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冠心病不同阶段临床特征与证素分布的回顾性横断面调查

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中国中药杂志 2024年第5期49卷 1406-1414页

作者：钟森杰赵新元高翔黄汝银陈洁吴辉方红城冼绍祥广州中医药大学第一附属医院广东广州510405 广州中医药大学博士后科研流动站广东广州510006 深圳市中西医结合医院广东深圳518104

回顾性采集2022年1月—2023年3月在广州中医药大学第一附属医院、深圳市中西医结合医院诊疗的冠心病(CHD)患者临床资料,描述性分析人口学特征、临床症状与舌脉特征,χ2检验分析不同阶段的证素及证素组合分布差异,探讨CHD不同病理阶段的... 详细信息

回顾性采集2022年1月—2023年3月在广州中医药大学第一附属医院、深圳市中西医结合医院诊疗的冠心病(CHD)患者临床资料,描述性分析人口学特征、临床症状与舌脉特征,χ2检验分析不同阶段的证素及证素组合分布差异,探讨CHD不同病理阶段的临床特征与证素规律。研究提取28条症状条目、10条舌象条目与7条脉象条目;归纳心、肺、肝、脾、肾5个主要病位,血瘀、痰湿、气滞、热(火)、水饮、气虚、阴虚、阳虚8个主要病性,凝练8种病性组合形式。证素分布的χ2检验结果示,肺、肝、脾、肾、血瘀、气滞、热(火)、水饮、气虚、阴虚、阳虚证素在CHD不同阶段的分布差异显著,肝、血瘀、热(火)、气滞证素在不稳定期占比最高,肺、脾、肾、水饮、气虚、阴虚、阳虚证素在终末期占比最高;气虚证素在经皮冠状动脉介入术(PCI)术后不同时间段的分布差异显著。证素组合的χ2检验结果示,单病位、多病位、单病性、双病性、多病性、单纯实证、虚实夹杂组合在CHD不同阶段的分布差异显著,单病位、单病性、单纯实证在稳定期占比最高,双病性在不稳定期占比最高,多病位、多病性、虚实夹杂在终末期占比最高。结果表明,稳定期痰瘀并重,不稳定期存在瘀毒致变的病理转折,PCI术后总体气虚加剧,终末期损及阴阳、水饮渐盛。CHD不同阶段的临床特征与证素分布存在显著差异,是以虚实消长、痰瘀共病为基本病机的病理过程。

关键词：冠心病急性冠脉综合征经皮冠状动脉介入术慢性心力衰竭证素回顾性研究

自动化顶空平衡-气相色谱法测定京杭运河中溶解甲烷

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中国环境科学 2024年第3期44卷 1507-1514页

作者：温军臧昆鹏潘凤梅申小龙魏康轩兰文港胡智伟陈啸鸣陈炳江李珊鲁嫣冉陈丽涵郭朋方双喜林溢陈圆圆刘硕徐宏辉浙江工业大学环境学院浙江杭州310014 浙江工业大学浙江碳中和创新研究院浙江杭州310014 浙江省气象科学研究所浙江杭州310008

将顶空平衡法和气相色谱仪相结合,通过自主设计和优化测试实现了技术升级,建立了可自动化进样并同步测定水中溶解CH_(4)和CO_(2)浓度的新型气相色谱系统及方法.结果表明,本系统线性范围宽且运行稳定,自动化程度更高,运行成本更低.该系统... 详细信息

将顶空平衡法和气相色谱仪相结合,通过自主设计和优化测试实现了技术升级,建立了可自动化进样并同步测定水中溶解CH_(4)和CO_(2)浓度的新型气相色谱系统及方法.结果表明,本系统线性范围宽且运行稳定,自动化程度更高,运行成本更低.该系统对CH_(4)的测定精密度优于0.16%,准确度优于0.02%,满足水中溶解CH_(4)浓度监测需求.基于本方法,于2022年8月对京杭大运河杭州段水体中溶解CH_(4)开展了试观测研究.结果显示:夏季京杭大运河杭州段水体中溶解CH_(4)浓度平均值为(642.4±423.3)nmol/L,饱和度平均值为(22310±14701)%,水-气界面CH_(4)扩散通量平均值为(548.57±603.70)μmol/(m^(2)·d),是大气CH_(4)的净源.根据该河段的面积,可估算观测期内CH_(4)的日均排放量约为1710mol,相当于大约38.31m^(3)天然气或约82.94kg碳.

