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饮水型精油复合酸化剂对肉鸡生长性能的影响及其抑菌功效

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现代畜牧兽医 2022年第11期 29-34页

作者：董雯雯黄铁军于海燕张世栋艾洪新李丽李峰蒋治国山东省农业科学院家禽研究所山东省家禽疫病诊断与免疫重点实验室山东济南250100 乐达(广州)香味剂有限公司广东广州510730

试验旨在研究饮水添加精油复合酸化剂对肉鸡生长性能的影响及其抑菌功效。选取1日龄AA肉鸡504只,随机分为4组,每组6个重复,每个重复21只鸡。各组鸡均饲喂基础日粮,对照组饮水中不添加酸化剂,各试验组分别于第1周全程及第2~6周每周的第3~... 详细信息

试验旨在研究饮水添加精油复合酸化剂对肉鸡生长性能的影响及其抑菌功效。选取1日龄AA肉鸡504只,随机分为4组,每组6个重复,每个重复21只鸡。各组鸡均饲喂基础日粮,对照组饮水中不添加酸化剂,各试验组分别于第1周全程及第2~6周每周的第3~4 d全天饮用0.15%、0.20%和0.30%比例的酸化剂。试验期42 d。取养殖场地下水,设置对照组和0.15%、0.20%和0.30%酸化剂添加试验组,测定水pH值、硬度。设空白对照组(配制好的选择性培养基,不作任何处理),并取养殖场地下水1 L,加入0.5麦氏比浊度的大肠杆菌或沙门氏菌标准菌株,随机分为4组;其中酸化剂添加组分别按0.15%、0.20%和0.30%的比例加入精油复合酸化剂,细菌对照组不添加酸化剂。测定酸化剂对水的抑菌效果。结果显示:与对照组相比,试验后期各试验组肉鸡平均体重显著升高(P<0.05),其中0.20%酸化剂添加组肉鸡42日龄平均体重相对最大,可达2963.95 g。与对照组相比,0.15%酸化剂添加组、0.20%酸化剂添加组肉鸡平均采食量和平均每只鸡全程采食量均显著降低(P<0.05)。与对照组相比,各试验组鸡料重比均显著降低(P<0.05)。与对照组相比,添加不同浓度液体酸化剂均能够显著降低养殖场地下水的pH值及硬度(P<0.05)。经不同浓度精油复合酸化剂处理后的培养皿中未见细菌生长。研究表明,使用酸化剂可显著改善鸡群生长性能和饲料转化率,利于减抗、限抗环境下肉鸡的健康养殖。

关键词：肉鸡精油复合酸化剂生长性能抑菌效果饮水添加剂

Joint Modulations of Electromagnetic Waves and Digital Signals on a Single Metasurface Platform to Reach Programmable Wireless Communications

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Engineering 2022年第1期8卷 86-95页

作者： Xiang Wan Chaokun Xiao He huang Qiang Xiao Wei Xu Yueheng Li Joerg Eisenbeis Jiawei Wang Ziai huang Qiang Cheng Shi Jin Thomas Zwick tiejun Cui State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China National Mobile Communications Research Lab Southeast UniversityNanjing 210096China Institute of Radio Frequency Engineering and Electronics(IHE) Karlsruhe Institute of Technology(KIT)Karlsruhe 76131Germany

In current wireless communication and electronic systems,digital signals and electromagnetic(EM)radiation are processed by different ***,we propose a mechanism to fuse the modulation of digital signals and the manipulation of EM radiation on a single programmable metasurface(PM).The PM consists of massive subwavelength-scale digital coding elements.A set of digital states of all elements forms simultaneous digital information roles for modulation and the wave-control sequence code of the *** designing digital coding sequences in the spatial and temporal domains,the digital information and farfield patterns of the PM can be programmed simultaneously and instantly in desired *** the experimental demonstration of the mechanism,we present a programmable wireless communication *** same system can realize transmissions of digital information in single-channel modes with beamsteerable capability and multichannel modes with multiple independent *** measured results show the excellent performance of the programmable *** work provides excellent prospects for applications in fifth-or sixth-generation wireless communications and modern intelligent platforms for unmanned aircrafts and vehicles.

关键词： Joint radar and communication Programmable metasurface Massive multiple-in and multiple-out

Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis

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Science China(Life Sciences) 2021年第9期64卷 1379-1391页

作者： Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi huang tiejun Li Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijing 100081China Beijing Advanced Innovation Center for Genomics(ICG) Biomedical Pioneering Innovation Center(BIOPIC)School of Life SciencesPeking UniversityBeijing 100871China School of Life Sciences and Beijing Advanced Innovation Center for Structural Biology Tsinghua UniversityBeijing 100084China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)Beijing 100081China College of Chemistry and Molecular Engineering and Beijing National Laboratory for Molecular Sciences Peking UniversityBeijing 100871China Institute for Cell Analysis Shenzhen Bay LaboratoryShenzhen 528107China

Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell ***,a predictor of oral leukoplakia prognosis has not yet been *** investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin *** of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with *** also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up *** malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)***,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia.

