Case Report:CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality

作     者：Hua-feng WANG Yi-zhi CHENG Huan-ping WANG Zhi-mei CHEN Ji-yu LOU Jie JIN 

作者机构：Department of Hematology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Institute of Hematology Zhejiang University Hangzhou 310003 China Key Lab of Combined Multi-Organ Transplantation Ministry of Public Health Hangzhou 310003 China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2009年第10卷第11期

页      面：833-838页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Trisomy 21 Acute myeloid leukemia Cluster of differentiation 19 (CD 19) 

摘      要：We report that a 63-year-old Chinese female had acute myeloblastic leukemia （AML） in which trisomy 21 （＋21） was found as the sole acquired karyotypic abnormality. The blasts were positive for rnyeloperoxidase, and the immunophenotype was positive for cluster of differentiation 19 （CD19）, CD33, CD34, and human leukocyte antigens （HLA）-DR. The chromosomal analysis of bone marrow showed 47,XX,＋21 [2]/46,XX[ 18]. Fluorescent in situ hybridization （FISH） showed that three copies of AML1 were situated in separate chromosomes, and that t（8;21） was negative. The patient did not have any features of Down syndrome. A diagnosis of CD 19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AML with trisomy 21 as the sole cytogenetie abnormality. The possible prognostic significance of the finding in AML with ＋21 as the sole acquired karyotypic abnormality was discussed.