检索结果-南通市图书馆

miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma

BIOCELL 2024年第4期48卷 581-590页

作者： LIJUAN ZHANG QINGYIN MENG LI Zhuang QUAN GONG XIANDA huang XUEQIN LI SHIJUAN LI GUOQIN WANG XICAI WANG Department of Rehabilitation and Palliative Medicine The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Department of Pathology The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Emergency Department(Outpatient Chemotherapy Center) The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Department of Cancer BioTreatment Center The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Department of Cancer Institute The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina

Background:Lung adenocarcinoma is a very pervasive histological form of lung cancers,and inhibiting metastasis is crucial for effective *** this investigation,we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain(PHTF2)in dictating the aggressiveness and metastasis of lung ***:We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal *** experiments including cell count kit(CCK)-8 growth assay,apoptosis analysis,migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma ***,we examined tumorigenesis and metastasis in a nude mouse ***:MiR-30a-5p exhibited downregulation pattern in lung adenocarcinoma *** of miR-30a-5p mimic in lung adenocarcinoma cells resulted in the suppression of malignant ***,the administration of miR-30a-5p mimic also curbed tumorigenesis and metastasis of lung adenocarcinoma cells in animal ***,PHTF2 was found to be a molecular target of *** PHTF2 counteracted the tumor-suppressive effect of the miR-30a-5p ***:miR-30a-5p functions as a tumor-suppressive molecule while PHTF2 acts as an oncogenic factor in the development and metastasis of lung ***,targeting miR-30a-5p and PHTF2 could be developed into a promising therapeutic approach for inhibiting metastasis in lung adenocarcinoma.

关键词： Lung cancer Malignant phenotype Tumor formation Tumor suppressor Oncogene

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高负荷变动率下核电汽轮机转子热应力数值模拟

引用

热力透平 2024年第1期53卷 43-46,52页

作者：顾先青程昆明叶成黄增宏上海核工程设计研究院有限公司上海200233 山东核电有限公司烟台265116

国内某大型核电汽轮机需要在线性负荷变动率为每分钟6%额定负荷工况下运行,这超出了当前国内建造的第三代核电的设计限制。汽轮机是影响机组负荷变动率的要素之一。采用ANSYS软件对汽轮机进行了有限元分析,模拟了汽轮机高压缸转子在负... 详细信息

国内某大型核电汽轮机需要在线性负荷变动率为每分钟6%额定负荷工况下运行,这超出了当前国内建造的第三代核电的设计限制。汽轮机是影响机组负荷变动率的要素之一。采用ANSYS软件对汽轮机进行了有限元分析,模拟了汽轮机高压缸转子在负荷变动率为每分钟6%额定负荷工况下的温度场和应力场,结合转子疲劳曲线,评估了该高变负荷运行工况对汽轮机转子疲劳寿命的影响。研究成果可以为“双碳”目标下提升核电机组运行灵活性、适应当前核能-多能耦合运行提供参考。

关键词：负荷变动率核电汽轮机转子热应力数值模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Three New Hydroxytetradecenals from Amomum tsao-ko with Protein Tyrosine Phosphatase 1B and Glycogen Phosphorylase Inhibitory Activity

引用

Phyton-International Journal of Experimental Botany 2024年第5期93卷 875-883页

作者： Xiaolu Qin Xinyu Li Yi Yang Mei huang Shengli Wu Pianchou Gongpan Lianzhang Wu Juncai He Changan Geng State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming650201China Nujiang Green Spice Industry Research Institute Lushui673100China University of Chinese Academy of Sciences Beijing100049China

The fruits of Amomum tsao-ko(Cao-Guo)were documented in Chinese Pharmacopoeia for the treatment of abdominal pain,vomiting,and *** our previous study,a series of diarylheptanes and flavonoids withα-glucosidase and protein tyrosine phosphatase 1B(PTP1B)inhibitory activity have been reported from the middle-polarity part of ***-ko,whereas the antidiabetic potency of the low-polarity constituents is still *** this study,three new hydroxytetradecenals,(2E,4E,8Z,11Z)-6R-hydroxytetradeca-2,4,8,11-tetraenal(1),(2E,4E,8Z)-6R-hydroxytetradeca-2,4,8-trienal(2)and(2E,4E)-6R-hydroxytetradeca-2,4-dienal(3)were obtained from the volatile oils of *** structures of compounds 1–3 were determined using spectroscopic data involving 1D and 2D nuclear magnetic resonance(NMR),high-resolution mass spectra(HRMS),and specific rotation([α]D).Their hypoglycemic activity was evaluated against glycogen phosphorylase(GPa)and *** 1 and 2 displayed moderate activity against PTP1B with inhibition rates of 33.8%−50.3%at 100 and 200μ***,compound 1 exhibited an obvious inhibitory effect on GPa(IC50=31.7μM),whereas compound 2 was *** study demonstrates hydroxytetradecenals as the characteristic components of ***-ko with therapeutic potential in diabetes.

