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Risk factors for local recurrence of middle and lower rectal carcinoma after curative resection

World Journal of Gastroenterology 2008年第30期14卷 4805-4809页

作者： Ze-Yu Wu Jin Wan Gang Zhao lin Peng Jia-lin Du Yuan Yao Quan-Fang Liu hua-huan lin Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China Department of Pathology Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM： To explore the risk factors for local recurrence of middle and lower rectal carcinoma after curative resection. METHODS： Specimens of middle and lower rectal carcinoma from 56 patients who received curative resection at the Department of General Surgery of Guangdong Provincial People＇s Hospital were studied. A large slice technique was used to detect mesorectal metastasis and evaluate circumferential resection margin status. The relations between clinicopathologic characteristics, mesorectal metastasis and circumferential resection margin status were identified in patients with local recurrence of middle and lower rectal carcinoma. RESULTS： Local recurrence of middle and lower rectal carcinoma after curative resection occurred in 7 of the 56 patients （12.5%）, and was significantly associated with family history （Х^2= 3.929, P = 0.047）, high CEA level （Х^2 = 4.964, P = 0.026）, cancerous perforation （Х^2 = 8.503, P = 0.004）, tumor differentiation （Х^2 = 9.315, P = 0.009） and vessel cancerous emboli （Х^2 = 11.879, P = 0.001）. In contrast, no significant correlation was found between local recurrence of rectal carcinoma and other variables such as age （Х^2 = 0.506, P = 0.477）, gender （Х^2 = 0.102, Z2 = 0.749）, tumor diameter （Х^2 = 0.421, P = 0.516）,tumor infiltration （Х^2 = 5.052, P = 0.168）, depth of tumor invasion （Х^2 = 4.588, P = 0.101）, lymph node metastases （Х^2 = 3.688, P = 0.055） and TNM staging system （Х^2 = 3.765, P = 0.152）. The local recurrence rate of middle and lower rectal carcinoma was 33.3% （4/12） in patients with positive circumferential resection margin and 6.8% （3/44） in those with negative circumferential resection margin. There was a significant difference between the two groups （Х^2 = 6.061, P = 0.014）. Local recurrence of rectal carcinoma occurred in 6 of 36 patients （16.7%） with mesorectal metastasis, and in 1 of 20 patients （5.0%） without mesorectal metastasis. However, there was no significant difference between the two groups （Х^2 = 1.6

关键词： Middle and lower rectal carcinoma Local recurrence Circumferential resection margin Mesorectal metastasis

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Study of circumferential resection margin in patients with middle and lower rectal carcinoma

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World Journal of Gastroenterology 2007年第24期13卷 3380-3383页

作者： Ze-Yu Wu Jin Wan Jing-hua Li Gang Zhao lin Peng Yuan Yao Jia-lin Du Quan-Fang Liu Zhi-Du Wang Zhi-Ming huang hua-huan lin Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China Zhong Shan Medical-College Sun Yat-sen University Guangzhou 510089 Guangdong Province China Department of Pathology Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM: To clarify the relationship between circumferential resection margin status and local and distant recurrence as well as survival of patients with middle and lower rectal carcinoma. The relationship between circumferential resection margin status and clinicopathologic characteristics of middle and lower rectal carcinoma was also evaluated. METHODS: Cancer specimens from 56 patients with middle and lower rectal carcinoma who received total mesorectal excision at the Department of General Surgery of Guangdong Provincial People's Hospital were studied. A large slice technique was used to detect mesorectal metastasis and evaluate circumferential resection margin status. RESULTS: Local recurrence occurred in 12.5% (7 of 56 cases) of patients with middle and lower rectal carcinoma. Distant recurrence occurred in 25% (14 of 56 cases) of patients with middle and lower rectal carcinoma. Twelve patients (21.4%) had positive circumferential resection margin. Local recurrence rate of patients with positive circumferential resection margin was 33.3% (4/12), whereas it was 6.8% (3/44) in those with negative circumferential resection margin (P = 0.014). Distant recurrence was observed in 50% (6/12) of patients with positive circumferential resection margin; conversely, it was 18.2% (8/44) in those with negative circumferential resection margin (P = 0.024). Kaplan-Meier survival analysis showed significant improvements in median survival (32.2 ± 4.1 mo, 95% CI: 24.1-40.4mo vs 23.0 ± 3.5 mo, 95% CI: 16.2-29.8 mo) for circumferential resection margin-negative patients over circumferential resection margin-positive patients (log-rank, P < 0.05). 37% T3 tumors examined were positive for circumferential resection margin, while only 0% T1 tumors and 8.7% T2 tumors were examined as circumferential resection margin. The difference between these three groups was statistically significant (P = 0.021). In 18 cancer specimens with tumor diameter ≥ 5 cm 7 (38.9%) were detected as positive c

