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News Recommendation System Based on Topic Embedding and Knowledge Embedding

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Wuhan University Journal of Natural Sciences 2023年第1期28卷 29-34页

作者： ZHANG Haojie sun hui QI Baiwen SHEN Zhidong Key Laboratory of Aerospace Information Security and Trusted Computing Ministry of Education/School of Cyber Science and EngineeringWuhan UniversityWuhan 430079HubeiChina Zhongnan Hospital Wuhan UniversityWuhan 430072HubeiChina Engineering Research Center of Cyberspace Yunnan UniversityKunming 650504YunnanChina

News recommendation system is designed to deal with massive news and provide personalized recommendations for *** capturing user preferences and modeling news and users is the key to news *** this paper,we propose a new framework,news recommendation system based on topic embedding and knowledge embedding(NRTK).NRTK handle news titles that users have clicked on from two perspectives to obtain news and user representation embedding:1)extracting explicit and latent topic features from news and mining users’preferences for them in historical behaviors;2)extracting entities and propagating users’potential preferences in the knowledge *** in a real-world dataset validate the effectiveness and efficiency of our approach.

关键词： news recommendation knowledge embedding topic embedding historical behavior

老年急性胰腺炎患者严重程度的评估:一种新的临床预测模型

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肝胆外科杂志 2024年第3期32卷 172-177页

作者：芮晨辉周大臣孙昀耿小平侯辉安徽医科大学第二附属医院合肥230601

目的本研究旨在筛选导致老年急性胰腺炎(AP)患者发展为重症急性胰腺炎的关键风险因素,并建立一个预测模型,精确评估老年AP患者的严重程度。方法回顾性分析2018年6月至2023年6月安徽医科大学第二附属医院收治的374名老年急性胰腺炎患者(... 详细信息

目的本研究旨在筛选导致老年急性胰腺炎(AP)患者发展为重症急性胰腺炎的关键风险因素,并建立一个预测模型,精确评估老年AP患者的严重程度。方法回顾性分析2018年6月至2023年6月安徽医科大学第二附属医院收治的374名老年急性胰腺炎患者(年龄>65岁),按照严重程度将患者分为重症急性胰腺炎组和非重症急性胰腺炎组,比较两组患者人院24 h内收集的临床指标的差异,利用多因素Logistic回归识别独立危险因素并构建Nomogram临床预测模型。结果重症急性胰腺炎组患者BISAP评分、合并高血压的比例显著高于非重症急性胰腺炎组患者。在实验室指标上,重症急性胰腺炎组白细胞、中性粒细胞百分比、血红蛋白、血细胞比容、血浆凝血酶原时间、纤维蛋白原、D-二聚体、尿素氮、肌酐、血钾显著高于非重症急性胰腺炎组,抗凝血酶-III活性、白蛋白显著低于非重症急性胰腺炎组。多因素Logistic回归分析结果显示,合并高血压(0R=1.88,95%CI:1.02~3.46,P=0.042)、BISAP评分高(0R=3.62,95%CI:2.28~5.75,P<0.001)、血细胞比容(0R=1.08,95%CI:1.02~1.14,P=0.006)、白蛋白低(0R=0.93,95%CI:0.88~0.98,P=0.008)是老年急性胰腺炎患者发展为重症急性胰腺炎的独立危险因素。预测模型的一致性指数为0.865(95%CI:0.825~0.906),模型的预测校准曲线与参考曲线接近,这提示该模型具有较好的区分能力和校准能力。临床决策曲线分析表明该模型具有良好的临床实用性。结论本研究强调高血压、高BISAP评分、高血细胞比容和低白蛋白是老年AP患者发展为SAP的显著危险因素。所建立的预测模型具备高度的预测价值和临床应用潜力,为医生在早期阶段制定治疗策略提供了重要依据。

关键词：重症急性胰腺炎老年预测模型

内镜下黏膜剥离术治疗早期胃癌及癌前病变的效果观察及护理体会

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山东医学高等专科学校学报 2024年第3期46卷 5-8页

