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The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： feng-hua wang Xiao-Tian Zhang Lei Tang Qi Wu Mu-Yan Cai Yuan-Fang Li Xiu-Juan Qu Hong Qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Chang wang Hao Liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji Yan Xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-Lin Yuan feng Bi Tian-Shu Liu Han Liang Yan-Qiao Zhang Guo-Xin Li Jun Liang Bao-Rui Liu Lin Shen Jin Li Rui-hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of China,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

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In Situ Electron Backscatter Diff raction Analysis for Microstructure Evolution and Deformation Models of Mg–Ce Alloy During Uniaxial Loading

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Acta Metallurgica Sinica(English Letters) 2019年第2期32卷 263-268页

作者： Fang-Wei Jiao Li Jin Jie Dong feng-hua wang National Engineering Research Center of Light Alloys Net Forming School of Material Sciences and Engineering Shanghai Jiaotong University

Previous studies showed that signifi cant increases in elongation in Mg–Ce alloys due to the Ce addition and the solute drag eff ect by Ce addition were ascribed to the non-basal dislocation slip activating and the texture altering. The microstructure evolution and deformation models of extruded Mg-0.5 wt%Ce alloy rods under uniaxial tension have been studied using in situ electron backscatter diff raction. The basal and non-basal slips were characterized by using slip line trace analysis. The results provide evidence for that pyramidal slip activated during deformation, besides basal slip and extension twinning, which contributes to the texture weakening and ductility increasing in Mg-0.5 wt%Ce alloy.

关键词： Texture Non-basal slip Twinning In situ electron backscattered diff raction(EBSD) Trace analysis

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Baeyer-Villiger oxidation of ketones with hydrogen peroxide catalyzed by Sn-aniline complex

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Chinese Chemical Letters 2007年第1期18卷 4-6页

作者： Qing hua Zhang Shou feng wang Zi Qiang Lei Key Laboratory of Polymer Materials of Gansu Province College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou 730070 China

Sn-aniline complex was prepared by a simple procedure. Cyclic and acyclic ketones were oxidized into lactones or esters with very high selectivity and yield with 30% hydrogen peroxide in the presence of Sn-aniline com... 详细信息

关键词： Baeyer-Villiger oxidation Sn-aniline complex Ketone oxidation Hydrogen peroxide

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Effect of antiallergic herbal agents on chloride channel-3 and immune microenvironment in nasal mucosal epithelia of allergic rhinitis rabbits

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Chinese Medical Journal 2010年第8期123卷 1034-1038页

作者： wang Li-feng XU Li-juan GUO feng-hua wang Li-na SHEN Xiao-hong Medical College of Nankai University Tianjin 300071 China

Background Allergic rhinitis （AR） is a Th2 dominant cytokine response. Chloride channel-3 （CIC-3） plays an important role in nasal mucosal edema and inflammatory pathologic changes in AR. Antiallergic herbal agents （AHA） are antiallergic herbal products. In the previous study, we have demonstrated that AHA clearly inhibited allergic medium and relieved allergic reaction of AR. The aim of this study was to evaluate the function of CIC-3 and discuss the possible therapeutic effects of AHA on immune microenvironment in AR. Methods AHA were produced and used to treat AR. An animal model of an AR rabbit was established by ovalbumin （OVA）. The rhinitis rabbits were randomly divided into three groups： AHA treated group （AHATG）, model group （MG） and healthy control group （HCG）. The expressions of CIC-3 protein were examined by immunohistochemical method. The mucosal epithelial cells of all the rabbit groups were primarily cultured with tissue culture method in vitro with or without rhlL-4 or rhlL-2. Furthermore, the expressions of CIC-3 mRNA were detected by real-time PCR. The levels of monocyte chemotactic factor-1 （MCP-1） and vascular cell adhesion molecule-1 （VCAM-1） protein in culture supernatants were measured by ELISA. Results The expressions of CIC-3 mRNA increased more in mucosal epithelial cells of MG than those in AHATG and HCG （P 〈0.01）. The levels of CIC-3 mRNA, MCP-1 and VCAM-1 protein in culture supernatants of MG were significantly higher than those in the other two groups （P 〈0.01）. Those were significantly increased in MG untreated 12 hours later than those in other two groups （P 〈0.01）. The expressions of CIC-3 mRNA, MCP-1 and VCAM-1 protein in culture supernatants of MG and HCG treated with rhlL-4 were significantly higher than those in the AHATG treated with rhlL-4 （P 〈0.01）. The levels of CIC-3 mRNA, MCP-1 and VCAM-1 protein in culture supernatants of all groups treated with rhlL-2 showed no significant changes （P 〉0.05）. Conclusions AHA can inhibit the

关键词： chloride channel-3 antiallergic herbal agents allergic rhinitis immune microenvironment

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A comparison of retroperitoneoscopic and open surgical renal pedicle lymphatic disconnection for the treatment of serious filarial chyluria

