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Involvement of glycated albumin in adipose-derived-stem cellmediated interleukin 17 secreting T helper cell activation

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World Journal of Stem Cells 2020年第7期12卷 621-632页

作者： Julien Pestel Maud Robert Sara Corbin hubert vidal Assia Eljaafari INSERM U1060 CarMen Batiment CENS-ELICentre Hospitalier Lyon SudPierre Bénite 69310France Faculty of Medicine UniversitéClaude Bernard Lyon 1Batiment CENS-ELICentre Hospitalier Lyon SudPierre Bénite 69310France Department of Surgery in Gastro-enterology Edouard Herriot HospitalLyon 69003France Public Health Department Hospices Civils de Lyon1 quai des célestins Lyon 69002France DO-IT Research Team Hospices Civils de Lyon1 quai des célestinsLyon 69002France

BACKGROUND Advanced glycation end products(AGE)are a marker of various diseases including diabetes,in which they participate to vascular damages such as retinopathy,nephropathy and *** those vascular complications,AGE are involved in altered metabolism in many tissues,including adipose tissue(AT)where they contribute to reduced glucose uptake and attenuation of insulin *** are known to contribute to type 1 diabetes(T1D)through promotion of interleukin(IL)-17 secreting T helper(Th17)*** To investigate whether lean adipose-derived stem cells(ASC)could be able to induce IL-17A secretion,with the help of *** As we have recently demonstrated that ASC are involved in Th17 cell promotion when they are harvested from obese AT,we used the same co-culture model to measure the impact of glycated human serum albumin(G-HSA)on human lean ASC interacting with blood mononuclear ***-17A and pro-inflammatory cytokine secretion were measured by *** of AGE(RAGE)together with intercellular adhesion molecule 1(ICAM-1),human leukocyte Antigen(HLA)-DR,cluster of differentiation(CD)41,and CD62P surface expressions were measured by ***-RAGE specific monoclonal antibody was added to co-cultures in order to evaluate the role of RAGE in IL-17A *** Results showed that whereas 1%G-HSA only weakly potentiated the production of IL-17A by T cells interacting with ASC harvested from obese subjects,it markedly increased IL-17A,but also interferon gamma and tumor necrosis factor alpha production in the presence of ASC harvested from lean *** was associated with increased expression of RAGE and HLA-DR molecule by cocultured ***,RAGE blockade experiments demonstrated RAGE specific involvement in lean ASC-mediated Th-17 cell ***,platelet aggregation and ICAM-1,which are known to be induced by AGE,were not involved in these *** Thus,our results demonstrated tha

关键词： Interleukin 17 secreting T helper cells Lean adipose tissue Type 1 diabetes Advanced glycation end products Adipose-derived stem cells

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Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver

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Journal of Molecular Cell Biology 2016年第2期8卷 129-143页

作者： Pierre Theurey Emily Tubbs Guillaume Vial Julien Jacquemetton Nadia Bendridi Marie-Agnes Chauvin Muhammad Rizwan Alam Muriel Le Romancer hubert vidal Jennifer Rieusset INSERM UMR-1060 CarMeN LaboratoryLyon 1 UniversityINRA U1235INSA of LyonRockefeller and Charles Merieux Lyon-Sud medical UniversitiesF-69003 LyonFrance Cancer Research Center of Lyon Centre Leon BerardUMR INSERM 1052CNRS 5286F-69373 LyonFrance Hospices Civils de Lyon Lyon-Sud HospitalEndocrinologyDiabetology and Nutrition ServiceF-69310 Pierre BeniteFrance

Mitochondria-associated endoplasmic reticulum membranes(MAM)play a key role in mitochondrial dynamics and function and in hepatic insulin *** mitochondria are important regulators of energy metabolism,the nutritional regulation of MAM in the liver and its role in the adaptation of mitochondria physiology to nutrient availability are *** this study,we found that the fasted to postprandial transition reduced the number of endoplasmic reticulum-mitochondria contact points in mouse *** of potential hormonal/metabolic signals revealed glucose as the main nutritional regulator of hepatic MAM integrity both in vitro and in *** reduced organelle interactions through the pentose phosphate-protein phosphatase 2A(PP-PP2A)pathway,induced mitochondria fission,and impaired *** MAM reduction counteracted glucose-induced mitochondrial ***,disruption of MAM integrity mimicked effects of glucose on mitochondria dynamics and *** glucose-sensing system is deficient in the liver of insulin-resistant ob/ob and cyclophilin D-KO mice,both characterized by chronic disruption of MAM integrity,mitochondrial fission,and altered mitochondrial *** data indicate that MAM contribute to the hepatic glucose-sensing system,allowing regulation of mitochondria dynamics and function during nutritional *** disruption of MAM may participate in hepatic mitochondrial dysfunction associated with insulin resistance.

