检索结果-南通市图书馆

Association between body mass index and the risk of bleeding in elderly patients with non-valvular atrial fibrillation taking dabigatran:a cohort study

引用

Journal of Geriatric Cardiology 2020年第4期17卷 193-201页

作者： Ming-hui LI Li-Hua HU Yu-Rong XIONG Yu YU Wei ZHOU Tao WANG Ling-Juan ZHU Xi LIU hui-hui bao Xiao-Shu CHENG Department of Cardiovascular Medicine the Second Affiliated Hospital of Nanchang UniversityJiangxiChina Center for Prevention and Treatment of Cardiovascular Diseases the Second Affiliated Hospital of Nanchang UniversityJiangxiChina Center of Cardiovascular Inner Mongolia People’s HospitalHohhotInner MongoliaChina

Background Uncertainty remains regarding the association between body mass index(BMI)and the risk of bleeding in patients with non-valvular atrial fibrillation(NVAF).We aimed to investigate the association between BMI and the risk of bleeding in elderly NVAF patients taking *** A total of 509 elderly NVAF patients,who were being treated at twelve centers in China from February 2015 to December 2017 and taking dabigatran,were *** exposure and outcome variables were BMI at baseline and bleeding events within the subsequent six months,*** proportional hazards regression analysis was used to evaluate the association between BMI and the risk of ***,the Cox proportional hazards regression with cubic spline functions and smooth curve fitting was *** During the six-month follow-up,50 participants experienced *** 1 kg/m^2 increase in BMI was associated with a 12%increased risk of bleeding(P=0.021).Compared to those with BMI values in Tertile 1(25.3 kg/m^2)were 2.71(95%CI:1.02–7.17)and 3.5(95%CI:1.21–8.70),*** Ptrend-value was significant in all *** adjusted smooth curve showed a linear association between BMI and *** of the stratified variables showed significant effect modification on the association between BMI and bleeding(Pinteraction>0.05).Conclusions BMI was significantly and positively associated with the risk of bleeding in elderly NVAF patients treated with dabigatran.

关键词： Atrial fibrillation Bleeding Body mass index Dabigatran

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of ketamine on proinflammatory cytokines and nuclear factor kappaB in polymicrobial sepsis rats

引用

World Journal of Gastroenterology 2006年第45期12卷 7350-7354页

作者： Xue-Min Song Jian-Guo Li Yan-Lin Wang Qing Zhou Zhao-hui Du bao-hui Jia Jian-Juan Ke Department of Anesthesiology Zhongnan Hospital of Wuhan University Wuhan 430071 Hubei Province China

AIM： To explore the effects of ketamine on hemodynamics, plasma proinflammatory cytokine （TNF-α and IL-6） levels and nuclear factor kappa B （NF-κB） activation during polymicrobial sepsis. METHODS： Male Sprague-Dawlay rats were subjected to cecal ligation and puncture （CLP） or sham operation. The rats were randomly assigned into four equal groups： sham CLP group, CLP group, ketamine （KT）Ⅰ group and KTⅡgroup. Thirty minutes before CLP, ketamine （5 mg/kg per hour and 10 mglkg per hour, respectively） was infused continuously through the left femoral vein cannula in KT Ⅰ group or KTⅡgroup. Sham CLP group and CLP group received 0.9% saline only （5 mL/kg per hour）. The right femoral artery was cannulated to monitor mean arterial pressure （MAP） and heart rates （HR）,and draw blood samples. The proinflammatory cytokine （TNF-α and IL-6） levels of plasma were measured using enzyme-linked immunosorbent assays （ELISA）. The hepatic NF-κB activation was determined by Western blot and HPIAS 2000 image analysis system. Twenty hours after CLP, the rats were killed by right femoral artery phlebotomization. RESULTS： CLP produced progressive hypotension, and a first increase followed by a decrease in HR. The hypotension was prevented, and the HR was slightly steady in ketamine treated rats. TNF-α levels of plasma reached a peak value at 2 h after CLP. Ketamine （KT Ⅰ group or KTⅡgroup） caused a significant decrease compared with CLP group at 2, 5 and 9 h time points after CLP （14.3 ± 1.9 vs 4.3 ± 0.9, 9.7 ± 1.4 vs 4.3 ± 0.9; 9.3 ± 1.5 vs 4.3 ± 0.9, 8.7 ± 1.4 vs 4.3 ±0.9; 6.0 ± 1.5 vs 5.0 ± 1.7, 5.3 ± 0.8 vs 5.0 ± 1.7; P 〈 0.01, respectively）. The IL-6 levels of plasma firstly ascended and then descended in CLP group, and reached a peak value at 9 h after CLP. Ketamine （KT I group or KTH group） caused a significant decrease compared with CLP group at 5, 9 or 20 h after CLP （135.0 ± 52.6 vs 60.0 ± 16.3, 112.5 ± 52.6 vs 60.0 ± 16.3; 410.0 ± 68.7 vs 62.5 ± 12.5, 250.0 ± 28.0 vs 62.5 ± 12.