作者：张敏徐慧超孙运军临沂市肿瘤医院山东临沂276034 临沂市人民医院

目的早期胃癌及癌前病变的治疗及护理方法。方法将60例早期胃癌及癌前病变患者随机分为两组,各30例。两组均行ESD治疗,对照组采用常规护理,观察组采用个体化心理护理联合体位护理。观察两组的临床效果。结果两组整块切除率及治愈性切除... 详细信息

目的早期胃癌及癌前病变的治疗及护理方法。方法将60例早期胃癌及癌前病变患者随机分为两组,各30例。两组均行ESD治疗,对照组采用常规护理,观察组采用个体化心理护理联合体位护理。观察两组的临床效果。结果两组整块切除率及治愈性切除率比较均无统计学意义(P>0.05);观察组不良反应发生率低于对照组(χ^(2)=4.44,P=0.035),护理后HAMA、自我护理能力、健康知识水平评分改善程度及护理满意度均优于对照组(P<0.01)。结论ESD治疗早期胃癌及癌前病疗效肯定;应用个体化心理护理联合体位护理临床效果更优。

关键词：早期胃癌癌前病变内镜下黏膜剥离术

Effects of polyol excipient stability during storage and use on the quality of biopharmaceutical formulations

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Journal of Pharmaceutical Analysis 2022年第5期12卷 774-782页

作者： Min-Fei sun Jia-Ning Liao Zhen-Yi Jing Han Gao bin-bin Shen You-Fu Xu Wei-Jie Fang Institute of Drug Metabolism and Pharmaceutical Analysis College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou Biopharm TownHangzhou310016China Zhejiang Haisheng Pharmaceutical Inc. TaizhouZhejiang318000China

Biopharmaceuticals are formulated using a variety of excipients to maintain their storage ***,some excipients are prone to degradation during repeated use and/or improper storage,and the impurities generated by their degradation are easily overlooked by end users and are usually not strictly monitored,affecting the stability of *** this study,we evaluated the degradation profile of polyol excipient glycerol during repeated use and improper storage and identified an unprecedented cyclic ketal impurity using gas chromatography with mass spectrometry(GC-MS).The other polyol excipient,mannitol,was much more stable than *** effects of degraded glycerol and mannitol on the stability of the model biopharmaceutical pentapeptide,thymopentin,were also *** thymopentin content was only 66.4% in the thymopentin formulations with degraded glycerol,compared to 95.8% in other formulations after the stress *** glycerol impurities(i.e.,aldehydes and ketones)reacted with thymopentin,affecting the stability of thymopentin *** conclusion,this work suggests that more attention should be paid to the quality changes of excipients during repeated use and *** testing of excipient stability under real or accelerated conditions by manufacturers would help avoid unexpected and painful results.

关键词： Excipient stability GC-MS Glycerol LC-MS/MS Mannitol Thymopentin

Molecular features of gastroenteropancreatic neuroendocrine carcinoma: A comparative analysis with lung neuroendocrine carcinoma and digestive adenocarcinomas

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Chinese Journal of Cancer Research 2024年第1期36卷 90-102页