关键词： MAM mitochondria dynamics hepatocytes glucose sensing pentose phosphate pathway PP2A

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Endocrine disrupting chemicals in mixture and obesity,diabetes and related metabolic disorders

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World Journal of Biological Chemistry 2017年第2期8卷 108-119页

作者： Brigitte Le Magueresse-Battistoni Emmanuel Labaronne hubert vidal Danielle Naville CarMeN Laboratory IN SERM U1060Facultede Medecine Lyon-Sud Univ-Lyon Car Me N LaboratoryINSERM U1060INRA U1397Universite Claude Bernard Lyon1INSA LyonCharles Merieux Medical School Univ-Lyon CarMeN LaboratoryINSERM U1060INRA U1397Universite Claude Bernard Lyon1INSA LyonCharles Merieux Medical School

Obesity and associated metabolic disorders represent a major societal challenge in health and quality of life with large psychological consequences in addition to physical disabilities. They are also one of the leading causes of morbidity and mortality. Although, different etiologic factors including excessive food intake and reduced physical activity have been well identified, they cannot explain the kinetics of epidemic evolution of obesity and diabetes with prevalence rates reaching pandemic proportions. Interestingly, convincing data have shown that environmental pollutants, specifically those endowed with endocrine disrupting activities, could contribute to the etiology of these multifactorial metabolic disorders. Within this review, we will recapitulate characteristics of endocrine disruption. We will demonstrate that metabolic disorders could originate from endocrine disruption with a particular focus on convincing data from the literature. Eventually, we will present how handling an original mouse model of chronic exposition to a mixture of pollutants allowed demonstrating that a mixture of pollutants each at doses beyond their active dose could induce substantial deleterious effects on several metabolic end-points. This proof-of-concept study, as well as other studies on mixtures of pollutants, stresses the needs for revisiting the current threshold model used in risk assessment which does not take into account potential effects of mixtures containing pollutants at environmental doses, e.g., the real life exposure. Certainly, more studies are necessary to better determine the nature of the chemicals to which humans are exposed and at which level, and their health impact. As well, research studies on substitute products are essential to identify harmless molecules.

关键词： Endocrine disrupting chemicals Persistent organic pollutants Phthalates Bisphenol A Metabolic disorders Insulin resistance

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Repsol石油公司园区

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建筑学报 2014年第4期 62-69页

作者： Jesús Román Concha Pe a Marcus Lassan Carolina Fernández Conchi Cobo Guillermo vidal Bodo Schumacher Laura Díaz hubert Lionnez María Millán Hugo Berenguer Guillermo Cervantes Beatriz Heras Zaloa Mayor María Martínez Miguel García Irene Zurdo María Iglesias Alfonso Quiroga 刘亦师拉斐尔.德.拉-霍兹建筑设计公司

Repsol石油公司总部园区位于马德里市中心的门德兹艾瓦罗(MendezAlvaro),是马德里中心市区唯一的一处公司总部园区,在可达性、可持续性和安全性等诸方面都进行了探索.该项目获得了美国绿色建筑协会的LEED白金认证,成为欧洲最“绿色”的... 详细信息

Repsol石油公司总部园区位于马德里市中心的门德兹艾瓦罗(MendezAlvaro),是马德里中心市区唯一的一处公司总部园区,在可达性、可持续性和安全性等诸方面都进行了探索.该项目获得了美国绿色建筑协会的LEED白金认证,成为欧洲最“绿色”的建筑之一.该项目严格依据条件苛刻的可持续设计原则进行设计和建设的,方案的可持续性、生态高效的交通体系、建材的可重复利用性等都是被LEED认证时被考查的重要因素.

关键词：石油公司 LEED 建筑师美术家 Repsol 建筑群园区

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