关键词： Cao-Guo PTP1B and GPa inhibitors diabetes mellitus volatile oils

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent Advances in Fault Diagnosis Techniques for Photovoltaic Systems:a Critical Review

引用

Protection and Control of Modern Power Systems 2024年第3期9卷 36-59页

作者： Bo Yang Ruyi Zheng Yiming Han Jianxiang huang Miwei Li Hongchun Shu Shi Su Zhengxun Guo the School of Electrical Engineering Kunming University of Science and TechnologyKunmingChina kunming University of Science and Technology KunmingChina the School of Faculty of Electric Power Engineering Kunming University of Science and TechnologyKunming 650500China the kunming Bureau of CSG EHV Transmission Company KunmingChina the Power Science Research Institute of Yunnan Power Grid Co. LtdKunmingChina

If a failure in the components of a photovoltaic(PV)system,such as PV module,controller,inverter,load,cable,*** undetected and uncorrected,it can seriously affect the efficiency,safety,and reliability of the entire PV power *** addition,fires can occur if specific faults,such as arc,ground,and line-to-line faults remain ***,PV system(PVS)fault diagnoses are crucial for PV power plant reliability,efficiency,and *** fault diagnosis methods and techniques for PVS components have been *** addition,with the development of PV devices,more advanced and intelligent diagnostic technologies are continuously being researched and ***,a systematic and thorough analysis,summary,and conclusion are still urgently ***,this paper introduces the types,causes,and impacts of PVS faults,and reviews and discusses the methods proposed in the literature for PVS fault diagnosis,and in particular,failures in PV *** attention is paid to the optimization direction of various fault diagnosis methods under different priorities,and their limitations,feasibility,complexity,and ***,challenges and suggestions are put forward for future research.

关键词： PVS monitoring system PV fault types PV diagnosis review.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Higher palaeoelevation in the Baoshan Basin:Implications for landscape evolution at the southeastern margin of the Tibetan Plateau

引用

Journal of Palaeogeography 2024年第3期13卷 563-580页

作者： Yong-Jiang huang Hao-Ran Zong Shi-Tao Zhang Arata Momohara Jin-Jin Hu Lin-Bo Jia Yun-Heng Ji Zhe-Kun Zhou Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201Yunnan ProvinceChina College of Forestry Shandong Agricultural UniversityTai'an 271018Shandong ProvinceChina Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina Graduate School of Horticulture Chiba UniversityChiba 271-8510Japan Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303Yunnan ProvinceChina

Surface uplift at the southeastern margin of the Tibetan Plateau has been widely studied,but more palaeoaltimetry data are required to better understand the elevation history of this geologically complex *** this study,fossil leaves of Abies(Pinaceae),a cool-temperate element,recovered from the latest Miocene-Pliocene Yangyi Formation of the southern Baoshan Basin,were used as a proxy to estimate the local *** on the regional modern altitude range(2100-4280 m)of the genus as well as regional temperature discrepancy(1.5℃)between the past and present,the palaeoelevation of the study area was calculated to be>2360 m above sea level as compared to 1670 m at *** result suggests that the southern Baoshan Basin experienced pronounced uplift prior to the time of fossil deposition,probably as a result of crustal shortening and thickening of the northern Baoshan Terrane during the *** infer that surface growth in areas south of the Dali Basin may have been greater than previously interpreted,and that a widespread plateau or plateau patches higher than 2000 m probably extended southwards into at least the Baoshan Basin by the latest *** also infer that the elevation of the southern Baoshan Basin has decreased by at least 690 m since then,in contrast to most other scenarios in which the elevation of the southeastern margin of the Tibetan Plateau has increased or remained close to modern levels since the late *** major cause of the inferred altitude decline is likely tectonic *** a transtensional graben basin,the Baoshan Basin has experienced pull-apart and base-fall movement since the late Miocene,which would reduce the altitude of its southern part located on the hanging *** erosion associated with the increased summer rainfall might also have played a role especially in reducing the local relief,although its contribution can be *** study provides one of the few palaeoelevation

关键词： Abies Lapse rate Palaeoaltimetry Surface uplift Tectonic movement Tibetan plateau