关键词： oral leukoplakia copy number alteration prognosis prediction

Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws

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International Journal of Oral Science 2021年第2期13卷 200-209页

作者： Ming Ma Lu Liu Ruirui Shi Jianyun Zhang Xiaotian Li Xuefen Li Jiaying Bai Jianbin Wang Yanyi huang tiejun Li Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)BeijingChina Beijing Advanced Innovation Center for Genomics(ICG) Biomedical Pioneering Innovation Center(BIOPIC)School of Life SciencesPeking UniversityBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina School of Life Sciences and Beijing Advanced Innovation Center for Structural Biology Tsinghua UniversityBeijingChina College of Chemistry and Molecular Engineering and Beijing National Laboratory for Molecular Sciences Peking UniversityBeijingChina Institute for Cell Analysis Shenzhen Bay LaboratoryGuangdongChina

Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis *** this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue *** frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for *** fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per *** found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and *** also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number *** further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA ***,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant ***,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression.

关键词： diagnosis precise profiling

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市政给排水工程的长距离顶管施工技术分析

科技资讯 2024年第11期22卷 177-179页

作者：李彬李奕君黄鹏飞李铁军蒋皓月中国市政工程中南设计研究总院有限公司湖北武汉430010

随着城市基础建设的日益完善,为了满足城市建设与发展的需求,市政给排水工程项目逐渐增多。长距离顶管技术可以有效降低挖土量,节约施工用地,在施工中逐渐替代了传统的埋管技术手段。长距离顶管技术的应用可以有效提高施工质量,降低对... 详细信息

随着城市基础建设的日益完善,为了满足城市建设与发展的需求,市政给排水工程项目逐渐增多。长距离顶管技术可以有效降低挖土量,节约施工用地,在施工中逐渐替代了传统的埋管技术手段。长距离顶管技术的应用可以有效提高施工质量,降低对环境的干扰与影响,是一种现代化的技术手段。分析市政给排水工程的长距离顶管施工技术,了解关键技术与工艺手段,可以有效提高施工综合质量。基于此,主要分析了市政给排水工程的长距离顶管施工技术要点。

关键词：市政给排水工程长距离顶管施工纠偏技术地表沉降监控测量

Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development

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Acta Pharmaceutica Sinica B 2021年第10期11卷 2957-2972页

作者： Yuli Wang Xingyan Zhang Yuyan Wang Wenjing Zhao Huling Li Lixing Zhang Xinping Li tiejun Zhang Hongbing Zhang He huang Changxiao Liu Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical ResearchTianjin 300193 China Tianjin Key Laboratory of Quality-Marker of Traditional Chinese Medicines Tianjin Institute of Pharmaceutical ResearchTianjin 300193 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China The Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Thoracic Medical OncologyBeijing Institute of Cancer ResearchBeijing 100142 China Department of Pharmacology Tianjin Medical UniversityTianjin 300070China MITRO Biotech Co. Ltd.Nanjing 211100China

Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance,preventing autoimmune responses,and minimizing tissue damage by regulating the duration and intensity of the immune ***,immune checkpoints are usually overexpressed in cancer cells or noninvasive cells in tumor tissues and are capable of suppressing the antitumor *** on substantial physiological analyses as well as preclinical and clinical studies,checkpoint molecules have been evaluated as potential therapeutic targets for the treatment of multiple types of *** the last few years,extensive evidence has supported the immunoregulatory effects of traditional Chinese medicines(TCMs).The main advantage of TCMs and natural medicine is that they usually contain multiple active components,which can act on multiple targets at the same time,resulting in additive or synergistic *** strong immune regulation function of traditional Chinese medicine on immune checkpoints has also been of great *** example,Astragalus membranaceus polysaccharides can induce anti-PD-1 antibody responses in animals,and these antibodies can overcome the exhaustion of immune cells under tumor immune ***,many other TCM molecules could also be novel and effective drug candidates for the treatment of ***,it is essential to assess the application of immune checkpoints in the development of new drugs and *** this review,we focus on research progress in the field of immune checkpoints based on three topics:(1)immune checkpoint targets and pathways,(2)development of novel immune checkpoint-based drugs,and(3)application of immune checkpoints in the development of TCMs.

关键词： Immune checkpoint Therapeutic target Signaling pathway Drug development Traditional Chinese medicine Immunoregulatory Cancer immunity

耐碳青霉烯类肺炎克雷伯菌及大肠埃希菌临床分离株耐药性及耐药基因分析

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药学实践与服务 2024年第10期42卷 439-444页

作者：黄韵张正银金英郑怡菁李铁军孙莉莉上海交通大学医学院附属仁济医院浦南分院检验科上海200125 上海交通大学医学院附属仁济医院浦南分院药剂科上海200125

目的分析住院患者临床分离的耐碳青霉烯类肺炎克雷伯菌(CR-Kpn)及大肠埃希菌(CR-Eco)耐药现状、耐药类型并检测其相关耐药基因,为临床治疗耐碳青霉烯类肠杆菌目细菌(CRE)感染,合理使用抗菌药物提供参考。方法收集上海交通大学附属仁济... 详细信息

