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Effects of acupoint versus non-acupoint electroacupuncture on cerebral cortical neuronal Bcl-2, Bax and caspase-3 expression in a rat model of focal cerebral ischemia

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Neural Regeneration Research 2008年第12期3卷 1308-1313页

作者： Jun Wang Junming Fan Yongshu Dong xia Huang Hongxia Zhang Laboratory of Pharmacology Henan Institute of Traditional Chinese Medicine Zhengzhou 450004 Henan Province China

BACKGROUND： Several studies have demonstrated that electroacupuncture by acupoint selection can inhibit cerebral cortical neuronal apoptosis following cerebral ischemia/reperfusion. OBJECTIVE： To validate the effects of electroacupuncture by acupoint selection on the expression level of cortical neuronal anti-apoptotic Bcl-2 protein and the apoptotic executive protein, caspase-3, in rat models of focal cerebral ischemia/reperfusion. DESIGN, TIME AND SETTING： This randomized grouping, neural cell and molecular biology animal experiment was performed at the Laboratory of Pharmacology of Traditional Chinese Medicine and the Laboratory Animal Center of Henan Institute of Traditional Chinese Medicine between November 2006 and May 2007. MATERIALS： Atotal of 40 healthy male adult Sprague-Dawley rats were randomly and evenly divided into four groups： sham-operated, model, electroacupuncture and non-aeupoint control. G6895 electro-acupuncture instruments were purchased from Shanghai Huayi Instrument Factory, China. Caspase-3, Bcl-2 and Bax kits were provided by Wuhan Boster Bioengineering Co., Ltd., China. METHODS： Middle cerebral artery occlusion was induced in the model, electroacupuncture and non-acupoint groups. In the electroacupuncture group, the acupoints Jianyu （LII5）, Waiguan （S J5）, Biguan （ST31）, and Zusanli （ST36） were given electroacupuncture. In the non-acupoint control group, at each time point （immediately after ischemia and after reperfusion, or 2 hours after reperfusion）, electroacupuncture was performed at the midpoints of Tianquan （PC2）-Quze （PC 3） line, Quze （PC 3）-Ximen （PC4） line, Zuwuli （LR10）-Yinbao （LR9） line, and Xiguan （LR7）-Zhongdu （LR6） line. Electroacupuncture parameters were set with a continuous wave with a frequency of 10 Hz, wave width 0.6 ms, voltage 1.5-3.0 V, and a duration of 10 minutes. The sham-operated and model groups received only animal fixation without electroacupuncture procedure. MAIN OUTCOME MEASURES： Five rats were selected f

关键词： electroacupuncture cerebral ischemia/reperfusion apoptosis caspase-3 Bcl-2 Bax

Liver-specific MettB ablation delays liver regeneration in mice

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Genes & Diseases 2022年第3期9卷 697-704页

作者： Jiaxiang Meng Zhicong Zhao Zhifeng Xi Qiang xia Department of Liver Surgery and Liver Transplantation Center Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127PR China

This study investigated the role of N6-methyladenosine RNA methylation in liver regeneration following partial hepatectomy in *** created a liver-specific knockout mouse model by the deletion of Mettl3,a key component of the N6-methyladenosine methyltransferase complex,using the albumin-Cre ***3 liver-specific knockout mice and their wild-type littermates were subjected to 2/3 partial *** changes in liver tissue at 48 h after partial hepatectomy were detected by *** and immunofluorescence were used to determine protein expression levels of Ki67,hepatocyte nuclear factor 4 alpha,and cytokeratin *** deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling was also *** weight/body weight ratios after partial hepatectomy were significantly lower in Mettl3 liverspecific knockout mice than in wild-type mice at 48 h after 2/3 partial hepatectomy(3.1%±0.11%vs.2.7%±0.03%).Compared with wild-type littermates,Mettl3 liver-specific knockout mice showed reduced bromodeoxyuridine staining and reduced Ki-67 expression at 48 h after 2/3 partial ***-seq analysis showed that Mettl3 liver-specific knockout delayed the cell cycle progression in murine liver by downregulating the expression levels of genes encoding cyclins D1,A2,B1,and *** of Mettl3-mediated N6-methyladenosine function led to attenuated liver regeneration by altering the mRNA decay of suppressor of cytokine signaling 6,thereby inhibiting the phosphorylation of signal transducer and activator of transcription 3 during early liver *** results demonstrated the importance of N6-methyladenosine mRNA modification in liver regeneration and suggest that Mettl3 targeting might facilitate liver regeneration.

