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Low contact resistivity and long-term thermal stability of Nb0.8Ti0.2FeSb/Ti thermoelectric junction

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Journal of Materials Science & Technology 2020年第5期40卷 113-118页

作者： Zhijie huang Li Yin Chaoliang Hu Jiajun Shen tiejun Zhu Qian Zhang Kaiyang Xia Jiazhan Xin Xinbing Zhao State Key Laboratory of Silicon Materials and School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Department of Materials Science and Engineering Institute of Materials Genome&Big DataHarbin Institute of TechnologyShenzhen 518055China

Although half-Heusler compounds are quite promising for thermoelectric power generation,there is only limited research on the interfacial structure between metal electrode and half-Heusler compounds for device *** work reports on the characteristics of Nb0.8Ti0.2Fe Sb/Ti junction and its evolution behavior during 973 *** Nb0.8Ti0.2Fe Sb/Ti interface consists of one Ti0.9Fe0.1 layer and one Fe-poor *** is an Ohmic contact and a low contact resistivity(0.15μΩcm^-2)in this junction,on account of the matching of working functions between Nb0.8Ti0.2Fe Sb and Ti0.9Fe0.1 *** high doping of Ti high carrier concentration in Nb Fe Sb matrix leads to a high carrier concentration,which results in inducing a large tunneling current at this *** aging treatment at 973 K,the Fe-poor layer and the Ti0.9 Fe0.1 layer continues to expand,resulting in the increase of the thickness of the interfacial layer and the contact *** interfacial electrical is only 1.9μcm^-2 after 25 days’*** thickness of the interface layer has a good linear relation with the square root of aging time,which firmly indicates that the growth of the layer is determined by mutual diffusion of Fe and Ti atoms across the *** low contract resistivity and long-time thermal stability demonstrate the great potential of Nb0.8Ti0.2Fe Sb/Ti thermoelectric junction in high efficiency half-Heusler TE devices.

关键词： Thermoelectric materials Half-Heusler alloys Electrode Contact resistivity Thermal stability

Gut microbial profiles and the role in lipid metabolism in Shaziling pigs

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Animal Nutrition 2022年第2期9卷 345-356页

作者： Jie Ma Yehui Duan Rui Li Xiaoxiao Liang tiejun Li Xingguo huang Yulong Yin Jie Yin Animal Nutritional Genome and Germplasm InnovationResearch Center College of Animal Science and TechnologyHunan Agricultural UniversityChangsha410128China Institute of Subtropical Agriculture Chinese Academy of SciencesChangsha410125China Henan Ground Biological Science&Technology Co. Ltd.China

Shaziling pig,a Chinese indigenous breed,has been classified as a fatty pig ***,the gut microbial development and role in lipid metabolism in Shaziling pigs has been rarely ***,we compared the lipid metabolic and microbial profiles at 30,60,90,150,210,and 300 d of age between Shaziling and Yorkshire ***,there were marked differences in the liver lipids(i.e.,cholesterol,glucose,and low-density lipoprotein)and the lipid related expressions(i.e.,SREBP1/2,LXRa/b,DGAT1/2,and FABP1-3)between Shaziling and Yorkshire *** sequencing in the ileal digesta and mucosa showed that Shaziling pigs had a higher a-diversity and higher abundances of probiotics,such as Lactobacillus johnsonii,Lactobacillus amylovorus,and Clostridium ***-five differentiated metabolites were further identified in the mucosa between Shaziling and Yorkshire pigs,which were enriched in the carbohydrate,protein,glucose and amino acid metabolism and bile acid ***,7 differentiated microbial species were markedly correlated with metabolites,indicating the role of gut microbiota in the host ***,the role of differentiated *** in lipid metabolism was validated in Duroc×Landrace×Yorkshire(DLY)pigs and the results showed that *** mono-colonization promoted lipid deposition and metabolism by altering gut microbiota(i.e.,Megasphaera elsdenii and ***)and DGAT1/DGAT2/CD36-PPARg gene *** conclusion,Shaziling pigs exhibited different metabolic and microbial profiles compared with Yorkshire pigs,which might have contributed to the diverse metabolic phenotypes,and the significant enrichment of *** in Shaziling pigs promoted lipid metabolism and obesity of DLY pigs,which provided a novel idea to improve the fat content of lean pigs.