关键词：顶空平衡气相色谱京杭大运河甲烷通量

Mechanistic insight into lysyl oxidase in vascular remodeling and angiogenesis

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Genes & Diseases 2023年第3期10卷 771-785页

作者： Zhao-Jun Wang Qi-Wen Guan hong-Hao Zhou Xiao-yuan Mao fang-hui chen Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Institute of Clinical Pharmacology Central South UniversityHunan Key Laboratory of PharmacogeneticsChangshaHunan 410078China Engineering Research Center of Applied Technology of Pharmacogenomics Ministry of EducationChangshaHunan 410078China National Clinical Research Center for Geriatric Disorders ChangshaHunan 410008China Department of Pharmacy The First Affliated Hospital of Gannan Medical UniversityGanzhouJiangxi 341000China

Vascular remodeling and angiogenesis are two key processes in the maintenance of vascular homeostasis and involved in a wide array of vascular pathologies. Following these processes, extracellular matrix (ECM) provides the mechanical foundation for vascular walls. Lysyl oxidase (LOX), the key matrix-modifying enzyme, has been demonstrated to significantly affect structural abnormality and dysfunction in the blood vessels. The role of LOX in vascular remodeling and angiogenesis has always been the subject in the current medical research. Therefore, we presently make a summarization of the biosynthesis of LOX and the mechanisms involved in vascular remodeling and angiogenesis, as well as the role of LOX in diseases associated with vascular abnormalities and the therapeutic potential via targeting LOX. In particular, we give a proposal that LOX likely reshapes matrisome-associated genes expressions in the regulation of vascular remodeling and angiogenesis, which serves as a mechanistic insight into the critical role of LOX in these two aspects. Additionally, LOX has also dual effects on the vascular dysfunction, namely, inhibition of LOX for improving hypertension, restenosis and malignant tumor while activation of LOX for curing arterial aneurysm and dissection. LOX-targeted therapy may provide a promising therapeutic strategy for the treatment of various vascular pathologies associated with vascular remodeling and angiogenesis.

关键词： Angiogenesis Disease pathology Lysyl oxidase Therapeutic target Vascular homeostasis Vascular remodeling

人苯丙氨酸羟化酶突变体p.R243Q、p.R241C和p.Y356X的体外表达及功能研究

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中国当代儿科杂志 2024年第2期26卷 188-193页

作者：庞永红高翔羽袁振亚黄辉王增芹彭磊李逸群刘杰刘冬陈桂荣徐州医科大学附属徐州妇幼保健院江苏徐州221009 东南大学附属徐州医院新生儿科江苏徐州221009

目的分析3种苯丙氨酸羟化酶(phenylalanine hydroxylase,PAH)突变体(p.R243Q、p.R241C和p.Y356X)的体外表达,确定3种突变体的致病性。方法利用生物信息学技术预测PAH突变体对PAH蛋白结构和功能的影响。构建相应的PAH突变型质粒,在人胚... 详细信息

目的分析3种苯丙氨酸羟化酶(phenylalanine hydroxylase,PAH)突变体(p.R243Q、p.R241C和p.Y356X)的体外表达,确定3种突变体的致病性。方法利用生物信息学技术预测PAH突变体对PAH蛋白结构和功能的影响。构建相应的PAH突变型质粒,在人胚胎肾细胞HEK293T中进行表达,采用定量逆转录聚合酶链反应检测3种PAH突变体的mRNA表达水平,利用蛋白质印迹法与酶联免疫吸附试验检测突变体的PAH蛋白表达水平。结果生物信息学分析预测结果显示,3种突变体均具备致病性。突变体p.R243Q和p.R241C质粒在HEK293T细胞中的mRNA表达水平与野生型类似(P>0.05),而p.Y356X突变体质粒的mRNA表达水平明显下降(P0.05)。结论p.R243Q、p.R241C和p.Y356X降低真核细胞中PAH蛋白的表达量,其中p.R241C和p.Y356X还影响PAH蛋白的功能,这3种PAH突变体均为致病性突变。

关键词：苯丙氨酸羟化酶缺乏症突变体体外表达细胞

A new monosaccharide from Swertia punicea Hemsl

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Chinese Chemical Letters 2009年第6期20卷 684-686页

作者： Luan yuan Tian Jia Chun chen Jin Bo fang qun Zhou Xue Bai Jian Qiu Zhou Xiang hong chen Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation Tongji School of Pharmaceutical Sciences Huazhong University of Science and Technology Wuhan 430030 China

A new compound named 1-hydrate, 3-deoxy-α-D-tagatofuranose was isolated from Swertia punicea Hemsl. The structure of compound was determined by 1D and 2D NMR, HRESIMS techniques.