作者： Jianwei Zhang Hanxiao Chen Junli Zhang Sha Wang Yanfang Guan Wenguang Gu Jie Li Xiaotian Zhang Jian Li Xicheng Wang Zhihao Lu Jun Zhou Zhi Peng Yu sun Yang Shao Lin Shen Minglei Zhuo Ming Lu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Radiation Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518172China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department I of Thoracic OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Medical Department Nanjing Geneseeq Technology Inc.Nanjing 210061China Geneplus-Beijing Beijing 102200China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: There is an ongoing debate about whether the management of gastroenteropancreatic(GEP)neuroendocrine carcinoma(NEC) should follow the guidelines of small-cell lung cancer(SCLC). We aim to identify the genetic differences of GEPNEC and its ***: We recruited GEPNEC patients as the main cohort, with lung NEC and digestive adenocarcinomas as comparative cohorts. All patients undergone next-generation sequencing(NGS). Different gene alterations were compared and analyzed between GEPNEC and lung NEC(LNEC), GEPNEC and adenocarcinoma to yield the remarkable ***: We recruited 257 patients, including 99 GEPNEC, 57 LNEC, and 101 digestive *** the mutations, KRAS, RB1, TERT, IL7R, and CTNNB1 were found to have different gene alterations between GEPNEC and LNEC samples. Specific genes for each site were revealed: gastric NEC(TERT amplification),colorectal NEC(KRAS mutation), and bile tract NEC(ARID1A mutation). The gene disparities between small-cell NEC(SCNEC) and large-cell NEC(LCNEC) were KEAP1 and CDH1. Digestive adenocarcinoma was also compared with GEPNEC and suggested RB1, APC, and KRAS as significant genes. The TP53/RB1 mutation pattern was associated with first-line effectiveness. Putative targetable genes and biomarkers in GEPNEC were identified in22.2% of the patients, and they had longer progression-free survival(PFS) upon targetable treatment [12.5 months vs. 3.0 months, HR=0.40(0.21-0.75), P=0.006].Conclusions: This work demonstrated striking gene distinctions in GEPNEC compared with LNEC and adenocarcinoma and their clinical utility.

关键词： Neuroendocrine carcinoma gastroenteropancreatic lung genetic alterations molecular markers

Functional mechanism on stem cells by tea(Camellia sinensis)bioactive compounds

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Food Science and Human Wellness 2022年第3期11卷 579-586页

作者： Yao Cheng Jiachen sun hui Zhao Hongxing Guo Jianying Li School of Biotechnology and Food Science Tianjin University of CommerceTianjin 300134China The Third Central Clinical College Tianjin Medical UniversityTianjin 300170China

Camellia sinensis(tea),one of the most popular commercial crops,is commonly applied in all parts of the *** main active ingredients of tea include polyphenols,alkaloids,polysaccharides,amino acids,aroma and volatile constitutes,all of which are potentially responsible for the activities of *** cells(SCs)are the immature and undifferentiated cells by a varying capacity for proliferation,self-renewal and the capability to differentiate into one or more different derivatives with specialized function or maintain their stem cell ***,a thorough review is conducted of the functional mechanism on SCs by tea bioactive compounds.

关键词： Functional mechanism Stem cell Camellia sinensis Bioactive compounds

Clinical features and treatment outcomes of major depressive disorder with genital symptoms

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Chinese Medical Journal 2024年第5期137卷 622-624页

作者： Xiaohui Wu Yuncheng Zhu Ping sun Shuo Wang Zhiguo Wu Jia Huang Lan Cao Yun Wang Yousong Su Zhijian Yao Zuowei Wang Fan Wang Yong Wang Daihui Peng Jun Chen Yiru Fang Department of Clinical Research Center&Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Mood Disorders Shanghai Hongkou Mental Health CenterShanghai 200083China Department of Psychiatry Nanjing Medical University Affiliated Brain HospitalNanjingJiangsu 210029China Department of Psychiatry&Affective Disorders Center Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai 200118China

To the Editor:Major depressive disorder(MDD)is a mood disorder characterized by complex patterns of emotional,cognitive,and behavioral symptomology and deficits in daily *** symptoms,including a reduction in libido and menstrual disturbances,have been considered to be a classic symptom of MDD for many *** evidence has reached a broad consensus that the incidence of genital symptoms is higher in patients with MDD than in the general population.A systematic review and meta-analysis found a bidirectional association between MDD and genital symptoms,with patients with MDD showing a 50–70%increased risk of developing genital symptoms,while individuals with genital symptoms had a 130–210%increased risk of developing MDD.^([1])As previously reported,50–70%of people with MDD experience sexual dysfunction.^([2])To date,few studies have focused on the comparison of clinical features between patients with MDD with and without genital symptoms,and the longitudinal prognosis.