关键词： Shaziling pig Gut microbiota Lipid metabolism Lactobacillus johnsonii Fatty acid

放射性核素肺显像预测肺癌切除术后肺功能研究

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深圳中西医结合杂志 2004年第4期14卷 214-216页

作者：赵永胜赵丛雯李成继黄铁军易炜何广仁深圳市第二人民医院核医学科广东深圳518035

目的探讨放射性核素肺显像在预测肺切除术后残余肺功能中的作用。方法 13例均经病理证实的原发性肺癌患者,术前分别进行肺灌注和肺通气显像,对术前1秒钟用力呼气容积的预测值与手术后2个月的实测值进行对比分析。结果放射性核素肺灌... 详细信息

目的探讨放射性核素肺显像在预测肺切除术后残余肺功能中的作用。方法 13例均经病理证实的原发性肺癌患者,术前分别进行肺灌注和肺通气显像,对术前1秒钟用力呼气容积的预测值与手术后2个月的实测值进行对比分析。结果放射性核素肺灌注显像法和放射性核素肺通气显像法的预测值与术后2个月的实测值均呈显著正相关,r 分别为0.981和0.971,P值均<0.01。肺灌注显像与通气显像所得结果一致。结论放射性核素肺显像预测肺切除术后肺功能方法可靠、易行,具有一定的临床实用价值。

关键词：放射性核素肺显像肺切除术肺功能预测

基于中医临床药师规范化培训模式的中药师能力提升路径探索

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中国中医药现代远程教育 2024年第4期22卷 190-192页

作者：徐熠刘静黄瑾徐玲玲吴铁军黄乾元范亮上海中医药大学附属岳阳中西医结合医院药学部上海200437

在新医改的大环境下,药学服务逐渐由以药品为中心转向了以患者为中心的模式,其中药师面临了越来越严峻的转型挑战。为保障中药临床合理用药,促进中药临床药学的发展,2016年起上海开展了中医临床药师在职规范化培训工作。此文通过总结上... 详细信息

在新医改的大环境下,药学服务逐渐由以药品为中心转向了以患者为中心的模式,其中药师面临了越来越严峻的转型挑战。为保障中药临床合理用药,促进中药临床药学的发展,2016年起上海开展了中医临床药师在职规范化培训工作。此文通过总结上海中医药大学附属岳阳中西医结合医院的中医临床药师培训教学模式,优化中医临床药师培养方案,着重突出培养中医临床药师的中医药临床思维、药学服务能力等,从而探索中医临床药师能力提升路径,为中医临床药师人才培养模式提供参考。

关键词：中医临床药师规范化培训提升路径

PPARγ基因沉默的人骨髓基质细胞对骨髓抑制小鼠造血功能的影响

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华中科技大学学报（医学版） 2024年第1期53卷 6-12页

作者：王雪梅黄纯兰周铁军李玉娇魏梦宇陈燕陈晓敏王万玥西南医科大学附属医院血液内科泸州646099 西南医科大学附属医院干细胞实验室泸州646099 西南医科大学附属医院病理科泸州646099

目的观察过氧化物酶体增殖激活受体γ(peroxisome proliferator activated receptor-gamma, PPARγ)基因沉默的人骨髓基质细胞HS-5对骨髓抑制小鼠造血功能的影响,并初步探讨其可能的作用机制。方法用X射线进行全身照射构建骨髓抑制小... 详细信息