关键词： Ketamine Sepsis Hemodynamics Tumor necrosis factor α Interleukin 6 Nuclear factor kappa B

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Individual and joint effects of borderline ankle-brachial index and high plasma total homocysteine on all-cause death in hypertensive adults

引用

Journal of Geriatric Cardiology 2022年第7期19卷 522-530页

作者： Jun-Pei LI Tian-Yu CAO Xiao-Yuan ZHA Yun YU Zi-Heng TAN Zai-Hua CHENG Hua-Bo YING Wei ZHOU Lin-Juan ZHU Tao WANG Li-Shun LIU hui-hui bao Xiao HUANG Xiao-Shu CHENG Department of Cardiology the Second Affiliated Hospital of Nanchang UniversityNanchangChina University of California Santa BarbaraCAUSA Rancheng Community Health Service Center WuyuanChina Center for Prevention and Treatment of Cardiovascular Diseases the Second Affiliated Hospital of Nanchang UniversityNan-changChina Graduate School at Shenzhen Tsinghua UniversityShenzhenChina

BACKGROUND The cardiovascular hazards of total homocysteine(tHcy)are long *** addition,despite the acknow-ledgment on the importance of low ankle-brachial index(ABI)(<0.9),borderline ABI(0.91-0.99)was once commonly *** study aims to explore the independent and joint effect of tHcy level and borderline ABI on all-cause death in hypertensive *** This study included 10,538 participants from China H-type Hypertension Registry *** was described into two groups:normal ABI(1.00-1.40)and borderline *** level was also divided into two groups:<15.02 and≥15.02μmo/*** groups were analyzed,using COX proportional hazard regression model,separately and pairwise to observe the independ-ent and joint effect on all-cause *** A total of 126(1.2%)deaths were observed in the 1.7 years follow-up *** ABI has a higher predicted risk of death than normal ABI(HR=1.87,95%CI:1.17-3.00)after adjusting for potential *** with tHcy level<15.02μmo/L(low tHcy),those with tHcy≥15.02μmo/L(high tHcy)had higher risk to event outcome(HR=1.99,95%CI:1.30-3.05).According to the cumulative hazard curve,group with borderline ABI and high tHcy level has significantly higher altitude and larger increasing rate over follow-up period compare to other *** those with borderline ABI,participants with high tHcy had higher death risk than those with low tHcy,nevertheless,no significant different between borderline and normal ABI among those with low tHcy *** Borderline ABI and tHcy level both have independent predictive value on all-cause *** combined group of borderline ABI and high tHcy has highest risk factor of outcomes,which suggested the mutual additive value of border-line ABI and *** attention should be given to the importance of borderline ABI in hypertensive population,especially with elevated tHcy level.

关键词： hypertensive death ankle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

引用

Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao hui-Lin Jiang bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

引用

Science China Chemistry 2025年第1期68卷 201-208页

作者： hui-Feng Wang Wen-Jie Shi Yu-Xin Yang bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

引用

Tungsten 2025年第1期7卷 112-119页

作者： Jia-hui Li Qing Zhao Dong-Ao Mao Kun Zhou bao-Kuan Chen Yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Independent and joint association of physical activity and sedentary behavior on all-cause mortality

引用

Chinese Medical Journal 2021年第23期134卷 2857-2864页

作者： Wei Zhou Wei Yan Tao Wang Ling-Juan Zhu Yan Xu Jun Zhao Ling-Ling Yu hui-hui bao Xiao-Shu Cheng Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center NanchangJiangxi 330006China Chronic Disease Prevention and Control Institute Jiangxi Province Center for Disease Control and PreventionNanchangJiangxi 330006China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China.

Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese *** aimed to examine the independent and joint association of PA and SB with all-cause mortality in southern ***:A cohort of 12,608 China Hypertension Survey participants aged≥35 years were enrolled in 2013 to 2014,with a follow-up period of 5.4 *** self-reported PA and SB were collected via the ***–Meier curves(log-rank test)and Cox proportional hazards regression were performed to evaluate the associations of PA and SB on all-cause ***:A total of 11,744 eligible participants were included in the *** an average of 5.4 years of follow-up,796 deaths *** risk of all-cause mortality was lower among participants with high PA than those with low to moderate level(5.2%vs.8.9%;hazards ratio[HR]:0.75,95%confidence interval[CI]:0.61–0.87).Participants with SB≥6 h had a higher risk of all-cause mortality than those with SB<6 h(7.8%vs.6.0%;HR:1.37,95%CI:1.17–1.61).Participants with prolonged SB(≥6 h)and inadequate PA(low to moderate)had a higher risk of all-cause mortality compared to those with SB<6 h and high PA(11.2%vs.4.9%;HR:1.67,95%CI:1.35–2.06).Even in the participants with high PA,prolonged SB(≥6 h)was still associated with the higher risk of all-cause mortality compared with SB<6 h(7.0%vs.4.9%;HR:1.33,95%CI:1.12–1.56).Conclusions:Among Chinese population,PA and SB have a joint association with the risk of all-cause *** with inadequate PA and prolonged SB had the highest risk of all-cause mortality compared with others.

