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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong guo-hui liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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A NEW WELL TEST MODEL FOR A TWO-ZONE LINEAR COMPOSITE RESERVOIR WITH VARIED THICKNESSES

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Journal of Hydrodynamics 2010年第6期22卷 804-809页

作者： ZHANG Lie-hui guo Jing-jing liu Qi-guo State Key Laboratory of Reservoir Geology and Exploitation Southwest Petroleum University Chengdu 610500China

This article presents a new well test model for two-zone linear composite reservoirs, where the rock and fluid properties as well as the formation thicknesses on both sides of the discontinuity are distinctly different. An analytical solution of pressure-transient behavior for a line-source, constant-rate well in this type of reservoir configuration is obtained with Fourier space transformation and Laplace transformation. By applying Duhamel principle, the wellbore storage and skins effects can easily be included. A set of type curves are generated and the sensitivities of the relevant parameters are discussed. A new correlating parameter MhDl√ηD is proposed to identify the pressure response in the pressure derivative curve. The model as well as the corresponding type curves are quite general that they are useful in predicting the production performance or analyzing the production data from this type of well-reservoir systems.

关键词： non-uniform thickness linear composite well test model type curve

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Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

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Rare Metals 2024年第4期43卷 1610-1621页

作者： Bing-Bing liu Yi-hui liu You-Bin Zhang Zhen-guo Qi guo-hui Qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

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A NEW WELL TEST MODEL FOR STRESS-SENSITIVE AND RADIALLY HETEROGENEOUS DUAL-POROSITY RESERVOIRS WITH NON-UNIFORM THICKNESSES

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Journal of Hydrodynamics 2011年第6期23卷 759-766页

作者： ZHANG Lie-hui, guo Jing-jing, liu Qi-guo State Key Laboratory of Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu 610500, China State Key Laboratory of Reservoir Geology and Exploitation Southwest Petroleum University Chengdu China

This article presents a new well test model for stress-sensitive composite dual-porosity reservoirs based on the concept of permeability modulus, where the rock and fluid properties as well as the formation thickness vary in the radial direction. An analytical solution in the Laplace space for the pressure-transient behavior for a line-source, constant-rate well of this type of reservoir is obtained with the Laplace transformation and the perturbation technique. The pressure and its derivative in the reservoir and the effects of relevant parameters on the pressure-transient response are obtained. The model as well as the corresponding type curves may be used in predicting the production performance or analyzing the production data for this type of reservoir.

关键词： non-uniform thickness stress-sensitive composite dual-porosity well test model type curve

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Antibonding orbital tailor and stress relief engineering for FeS2 complex toward superior sodium storage

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Rare Metals 2024年第10期43卷 5048-5059页

作者： You-Bin Zhang Zhen-guo Qi Fu-Sheng liu guo-hui Qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and Technology Shandong Synergetic Innovation Center of Ecological and Chemical Engineering

The sluggish kinetics behaviors and vast volume variations of Na+hosts to FeS2anode involved intercalation,and conversion reactions plague its applicability of sodium-ion batteries （SIBs）.Here,a significantly expedited kinetics via cation intercalation and considerably relieved stress accumulation by constructing the concave scaffold protector are approached for *** Mn2+intercalation into FeS2,a new stable Mn–FeS2was generated with distorted coordination;elevated antibonding orbital occupancy and lowed d band center to the release of more free Na+were achieved,which was further encapsulated by hollow bowl-like carbon spheres （BC）This cation intercalation and concave morphology strategies confer Mn–FeS2@BC significantly enhanced electron ion transport kinetics via reversed electron transfer to FeS2fast desolvation kinetics,and evidently depressed structural deformation during Na+insertion and ***,Mn–FeS2@BC delivers the longevity and stable Na+storage capacity in both half and full cell ***,Mn–FeS2@BC also displays excellen adaptability in a wider temperature *** work proposes new views into the deep regulation of electrochemical performance of transition metal anodes via intercalation chemistry and concave engineering.