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Artificial intelligence-based analysis of tumor-infiltrating lymphocyte spatial distribution for colorectal cancer prognosis

引用

Chinese Medical Journal 2024年第4期137卷 421-430页

作者： Ming Cai Ke Zhao Lin Wu Yanqi huang Minning Zhao Qingru Hu Qicong Chen Su Yao Zhenhui Li Xinjuan Fan Zaiyi Liu Department of Radiology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application GuangzhouGuangdong 510080China Guangdong Cardiovascular Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China Department of Pathology The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunmingYunnan 650118China The Second School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdong 510515China Institute of Computing Science and Technology Guangzhou UniversityGuangzhouGuangdong 510006China Department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China Department of Pathology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655China

Background:Artificial intelligence(AI)technology represented by deep learning has made remarkable achievements in digital pathology,enhancing the accuracy and reliability of diagnosis and prognosis *** spatial distribution of CD3^(+)and CD8^(+)T cells within the tumor microenvironment has been demonstrated to have a significant impact on the prognosis of colorectal cancer(CRC).This study aimed to investigate CD3_(CT)(CD3^(+)T cells density in the core of the tumor[CT])prognostic ability in patients with CRC by using AI ***:The study involved the enrollment of 492 patients from two distinct medical centers,with 358 patients assigned to the training cohort and an additional 134 patients allocated to the validation *** facilitate tissue segmentation and T-cells quantification in whole-slide images(WSIs),a fully automated workflow based on deep learning was *** the completion of tissue segmentation and subsequent cell segmentation,a comprehensive analysis was ***:The evaluation of various positive T cell densities revealed comparable discriminatory ability between CD3_(CT) and CD3-CD8(the combination of CD3^(+)and CD8^(+)T cells density within the CT and invasive margin)in predicting mortality(C-index in training cohort:0.65 vs.0.64;validation cohort:0.69 vs.0.69).The CD3_(CT) was confirmed as an independent prognostic factor,with high CD3_(CT) density associated with increased overall survival(OS)in the training cohort(hazard ratio[HR]=0.22,95%confidence interval[CI]:0.12–0.38,P<0.001)and validation cohort(HR=0.21,95%CI:0.05–0.92,P=0.037).Conclusions:We quantify the spatial distribution of CD3^(+)and CD8^(+)T cells within tissue regions in WSIs using AI *** CD3_(CT) confirmed as a stage-independent predictor for OS in CRC ***,CD3_(CT) shows promise in simplifying the CD3-CD8 system and facilitating its practical application in clinical settings.

关键词： Colorectal cancer Artificial intelligence Deep learning Digital pathology Prognosis Immune cells CD3 CD8 TME

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Meeting of Young Minds--Lancang-Mekong Young Entrepreneurs Forum in kunming

引用

China Report ASEAN 2024年第8期9卷 60-61页

作者： huang Jiangqin Wang Xiang 不详

On July 23,the Lancang-Mekong Young Entrepreneurs Forum,themed“Deepen Cooperation,Share Prosperity,”was held in kunming,southwest China’s Yunnan *** forum,initially proposed by Chinese Premier Li Qiang at the Fourth Lancang-Mekong Cooperation Leaders’Meeting in December 2023,aimed to enhance practical cooperation among youth in the Lancang-Mekong region and accelerate the development of the Lancang-Mekong Economic Development *** 100 representatives of youth organizations and young entrepreneurs from Lancang-Mekong countries attended the event.

关键词： Forum southwest kunming

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

壳聚糖添加量对大米淀粉老化的影响

引用

广西科技大学学报 2024年第3期35卷 132-137页

作者：王昊翊张昆明唐湘毅黄永春广西科技大学生物与化学工程学院广西柳州545006 广西糖资源绿色加工重点实验室(广西科技大学) 广西柳州545006 广西高校糖资源加工重点实验室(广西科技大学) 广西柳州545006

为探究壳聚糖添加量对大米淀粉老化性质的影响,采用差示扫描量热仪、红外光谱(FTIR)和X射线衍射仪对添加不同添加量壳聚糖的老化大米淀粉进行测试,以老化大米淀粉的回生焓值、R值以及相对结晶度等3项指标来评价壳聚糖添加量对大米淀粉... 详细信息

