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Particuology 2023年第10期81卷 162-173页

作者： Xu-Feng Zang Shengchen Yang Ying Zou Yingying Zhang Tao Huang hui-ling xia School of Science Huzhou UniversityHuzhou313000China Department of Engineering Technology Huzhou CollegeHuzhou313000China Laboratory Management Department Huzhou UniversityHuzhou313000China

In recent years,researches on improving high-voltage performance of lithium-ion batteries incorporating LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM523)and artificial graphite(AG)have been widely ***,limited attentions have been paid to understand the effects and influence mechanisms of charge and discharge rates and charge limit currents on cyclability of NCM523/AG ***,a∼1.9 Ah NCM523/AG pouch cell is employed,whose electrochemical and structural evolutions after 800 cycles at various rates are comprehensively *** find that cycling performances are strongly influenced by charge rate,followed by limit current and discharge *** cell charged at a high rate and cell charged until reaching a low limit current both exhibit low capacity retentions compared to the cell discharged at a high *** failure reasons are analyzed by advanced *** reveal that NCM523 cathodes of the cells deteriorated early experience severe transition metal dissolution,lattice distortion,and partial phase ***,the deposited transition metals on AG anodes catalyze the electrolyte consumption,lithium plating and active area ***,these side reactions notably increase cell impedance and electrochemical ***,these findings clearly outline the challenges and optimization direction for high-rate NCM523/AG cells.

关键词： Lithium-ion batteries Artificial graphite LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) Cycle life Charge-dischargerate Failure mechanism

Mangiferin Promotes Bregs Level,Activates Nrf2 Antioxidant Signaling,and Inhibits Proinflammatory Cytokine Expression in Murine Splenic Mononuclear Cells In Vitro

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Current Medical Science 2021年第3期41卷 454-464页

作者： Zhi-zhi QIN Jun RUAN Meng-ran LEE Kang SUN Ping CHEN Yan CHEN Mei HONG ling-hui xia Jun FANG Hao TANG Department of Hematology Institute of HematologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Hematology Huaihe Hospital of Henan UniversityKaifeng 475000China Department of Gastroenterology Wuhan Resources&Wisco General HospitalWuhan 430080China Collaborative Innovation Center of Hematology Soochow UniversitySuzhou 215000China Department of Cardiovascular Surgery Zhongnan HospitalWuhan UniversityWuhan 430071China

Recent studies indicated that regulatory B cells(Bregs)and nuclear factor erythroid 2-related factor 2(Nrf2)antioxidant signaling pathway play important roles in the pathogenesis of chronic graft-versus-host disease(cGVHD).Mangiferin(MA),a polyphenol compound,has been reported to activate Nrf2/antioxidant-responsive element(ARE)signaling *** study was aimed to investigate the effects of MA on Bregs and Nrf2 antioxidant signaling in murine splenic mononuclear cells(MNCs)in *** results revealed that MA could increase the Bregs level in murine splenic ***,MA up-regulated the expression of Bregs-associated immunosuppressive factor interleukin-10(IL-10)by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)and extracellular signal-regulated kinase(ERK)signaling in murine splenic ***,MA inhibited the proinflammatory cytokines IL-2 and interferon-y(INF-y)at both mRNA and protein *** also enhanced the transcription and protein expression of Nrf2 and NADPH quinine oxidoreductase 1(NQOl),whereas decreased that of Kelch-like ECH-associated protein 1(Keapl)in murine splenic ***,MA promoted the proliferation and inhibited the apoptosis of murine splenic *** results suggested that MA exerts immunosuppressive effects by upregulating the Bregs level,activating the Nrf2 antioxidant pathway,and inhibiting the expression of pro-immunoinflammatory ***,as a natural immunomodulatory and anti-inflammatory agent,may have a potential role in the prophylaxis and treatment of cGVHD.

关键词： mangiferin regulatory B cells nuclear factor erythroid 2-related factor 2 interleukin-10 immunomodulation anti-inflammation

Influence of irbesartan on expression of ILK and its relationship with epithelial-mesenchymal transition in mice with unilateral ureteral obstruction

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Acta Pharmacologica Sinica 2007年第11期28卷 1810-1818页

作者： Bi-cheng LIU~1,hui-ling xia,Ji-ning WU,xiao-liang ZHANG,Dian-ge LIU,Yu-xiang GONGInstitute of Nephrology,Zhong Da Hospital,Southeast University.Nanjing 210009,China Institute of Nephrology Zhong Da Hospital Southeast University Nanjing China

