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Preparation and corrosion resistance of rare earth-silane composite conversion coatings on magnesium-lithium alloy surface

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Rare Metals 2023年第3期42卷 1011-1017页

作者： fang-fang Xu Yong Zhao Yue Xu School of Chemistry and Environment Beihang UniversityBeijing 100191China

The poor corrosion resistance of magnesiumlithium alloy surface works against its application in aerospace,automobile,electronics,*** this research,some kinds of non-toxic and non-polluting rare earth and silane(RE-Si)composite conversion coatings were built up on Mg-Li alloy surface,and formation process of coatings was *** parameters for coating preparation were determined,including immersion time and temperature,pH value of conversion solution and curing *** optimized technological parameters for preparation of RE-Si composite coating were finally *** influence of doping nanoparticles on RE-Si composite coating was also discussed,and the microstructure of coatings shows that the addition of nanoparticles can effectively improve the compactness and uniformity of composite *** corrosion resistance of specimens with RE-Si composite conversion coating is improved to a great extent compared with those of substrate or specimens with single rare earth(RE)conversion coating or with silane *** result also indicates that corrosion resistance of RE-Si composite coating doping with nanoparticles is further *** of the composite coatings was analyzed,and the effect of RE elements and silane on coating formation process was *** resistance mechanism of composite coatings on Mg-Li alloy surface was discussed.

关键词： Magnesium-lithium alloy Rare earth-silane composite coating Nanoparticles Corrosion resistance

Tuning Out-of-Plane Spin Polarization Using in-Plane Magnetic Fields in a Quasi-One-Dimensional Quantum Wire Embedded in （110） Plane

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Chinese Physics Letters 2014年第3期31卷 148-151页

作者： SUN Jin-fang CHENG fang The State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 Department of Physics and Electronic Science Changsha University of Science and Technology Changsha 410004

We investigate theoretically the combination effect of an in-plane magnetic field and spin-orbit interactions （SOIs） on the spin and charge transport property of a quasi-one-dimensional quantum wire embedded in the （110） crystallographic plane. We find that the oscillations of the conductance induced by the SOIs become more significant and different for the spin-up and spin-down electrons in the presence of the in-plane magnetic field. The conductance exhibits a significant anisotropic behavior and electrons exhibit out-of-plane spin polarization which can be tuned by an in-plane magnetic field. These features offer us an efficient way to control SOI-induced spin transport using in-plane magnetic fields.

关键词： Semiconductor quantum wires

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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西藏产业经济发展耦合协调度分析

高原农业 2025年第1期9卷 133-140页

作者：高坤周芳西藏农牧学院植物科学学院西藏农牧学院资源与环境学院西藏林芝860000

通过选取2011-2021年西藏三大产业总值作为指标数据,运用耦合协调度模型对西藏产业经济发展耦合作用进行实证分析。结果表明,2011-2021年西藏产业经济发展指数总体呈上升趋势,第一产业综合指数年均增长4.5%,依然是西藏经济发展中的基础... 详细信息

通过选取2011-2021年西藏三大产业总值作为指标数据,运用耦合协调度模型对西藏产业经济发展耦合作用进行实证分析。结果表明,2011-2021年西藏产业经济发展指数总体呈上升趋势,第一产业综合指数年均增长4.5%,依然是西藏经济发展中的基础性产业;第二产业综合指数年均增长率为4.1%,其提供的设施保障能力不断加强;第三产业综合指数年均增长高达12.5%,其经济带动效果作用不断提升;西藏三大产业与经济发展的协调度由0.144提高到0.94,总体呈现水平向上的趋势,其协同互动发展机制正不断完善。在未来的发展中,西藏仍需要完善第一产业基础性功能,提升第二产业的自主创新能力,稳定第三产业对经济增长的推动作用,注重产业协调发展,促进西藏经济高质量发展。

关键词：西藏产业经济发展耦合协调度灰色关联度

Single-metal-atom site with high-spin state embedded in defective BN nanosheet promotes electrocatalytic nitrogen reduction