为探究壳聚糖添加量对大米淀粉老化性质的影响,采用差示扫描量热仪、红外光谱(FTIR)和X射线衍射仪对添加不同添加量壳聚糖的老化大米淀粉进行测试,以老化大米淀粉的回生焓值、R值以及相对结晶度等3项指标来评价壳聚糖添加量对大米淀粉老化的影响。结果表明:添加壳聚糖使老化大米淀粉回生焓值增大;FTIR分析结果证实了添加壳聚糖使老化大米淀粉的短程有序性降低;壳聚糖添加量为0.5g(占淀粉干重3.3%)时,淀粉短期回生阶段的短程有序性最低,添加量为0.4g(占淀粉干重2.7%)时,淀粉长期回生阶段的短程有序性最低;老化大米淀粉结构的长程有序性同壳聚糖添加量有关:壳聚糖添加量为0.1g(占淀粉干重0.7%)时,壳聚糖能降低淀粉的相对结晶度,添加量增加到0.5g(占淀粉干重3.3%)后,壳聚糖增大淀粉的相对结晶度,且老化时间越长,使淀粉相对结晶度增大所需的壳聚糖添加量越大。研究结果有助于拓宽壳聚糖的应用范围,也为淀粉老化的调控提供了新思路。

关键词：大米淀粉壳聚糖老化短程有序性长程有序性

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

MOF and its derivative materials modified lithium-sulfur battery separator:a new means to improve performance

引用

Rare Metals 2024年第6期43卷 2418-2443页

作者： Rong-Wei huang Yong-Qi Wang Dan You Wen-Hao Yang Bin-Nan Deng Fei Wang Yue-Jin Zeng Yi-Yong Zhang Xue Li National Local Joint Engineering Research Center for Lithium-Ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Batteries Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Centre of Chemistry for Energy MaterialsState-Province Joint Engineering Laboratory of Power Source Technology for New Energy VehicleEngineering Research Center of Electrochemical TechnologyMinistry of EducationCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

In recent years,lithium-sulfur batteries(LSBs)are considered as one of the most promising new generation energies with the advantages of high theoretical speeific capacity of sulfur(1675 mAh·g^(-1)),abundant sulfur resources,and environmental friendliness storage technologies,and they are receiving wide attention from the ***,the problems of the shuttle effect and lithium dendrite growth in LSBs have limited their practical application,so there is a need to find ways to solve these *** is an excellent choice to use novel materials to modify battery *** those novel materials,the metal-organic framework(MOF)has the properties of regular pores and controllable *** applied as a positive electrode and diaphragm,it can restrain the shuttle effect and lithium dendrite growth,especially since it shows excellent performance in diaphragm ***,various design strategies and synthesis methods of MOF-modified separators are reviewed in this paper,and the applications of MOF in LSBs separators in different forms are introduced,including the composite of MOF and carbon-based materials,the compounding of MOF and polymer,self-carbonization to form MOF-derived *** the same time,different characterization techniques are systematically reviewed to obtain the physical and chemical properties of MOF particles and the working mechanism of MOF-modified diaphragm,which provides a basis for further research in this ***,some future research trends and directions are put forward to fully tap the future commercial potential of MOF-modified diaphragm in LSBs.

关键词： MOF Lithium-sulfur battery Modified diaphragms Design strategies Prospect Characterization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regulating Effect of Substrate Temperature on Sputteringgrown Ge/Si QDs under Low Ge Deposition

引用

Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 888-894页

作者：舒启江 YANG Linjing LIU Hongxing 黄鹏儒 Institute of Information Yunnan University of Chinese MedicineKunming 650500China Guangxi Key Laboratory of Information Materials and Guangxi Collaborative Innovation Center of Structure and Property for New Energy and Materials School of Material Science&EngineeringGuilin University of Electronic TechnologyGuilin 541004China

The effect of deposition temperature on the morphology and optoelectronic performance of Ge/Si QDs grown by magnetron sputtering under low Ge deposition(~4 nm)was investigated by atomic force microscopy,Raman spectroscopy,and photoluminescence(PL)*** experimental results indicate that temperatures higher than 750℃effectively increase the crystallization rate and surface smoothness of the Si buffer layer,and temperatures higher than 600℃significantly enhance the migration ability of Ge atoms,thus increasing the probability of Ge atoms meeting and nucleating to form QDs on Si buffer layer,but an excessively high temperature will cause the QDs to undergo an Ostwald ripening process and thus develop into super large *** addition,some PL peaks were observed in samples containing small-sized,high-density Ge QDs,the photoelectric properties reflected by these peaks were in good agreement with the corresponding structural characteristics of the grown *** results demonstrate the viability of preparing high-quality QDs by magnetron sputtering at high deposition rate,and the temperature effect is expected to work in conjunction with other controllable factors to further regulate QD growth,which paves an effective way for the industrial production of QDs that can be used in future devices.

关键词： Ge/Si QDs deposition temperatures evolution law photoelectric performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：