关键词： Liver regeneration METTL3 N6-methyladenosine Socs6 STAT3

Coupling Enhancement of a Flexible BiFeO_(3) Film-Based Nanogenerator for Simultaneously Scavenging Light and Vibration Energies

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Nano-Micro Letters 2022年第12期14卷 137-150页

作者： xiao Han Yun Ji Li Wu Yanlong xia Chris RBowen Ya Yang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400People’s Republic of China Department of Mechanical Engineering University of BathBath BA27AKUK School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Center On Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004People’s Republic of China

Coupled nanogenerators have been a research hotspot due to their ability to harvest a variety of forms of energy such as light,mechanical and thermal energy and achieve a stable direct current *** films are frequently investigated for photovoltaic applications due to their unique photovoltaic properties and bandgap-independent photovoltage,while the flexoelectric effect is an electromechanical property commonly found in solid ***,we effectively construct a new form of coupled nanogenerator based on a flexible BiFeO_(3) ferroelectric film that combines both flexoelectric and photovoltaic effects to successfully harvest both light and vibration *** device converts an alternating current into a direct current and achieves a 6.2% charge enhancement and a 19.3%energy enhancement to achieve a multi-dimensional"1+1>2"coupling enhancement in terms of current,charge and *** work proposes a new approach to the coupling of multiple energy harvesting mechanisms in ferroelectric nanogenerators and provides a new strategy to enhance the transduction efficiency of flexible functional devices.

关键词： Ferroelectric film Coupled nanogenerators Photovoltaic effect Flexoelectric effect Energy collection

A Simulation Study on the Evolution of Groundwater Circulation Systems in Cenozoic Basins of Northern China

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Acta Geologica Sinica(English Edition) 1998年第1期72卷 100-107页

作者： SHI Dehong YIN xia SUN Jichao YIN Zhengzhou Institute of Hydro geology and Engineering Geology CAGS Zhengding Hebei Province 050803

Three Cenozoic basins—the Qaidam basin, the Weihe graben-type basin and the North China plain—which are different in climatic conditions, geological settings and run—off types, are selected for the study. Based on an analysis of background information of the transect along the middle-latitude region, studies of groundwater dynamics, geochemistry, simulation of water circulation of the main elements as well as isotopic chronology, the information on global changes is collected, the formation of groundwater circulation systems and their evolution under stacked impacts of natural conditions and human activities are discussed, and a correlation is made between the evolutionary features of the above systems in these basins since 25 ka B.P. All these have laid a good foundation for further generalizing the evolutionary model of land water in northern China.

关键词： Cenozoic basins groundwater circulation system evolutionary modelling

Effects of folic acid and vitamin B12 adjuvant therapy on serum inflammatory cytokines, Hcy and NT-proBNP in elderly patients with coronary heart disease and chronic heart failure

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Journal of Hainan Medical University 2017年第13期23卷 26-29页

作者： ling-Zhi Dou Yi-Gang Zhang Qiu-Mei Cao Zi-xia Liu Department of Cardiology Xuzhou Central HospitalXuzhou 221009 China Elderly General Ward of Zhejiang Hospital ZhejiangHangzhou 310013China

