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驱动蛋白家族成员26B在膀胱癌中的表达及与临床病理特征、预后的关系

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医学信息 2024年第9期37卷 107-111页

作者：卢保德龙贤黄勇平右江民族医学院附属医院泌尿外科

目的探讨驱动蛋白家族成员26B(KIF26B)在膀胱癌中的表达与临床病理特征及预后的关系。方法从TCGA数据库下载膀胱癌RNA表达谱及临床数据，用R语言相关数据包分析KIF26B在膀胱癌中的表达水平及与临床病理、预后的关系。收集2019年5月-2... 详细信息

目的探讨驱动蛋白家族成员26B(KIF26B)在膀胱癌中的表达与临床病理特征及预后的关系。方法从TCGA数据库下载膀胱癌RNA表达谱及临床数据，用R语言相关数据包分析KIF26B在膀胱癌中的表达水平及与临床病理、预后的关系。收集2019年5月-2021年6月在右江民族医学院附属医院接受手术治疗的60例膀胱癌及癌旁组织样本，采用qRT-PCR检测KIF26B在膀胱癌组织中的表达水平，分析KIF26B表达与临床病理特征的关系。结果 TCGA数据库中，膀胱癌组织KIF26B表达高于癌旁正常组织（P0.05）;KIF26B高表达患者肿瘤特异性生存期和总生存期均低于KIF26B低表达者（P0.05）。结论 KIF26B在膀胱癌中高表达，与膀胱癌的临床病理特征及预后相关。

关键词：膀胱癌驱动蛋白家族成员26B 临床病理特征

Proboscipedia and Sex combs reduced are essential for embryonic labial palpus specification in Bombyx mori

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Journal of Integrative Agriculture 2020年第6期19卷 1482-1491页

作者： ZHANG Ru ZHANG Zhong-jie YU Ye huang yong-ping QIAN Ai-rong TAN An-jiang Faculty of Life Sciences Northwestern Polytechnical UniversityXi'an 710072P.R.China Key Laboratory of Insect Developmental and Evolutionary Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032.P.R.China

Hox genes of proboscipedia(pb)and Sex combs reduced(Scr)and their cofactors are required for determi nation of in sect mouthpart identity and play important roles in in sect orga n morphoge ***,i n the lepidoptera n in sects,in cludi ng many agricultural and forest pests,the roles of these genes in determi nation of mouthpart morphogenesis are un *** we report that both BmPB(Gene ID:101740380)and BmSCR(Gene ID:692761)are essential for labial palpus specification in a lepidoptera n model in sect,the silkworm,Bombyx *** embry onic morphoge nesis,CRISPR/Cas9-mediated mutagenesis of BmPB induced transformation of labial palpus into thoracic leg and BmSCR mutation transformed labial palpus into *** of Hox-related cofactor extradenticle(BmEXD;Gene ID:692478)and its nuclear localization factor homothorax(BmHTH;Gene ID:576938425)also induced distortion of embryonic labial ***,mutagenesis of each of the four genes induced severe degeneration of spigot morphogenesis,an important part of spinneret *** real-time PCR analysis further revealed that the transcriptional interaction among these *** data thus provide no vel evidence for Hox gene regulati on of in sect embry onic patterning.

关键词： Bombyx mori Hox genes CRISPR/Cas9 embryonic patterning

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湖北省优质稻适宜栽培期的区划研究

长江流域资源与环境 2024年第8期33卷 1821-1832页

作者：杨青青穆麒麟刘越胡玉婷刘洋旋严鹏陈龙周田小海黄永平长江大学农学院湖北荆州434025 荆州农业气象试验站湖北荆州434020 主要粮食作物产业化湖北省协同创新中心湖北荆州434025

湖北省优质稻灌浆期常在高温下完成,品质和产量显著降低。开展优质稻气候适宜性区划,规划优质稻在不同地区的合理灌浆期,是发展优质稻的一项基础工作。在前期研究基础上,以湖北省75个国家级气象观测站1991~2020年的逐日气象资料,采用5d... 详细信息