关键词： Middle and lower rectal carcinoma Circumferential resection margin Prognosis

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Prognostic value of lateral lymph node metastasis for advanced low rectal cancer

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World Journal of Gastroenterology 2007年第45期13卷 6048-6052页

作者： Ze-Yu Wu Jin Wan Jing-hua Li Gang Zhao Yuan Yao Jia-lin Du Quan-Fang Liu lin Peng Zhi-Du Wang Zhi-Ming huang hua-huan lin Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China Department of Clinical Laboratory The First Affiliated Hospital Huangpu Division Sun Yat-Sen University Guangzhou 510089 Guangdong Province China Department of Pathology Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM： To evaluate the risk factors for lateral lymph node metastasis in patients with advanced low rectal cancer, in order to make the effective selection of patients who could benefit from lateral lymph node dissection, as well as the relationship of lateral lymph node metastasis with local recurrence and survival of patients with advanced low rectal cancer. METHODS： A total of 96 consecutive patients who underwent curative surgery with lateral pelvic lymphadenectomy for advanced lower rectal cancer were retrospectively analyzed. The relation of lateral lymph node metastasis with clinicopathologic characteristics, local recurrence and survival of patients was identified. RESULTS： Lateral lymph node metastasis was observed in 14.6% （14/96） of patients with advanced low rectal cancer. Lateral lymph node metastasis was detected in 10 （25.0%） of 40 patients with tumor diameter ≥ 5 cm and in 4 （7.1%） of 56 patients with tumor diameter 〈 5 cm. The difference between the significant （X^2 = 5.973, P = two groups was statistically 0.015）. Lateral lymph node metastasis was more frequent in patients with 4/4 diameter of tumor infiltration （7 of 10 cases, 70.0%）, compared with patients with 3/4, 2/4 and 1/4 diameter of tumor infiltration （3 of 25 cases, 12.0%; 3 of 45 cases, 6.7%; 1 of 16 cases, 6.3%）（X^2 = 27.944, P = 0.0001）. The lateral lymph node metastasis rate was 30.0% （9 of 30 cases）, 9.1% （4 of 44 cases） and 4.5% （1 of 22cases） for poorly, moderately and well-differentiated carcinoma, respectively. The difference between the three groups was statistically significant （X^2 = 8.569, P = 0.014）. Local recurrence was 18.8% （18 of 96 cases）, 64.3% （9 of 14 cases）, and 11.0% （9 of 82 cases） in patients with advanced low rectal cancer, in those with and without lateral lymph node metastasis, respectively. The difference between the two groups was statistically significant （X^2 = 22.308, P = 0.0001）. Kaplan-Meier survival analysis showed significant improvements in median sur

关键词： Low rectal cancer Lateral lymph nodemetastasis Local recurrence Prognosis

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Isolated splenic tuberculosis:A case report

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World Journal of Gastrointestinal Pathophysiology 2010年第3期1卷 109-111页

作者： Feng Zhan, Chang-Jun Wang, Ju-Ze lin, Pei-Jin Zhong, Wei-Zhong Qiu, hua-huan lin, Yan-Hui Liu, Zhen-Jun Zhao Feng Zhan Chang-Jun Wang Ju-Ze Lin Pei-Jin Zhong Wei-Zhong Qiu Department of Traditional Chinese Medicine Guangdong General Hospital Guangzhou 510080 Guangdong Province China.