Objective:To investigate the effect of folic acid combined with vitamin B12 supplementation with conventional drugs on the levels of serum inflammatory factors, Hcy and NT-proBNP in elderly patients with chronic heart ***:89 elderly patients with chronic heart failure were randomly divided into control group (n=47) and observation group (n=42) based on the random data table. The control group was given diuretics, ACEI andβ receptor inhibitor group of three categories of drugs combined treatment, on this basis, the observation group supplemented by folic acid tablets and vitamin B12 treatment, both groups were treated for 8 weeks. The levels of TNF-α, hs-CRP and visfatin, Hcy and NT-proBNP were measured before and after treatment in both ***: There was no significant difference in TNF-α, hs-CRP, visfatin, Hcy and NT-proBNP between the control group and the observation group before treatment. After treatment, the levels of TNF-α, hs-CRP, visfatin, Hcy and NT-proBNP in the two groups decreased significantly ,the difference was significant, the level of the above indexes of the observation group after treatment was significantly lower than that of the control group ,the difference was statistically ***: Folic acid combined with vitamin B12 can reduce the levels of serum inflammatory factors, Hcy and NT-proBNP in elderly patients with coronary heart disease and heart failure, which has certain clinical value.

关键词： Coronary heart disease Chronic heart failure Folic acid Vitamin B12

Global patterns of the responses of leaf-level photosynthesis and respiration in terrestrial plants to experimental warming

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Journal of Plant Ecology 2013年第6期6卷 437-447页

作者： Junyi Liang Jianyang xia lingli Liu Shiqiang Wan State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesXiangshanBeijing 100093China University of Chinese Academy of Sciences YuquanluBeijing 100049China State Key laboratory of Cotton Biology Key Laboratory of Plant Stress BiologyCollege of Life SciencesHenan UniversityKaifengHenan 475004China

Aims The balance between leaf photosynthesis and respiration of terrestrial plants determines the net carbon(C)gain by vegetation and consequently is important to climate–C cycle *** study is to reveal the global patterns of the responses of leaf-level net photosynthesis and dark respiration to elevated *** Data for leaf-level net photosynthesis rate(P_(n))and dark respiration rate(R_(d))in natural terrestrial plant species with standard deviation(or standard error or confidence interval)and sample size were collected from searched literatures on Web of *** a metaanalysis was conducted to estimate the effects of experimental warming on leaf-level P_(n) and R_(d) of terrestrial *** findings Across all the plants included in the analysis,warming enhanced P_(n) and R_(d) significantly by 6.13 and 33.14%,***,the responses were plant functional type(PFT)***,photosynthesis of C_(4) herbs responded to experimental warming positively but that of C_(3) herbs did not,whereas their respiratory responses were similar,suggesting C_(4) plants would benefit more from *** photosynthetic response declined linearly with increasing ambient *** respiratory responses linearly enhanced with the increase in warming *** addition,a thermal acclimation of R_(d),instead of P_(n),was *** greater proportion of fixed C was consumed(greater R_(d)/P_(n) ratio),warming significantly enhanced the daily net C balance at the leaf *** provides an important mechanism for the positive responses of plant biomass and net primary productivity to ***,the findings,including the contrastive responses of different PFTs and the enhancement in daily leaf net C balance,are important for improving model projection of the climate–C cycle feedback.

关键词： acclimation meta-analysis plant functional type photosynthesis respiration

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长江航道水下数字高程模型自动化处理系统

水运工程 2016年第5期 110-115页

作者：夏辉宇长江南京航道局江苏南京210011

手动处理生成航道水下数字高程模型(DEM)费时耗力,存在着效率瓶颈。提出并构建长江航道水下数字高程模型自动化处理系统。该系统由水深数据自动监测读取模块、DEM自动处理模块、成果自动加工模块以及流程监控显示模块组成,实现了从原始... 详细信息

手动处理生成航道水下数字高程模型(DEM)费时耗力,存在着效率瓶颈。提出并构建长江航道水下数字高程模型自动化处理系统。该系统由水深数据自动监测读取模块、DEM自动处理模块、成果自动加工模块以及流程监控显示模块组成,实现了从原始水深点自动监测到规则格网DEM及其专题图的快速自动化处理,有效节省了人工操作,提高了DEM产品的时效性,解决了效率瓶颈问题。

关键词：长江航道水下地形数字高程模型不规则三角网 ArcGIS

Business Plan for Apiculture Project of TianYuan Company

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Business Plan for Apiculture Project of TianYuan Company