湖北省优质稻灌浆期常在高温下完成,品质和产量显著降低。开展优质稻气候适宜性区划,规划优质稻在不同地区的合理灌浆期,是发展优质稻的一项基础工作。在前期研究基础上,以湖北省75个国家级气象观测站1991~2020年的逐日气象资料,采用5d滑动平均法确定各地水稻灌浆期的高温、缓温和适温等3类适宜界限日期;以各地缓温和适温栽培期时长为主指标,采用模糊聚类统计方法完成湖北省不同区域优质稻适宜栽培期类型划分,并对不同区域影响优质稻的主要气象资源条件进行了比较分析。结果表明,不同区域适宜栽培期的季节分布和时间长短各不相同,湖北省全域上适于优质稻灌浆的时间普遍较短,是其发展优质稻的一个重大缺陷。湖北省优质稻适宜栽培期可分为4个区域,分别为鄂西山地短季优质稻区,鄂西北适温高光优质稻区,鄂中东高温秋短优质稻区和鄂东南高温秋长优质稻区。该区划图在地理上呈现出由东南向西北的鱼鳞状次第衔接分布。其中,前二区域适于和较适于优质稻。不同区域发展优质稻在气候上的差异,主要可以归结为气温及其适宜性栽培期限和日照时数及光热熵等参数的差异。总之,湖北省优质稻产业应将抗热避热和区域合理布局作为其技术发展的重点。

关键词：优质稻栽培期区划灌浆期气象学

Superiority of a Convolutional Neural Network Model over Dynamical Models in Predicting Central Pacific ENSO

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Advances in Atmospheric Sciences 2024年第1期41卷 141-154页

作者： Tingyu WANG ping huang Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science&TechnologyNanjing 210044China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The application of deep learning is fast developing in climate prediction,in which El Ni?o–Southern Oscillation(ENSO),as the most dominant disaster-causing climate event,is a key *** studies have shown that deep learning methods possess a certain level of superiority in predicting ENSO *** present study develops a deep learning model for predicting the spatial pattern of sea surface temperature anomalies(SSTAs)in the equatorial Pacific by training a convolutional neural network(CNN)model with historical simulations from CMIP6 *** with dynamical models,the CNN model has higher skill in predicting the SSTAs in the equatorial western-central Pacific,but not in the eastern *** CNN model can successfully capture the small-scale precursors in the initial SSTAs for the development of central Pacific ENSO to distinguish the spatial mode up to a lead time of seven months.A fusion model combining the predictions of the CNN model and the dynamical models achieves higher skill than each of them for both central and eastern Pacific ENSO.

关键词： ENSO diversity deep learning ENSO prediction dynamical forecast system

ThSiO_4:V^(4+)晶体的光谱及EPR参量的理论研究

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人工晶体学报 2008年第5期37卷 1145-1147页

作者：黄永平宜宾学院物理与电子工程系宜宾644007

基于晶体场理论,采用3d1离子在D2d对称中的晶场能级公式和EPR参量高阶微扰公式,计算了ThSiO4:V4+晶体的光谱和电子顺磁共振(EPR)参量g因子g∥,g⊥和超精细结构常数A∥,A⊥。计算结果与实验发现很好吻合。由于晶体中顺磁杂质中心的EPR参... 详细信息

基于晶体场理论,采用3d1离子在D2d对称中的晶场能级公式和EPR参量高阶微扰公式,计算了ThSiO4:V4+晶体的光谱和电子顺磁共振(EPR)参量g因子g∥,g⊥和超精细结构常数A∥,A⊥。计算结果与实验发现很好吻合。由于晶体中顺磁杂质中心的EPR参量与其缺陷结构密切相关,本计算还获得了V4+杂质中心缺陷结构的信息。对上述结果进行了讨论。