关键词： Swertia punicea Hemsl. Monosaccharide 1-Hydrate 3-Deoxy -α-D-tagatofuranose

A Novel Method of the Preparation ofChemically Modified Electrodes

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Chemical Research in Chinese Universities 1995年第1期11卷 67-70页

作者： LI Gen-xi LIAO Xiang-min fang hui-qun and chen hong-yuan(Department of Chemistry,Institute of Coordination Chemistry ,Nanjing University,Manjing,210008 ) NANJING UNIV INST COORDINAT CHEMDEPT CHEMNANJING 210008PEOPLES R CHINA

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关键词： Chemically modified electrodes Preparation method silver Phenoth-iazine Hemoglobin

A novel linear microprobe array for the fabrication of neural microelectrodes

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Science China(Technological Sciences) 2015年第2期58卷 346-351页

作者： ZHAO Shan Shan PEI Wei Hua ZHAO hui WANG Yi Jun chen San yuan chen yuan fang ZHANG He GUO Dong Mei GUI Qiang chen hong Da State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Institute for Neural Computation University of California San Diego

A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from *** LMPA leverages the properties of conventional microwire with additional features of naturally formed regular *** the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’rear ends,the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the *** fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy(EIS)and in vivo *** SNR of the spikes recorded was 6.

关键词： LMPA regular spacing cleavage fracture V-groove

The Influence of Transgenic cry1Ab/cry1Ac,cry1C and cry2A Rice on Non-Target Planthoppers and Their Main Predators Under Field Conditions

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Agricultural Sciences in China 2011年第11期10卷 1739-1747页

作者： HANYu XU Xue-liang MA Wei-hua yuan Ben-qi WANG hui LIU fang-zhou WANG Man-qun WU Gang HUA hong-xia Hubei lnsect Resources Utilization and Sustainable Pest Management Key Laboratory College of Plant Science and Technology HuazhongAgricultural University Wuhan 430070 P.R.China

Transgenic Bt rice has been shown to be an effective means of controlling Lepidoptera pests of rice. However, the potential roles of transgenic rice on planthoppers and their predators need to be investigated before its commercialization. Population density, species dominance and population dynamics are important parameters of arthropods populations in field. So the impacts of three transgenic Bt rice strains expressing crylAb/crylAc, crylC and cry2A on population density, species dominance and population dynamics of three species of planthoppers （Nilaparvata lugens, Sogatella furcifera and Laodelphax striatellus） and their three main predators （ Cyrtorhinus lividipennis, Pirata subpiraticus and Theridium octomaculatum） were evaluated at three sites in Hubei Province, China, in the current study. The results showed that among three species of planthoppers, both in transgenic and non-transgenic rice field, the predominant species ofplanthoppers within phytophagous guild was S. furcifera at any site either growing season （46-50%）. Significantly higher population density ofN. lugens was observed in T2A-1 field relative to Minghui 63 field at Wuxue in 2010. The species dominance of predator, P. subpiraticus, in TT51 field was significantly higher than that in T 1 C-19 and T2A-1 fields in 2009 at Xiaogan site. Sampling date significantly influenced six arthropods except for P. subpiraticus in 2010. The interaction between rice strain^sampling date had no significant adverse effects on the population dynamics of three species of planthoppers and their predators, except for several individual species in 2009. The interaction among rice strain^sampling date^sampling site also had no significant effect on six arthropods except for S. furcifera in 2009. The results indicated that transgenic Bt rice expressing crylAb/crylAc, cry2A and crylC had no significant adverse effects on the population dynamics of three planthoppers and their predators in most investigated data and samp

关键词： planthopper predator transgenic Bt rice population dynamics species dominance population density

A New Thionine Modified Electrode by Anchorage to Bi-(2-aminoethyl)-aminodithiocarboxyl Acid Self-assembled Monolayers through Coordination with Cu^(2+#)

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Chinese Chemical Letters 1997年第11期8卷 993-996页

作者： Jing Juan XU hong yuan chen Rui qun fang (Department of Chemistry, the State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093) Department of Chemistry State Key Lab. of Coord. Chemistry Nanjing University Nanjing 210093 China

A new method for preparing chemically modified gold electrode by anchoring thionine to self-assembled bi - (2 -aminoethyl) -aminodithiocarboxyl acid(BANTC) monolayers through coordination with Cu2+ is described. This thionine modified electrode exhibits two-new redox *** protons were involved in the electrochemical process undergone by the couple I in the pH range of 5.0-10.0. The apparent surface electron transfer rate constant is about 0.050s-1.

关键词： aminodithiocarboxyl Acid Self-assembled Monolayers through Coordination with Cu A New Thionine Modified Electrode by Anchorage to Bi aminoethyl