关键词： symptoms Clinical features

超声引导下锐性开通自体动静脉内瘘闭塞病变的疗效及安全性研究

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中国医学创新 2024年第22期21卷 50-54页

作者：王稻刘灏灏孙纷纷许辉萍乡市人民医院肾内科江西萍乡337000

目的:探讨超声引导下锐性开通自体动静脉内瘘(AVF)闭塞病变的临床疗效。方法:选取2020年9月—2022年12月萍乡市人民医院收治的60例AVF闭塞患者,按随机数字表法分为观察组和对照组,各30例。对照组给予局部溶栓联合经皮腔内血管成形术(PTA... 详细信息

目的:探讨超声引导下锐性开通自体动静脉内瘘(AVF)闭塞病变的临床疗效。方法:选取2020年9月—2022年12月萍乡市人民医院收治的60例AVF闭塞患者,按随机数字表法分为观察组和对照组,各30例。对照组给予局部溶栓联合经皮腔内血管成形术(PTA)治疗,观察组给予超声引导下锐性开通联合PTA治疗。比较两组手术成功率和术后并发症发生率,比较两组不同时间点内瘘直径、横断面积和肱动脉血流量。结果:观察组手术成功率为93.33%,高于对照组的73.33%,差异有统计学意义(P0.05)。两组术后并发症发生率比较,差异无统计学意义(P>0.05)。结论:超声引导下锐性开通AVF闭塞病变,手术成功率更高,能明显扩大患者内瘘直径和横断面积,提高肱动脉血流量。

关键词：自体动静脉内瘘病变经皮腔内血管成形术锐性开通技术安全性

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透明细胞乳头状肾细胞肿瘤临床病理研究

临床与病理杂志 2024年第2期44卷 261-267页

作者：彭森孙辉王雪王朝夫吴迪徐州市中心医院病理科江苏徐州221000 上海交通大学医学院附属瑞金医院病理科上海200025

目的:透明细胞乳头状肾细胞肿瘤(clear cell papillary renal cell tumor,CCPRCT)是一种少见但重要的肾肿瘤类型,与其他肾细胞肿瘤具有类似的形态学特征,易导致误诊。本研究旨在探讨CCPRCT的临床病理特征、诊断及鉴别诊断要点,以提高其... 详细信息

目的:透明细胞乳头状肾细胞肿瘤(clear cell papillary renal cell tumor,CCPRCT)是一种少见但重要的肾肿瘤类型,与其他肾细胞肿瘤具有类似的形态学特征,易导致误诊。本研究旨在探讨CCPRCT的临床病理特征、诊断及鉴别诊断要点,以提高其病理诊断的准确性。方法:收集15例CCPRCT患者,观察其临床及影像学特点,分析其镜下形态、免疫表型,并复习相关文献。结果:15例患者中,男10例,女5例,年龄为(54±17)岁,10例患者肿瘤位于左肾,5例患者肿瘤位于右肾。组织学上肿瘤均由增厚的纤维囊包裹,并局限于肾实质内;肿瘤细胞排列成乳头状、管状、囊状、腺泡及实性等结构;乳头由小到中等大小、透明细胞质的单层细胞组成,肿瘤均为世界卫生组织/国际泌尿病理学会(World Health Organization/International Society of Urological Pathology,WHO/ISUP)1级或2级;细胞核反极性分布,即核上移,靠近腔面,远离基底,类似鲨鱼牙齿排列。免疫组织化学染色显示:细胞角蛋白7、碳酸酐酶9(carbonic anhydrase 9,CA9)和高分子量细胞角蛋白(34βE12)均为阳性表达;α甲基酰基辅酶A消旋酶、CD117、转录因子E3均为阴性表达;CCPRCT中典型的CA9表现方式是“U型”着色,即腔缘不表达,基底和侧面表达。患者术后随访均未见复发或转移。结论:CCPRCT是一种惰性肾细胞肿瘤,预后好,临床可能存在过诊断,其形态学为特征性的核朝向腔缘的线性排列,特殊的免疫表型CA9呈“U型”阳性,可以与其他肾细胞肿瘤区分开来,但仍然需要积累更多患者来阐释其预后。

关键词：透明细胞乳头状肾细胞肿瘤病理学特征诊断鉴别诊断

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