关键词：晶体场理论电子顺磁共振参量缺陷结构 ThSiO4:V^4+晶体

Supramolecular polymer-based gel fracturing fluid with a double network applied in ultra-deep hydraulic fracturing

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Petroleum Science 2024年第3期21卷 1875-1888页

作者： yong-ping huang yong Hu Chang-Long Liu Yi-Ning Wu Chen-Wei Zou Li-Yuan Zhang Ming-Wei Zhao Cai-Li Dai School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China Shandong Key Laboratory of Oilfield Chemistry China University of Petroleum(East China)Qingdao 266580ShandongPR China SINOPEC Petroleum Exploration and Production Research Institute Beijing102206PR China CNOOC China Co Ltd Tianjin BranchTianjin300459PR China

A gel based on polyacrylamide,exhibiting delayed crosslinking characteristics,emerges as the preferred solution for mitigating degradation under conditions of high temperature and extended shear in ultralong *** viscosity/viscoelasticity of the fracturing fluid was required to maintain excellent proppant suspension properties before *** into account both the cost and the potential damage to reservoirs,polymers with lower concentrations and molecular weights are generally *** this work,the supramolecular action was integrated into the polymer,resulting in significant increases in the viscosity and viscoelasticity of the synthesized supramolecular polymer *** double network gel,which is formed by the combination of the supramolecular polymer system and a small quantity of Zr-crosslinker,effectively resists temperature while minimizing permeability damage to the *** results indicate that the supramolecular polymer system with a molecular weight of(268—380)×10^(4)g/mol can achieve the same viscosity and viscoelasticity at 0.4 wt%due to the supramolecular interaction between polymers,compared to the 0.6 wt%traditional polymer(hydrolyzed polyacrylamide,molecular weight of 1078×10^(4)g/mol).The supramolecular polymer system possessed excellent proppant suspension properties with a 0.55 cm/min sedimentation rate at 0.4 wt%,whereas the0.6 wt%traditional polymer had a rate of 0.57 cm/*** comparison to the traditional gel with a Zrcrosslinker concentration of 0.6 wt%and an elastic modulus of 7.77 Pa,the double network gel with a higher elastic modulus(9.00 Pa)could be formed only at 0.1 wt%Zr-crosslinker,which greatly reduced the amount of residue of the fluid after *** viscosity of the double network gel was66 m Pa s after 2 h shearing,whereas the traditional gel only reached 27 m Pa s.

关键词： Ultra-deep reservoir Gel fracturing fluid Double network Supramolecular polymer system Proppant suspension property

Spray characteristics of different regions downstream of a swirl cup

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Chinese Journal of Aeronautics 2024年第8期37卷 124-143页

作者： Donghui WANG yong huang Hongzhou ZHANG Collaborative Innovation Center of Advanced Aero-Engine School of Energy and Power EngineeringBeihang UniversityBeijing 102206China National Key Laboratory of Science and Technology School of Energy and Power EngineeringBeihang UniversityBeijing 102206China

The spray characteristics of different regions downstream of swirl cups play a critical role in cold start and re-ignition of gas *** spray measurements were performed at the fuel pressures of 0.5,0.8,1.0,1.5,and 2.0 MPa and the fuel temperatures of-23,-13,-3,7,17 and 27℃,*** droplet size,droplet velocity,droplet number,and instantaneous spatial spray image of sprays from an aviation kerosene Jet-A were measured using a two-component phase Doppler particle analyzer and a digital off-axis holography *** the fuel pressure and temperature increase,the Sauter Mean Diameter(SMD)and spray non-uniformity of the Spray Shear Layer(SSL)gradually *** the fuel pressure increases,the SMD and spray non-uniformity of the Central Toroidal Recirculation Zone(CTRZ)gradually decrease,and the slopes of these curves both *** the fuel pressure increases,the SMD and spray nonuniformity of the CTRZ rapidly decrease at the fuel temperature of23℃,while slightly decrease at the fuel temperature of 27℃.The droplets in the CTRZ come from 3 different sources:simplex nozzle,venturi,and outside the *** the fuel pressure increases,the proportion of droplets recirculated from outside the CTRZ *** study proposed the concept of the“pressure critical point”for the swirl *** the fuel temperature decreases,the proportion of droplets recirculated from outside the CTRZ increases below the critical pressure,while decreases above the critical *** addition,through the models of liquid film formation and breakup on the curved cylindrical wall,a semi-theoretical model was established to predict the SMD of SSL for swirl *** prediction uncertainty of this model is less than 6%for all 14 conditions in this paper.