目的观察过氧化物酶体增殖激活受体γ(peroxisome proliferator activated receptor-gamma, PPARγ)基因沉默的人骨髓基质细胞HS-5对骨髓抑制小鼠造血功能的影响,并初步探讨其可能的作用机制。方法用X射线进行全身照射构建骨髓抑制小鼠模型,造模后2 h,将小鼠随机分为3组,分别为实验组(尾静脉注射PPARγ RNAi干扰的HS-5细胞)、对照组(尾静脉注射未行PPARγ RNAi干扰的HS-5细胞)、空白组(尾静脉注射等量的生理盐水),每组5只。各组于放疗前、放疗后24 h、放疗后1周、放疗后2周进行外周血常规检测。对HS-5细胞在体外进行成骨、成脂诱导,分为实验组(PPARγ RNAi干扰的HS-5细胞)、对照组(未干扰PPARγ的HS-5细胞)、空白组(未行成骨/成脂诱导分化的HS-5细胞),观察成骨/成脂染色情况。采用CCK-8实验检测PPARγ基因沉默的HS-5细胞对小鼠骨髓造血干细胞(hemopoietic stem cell, HSC)增殖的影响,分为实验组(PPARγ RNAi干扰的HS-5细胞经成骨诱导分化3 d后,与小鼠HSC共培养)、阳性对照组(50μmol/L PPARγ抑制剂处理的HS-5细胞经成骨诱导分化3 d后,与小鼠HSC共培养)、阴性对照组(未干扰PPARγ的HS-5细胞经成骨诱导分化3 d后,与小鼠HSC共培养)、空白组(小鼠HSC单独培养,不与HS-5细胞共培养)。结果放疗后,各组小鼠血常规指标均呈先降低后升高趋势,放疗后1周,三组小鼠血小板、白细胞水平差异显著,且实验组>对照组>空白组(均P<0.05);放疗后2周,三组小鼠脂肪空泡面积百分比差异显著,且实验组<对照组<空白组(均P<0.05),经Pearson相关分析显示,血常规各指标与血清PPARγ表达水平呈负相关(均P<0.05),与脂肪空泡面积百分比呈负相关(均P<0.05)。在体外成骨/成脂诱导分化后,实验组与对照组相比,橙红色的细胞比例明显降低,红色钙结节比例明显增高;成骨分化诱导3 d后,实验组、阳性对照组、阴性对照组人骨髓基质细胞均与小鼠HSC细胞进行共培养,空白组则单纯培养HSC细胞,结果显示共培养24、48、72 h后,实验组、阳性对照组小鼠HSC细胞增殖水平均高于阴性对照组和空白组(均P<0.05)。结论 PPARγ基因沉默的HS-5植入骨髓抑制小鼠后有助于小鼠造血功能增强。PPARγ基因被干扰沉默后,可增强HS-5细胞的成骨分化能力,减弱HS-5细胞的成脂分化能力,而成骨分化诱导的HS-5细胞能进一步增强小鼠HSC的增殖能力。

关键词：过氧化物酶体增殖激活受体γ 人骨髓基质细胞骨髓抑制小鼠造血功能成骨/成脂分化

SURFACE STRESS EFFECT IN MECHANICS OF NANOSTRUCTURED MATERIALS

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Acta Mechanica Solida Sinica 2011年第1期24卷 52-82页

作者： Jianxiang Wang Zhuping huang Huiling Duan Shouwen Yu Xiqiao Feng Gangfeng Wang Weixu Zhang tiejun Wang LTCS and Department of Mechanics and Aerospace Engineering College of Engineering Peking University Beijing 100871 China AML Department of Engineering Mechanics Tsinghua University Beijing 100084 China SV Lab Deparment of Engineering Mechanics School of Aerospace Engineering Xi＇an Jiaotong University Xi＇an 710049 China