目的分析住院患者临床分离的耐碳青霉烯类肺炎克雷伯菌(CR-Kpn)及大肠埃希菌(CR-Eco)耐药现状、耐药类型并检测其相关耐药基因,为临床治疗耐碳青霉烯类肠杆菌目细菌(CRE)感染,合理使用抗菌药物提供参考。方法收集上海交通大学附属仁济医院浦南分院2022年1月至12月患者临床标本分离的CR-Kpn、CR-Eco非重复分离株共400株,使用肉汤微量稀释法检测分离株对临床常用的抗菌药物的最低抑菌浓度,并通过耐药表型检测、聚合酶链反应(PCR)对CRE的碳青霉烯酶及其相关耐药基因进行检测。结果400株菌株中,检出CRE 51株(12.75%),CRE对替加环素、多黏菌素B的敏感率>95%。51株CRE中有49株产碳青霉烯酶,其中携带bla_(KPC) 34株(66.67%)、携带bla_(NDM) 13株(25.49%)、携带bla_(OXA-482)株(3.92%)。结论和其他临床常用抗菌药物相比,替加环素和多黏菌素B对产碳青霉烯酶的CR-Kpn及CR-Eco具有较好的体外抗菌活性。此外,耐药表型检测和基因型检测有较好的符合性,临床微生物实验室可持续跟踪检测CRE耐药表型和基因型,根据实际情况制订用药方案。

关键词：耐碳青霉烯类肠杆菌碳青霉烯酶表型碳青霉烯酶耐药基因耐药性

刘铁军教授运用通腑除秽法治疗溃疡性结肠炎经验

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亚太传统医药 2024年第8期20卷 130-133页

作者：王慧李济同黄旭鹏李润阳王文帆刘铁军长春中医药大学长春中医药大学附属医院

溃疡性结肠炎是一种慢性非特异性肠道炎症性疾病，属于中医学“痢疾”“肠澼”“泄泻”等范畴。该病发病率呈逐年上升趋势，具有易复发和病程长的特点，严重影响患者的生活质量和身心健康。刘铁军教授认为溃疡性结肠炎的病机关键是“腑... 详细信息

溃疡性结肠炎是一种慢性非特异性肠道炎症性疾病，属于中医学“痢疾”“肠澼”“泄泻”等范畴。该病发病率呈逐年上升趋势，具有易复发和病程长的特点，严重影响患者的生活质量和身心健康。刘铁军教授认为溃疡性结肠炎的病机关键是“腑毒”,肝郁脾虚、食积脾胃、湿热蕴肠、血瘀肠络、脾肾两虚是形成腑毒的重要前提。治疗采用“通腑除秽法”,具体应用以疏肝实脾畅腑毒、消食导滞下腑毒、清热燥湿祛腑毒、化瘀通络消腑毒、健脾益肾通腑毒来治疗溃疡性结肠炎，临床常用经典名方加减化裁治疗，取得了良好疗效。

关键词：通腑除秽法脏毒腑秽溃疡性结肠炎刘铁军名医经验

以临床获益-风险为导向的中西药相互作用研究策略与方法

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中草药 2024年第6期55卷 1780-1787页

作者：李自强吕春晓潘桂湘樊官伟庄朋伟于海洋李遇伯朱立勤张铁军李川谢雁鸣张伯礼黄宇虹天津中医药大学第二附属医院天津300250 天津中医药大学第一附属医院天津300380 天津中医药大学天津301617 天津市第一中心医院天津300192 天津药物研究院天津300462 中国科学院上海药物研究所上海201203 中国中医科学院中医临床基础医学研究所北京100700 组分中药国家重点实验室天津301617

随着中西医结合模式的推广,中西药联用的合理性与安全性话题引起医药界乃至社会各界的广泛关注。面对中西药联用的临床获益-风险证据不足、科学内涵尚不明确的现状,探索基于临床实践的中西药相互作用(Chinese and western medicine inte... 详细信息

随着中西医结合模式的推广,中西药联用的合理性与安全性话题引起医药界乃至社会各界的广泛关注。面对中西药联用的临床获益-风险证据不足、科学内涵尚不明确的现状,探索基于临床实践的中西药相互作用(Chinese and western medicine interactions,CWI)研究路径,有助于回答中西药联用的合理性与安全性。据此提出以临床获益-风险为导向的CWI发现和评价的研究策略:(1)构建以临床获益-风险信号为主、以物质体内暴露信号为辅的CWI发现路径;(2)探索以代谢酶、转运体等药动学靶标及功效靶标为突破点的相互作用评价路径;(3)形成以临床价值为导向的CWI发现及评价的证据体系。旨在优化并推广合理的中西药联用方案,揭示中西药联用有效性与安全性的科学内涵,助力提高中西医结合临床水平。

关键词：中西药联用草药-药物相互作用临床风险信号代谢酶转运体药物-药物相互作用获益-风险评估