关键词： Concave engineering FeS2 Intercalation chemistry Sodium capture

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What is responsible for acute myocardial infarction in combination with aplastic anemia? A case report and literature review

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World Journal of Clinical Cases 2022年第32期10卷 11955-11966页

作者： Ya-Nan Zhao Wei-Wei Chen Xiao-Yu Yan Kun liu guo-hui liu Ping Yang Department of Cardiology China-Japan Union Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Cardiology Jilin Provincial Cardiovascular Research InstituteChangchun 130000Jilin ProvinceChina Department of Cardiology Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular DiseaseChangchun 130000Jilin ProvinceChina

BACKGROUND Aplastic anemia(AA)complicated with myocardial infarction(MI)is rare and associated with poor ***,we present a case of AA with recurrent acute MI(AMI)in a patient treated with cyclosporine A(CsA)and *** this patient,we suspect the long-term use of medication linked to platelets *** SUMMARY In 2017,a 45-year-old man was rushed to the emergency department of China-Japan Union Hospital due to precordial pain for 5 *** on his symptoms,medical history,blood tests,and findings from coronary angiography(CAG),the patient was diagnosed with acute anterior wall,ST-segment elevated MI,Killip II grade,AA,and *** 2021,the patient was readmitted to the hospital for 2 h due to chest *** the patient’s platelet count was 30×109/L and he had severe thrombocytopenia,we performed CAG following platelet *** coherence tomography revealed lipid plaque and thrombus mass in his right coronary *** antithrombotic approach was adjusted to employ only anticoagulants(factor Xa inhibitors)and adenosine diphosphate inhibitors(clopidogrel)after assessing the risk of bleeding/thrombotic ***-term follow-up revealed that the patient had made a good *** Patients with AA should be closely monitored for the risk of thrombosis and cardiovascularevents, particularly when taking stanozolol or CsA for an extended period of time.

关键词： Aplastic anemia Myocardial infarction Cyclosporine A Stanozolol Percutaneous coronary intervention Case report

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Ultralow-phase-noise and broadband frequency-hopping coupled optoelectronic oscillator under quiet point operation

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Photonics Research 2024年第8期12卷 1785-1793页

作者： hui liu MINGYANG guo TIAN ZHANG JIAN DAI KUN XU State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Advancements in microwave photonics have yielded novel approaches for generating high-purity microwave *** these,optoelectronic oscillators(OEOs)and coupled optoelectronic oscillators(COEOs)have demonstrated the capability to generate frequency-independent microwaves with exceptionally low phase ***,the tunability of the oscillators is rather limited due to the necessity for narrowband electronic bandpass filters,presenting challenges in achieving both wide and rapid tuning ***,we present a COEO featuring ultralow phase noise,flexible tuning capability,and high *** is achieved through a quiet point(QP)-operated harmonic mode-locked fiber laser,which effectively mitigates optical amplifier noise and supermode competition,thus significantly diminishing the necessity for ultra-narrow electronic *** to the liberated tuning ability,we present an oscillator that can be tuned from 2 GHz to 18 GHz,with phase noise as low as-140 d Bc/Hz at 10 k Hz under the QP *** then illustrate the practical application of the proposed oscillator in generating frequency-hopping signals with consistent spurious modes less than-85 d Bc,absolute phase noise below-135 d Bc/Hz at 10 k Hz,hopping resolution of 1.25 MHz,and fractional frequency stability below 6.1×10^(-12)at 1 s averaging time when locked to a *** presented COEO structure emerges as a compelling solution for agile and low-noise microwave sources in advanced wireless communication and radar systems.

关键词： optoelectronic tuning amplifier

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Atorvastatin Attenuates Myocardial Hypertrophy Induced by Chronic Intermittent Hypoxia In Vitro Partly through miR-31/PKCε Pathway

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Current Medical Science 2018年第3期38卷 405-412页

作者： Jie REN Wei liu Guang-cai LI Meng JIN Zhen-xi YOU hui-guo liu Yi HU Department of Respiratory and Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Respiratory and Critical Care Medicine The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan 430010 China