关键词： Swirl cup Sauter Mean Diameter(SMD) Spray non-uniformity Atomizing regions Semi-theoretical prediction Spray nozzles

Identification and characterization of camptothecin tailoring enzymes in Nothapodytes tomentosa

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Journal of Integrative Plant Biology 2024年第6期66卷 1158-1169页

作者： Yin Chen Jian-ping huang yong-Jiang Wang Meng-Ling Tu Junheng Li Bingyan Xu Guoqing Peng Jing Yang Sheng-Xiong huang State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for Economic Plants and Biotechnology Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Camptothecin is a complex monoterpenoid indole alkaloid with remarkable antitumor *** that two C-10 modified camptothecin derivatives,topotecan and irinotecan,have been approved as potent anticancer agents,there is a critical need for methods to access other aromatic ringfunctionalized congeners(e.g.,C-9,C-10,etc.).However,contemporary methods for chemical oxidation are generally harsh and low-yielding when applied to the camptothecin scaffold,thereby limiting the development of modified *** herein,we have identified four tailoring enzymes responsible for C-9 modifications of camptothecin from Nothapodytes tomentosa,via metabolomic and transcriptomic *** consist of a cytochrome P450(Nt CPT9H)which catalyzes the regioselective oxidation of camptothecin to 9-hydroxycamptothecin,as well as two methyltransferases(Nt OMT1/2,converting 9-hydroxycamptothecin to 9-methoxycamptothecin),and a uridine diphosphate-glycosyltransferase(Nt UGT5,decorating 9-hydroxycamptothecin to9-β-D-glucosyloxycamptothecin).Importantly,the critical residues that contribute to the specific catalytic activity of Nt CPT9H have been elucidated through molecular docking and mutagenesis *** work provides a genetic basis for producing camptothecin derivatives through metabolic *** will hasten the discovery of novel C-9 modified camptothecin derivatives,with profound implications for pharmaceutical manufacture.

关键词： camptothecin biosynthesis enzymatic assay Nothapodytes tomentosa tailoring enzyme transcriptomic analysis

Homological Transfer between Additive Categories and Higher Differential Additive Categories

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1325-1344页

作者： Xi TANG Zhao yong huang School of Science Guilin University of Aerospace TechnologyGuilin 541004P.R.China Department of Mathematics Nanjing UniversityNanjing 210093P.R.China

Given an additive category C and an integer n≥*** higher differential additive category consists of objects X in C equipped with an endomorphism ϵ_(X)satisfying ϵ_(X)^(n).Let R be a,finite-dimensional basic algebra over an algebraically closed field and T the augmenting functor from the category of finitely generated left R-modules to that of finitely generated left R/(t^(n))-*** is proved that a finitely generated left R-module M isτ-rigid(respectively,(support)τ-tilting,almost completeτ-tilting)if and only if so is T(M)as a left R[t]/(t^(n))-***,R isτm-selfinjective if and only if so is R[t]/(t^(n)).

关键词： Higher differential objects Wakamatsu tilting subcategories G_(ω)-projective modules sup-portτ-tilting modules τ_(m)-selfinjective algebras precluster tilting subcategories