作者： xia Ailing 兰州大学

学位级别：硕士

The long standing history of beekeeping and bee products in China’s aquaculture industry have accumulated and deposited solid experiences and advantage. However, with the continuous development of market economy,industrialization, informationization and urbanization, the increasingly pursuit of health and safety products by people, the traditional beekeeping and bee products can not meet the corresponding needs of social development. Holding the attitude of scientific development, following the natural law of development are the critical points of meeting this needs. Apiculture can maintain the diversity of natural species, can increase the output of crops and at the same time improve the natural environment, can provide the community with high quality and safety of bee food products, and constantly improve the health of people’s living standards as well. So for the common benign development of social and economic benefits, the protection of safety bee products from field to table, the beekeeping and it’s products have an extremely practical and long-term significance. The apiculture of this business plan is an energy-saving project, which can effectively improve crop yields, is the important guarantee of sustainable development of agriculture. As the important part of modern ecological agriculture, it plays a unique role in the national economy developmentThe series products of this business plan are value-added products through enhancing the traditional extensive processing mode to further intensive pattern, so to provide better and more safety bee products. Guangdong province is one of relative developed provinces in China however with unbalanced area distribution. In the mountain areas, economy are relatively backward where many farmers are still in poverty. But for apiculture it has many unique advantages such as excellent natural environment, rich nectar source plants and long flowering period. Farmers can take advantage of the local bee breeding economy to

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Effects of Filler-Asphalt Ratio on the Properties of Lignin and Polyester Fiber Reinforced SMPU/SBS Modified Asphalt Mortar

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Journal of Renewable Materials 2023年第8期11卷 3387-3402页

作者： Wenjing xia Jinhui Wang Tao Xu Nan Jiang College of Civil Engineering Nanjing Forestry UniversityNanjing210037China College of Civil Engineering Yancheng Institute of TechnologyYancheng224051China

To understand the effects ofﬁller-asphalt ratio on different properties of lignin and polyesterﬁber reinforced shape memory polyurethane(SMPU)/styrene butadiene styrene(SBS)composite modiﬁed asphalt mortar(PSAM),as well as to reveal the reinforcing and toughening mechanisms of lignin and polyesterﬁbers on PSAM,SMPU,SBS and mineral powder wereﬁrst utilized to prepare *** the conventional,rheological and anti-cracking properties of ligninﬁber reinforced PSAM(LFAM)and polyesterﬁber reinforced PSAM(PFAM)at dif-ferentﬁller-asphalt ratios were *** results indicate that the shear strength,deformation resistance and viscosity are increased after adding 0.8wt%ligninﬁber or polyesterﬁber and increasing theﬁller-asphalt ratio from 0.8 to *** optimalﬁller-asphalt ratio of 1.0 is proposed after comprehensive performance assessments of ***ﬁber shows a better reinforcing effect than ligninﬁber,but its improvement in the thermal stability of PSAM is not signiﬁcant at high ***,the complex modulus,storage modulus,loss modulus and rutting resistance factor of PSAM are improved after adding ligninﬁber and polyesterﬁber,as well as show an increasing trend as theﬁller-asphalt ratio is raised,but the phase angle is gradually ***,the increase of elastic components in PSAM effectively enhances the anti-deformation ability of PSAM at high temperatures,and polyesterﬁber more obviously improves the high-temperature deformation resistance of PSAM than ligninﬁ***,the anti-cracking performance of PFAM and LFAM at low temperatures is reduced by 74.2%and 46.7%,respectively,as theﬁller-asphalt ratio is raised from 0.8 to *** low-temperature anti-cracking performance of LFAM is lower than that of PFAM at the sameﬁller-asphalt ratio,even lower than that of *** with ligninﬁber,the anti-cracking performance and deformation resistance of PSAM at low temperature is more greatly enhanced by polyester ﬁber.

关键词： Asphalt mortar ﬁber reinforcement ﬁller-asphalt ratio anti-cracking performance high-temperature stability deformation resistance