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Nano Research 2021年第11期14卷 4211-4219页

作者： Cong fang Wei An College of Chemistry and Chemical Engineering Shanghai University of Engineering ScienceShanghai201620China

Single-atom catalysts (SACs) especially supported on two-dimensional nitrogen-doped carbon substrate have been widely reported to be able to effectively promote electrocatalytic N_(2) reduction reaction (eNRR). The precise design of single-metal-atom active site (SMAS) calls for fundamental understanding of its working mechanism for enhanced eNRR performance. Herein, by means of density functional theory calculations, we theoretically investigate the eNRR performance of nine prototypical SMAS, namely, MN_(2)B_(2) (M: transition metals of IIIB, IVB and VB groups) which comprises of asymmetric ligands of N_(2)B_(2) embedded in defective BN nanosheet. Our results reveal the significant role of spin state of SMAS in tuning the potential-determining steps of eNRR, in which MN_(2)B_(2) site with higher spin magnetic moment (μ) is beneficial to reducing limiting potentials (U_(L)) of eNRR. Specially, CrN_(2)B_(2) (μ = 4μB), VN_(2)B_(2) (μ = 3μB) and MoN_(2)B_(2) (μ = 2μB) demonstrate high activity and selectivity to eNRR. The asymmetric ligands of N_(2)B_(2) are deemed to be superior over mono-symmetric ligands. More importantly, our results demonstrate that breaking (or deviating) of the scaling relations between key N-containing intermediates (*N_(2)H/*N_(2) and *NH2/*N_(2)) on MN_(2)B_(2) can be realized by enhancing spin state of SMAS which renders the active site a balanced N-affinity critical for efficient eNRR. This observation is validated by the calculated Sabatier volcano-shape relation between eNRR limiting potentials and N_(2) adsorption energy. Our study develops the guidance for catalyst design to boost eNRR performance by tuning the spin state of an active site.

关键词： electrocatalysis N_(2)reduction BN nanosheet spin state single-atom catalyst jdensity functional theory(DFT)

中药治疗腰椎椎体间融合术后发热的炎症信号通路

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中国组织工程研究 2025年第21期29卷 4568-4575页

作者：方雨婷彭宏庞玉洁南阳市中医院河南省南阳市473000

背景:术后发热是后路腰椎椎体间融合后常见临床症状之一,目前没有明确的病因病机,患者术后体温易反复,病程较久,西药治疗效果欠佳,影响患者术后恢复。目的:综述总结炎症信号通路和术后发热的关联及中药防治后路腰椎椎体间融合后发热的机... 详细信息

背景:术后发热是后路腰椎椎体间融合后常见临床症状之一,目前没有明确的病因病机,患者术后体温易反复,病程较久,西药治疗效果欠佳,影响患者术后恢复。目的:综述总结炎症信号通路和术后发热的关联及中药防治后路腰椎椎体间融合后发热的机制,为研究术后发热继续探索新的治疗药物。方法:检索CNKI中国期刊全文数据库、万方数据库和PubMed数据库2006年6月至2023年12月收录的文献,中文检索词为“中药,术后发热,炎症,白细胞介素1,白细胞介素6,白细胞介素8,干扰素γ,肿瘤坏死因子,前列腺素E2,p38丝裂原活化蛋白激酶,核因子κB,Toll样受体,Janus激酶/信号转导和转录激活因子,Notch信号通路”;英文检索词为“medicinal herb,postoperative fever,inflammation,interleukin-1,interleukin-6,interleukin-8,γ-interferon,tumor necrosis factor,Prostaglandin E2,p38 mitogen-activated protein kinase,nuclear factor-κB,toll-like receptor,janus kinases/signal transducer and activator of transcription,notch signaling pathway”。阅读文章剔除研究内容不相关、质量差的文献,纳入100篇文献进行归纳总结。结果与结论:(1)手术造成软组织创伤促使机体释放炎症因子,促炎因子作用于下丘脑前部的体温调节中心,促使发热;(2)术后切口内出血及渗液等的吸收,吞噬细胞吞噬坏死细胞的蛋白分解产物后,产生内生致热原(白细胞介素、肿瘤坏死因子、干扰素等)导致发热;(3)细胞因子通过炎症信号通路发挥致炎作用,促使发热;(4)中药或中药复方可以调控炎症信号通路发挥抗炎解热作用防治术后发热;目前中药作用机制尚无定论,应深入研究阐明中医药防治术后发热的相关信号通路,运用现代技术把细胞分子技术与中医药药理作用机制联系起来,以便指导临床医生用药,促进患者术后恢复;(5)中药联合西药治疗术后发热是未来的研究热点,应充分发挥中医药优势,明确不同证型应用中药单体或有效成分提取物和中药汤剂的靶点作用机制。