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Chinese Medical Journal 2007年第10期120卷 932-934页

作者： LAN Wei-hua JIN feng-shuo wang Luo-fu ZHU Fang-qiang Department of Urology Daping Hospital ＆ Research Institute of Field Surgery Third Military Medical University Chongqing 400042 China

Currently the most effective clinical management for serious intractable chyluria is renal pedicle lymphatic disconnection, which generally consists of nephrolympholysis, renal hilar lymphatic vessel stripping and ureterolympholysis. In most conventional open surgical procedures, a lumbar incision is used and perinephrium and adipose capsule of kidney cut open, resulting in a heavy injury and long interval of postoperative recovery. The laparoscopic technique, with minimal invasion, less complications and rapid postoperative recovery, is being utilized more and more as the alternative surgical technique for urological disease.

关键词： chyluria laparoscopy surgical procedures, minimally invasive

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The efficacy and safety of modified FOLFIRINOX as first-line chemotherapy for Chinese patients with metastatic pancreatic cancer

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Cancer Communications 2019年第1期39卷 245-252页

作者： Zhi-Qiang wang Fei Zhang Ting Deng Le Zhang Fen feng feng-hua wang Wei wang De-Shen wang Hui-Yan Luo Rui-hua Xu Yi Ba Yu-Hong Li Department of Medical Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center651 Dongfeng East RoadGuangzhou 510060GuangdongPeople’s Republic of China Department of Gastrointestinal Medical Oncology National Clinical Research Center of CancerKey Laboratory of Cancer Prevention and TherapyTianjin Medical University Cancer Institute and HospitalTianjin 300060People’s Republic of China Cancer Center The First People’s Hospital of FoshanFoshan 528000GuangdongPeople’s Republic of China

Background: Oxaliplatin, irinotecan, 5-fluorouracil, and l-leucovorin (FOLFIRINOX) has become one of the first-line treatment options for advanced pancreatic cancer (PC). However, the relatively high rate of grade 3 or 4 adverse events associated with the standard dosage of FOLFIRINOX limits its widespread use in clinical practice. In this study, we were to evaluate the efficacy and safety of a modified FOLFIRINOX regimen as a first-line chemotherapy for Chinese patients with metastatic PC. Methods: Patients with histologically confirmed primary metastatic pancreatic adenocarcinoma with an Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2 were recruited to receive the modified FOLFIRINOX regimen (intravenous infusion of oxaliplatin, 65 mg/m2;irinotecan, 150 mg/m2;l-leucovorin, 200 mg/ m2;and 5-fluorouracil, 2400 mg/m2, repeated every 2 weeks). The treatment was continued for 12 cycles unless the patient had progressive disease (PD), stable disease (SD) with symptom deterioration, unacceptable adverse events, or requested to terminate the treatment prematurely. The primary endpoint was objective response rate (ORR). Results: Sixty-five patients were enrolled from July 2012 to April 2017 in three institutions, and they all received at least one cycle of chemotherapy, with a median of 8 cycles (range 1-12 cycles). No complete response was observed. Twenty-one (32.3%) patients had partial responses, and 27 (41.5%) had SD. The ORR and disease control rate of the study cohort was 32.3% and 73.8%. The estimated median overall survival and progression-free survival were 11.60 (95% confidence interval [CI] 8.76-14.44) and 5.77 (95% CI 5.00-6.54) months. Major grade 3 or 4 adverse events included neutropenia (12.3%) and diarrhea (6.2%). No treatment-related death was observed. Conclusions: Modified FOLFIRINOX was well-tolerated and might be a promising option as first-line therapy for Chinese patients with metastatic PC.

关键词： Pancreatic cancer Metastatic Chemotherapy FOLFIRINOX Dose modification First-line Multicenter Overall response rate Efficacy Safety

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Case Report:CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 833-838页

作者： hua-feng wang Yi-zhi CHENG huan-ping wang Zhi-mei CHEN Ji-yu LOU Jie JIN Department of Hematology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Institute of Hematology Zhejiang University Hangzhou 310003 China Key Lab of Combined Multi-Organ Transplantation Ministry of Public Health Hangzhou 310003 China

We report that a 63-year-old Chinese female had acute myeloblastic leukemia （AML） in which trisomy 21 （＋21） was found as the sole acquired karyotypic abnormality. The blasts were positive for rnyeloperoxidase, and the immunophenotype was positive for cluster of differentiation 19 （CD19）, CD33, CD34, and human leukocyte antigens （HLA）-DR. The chromosomal analysis of bone marrow showed 47,XX,＋21 [2]/46,XX[ 18]. Fluorescent in situ hybridization （FISH） showed that three copies of AML1 were situated in separate chromosomes, and that t（8;21） was negative. The patient did not have any features of Down syndrome. A diagnosis of CD 19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AML with trisomy 21 as the sole cytogenetie abnormality. The possible prognostic significance of the finding in AML with ＋21 as the sole acquired karyotypic abnormality was discussed.