This review article summarizes the advances in the surface stress effect in mechanics of nanostructured elements, including nanoparticles, nanowires, nanobeams, and nanofilms, and heterogeneous materials containing nanoscale inhomogeneities. It begins with the fundamental formulations of surface mechanics of solids, including the definition of surface stress as a surface excess quantity, the surface constitutive relations, and the surface equilibrium equations. Then, it depicts some theoretical and experimental studies of the mechanical properties of nanostructured elements, as well as the static and dynamic behaviour of cantilever sensors caused by the surface stress which is influenced by adsorption. Afterwards, the article gives a summary of the analytical elasto-static and dynamic solutions of a single as well as multiple inhomogeneities embedded in a matrix with the interface stress prevailing. The effect of surface elasticity on the diffraction of elastic waves is elucidated. Due to the difficulties in the analytical solution of inhomogeneities of complex shapes and configurations, finite element approaches have been developed for heterogeneous materials with the surface stress. Surface stress and surface energy are inherently related to crack propagation and the stress field in the vicinity of crack tips. The solutions of crack prob- lems taking into account surface stress effects are also included. Predicting the effective elastic and plastic responses of heterogeneous materials while taking into account surface and interface stresses has received much attention. The advances in this topic are inevitably delineated. Mechanics of rough surfaces appears to deserve special attention due to its theoretical and practical implications. Some most recent work is reviewed. Finally, some challenges are pointed out. They include the characterization of surfaces and interfaces of real nanomaterials, experimental mea- surements and verification of mechanical parameters o

关键词： surface/interface stress size-effect nanowires nanobeams nanofilms nanoinhomogeneities cantilevers elastic wave crack elastic constants rough surface effective surface stress

Opportunities of prebiotics for the intestinal health of monogastric animals

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Animal Nutrition 2020年第4期6卷 379-388页

作者： Md A.K.Azad Jing Gao Jie Ma tiejun Li Bie Tan Xingguo huang Jie Yin College of Animal Science and Technology Hunan Agricultural UniversityHunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryChangsha410128China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionChangsha410125China University of Chinese Academy of Sciences Beijing100049China

The goal of prebiotic applications from different sources is to improve the gut ecosystem where the host and microbiota can benefit from *** has already been recognized that prebiotics have potential roles in the gut ecosystem because gut microbiota ferment complex dietary macronutrients and carry out a broad range of functions in the host body,such as the production of nutrients and vitamins,protection against pathogens,and maintenance of immune system *** gut ecosystem is very crucial and can be affected by numerous factors consisting of dietary constituents and commensal *** review focuses on recent scientific evidence,confirming a beneficial effect of prebiotics on animal health,particularly in terms of protection against pathogenic bacteria and increasing the number of beneficial bacteria that may improve epithelial cell barrier *** has also been reviewed that modification of the gut ecosystem through the utilization of prebiotics significantly affects the intestinal health of ***,the identification and characterization of novel potential prebiotics remain a topical issue and elucidation of the metagenomics relationship between gut microbiota alteration and prebiotic substances is necessary for future prebiotic studies.

关键词： Prebiotics Gut microbiota Intestinal health Short-chain fatty acids

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刘铁军运用中药麻黄扶正祛邪经验探微

江西中医药 2024年第1期55卷 34-36页

作者：黄旭鹏王汉苏博扬张芮王毅刘铁军长春中医药大学长春130117 长春中医药大学附属医院长春130021

刘铁军在临床中发现佐以小剂量麻黄可助鼓舞正气、抗邪外出。通过对麻黄功效的再认识,从辛温通阳、轻清透邪功效出发,以中医阳气、卫气和西医神经系统、现代免疫学角度,进一步揭示麻黄鼓舞正气、抗邪外出之效,拓宽麻黄的应用范围。

关键词：麻黄正气免疫扶正祛邪名老中医经验

DETECTION OF ^(36)C1 WITH A ACCELERATOR MASS SPECTROMETRY

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Chinese Physics Letters 1989年第12期6卷 529-532页

作者： JIANG Songsheng MA tiejun JIANG Shan YANG Bingfan WANG Xun huang Qi Institute of Atomic Energy Beijing 102413 Institute of Salt Lake Academia SinicaXining 810008

An accelerator mass spectrometry (AMS) system based on the HI-I3 tandem accelerator at the Institute of Atomic Energy (IAE) is described, and the first detection of ^(36)Cl with our AMS system is reported. The electrostatic deflector completely rejects isotopic background, ^(35)Cl and ^(37)Cl. The ionization chamber distinguishs ^(36)Cl from isobaric background, ^(36)S. The measurement of ^(36)Cl with two samples is presented.

关键词： system electrostatic accelerator