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脊髓小脑共济失调中浦肯野神经元信号转导异常的研究进展

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生理学报 2024年第1期76卷 77-88页

作者：吴琼黄青芸谭国鹤广西医科大学转化医学研究中心长寿与老年相关疾病教育部重点实验室广西医科大学基础医学院广西脑科学研究重点实验室南宁530021

脊髓小脑共济失调(spinocerebellar ataxias,SCAs)是一组常染色体显性遗传性神经退行性疾病。目前已知的SCAs亚型众多,具有明显的遗传异质性和临床变异性。浦肯野神经元变性和小脑萎缩是大部分SCAs亚型共同的病理特征。浦肯野神经元的... 详细信息

脊髓小脑共济失调(spinocerebellar ataxias,SCAs)是一组常染色体显性遗传性神经退行性疾病。目前已知的SCAs亚型众多,具有明显的遗传异质性和临床变异性。浦肯野神经元变性和小脑萎缩是大部分SCAs亚型共同的病理特征。浦肯野神经元的生理功能受到多重因素的调节,其信号转导功能障碍会导致小脑运动控制能力失常。本文主要综述了SCAs中浦肯野神经元电压门控离子通道、细胞内钙信号及谷氨酸信号转导异常,旨在为深入理解SCAs的共同发病机制、寻找并开发特异性治疗方法提供理论依据。

关键词：脊髓小脑共济失调浦肯野神经元信号转导离子通道

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党和国家监督贯通协调机制研究

湘潭大学学报（哲学社会科学版） 2024年第1期48卷 36-45页

作者：吴建雄黄琼湘潭大学法学院湖南湘潭411105

党和国家监督贯通协调机制,是权力监督与权利监督的功能互补和有机结合,是跳出历史周期率“两个答案”即党的自我革命和人民监督理论的制度成果。党和国家监督贯通协调机制总体架构由党的集中统一领导机制、党内监督主导机制以及纪检监... 详细信息

党和国家监督贯通协调机制,是权力监督与权利监督的功能互补和有机结合,是跳出历史周期率“两个答案”即党的自我革命和人民监督理论的制度成果。党和国家监督贯通协调机制总体架构由党的集中统一领导机制、党内监督主导机制以及纪检监察监督统筹机制来支撑。党的集中统一领导机制涵盖党对监督体系中的各个监督要素的全面领导,是构建党和国家监督体系的基本前提和根本保证。党内监督主导机制是监督体系中各类监督的方向引领和重要示范。纪检监察统筹机制的功能是:跟进和落实党内监督、保障和接受人大监督、指导和衔接行政监督、衔接和加强司法监督、保障和支持民主监督、接受和引导群众监督及舆论监督、整合和协调审计财会统计监督力量,使党和国家监督体系的制度效能得到充分发挥。

关键词：监督体系领导机制主导机制统筹机制贯通协调

96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 649-660页

作者： Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu qiong wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group Department of Infectious Diseases and Hepatology Unit Institutes of Liver Diseases Research of Guangdong ProvinceNan-fang HospitalSouthern Medical UniversityGuangzhouGuangdongChina The First Hospital of Jilin University Chang-chunJilinChina The First Affiliated Hospital of Xinjiang Medical University UrumqiXinjiangChina The Second Xiangya Hospital of Central South University ChangshaHunanChina Chongqing University Three Gorges Hospital ChongqingChina Mengchao Hepatobiliary Hospital of Fujian Medical University FuzhouFujianChina Liuzhou People’s Hospital LiuzhouGuangxiChina The Third Affiliated Hospital of Zhongshan University GuangzhouGuangdongChina Xiangya Hospital of Central South University ChangshaHunanChina The First Affiliated Hospital of Xinxiang Medical University XinxiangHenanChina West China Hospital of Sichuan University ChengduSichuanChina The Southwest Hospi-tal of AMU ChongqingChina Affiliated Hospital of Zunyi Medical University ZunyiGuizhouChina Henan Provincial People’s Hospital ZhengzhouHenanChina The Third Xiangya Hospital of Central South University ChangshaHunanChina The Fourth Affiliated Hospital of Harbin Medical University HarbinHeilongjiangChina The First Affiliated Hospi-tal of Anhui Medical University HefeiAnhuiChina Tianjin Third Central Hospital TianjinChina The Second Affiliated Hospital of Chongqing Medical University ChongqingChina Jiangsu Hansoh Pharmaceutical Group Co. LtdLianyungangJiangsuChina Members listed in the Supplementary File 1

Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of ***,we update 96-week comparison ***:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 *** virological suppression was defined as HBV DNA levels<20 IU/mL at week *** was evaluated thoroughly with focusing on bone,renal,and metabolic ***:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative *** efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at ***-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving *** addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite ***:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796).