We present a rare case of a 36 year old man who presented with recurrent fever but no other symptoms. Laboratory data provided no specific information for diagnosis. Abdominal ultrasonography revealed splenomegaly with multiple small hypoechoic lesions within the spleen. Computed tomography of abdomen showed a hypodense diffuse lesion. A diagnosis of isolated splenic tuberculosis was confirmed after a splenic puncture and histopathological examination.

关键词： Splenic tuberculosis

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配置点谱方法-人工压缩法(SCM-ACM)求解不可压缩流体流动

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计算力学学报 2018年第3期35卷 304-309页

作者：牟永强郝建超张敬奎董华林欢青岛理工大学环境与市政工程学院青岛266033

开发了配置点谱方法SCM(spectral collocation method)与人工压缩法ACM(artificial compressibility method)相结合的方法 SCM-ACM,用于求解不可压缩粘性流动问题。选取典型的方腔顶盖驱动流为研究测试对象,首先建立人工压缩格式的控制... 详细信息

开发了配置点谱方法SCM(spectral collocation method)与人工压缩法ACM(artificial compressibility method)相结合的方法 SCM-ACM,用于求解不可压缩粘性流动问题。选取典型的方腔顶盖驱动流为研究测试对象,首先建立人工压缩格式的控制方程,其次采用SCM离散控制方程的空间偏微分项,推导出矩阵形式的代数方程,最后测试了SCM-ACM代码的有效性。结果显示,SCM-ACM能够有效求解不可压缩流动问题,并继承了谱方法的指数收敛特性,且具有ACM求解过程简单及易于实施的特点。

关键词： SCM-ACM 配置点谱方法人工压缩法顶盖驱动流不可压缩流动

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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding Pan Pan Li Bo Peng hua Bai lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： huan Pei Ren-lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Feedback maximization of reliability of MDOF quasi integrable-Hamiltonian systems under combined harmonic and white noise excitations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第9期10卷 1245-1251页

作者： lin-cong CHEN Rong-hua huan Wei-qiu ZHU Department of Mechanics State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

We studied the feedback maximization of reliability of multi-degree-of-freedom （MDOF） quasi integrable-Hamiltonian systems under combined harmonic and white noise excitations. First, the partially averaged Ito equations are derived by using the stochastic averaging method for quasi integrable-Hamiltonian systems under combined harmonic and white noise excitations. Then, the dynamical programming equation and its boundary and final time conditions for the control problems of maximizing the reliability is established from the partially averaged equations by using the dynamical programming principle. The nonlinear stochastic optimal control for maximizing the reliability is determined from the dynamical programming equation and control constrains. The reliability function of optimally controlled systems is obtained by solving the final dynamical programming equation. Finally, the application of the proposed procedure and effectiveness of the control strategy are illustrated by using an example.

关键词： Stochastic optimal control Dynamical programming Quasi integrable-Hamiltonian system Stochastic averaging Combined harmonic and white noise excitation Reliability

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单根碳纤维导热性能实验研究

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青岛理工大学学报 2017年第2期38卷 80-84页

作者：李丁董华林欢张文婵王洪伟青岛理工大学环境与市政工程学院青岛266033

采用瞬态电热理论模型,分析了微尺度热传导效应下微纳米材料热扩散率的测量方法,测量了直径7μm的单根PAN基碳纤维热扩散率并由此导出热导率.在室温下,测量得到3根碳纤维样品热扩散率和热导率,相对偏差均在1%以内.重点分析了辐射对实验... 详细信息

采用瞬态电热理论模型,分析了微尺度热传导效应下微纳米材料热扩散率的测量方法,测量了直径7μm的单根PAN基碳纤维热扩散率并由此导出热导率.在室温下,测量得到3根碳纤维样品热扩散率和热导率,相对偏差均在1%以内.重点分析了辐射对实验结果的影响.在不同温度下,测量得到碳纤维的热扩散率和热导率均随温度升高呈现增长趋势.

关键词：瞬态电热技术碳纤维热扩散率热导率

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