene by introducing the Ca^(2+)into the ***,the association-disassociation process can be switched reversibly and repeatedly.

关键词： Molecular tweezer Fullerene recognition Supramolecular chemistry Conformation conversion Coordination

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