Aim:Irbesartan,a new antagonist of the type Ⅰ angiotensin Ⅱ receptor,has beenproven to be renal protective in both diabetic and non-diabetic nephropathy,butits exact mechanism is still *** we investigated the influence ofirbesartan on the expression of the integrin-linked kinase (ILK) and its relation-ship with epithelial-mesenchymal transition (EMT) in mice with unilateral ureteralobstruction (UUO).Methods:The mice were randomly divided into 3 groups:sham operation (C,n=20),UUO (n=40),and UUO with irbesartan treatment(UUO+irbesartan,n=40).Irbesartan was given at a dose of 50 mg/kg body weightper day by *** experimental animals in the control group received thesame volume of vehicle (0.9% saline solution).The animals were sacrificed at d 1,3,7,and 14,respectively,after the ***:The expression of the ILK atmRNA and protein levels were significantly increased in the UUO group 1 d afterthe surgery,which was significantly decreased by treatment with irbesartan (P<0.01,respectively).The expression of α-smooth muscle actin (α-SMA) was sig-nificantly increased,while E-cadherin was decreased in mice with UUO at d 3 afterthe *** with irbesartan significantly abrogated such effects (P<0.01).The immunohistochemistry analysis indicated that the protein expressionof the ILK was positively correlated with α-SMA,but negatively with ***:These results suggested that irbesartan attenuated renaltubulointerstitial fibrosis in UUO mice,which may be related to the inhibition ofILK expression,subsequently preventing the tubular EMT.

关键词： irbesartan integrin-linked kinase epithelialmesenchymal transition tubulointerstitial fibrosis

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao hui-Lin Jiang Bao-xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

Long-term follow-up of haploidentical transplantation in relapsed/refractory severe aplastic anemia:a multicenter prospective study

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Science Bulletin 2022年第9期67卷 963-970,M0004页

作者： Lan-Ping Xu Zheng-Li Xu Shun-Qing Wang De-Pei Wu Su-Jun Gao Jian-Min Yang ling-hui xia Qi-Fa Liu Ming Jiang Hai Bai Xi Zhang Xin Wang xiao-Jun Huang Peking University People's Hospital Peking University Institute of HematologyBeijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Department of Hematology Guangzhou First People's HospitalGuangzhou 510180China Department of Hematology The First Affiliated Hospital of Soochow UniversitySoochow 215004China Department of Hematology The First Hospital of Jilin UniversityChangchun 130061China Department of Hematology Changhai Hospital Affiliated to Second Military Medical UniversityShanghai 200433China Department of Hematology Xiehe Hospital Affiliated to Huazhong University of Science and Technology.Wuhan 430022China Department of Hematology Nanfang Hospital Affiliated to Southern Medical UniversityGuangzhou 510515China Department of Hematology The First Affiliated Hospital of Xinjiang Medical UniversityUrumchi 830054China Department of Hematology General Hospital of Lanzhou Military Region of PLALanzhou 730050China Medical Center of Hematology The Second Affiliated Hospital of Army Medical UniversityChongqing 400037China Department of Hematology Shandong Provincial HospitalJinan 250021China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China Peking-Tsinghua Center for Life Sciences Beijing 100044China

In recent decades,haploidentical stem cell transplantation(haplo-SCT)to treat severe aplastic anemia(SAA)has achieved remarkable ***,long-term results are still *** conducted a multicenter prospective study involving SAA patients who underwent haplo-SCT as salvage ***-term outcomes were assessed,mainly focusing on survival and quality of life(QoL).Longitudinal QoL was prospectively evaluated during pretransplantation and at 3 and 5 years posttransplantation using the SF-36 scale in adults and the PedsQL 4.0 scale in children.A total of 287 SAA patients were enrolled,and the median follow-up was 4.56 years(range,3.01–9.05 years)among surviving *** the long-term follow-up,268 of 275 evaluable patients(97.5%)obtained sustained full donor chimerism,and 93.4%had complete hematopoietic *** estimated overall survival and failure-free survival for the whole cohort at 9 years were 85.4%±2.1%and 84.0%±2.2%,***(≥18 years)and a poorer performance status(ECOG>1)were identified as risk factors for survival *** Qo L recovery after haplo-SCT,we found that QoL progressively improved from pretransplantation to the 3-year and 5-year time points with statistical *** occurrence of chronic graft versus host disease was a risk factor predicting poorer QoL scores in both the child and adult *** the last followup,74.0%of children and 72.9%of adults returned to normal school or *** inspiring long-term outcomes suggest that salvage transplantation with haploidentical donors can be routine practice for SAA patients without human leukocyte antigen(HLA)-matched donors.