关键词： Trisomy 21 Acute myeloid leukemia Cluster of differentiation 19 (CD 19)

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Maximum Principle for Stochastic Control System with Elephant Memory and Jump Diffusion

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Journal of Systems Science & Complexity 2024年第4期37卷 1392-1412页

作者： feng Siqi GAO Lei wang Guangchen XIAO hua School of Control Science and Engineering Shandong UniversityJinan 250061China School of Economics Shandong UniversityJinan 250100China School of Mathematics and Statistics Shandong UniversityWeihai 264209China

Motivated by a duopoly game problem,the authors study an optimal control problem where the system is driven by Brownian motion and Poisson point process and has elephant memory for the control variable and the state ***,the authors establish the unique solvability of an anticipated backward stochastic differential equation,derive a stochastic maximum principle,and prove a verification theorem for the aforementioned optimal control ***,the authors generalize these results to nonzero-sum stochastic differential game ***,the authors apply the theoretical results to the duopoly game problem and obtain the corresponding Nash equilibrium solution.

关键词： Anticipated backward stochastic differential equation elephant memory Fréchet derivative maximum principle stochastic delayed differential equation

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Spatial patterns and determinants of Moraceae richness in China

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Journal of Plant Ecology 2022年第6期15卷 1142-1153页

作者： hua-feng wang Xiaoting Xu Xia-Lan Cheng Yunpeng Liu Ao Luo Tong Lyu Wen-Long wang Mir Muhammad Nizamani Zhiheng wang Key Laboratory of Tropical Biological Resources of Ministry of Education College of Tropical CropsHainan UniversityHaikou 570228China Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengdu 610065China Institute of Ecology and Key Laboratory for Earth Surface Processes of the Ministry of Education College of Urban and Environmental SciencesPeking UniversityBeijing 100871China

Understanding large-scale patterns of biodiversity and their drivers remains central in *** hypotheses have been proposed,including hydrothermal dynamic hypothesis,tropical niche conservatism hypothesis,Janzen’s hypothesis and a combination model containing energy,water,seasonality and habitat ***,their relative contributions to groups with different lifeforms and range sizes remain controversial,which have limited our ability to understand the general mechanisms underlying species richness *** we evaluated how lifeforms and species range sizes influenced the relative contributions of these three hypotheses to species richness patterns of a tropical family *** distribution data of Moraceae species at a spatial resolution of 50 km×50 km and their lifeforms(***,small trees and large trees)were *** species richness patterns were estimated for the entire family,different life forms and species with different range sizes *** effects of environmental variables on species richness were analyzed,and relative contributions of different hypotheses were evaluated across life forms and species range size *** species richness patterns were consistent across different species groups and the species richness was the highest in Sichuan,Guangzhou and Hainan provinces,making these provinces the hotspots of this *** seasonality is the primary factor in determining richness variation of *** best combination model gave the largest explanatory power for Moraceae species richness across each group of range size and life forms followed by the hydrothermal dynamic hypothesis,Janzen’s hypothesis and tropical niche conservatism *** these models has a large shared effects but a low independent effect(<5%),except rare *** findings suggest unique patterns and mechanisms underlying rare species richness and provide a theoretical basis for protection of the Moraceae species in China

关键词： hydrothermal dynamic hypothesis tropical niche conservatism hypothesis Janzen’s hypothesis Moraceae environmental factor China

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Cr-catalyzed allylic C(sp^(3))–H addition to aldehydes enabled by photoinduced ligand-to-metal charge transfer

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Science China Chemistry 2024年第5期67卷 1589-1595页

作者： Xianrong Zeng feng-hua Zhang Runchen Lai Xiaoyu Lin Zhaobin wang Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Department of ChemistrySchool of Science and Research Center for Industries of the FutureWestlake UniversityHangzhou 310030China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Instrumentation and Service Center for Molecular SciencesWestlake UniversityHangzhou 310024China

Photoinduced ligand-to-metal charge transfer(LMCT) has emerged as an effective strategy for synthesizing organic molecules in a sustainable manner. However, the majority of existing reports on selective C(sp^(3))–H bond functionalization via photoinduced LMCT focus on the use of late transition metals or rare-earth metals for radical additions or cross-couplings. In contrast, the utilization of photoinduced LMCT with 3d early transition metals poses a significant challenge. Herein, we describe an unprecedented approach to allylic C(sp^(3))–H addition to aldehydes, employing chromium(Cr) complexes as catalysts through visible-light-induced LMCT. By investigating the reaction pathway through various mechanistic studies, including radical trapping, kinetic isotope effect(KIE) analysis, and transient absorption spectroscopy, valuable insights have been gained. The proposed mechanism suggests the intermediacy of bromine radicals through homolysis of the Cr–Br bond. Notably, this protocol expands our understanding of the photochemical properties of earth-abundant Cr complexes.

关键词： Cr catalysis photoinduced ligand-to-metal charge transfer hydrogen-atom transfer carbonyl addition

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