关键词： Physical activity Sedentary behavior All-cause mortality Joint association

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Peripheral leukocyte count and risk of bleeding in patients with non-valvular atrial fibrillation taking dabigatran: a real-world study

引用

Chinese Medical Journal 2019年第18期132卷 2150-2156页

作者： Wei Zhou Tao Wang Ling-Juan Zhu Ming-Hua Wen Li-Hua Hu Xiao Huang Chun-Jiao You Ju-Xiang Li Yan-Qing Wu Qing-Hua Wu hui-hui bao Xiao-Shu Cheng Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China

Background: The association between peripheral leukocyte count and bleeding events in nonvalvular atrial fibrillation (NVAF) patients treated with dabigatran remains unclear. This study aimed to explore the association between leukocyte count and bleeding events after excluding other confounders in NVAF patients taking dabigatran. Methods: A total of 851 NVAF patients treated with dabigatran (110 mg bid) were recruited from 12 centers in China from February 2015 to December 2017. Follow-up was completed by May 2018. The exposure and outcome variables were leukocyte count measured at baseline and the number of bleeding events within the subsequent 6 months. Multivariate Cox proportional hazards models were constructed to analyze independent associations, and a Cox proportional hazards regression with cubic spline functions and smooth curve fitting (penalized spline method) was used to address nonlinearity between leukocyte count and bleeding. The inflection point was calculated using a recursive algorithm, and then a two-piecewise Cox proportional hazards model for both sides of the inflection point was constructed. Results: During 6-month follow-up, 87 participants occurred bleeding events. For every 1×10^9/L increase in leukocyte count, the risk of bleeding increased by 11%(hazard ratio [HR]: 1.11, 95% confidence interval [CI]: 0.99–1.25). The smooth curve showed nonlinear relationship between leukocyte count and bleeding events. The inflection point of the leukocyte count was 6.75×10^9/L. For leukocyte counts < 6.75×10^9/L, the HR (95% CI) was 0.88 (0.69–1.13), and for leukocyte counts ≥ 6.75×10^9/L, the HR (95% CI) was 1.28 (1.09–1.51). Conclusion: This study found a J-shaped association between baseline leukocyte count and risk of bleeding in NVAF patients treated with dabigatran.

关键词： Peripheral leukocyte count Bleeding Nonvalvular atrial fibrillation Threshold effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

应用德尔菲法建立寄生虫病健康教育作品评价体系

引用

中国血吸虫病防治杂志 2018年第3期30卷 307-311,328页

作者：朱慧慧钱门宝周长海诸廷俊陈颖丹中国疾病预防控制中心寄生虫病预防控制所国家卫生和计划生育委员会寄生虫病原与媒介生物学重点实验室科技部国家级热带病国际联合研究中心世界卫生组织热带病合作中心上海200025

目的应用德尔菲研究方法建立寄生虫病健康教育作品评价体系,为健康教育作品评价提供参考。方法成立专家组,通过头脑风暴和面对面讨论确定寄生虫病健康教育作品评价指标。而后基于评价指标设计问卷,通过两轮专家咨询,最终确定各评价指标... 详细信息

目的应用德尔菲研究方法建立寄生虫病健康教育作品评价体系,为健康教育作品评价提供参考。方法成立专家组,通过头脑风暴和面对面讨论确定寄生虫病健康教育作品评价指标。而后基于评价指标设计问卷,通过两轮专家咨询,最终确定各评价指标的权重,形成完整的寄生虫病健康教育作品评价体系。结果专家组分别确定了平面作品、实物作品和影音作品的评价指标,3类作品分别包含4个一级指标和12个二级指标。通过两轮专家咨询,23位专家达成了一致意见,认为在一级指标中最重要的是作品的"科学性"和"可接受性";而在二级指标中,"信息准确性"和"行为指导性"最为重要。结论建立了科学、合理的评价体系,该体系可应用于寄生虫病健康教育作品的综合评价。

关键词：寄生虫病健康教育作品评价指标德尔菲法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A versatile synthetic strategy towards rare earth based metal-organic frameworks

引用

Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo Ya-Qing Feng bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：