关键词： Aplastic anemia Haploidentical Long-term follow-up Quality of life

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高能量无线传感网络隐藏异常结构数据识别

计算机仿真 2018年第10期35卷 309-312页

作者：侯慧玲王崇霞长治学院计算机系山西长治046011

为了保障高能量无线传感网络的稳定运行,需要对高能量无线传感网络中隐藏的异常结构数据进行识别,采用当前数据识别方法对高能量无线传感网络中隐藏的异常结构数据进行识别时,存在识别效率差、抗干扰性能低的问题。基于高能量无线传感网... 详细信息

为了保障高能量无线传感网络的稳定运行,需要对高能量无线传感网络中隐藏的异常结构数据进行识别,采用当前数据识别方法对高能量无线传感网络中隐藏的异常结构数据进行识别时,存在识别效率差、抗干扰性能低的问题。基于高能量无线传感网络,提出一种异常结构数据识别方法。构建高能量无线传感网络数据传输的模型,通过高能量无线传感网络隐藏异常结构数据信号解析模型对异常结构数据信号进行解析,提高异常结构数据的识别效率。对高能量无线传感网络中的数据进行预处理,去除数据中存在的噪声,提高方法的抗干扰性能,采用小波分解的方法对流量序列中存在的细节信号进行展示,完成高能量无线传感网络中隐藏的异常结构数据识别。仿真结果表明,上述方法的抗干扰性能强、识别效率高。

关键词：无线传感网络异常结构数据识别方法

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高职院校图书馆美学

邢台职业技术学院学报 2005年第4期22卷 52-53页

作者：凌会侠邢台职业技术学院图书馆河北邢台054035

本文对图书馆美学的概念、内容体系和功能等方面的研究成果作初步整理,并结合高职院校的图书馆建设提出了如何营造图书馆美学的建议。

关键词：图书馆美学内涵功能

浅议现代设计与“传统性”和“民族性”的关系

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科技情报开发与经济 2009年第29期19卷 160-161页

作者：凌会侠邢台职业技术学院图书馆河北邢台054035

阐述了文化传统和传统文化两个概念的区别,探讨了文化与传统、设计与传统的关系,论述了"传统性"和"民族性"对现代设计的影响,指出了现代设计的未来发展方向。

关键词：文化传统传统文化现代设计艺术设计传统性民族性

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浅议设计的发展趋势

科技情报开发与经济 2010年第21期20卷 133-134页

作者：凌会侠邢台职业技术学院河北邢台054035

通过对人性化设计、生态化设计、非物质化设计、艺术化设计某些特征的分别描述,揭示了设计发展的主要趋势,分析了这些趋势对现在及未来生活的影响和意义。

关键词：设计人性化生态化数字化信息化

基于多芯光纤错位熔接结构的温度与折射率同时测量传感器

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光电子．激光 2018年第3期29卷 243-248页

作者：胡义慧孙四梅毛敏江超郭小珊黄会玲夏果湖北师范大学物理与电子科学学院湖北黄石435002

提出了一款由输入单模光纤(SMF)-多芯光纤(MCF)-多模光纤(MMF)-输出SMF错位熔接构成的光纤Mach-Zehnder干涉仪(MZI)结构,实现了环境温度和折射率的同时测量。实验结果表明,随着环境温度的变化,传感器透射谱峰值波长线性漂移,灵敏度达到5... 详细信息

提出了一款由输入单模光纤(SMF)-多芯光纤(MCF)-多模光纤(MMF)-输出SMF错位熔接构成的光纤Mach-Zehnder干涉仪(MZI)结构,实现了环境温度和折射率的同时测量。实验结果表明,随着环境温度的变化,传感器透射谱峰值波长线性漂移,灵敏度达到54.238pm/℃,而透射谱峰值强度随温度变化不敏感;随着环境折射率的变化,传感器透射谱峰值强度线性变化,灵敏度达到10.704dB/RIU(RIU为折射率单位),而透射谱峰值波长随环境折射率变化不敏感。通过同时监测传感器输出光谱的峰值波长漂移量和峰值强度变化量,能够实现温度与折射率的同时测量。在温度与折射率测量时分别利用波长调制法与强度调制法,因此它们同时测量不存在交叉感染。本文传感器具有结构简单、制作容易和灵敏度高等优点,在生物、化学和医学等领域有广泛的应用前景。

关键词：光纤传感器 Mach-Zehnder干涉仪(MZI) 光纤熔接技术多芯光纤(MCF) 折射率和温度