关键词： Hepatitis B Liver function tests Viral hepatitis Liver Osteoporosis

The Comparison Between Two Kinds of Integrative Medicine Therapy with the Single Mifepristone in the Treatment of Uterine Fibroids

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World Journal of Integrated Traditional and Western Medicine 2021年第1期7卷 29-33页

作者： ZHU Jun huang Juan JIANG Tao CHEN Yu-Rong wu qiong Affiliated Suizhou Hospital of Hubei University of Medicine Suizhou Central HospitalSuizhou 441300China Suizhou Maternal and Child Health Hospital Suizhou 441301China

Objective:To compare the clinical efficacy of Gongliuqing Capsule(宫瘤清胶囊)combined with mifepristone,Guizhi Fuling Capsule(桂枝茯苓胶囊)combined with mifepristone,and single mifepristone in the treatment of uterine ***:Retrospective analysis was performed on 307 patients with uterine fibroids receiving drug treatment in our *** 307 patients has been divided into three groups according to the different drug delivery scheme,GLM group of 125 patients taking Gongliuqing Capsule and mifepristone,GFM group of 113 patients taking Guizhi Fuling Capsule(桂枝茯苓胶囊)and mifepristone,SM group of 69 patients only taking *** of the cure rate and effective rate,volume of menstruation,menstrual period and uterine fibroids,level of estrogen and the incidence of adverse reaction of the patients of the 3 ***:After 90days of treatment,the efficiency of GLM and GFM group were higher than that of SM group(P0.05).The cure rate of GLM group was higher than that of the other two groups,and the difference was statistically significant(P0.05).There was no significant difference in the incidence of other sex hormone level and adverse reactions(P>0.05).Conclusions:Compared with the SM to treat uterine fibroids,the integrative medicine therapy were *** them,Gongliuqing Capsule(宫瘤清胶囊)combined with mifepristone has the highest cure rate.

关键词： Uterine fibroids Gongliuqing Capsule Guizhi Fuling Capsule Efficacy Mifepristone

Beneficial effects of moderate to vigorous physical activity on cardiovascular disease among Chinese adults

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Journal of Geriatric Cardiology 2020年第2期17卷 85-95页

作者： qiong LIU Fang-Chao LIU Ke-Yong huang Jian-Xin LI Xue-Li YANG Xin-Yan WANG Ji-Chun CHEN Xiao-Qing LIU Jie CAO Chong SHEN Ling YU Fang-Hong LU Xian-Ping wu Lian-Cheng ZHAO Ying LI Dong-Sheng HU Xiang-Feng LU Jian-Feng huang Dong-Feng GU Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijingChina Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhouChina Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjingChina Department of Cardiology Fujian Provincial HospitalFuzhouChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinanChina Sichuan Center for Disease Control and Prevention ChengduChina Department of Prevention Medicine Shenzhen University School of MedicineShenzhenChina

Background In China,lack of evidence remains a significant challenge for the national initiative to promote physical activity(PA).We aimed to quantify the beneficial effects of meeting or maintaining the recommended PA level[150 minutes per week(min/wk)of moderate PA or 75 min/wk of vigorous PA or an equivalent combination]on incident cardiovascular disease(CVD)among Chinese *** We included 100,560 participants without history of CVD from three cohorts in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)*** proportional hazards models were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for CVD events and its subtypes,including stroke,coronary heart disease,heart failure,and CVD *** During a median follow-up of 7.3 years(range:6–15 years),777,163 person-years and 4693 incident CVD events were *** with participants who were inactive at baseline,the multivariable adjusted HR(95%CI)of developing CVD was 0.74(0.69–0.79)for those who met recommended moderate to vigorous physical activity(MVPA)level at ***,the risk of CVD incidence was reduced with increment of MVPA(Ptrend<0.001),and the HR(95%CI)of highly-active versus inactive category was 0.62(0.56–0.68).Compared with individuals who were inactive both at the baseline and follow-up,those keeping active over the period of follow-up had a substantial lower risk of incident CVD with the HR(95%CI)of 0.57(0.43–0.77).Conclusions The findings demonstrated that meeting and maintaining the recommended MVPA level could reduce the cardiovascular *** adoption of the PA recommendations would have considerable health impacts to the Chinese population.

关键词： Cardiovascular disease China Cohort study Physical activity

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基于超宽带雷达的运动人体目标跟踪成像算法

电子学报 2011年第3期39卷 531-537页

作者：黄琼吴世有孟升卫陈洁方广有上海航天技术研究院802所中国科学院电子学研究所哈尔滨工业大学

超宽带雷达用于人体探测,在大规模城区巷战、反恐斗争和灾害救援等方面有着广阔的应用前景.传统的超宽带成像算法在识别能力及计算效率上已不能满足要求.本文针对运动人体目标场景建立系统模型,将人体运动等效为天线移动扫描,基于快速SE... 详细信息

超宽带雷达用于人体探测,在大规模城区巷战、反恐斗争和灾害救援等方面有着广阔的应用前景.传统的超宽带成像算法在识别能力及计算效率上已不能满足要求.本文针对运动人体目标场景建立系统模型,将人体运动等效为天线移动扫描,基于快速SEABED成像算法提出一种用于超宽带雷达的动目标跟踪成像算法.仿真与实验结果验证了算法的有效性和可行性,该算法对系统硬件要求低,实时性好,准确度高,能完成对运动目标速度估计及运动轨迹跟踪,并对目标边界成像.

关键词：超宽带雷达边界散射变换 SEABED算法目标边界成像动目标跟踪

Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1874-1888页

作者： Penglei Wang Xuechao Jia Bingbing Lu Han huang Jialin Liu Xuejiao Liu qiong wu Yamei Hu Pan Li Huifang Wei Tingting Liu Dengyun Zhao Lingwei Zhang Xueli Tian Yanan Jiang Yan Qiao Wenna Nie Xinli Ma Ruihua Bai Cong Peng Zigang Dong Kangdong Liu Department of Pathophysiology Basic Medicine Research CenterSchool of Basic Medical SciencesAMSZhengzhou University450000 ZhengzhouChina China-US(Henan)Hormel Cancer Institute 450000 ZhengzhouChina The Department of Pathology Affiliated Cancer Hospital of Zhengzhou University450000 ZhengzhouChina The Department of Dermatology Xiangya HospitalCentral South University410078 ChangshaChina The Collaborative Innovation Center of Henan Province for Cancer Chemoprevention 450000 ZhengzhouChina State Key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou University450000 ZhengzhouChina Provincial Cooperative Innovation Center for Cancer Chemoprevention Zhengzhou UniversityZhengzhouChina

Constitutive activation of RAS-RAF-MEK-ERK signaling pathway(MAPK pathway)frequently occurs in many cancers harboring RAS or RAF oncogenic *** of the paradoxical activation induced by a single use of BRAF or MEK inhibitors,dual-target RAF and MEK treatment is thought to be a promising *** this work,we evaluated erianin is a novel inhibitor of CRAF and MEK1/2 kinases,thus suppressing constitutive activation of the MAPK signaling pathway induced by BRAF V600E or RAS *** enzyme profiling,surface plasmon resonance(SPR),isothermal titration calorimetry(ITC),cellular thermal shift assay,computational docking,and molecular dynamics simulations were utilized to screen and identify erianin binding to CRAF and MEK1/*** assay,luminescent ADP detection assay,and enzyme kinetics assay were investigated to identify the efficiency of erianin in CRAF and MEK1/2 kinase ***,erianin suppressed BRAF V600E or RAS mutant melanoma and colorectal cancer cell by inhibiting MEK1/2 and CRAF but not BRAF kinase ***,erianin attenuated melanoma and colorectal cancer in ***,we provide a promising leading compound for BRAF V600E or RAS mutant melanoma and colorectal cancer through dual targeting of CRAF and MEK1/2.

关键词： MEK1/2 BRAF activation

A Light Weight Detection Network with Anchor-based Pooling Module

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A Light Weight Detection Network with Anchor-based Pooling M...

辛几何理论和辛差分格式算法在目标散射场计算中的应用

第三十九届中国控制会议

作者： Zhendong huang Chunlin Chen qiong wu Weibing Li Zhao ding Qiang Ling University of Science and Technology of China Technical Center Anhui JiangHuai Automobile Group CO.Ltd.

Both latency and accuracy are critical metrics for object detection applications. To pursue a good trade-off between accuracy and computational cost in realistic scenarios, this paper proposes a detection network based on YOLOv3. By modifying the backbone of YOLOv3, especially reucing the number of layers, the proposed detection network yields desirable real-time performance with small accuracy loss. Besides, an anchor-based pool module（APM） is utilized to improve the detection network’s adaptability to different aspect ratios of anchor boxes. The proposed detection network is realized and implemented by an embedded platform of Nvidia Xavier. Experiments show that our network can effectively improve accuracy while meeting the timeliness needs of embedded devices, and APM provides stronger features to the detection network.

关键词： Object detection Yolov3 Light weight

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中国科学技术大学学报 2006年第11期36卷 1160-1164页

作者：吴琼黄志祥吴先良安庆师范学院数学与计算科学学院安徽安庆246011 安徽大学教育部计算智能与信号处理重点实验室安徽合肥230039

通过分析辛几何理论、辛差分格式和显示辛差分格式,提出了一种将辛差分格式算法与辛几何理论结合起来,计算复杂目标散射场的新方法,该方法具有长时间的守恒性和精确性.还给出二维椭圆形反射天线焦散区散射场的计算实例,计算结果证明了... 详细信息

通过分析辛几何理论、辛差分格式和显示辛差分格式,提出了一种将辛差分格式算法与辛几何理论结合起来,计算复杂目标散射场的新方法,该方法具有长时间的守恒性和精确性.还给出二维椭圆形反射天线焦散区散射场的计算实例,计算结果证明了辛几何理论结合辛差分格式求解散射场方法的有效性.

关键词：辛几何理论辛差分格式焦散区