Mangiferin Promotes Bregs Level,Activates Nrf2 Antioxidant Signaling,and Inhibits Proinflammatory Cytokine Expression in Murine Splenic Mononuclear Cells In Vitro
作者机构：Department of HematologyInstitute of HematologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of HematologyHuaihe Hospital of Henan UniversityKaifeng 475000China Department of GastroenterologyWuhan Resources&Wisco General HospitalWuhan 430080China Collaborative Innovation Center of HematologySoochow UniversitySuzhou 215000China Department of Cardiovascular SurgeryZhongnan HospitalWuhan UniversityWuhan 430071China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2021年第41卷第3期
页 面：454-464页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the National Natural Science Foundation of China(No.81470347,No.81974003) The authors would like to thank the Department of Central Laboratory,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China,for providing relevant experimental facilities and technical support
主 题：mangiferin regulatory B cells nuclear factor erythroid 2-related factor 2 interleukin-10 immunomodulation anti-inflammation
摘 要：Recent studies indicated that regulatory B cells(Bregs)and nuclear factor erythroid 2-related factor 2(Nrf2)antioxidant signaling pathway play important roles in the pathogenesis of chronic graft-versus-host disease(cGVHD).Mangiferin(MA),a polyphenol compound,has been reported to activate Nrf2/antioxidant-responsive element(ARE)signaling *** study was aimed to investigate the effects of MA on Bregs and Nrf2 antioxidant signaling in murine splenic mononuclear cells(MNCs)in *** results revealed that MA could increase the Bregs level in murine splenic ***,MA up-regulated the expression of Bregs-associated immunosuppressive factor interleukin-10(IL-10)by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)and extracellular signal-regulated kinase(ERK)signaling in murine splenic ***,MA inhibited the proinflammatory cytokines IL-2 and interferon-y(INF-y)at both mRNA and protein *** also enhanced the transcription and protein expression of Nrf2 and NADPH quinine oxidoreductase 1(NQOl),whereas decreased that of Kelch-like ECH-associated protein 1(Keapl)in murine splenic ***,MA promoted the proliferation and inhibited the apoptosis of murine splenic *** results suggested that MA exerts immunosuppressive effects by upregulating the Bregs level,activating the Nrf2 antioxidant pathway,and inhibiting the expression of pro-immunoinflammatory ***,as a natural immunomodulatory and anti-inflammatory agent,may have a potential role in the prophylaxis and treatment of cGVHD.
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