关键词：中药腰椎椎体间融合术后发热炎症白细胞介素干扰素γ 肿瘤坏死因子信号通路

New emergy indices for sustainable development

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Journal of Environmental Sciences 2003年第4期15卷 562-569页

作者： LUHong-fang LANSheng-fang LILei PENGShao-lin SouthChinaInstituteofBotany ChineseAcademyofSciencesGuangzhou510650China. SouthChinaAgriculturalUniversity Guangzhou510642China)

The emergy indices for the evaluation of system's sustainable development ability were studied. Results indicated that the emergy indices are simplified and merged, and a new emergy index for sustainable development(EISD) is deduced. Employing EISD, two cases are conducted. The first one is to compare three different dike pond agro ecological engineering modes, which are: melon melon cabbage four domestic fishes(mode Ⅰ), melon melon cabbage pig four domestic fishes (mode Ⅱ) and melon melon cabbage pig four domestic fishes combined with Siniperca chuatsi B. ( mode Ⅲ). The result is that the EISD of mode Ⅰ is 0.53. ModeⅡ's EISD is 5.26 times of mode Ⅰ, and mode Ⅲ's EISD is 6.83 times of mode Ⅰ. The second one is to evaluate the development of Zhongshan City, Pearl Delta, during 1996 to 2000. The result indicated that the EISD of Zhongshan had appreciably declined from 1996 to 1998, and quickly improved from 1998 to 2000, partly because of its environment protection and product construction. Both of the two cases studies showed that EISD can assessment the sustainable development ability more roundly, with the consideration of environmental impact and social\|economic effect at the same time.

关键词： indices emergy sustainable development

不同热处理蛋黄脂质对小鼠学习认知能力下降的缓解能力

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食品工业科技 2025年第1期46卷 367-376页

作者：吴瑶刘铭坤方冰张明合肥工业大学食品与生物工程学院安徽合肥230061 中国农业大学营养与健康系北京100083 北京工商大学食品与健康学院北京100048

为探讨不同温度处理下蛋黄脂质对小鼠学习认知能力下降的缓解能力的差异。本研究利用小鼠认知障碍模型,比较95℃(水浴30 min)和121℃(灭菌锅加热30 min)热处理蛋黄脂质组分改善小鼠学习认知能力的差异。研究结果表明,相较于121℃热处理... 详细信息

为探讨不同温度处理下蛋黄脂质对小鼠学习认知能力下降的缓解能力的差异。本研究利用小鼠认知障碍模型,比较95℃(水浴30 min)和121℃(灭菌锅加热30 min)热处理蛋黄脂质组分改善小鼠学习认知能力的差异。研究结果表明,相较于121℃热处理的蛋黄脂质,95℃热处理的蛋黄脂质更有效地降低了Tau蛋白的磷酸化和Aβ1-40、GSK-3β表达,下调了促炎因子的表达,其提升小鼠的学习记忆能力的效果更好。95℃热处理蛋黄脂质中的多不饱和脂肪酸以及DHA较121℃热处理的蛋黄脂质显著增加(P<0.05)。因此,过度的加热条件,会破坏蛋品中DHA等多不饱和脂肪酸,削弱蛋黄脂质的改善认知的生物活性。本研究为蛋制品的热加工工艺的优化提供参考依据。

关键词：蛋黄脂质热处理学习和记忆

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin