Beneficial effects of moderate to vigorous physical activity on cardiovascular disease among Chinese adults

作     者：Qiong LIU Fang-Chao LIU Ke-Yong HUANG Jian-Xin LI Xue-Li YANG Xin-Yan WANG Ji-Chun CHEN Xiao-Qing LIU Jie CAO Chong SHEN Ling YU Fang-Hong LU Xian-Ping WU Lian-Cheng ZHAO Ying LI Dong-Sheng HU Xiang-Feng LU Jian-Feng HUANG Dong-Feng GU Qiong LIU;Fang-Chao LIU;Ke-Yong HUANG;Jian-Xin LI;Xue-Li YANG;Xin-Yan WANG;Ji-Chun CHEN;Xiao-Qing LIU;Jie CAO;Chong SHEN;Ling YU;Fang-Hong LU;Xian-Ping WU;Lian-Cheng ZHAO;Ying LI;Dong-Sheng HU;Xiang-Feng LU;Jian-Feng HUANG;Dong-Feng GU

作者机构：Key Laboratory of Cardiovascular EpidemiologyChinese Academy of Medical SciencesBeijingChina Department of EpidemiologyFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Division of EpidemiologyGuangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhouChina Department of Epidemiology and BiostatisticsSchool of Public HealthNanjing Medical UniversityNanjingChina Department of CardiologyFujian Provincial HospitalFuzhouChina Cardio-Cerebrovascular Control and Research CenterInstitute of Basic MedicineShandong Academy of Medical SciencesJinanChina Sichuan Center for Disease Control and PreventionChengduChina Department of Prevention MedicineShenzhen University School of MedicineShenzhenChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2020年第17卷第2期

页      面：85-95页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2017-I2M-1-004 & 2019-I2M-2-003) the National Key Research and Development Program of China(2017 YFC0211703 & 2018YFE0115300 & 2018YFC1311703 & 2017YFC0908401) the National Natural Science Foundation of China(91643208) 

主　　题：Cardiovascular disease China Cohort study Physical activity 

摘      要：Background In China,lack of evidence remains a significant challenge for the national initiative to promote physical activity(PA).We aimed to quantify the beneficial effects of meeting or maintaining the recommended PA level[150 minutes per week(min/wk)of moderate PA or 75 min/wk of vigorous PA or an equivalent combination]on incident cardiovascular disease(CVD)among Chinese *** We included 100,560 participants without history of CVD from three cohorts in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)*** proportional hazards models were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for CVD events and its subtypes,including stroke,coronary heart disease,heart failure,and CVD *** During a median follow-up of 7.3 years(range:6–15 years),777,163 person-years and 4693 incident CVD events were *** with participants who were inactive at baseline,the multivariable adjusted HR(95%CI)of developing CVD was 0.74(0.69–0.79)for those who met recommended moderate to vigorous physical activity(MVPA)level at ***,the risk of CVD incidence was reduced with increment of MVPA(Ptrend0.001),and the HR(95%CI)of highly-active versus inactive category was 0.62(0.56–0.68).Compared with individuals who were inactive both at the baseline and follow-up,those keeping active over the period of follow-up had a substantial lower risk of incident CVD with the HR(95%CI)of 0.57(0.43–0.77).Conclusions The findings demonstrated that meeting and maintaining the recommended MVPA level could reduce the cardiovascular *** adoption of the PA recommendations would have considerable health impacts to the Chinese population.