Association between body mass index and the risk of bleeding in elderly patients with non-valvular atrial fibrillation taking dabigatran:a cohort study

作     者：Ming-Hui LI Li-Hua HU Yu-Rong XIONG Yu YU Wei ZHOU Tao WANG Ling-Juan ZHU Xi LIU Hui-Hui BAO Xiao-Shu CHENG Ming-Hui LI;Li-Hua HU;Yu-Rong XIONG;Yu YU;Wei ZHOU;Tao WANG;Ling-Juan ZHU;Xi LIU;Hui-Hui BAO;Xiao-Shu CHENG

作者机构：Department of Cardiovascular Medicinethe Second Affiliated Hospital of Nanchang UniversityJiangxiChina Center for Prevention and Treatment of Cardiovascular Diseasesthe Second Affiliated Hospital of Nanchang UniversityJiangxiChina Center of CardiovascularInner Mongolia People’s HospitalHohhotInner MongoliaChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2020年第17卷第4期

页      面：193-201页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Major New Drug Creation Program from National Science and Technology Major Project of China(2014ZX09303305) 

主　　题：Atrial fibrillation Bleeding Body mass index Dabigatran 

摘      要：Background Uncertainty remains regarding the association between body mass index(BMI)and the risk of bleeding in patients with non-valvular atrial fibrillation(NVAF).We aimed to investigate the association between BMI and the risk of bleeding in elderly NVAF patients taking *** A total of 509 elderly NVAF patients,who were being treated at twelve centers in China from February 2015 to December 2017 and taking dabigatran,were *** exposure and outcome variables were BMI at baseline and bleeding events within the subsequent six months,*** proportional hazards regression analysis was used to evaluate the association between BMI and the risk of ***,the Cox proportional hazards regression with cubic spline functions and smooth curve fitting was *** During the six-month follow-up,50 participants experienced *** 1 kg/m^2 increase in BMI was associated with a 12%increased risk of bleeding(P=0.021).Compared to those with BMI values in Tertile 1(25.3 kg/m^2)were 2.71(95%CI:1.02–7.17)and 3.5(95%CI:1.21–8.70),*** Ptrend-value was significant in all *** adjusted smooth curve showed a linear association between BMI and *** of the stratified variables showed significant effect modification on the association between BMI and bleeding(Pinteraction0.05).Conclusions BMI was significantly and positively associated with the risk of bleeding in elderly NVAF patients treated with dabigatran.