Gut microbial profiles and the role in lipid metabolism in Shaziling pigs

作     者：Jie Ma Yehui Duan Rui Li Xiaoxiao Liang Tiejun Li Xingguo Huang Yulong Yin Jie Yin Jie Ma;Yehui Duan;Rui Li;Xiaoxiao Liang;Tiejun Li;Xingguo Huang;Yulong Yin;Jie Yin

作者机构：Animal Nutritional Genome and Germplasm InnovationResearch CenterCollege of Animal Science and TechnologyHunan Agricultural UniversityChangsha410128China Institute of Subtropical AgricultureChinese Academy of SciencesChangsha410125China Henan Ground Biological Science&Technology Co.Ltd.China 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2022年第9卷第2期

页      面：345-356页

核心收录：

学科分类：0905[农学-畜牧学] 0906[农学-兽医学] 09[农学] 

基　　金：the National Natural Science Foundation(32172761,U19A2037,and U20A2055) Earmarked Fund for China Agriculture Research System(CARS-35) Young Elite Scientists Sponsorship Program by CAST(2019-2021QNRC001) Hunan Science Foundation for Outstanding Young Scholars(2020JJ3023) 

主　　题：Shaziling pig Gut microbiota Lipid metabolism Lactobacillus johnsonii Fatty acid 

摘      要：Shaziling pig,a Chinese indigenous breed,has been classified as a fatty pig ***,the gut microbial development and role in lipid metabolism in Shaziling pigs has been rarely ***,we compared the lipid metabolic and microbial profiles at 30,60,90,150,210,and 300 d of age between Shaziling and Yorkshire ***,there were marked differences in the liver lipids(i.e.,cholesterol,glucose,and low-density lipoprotein)and the lipid related expressions(i.e.,SREBP1/2,LXRa/b,DGAT1/2,and FABP1-3)between Shaziling and Yorkshire *** sequencing in the ileal digesta and mucosa showed that Shaziling pigs had a higher a-diversity and higher abundances of probiotics,such as Lactobacillus johnsonii,Lactobacillus amylovorus,and Clostridium ***-five differentiated metabolites were further identified in the mucosa between Shaziling and Yorkshire pigs,which were enriched in the carbohydrate,protein,glucose and amino acid metabolism and bile acid ***,7 differentiated microbial species were markedly correlated with metabolites,indicating the role of gut microbiota in the host ***,the role of differentiated *** in lipid metabolism was validated in Duroc×Landrace×Yorkshire(DLY)pigs and the results showed that *** mono-colonization promoted lipid deposition and metabolism by altering gut microbiota(i.e.,Megasphaera elsdenii and ***)and DGAT1/DGAT2/CD36-PPARg gene *** conclusion,Shaziling pigs exhibited different metabolic and microbial profiles compared with Yorkshire pigs,which might have contributed to the diverse metabolic phenotypes,and the significant enrichment of *** in Shaziling pigs promoted lipid metabolism and obesity of DLY pigs,which provided a novel idea to improve the fat content of lean pigs.