Atorvastatin is proven to ameliorate cardiac hypertrophy induced by chronic intermittent hypoxia （CIH）. However, little is known about the mechanism by which atorvastatin modulates CIH-induced cardiac hypertrophy, and whether specific hypertrophyrelated microRNAs are involved in the modulation. MiR-31 plays key roles in the development of cardiac hypertrophy induced by ischemia/hypoxia. This study examined whether miR-31 was involved in the protective role of atorvastatin against CIH-induced myocardial hypertrophy. H9c2 cells were subjected to 8-h intermittent hypoxia per day in the presence or absence of atorvastatin for 5 days. The size of cardiomyocytes, and the expression of caspase 3 and miR-31 were determined by Western blotting and RT-PCR, respectively. MiR-31 mimic or Ro 31-8220, a specific inhibitor of protein kinase C epsilon （PKCε）, was used to determine the role of miR-31 in the anti-hypertrophic effect of atorvastatin on cardiomyocytes. PKCε in the cardiomyocytes with miR-31 upregulation or downregulation was detected using RT-PCR and Western blotting. The results showed that CIH induced obvious enlargement of cardiomyocytes, which was paralleled with increased atrial natriuretic peptide （ANP）, brain natriuretic peptide （BNP）, and slow/beta cardiac myosin heavy-chain （MYHT） mRNA levels. All these changes were reversed by the treatment with atorvastatin. Meanwhile, miR-31 was increased by CIH in vitro. Of note, the atorvastatin pretreatment significantly increased the mRNA and protein expression of PKCε and decreased that of miR-31. Moreover, overexpression of miR-31 abolished the anti-hypertrophic effect of atorvastatin on cardiomyocytes. Upregulation and downregulation of miR-31 respectively decreased and increased the mRNA and protein expression of PKCε. These results suggest that atorvastatin provides the cardioprotective effects against CIH probably via up-regulating PKCε and down-regulating miR-31.

关键词： atorvastatin chronic intermittent hypoxia myocardial remodeling miR-31 protein kinase C epsilon

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Application of the Guiding Template Designed by Three-dimensional Printing Data for the Insertion of Sacroiliac Screws:a New Clinical Technique

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Current Medical Science 2018年第6期38卷 1090-1095页

作者： Yi liu Wu ZHOU Tian XIA Jing liu Bo-bin MI Liang-cong HU Zeng-wu SHAO guo-hui liu Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

This study is aimed to explore the clinical application of the guiding template designed by three-dimensional printing data for the insertion of sacroiliac screws.A retrospective study of 7 cases (from July 2016 to December 2016),in which the guiding template printed by the three-dimensional printing technique was used for the insertion of sacroiliac screws of patients with posterior ring injuries of pelvis,was ***,4 males and 3 females were included in template group,aged from 38to 65years old (mean 50.86±8.90).Of them,5 had sacral fractures (3 with Denis type Ⅰ and 2 with type Ⅱ)and 2 the separation of sacroiliac *** templates were firstly made by the three-dimensional printing technique based on the pre-operative CT data. Surgical operations for the stabilization of pelvic ring by applying the guiding templates were carried out.A group of 8 patients with sacroiliac injuries treated by percutaneous sacroiliac screws were analyzed as a control group *** time of each screw insertion,volume of intra-operative blood loss,and the exposure to X ray were analyzed and the Matta's radiological criteria were used to evaluate the reduction *** Majeed score was used to evaluate postoperative living *** visual analogue scale (VAS)was applied at different time points to judge pain relief of *** the 7 patients in the template group were closely followed up radiographically and clinically for 14 to 20 months,mean (16.57±2.44)*** 9 sacroiliac screws for the S 1 and S2 vertebra were inserted in the 7 *** time length for each screw insertion ranged from 450 to 870 s,mean (690.56±135.68)s,and the number of times of exposure to X ray were 4 to 8,mean (5.78±1.20).The intra-operative blood loss ranged from 45to 120 mL,mean (75±23.32)*** to Matta's radiology criteria,the fracture and dislocation reduction were excellent in 6cases and good in *** pre-operative VAS score ranged from 5.2 to 8.1

关键词： sacroiliac screws three-dimensional printing technique posterior pelvic ring injury guiding template

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The key mediator of diabetic kidney disease:Potassium channel dysfunction

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Genes & Diseases 2024年第4期11卷 188-200页

作者： Jia guo Chaojie Zhang hui Zhao Yufan Yan Zhangsuo liu Nephrology Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province ZhengzhouHenan 450052China Research Center for Kidney Disease ZhengzhouHenan 450052China

Diabetic kidney disease is a leading cause of end-stage renal disease,making it a global public health *** molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex ***,exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney *** channels are important proteins that maintain the physiological functions of cells and *** ion channels,potassium channels stand out,because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell *** potassium channel abnormalities have been found to be closely related to diabetic kid-ney disease progression and genetic susceptibility,such as K_(ATP),K_(ca),K_(ir),and K_(v).In this review,we summarized the roles of different types of potassium channels in the occurrence and devel-opment of diabetic kidney disease to discuss whether the development of DKD is due to potas-sium channel dysfunction and present new ideas for the treatment of DKD.

关键词： Channel dysfunction Diabetic kidney disease End-stage renal disease lon channel Potassium

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