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Functional switching of ATM:sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells

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Chinese Journal of Cancer 2012年第8期31卷 364-372页

作者： Yan Li hua Xiong Da-qing yang The Hormel Institute University of MinnesotaAustinMN 55912USA

Ataxia-telangiectasia(A-T) is an autosomal recessive disorder characterized by cerebellar ataxia and oculocutaneous *** gene mutated in this disease,ATM(A-T,mutated),encodes a 370-kDa Ser/Thr protein *** not only mediates cellular response to DNA damage but also acts as an activator of Akt in response to ***,despite intensive studies,the mechanism underlying the neuronal degeneration symptoms of human A-T is still poorly *** found that the topoisomerase inhibitors etoposide and camptothecin readily induced apoptosis in undifferentiated proliferating SH-SY5Y cells but could not induce apoptosis in neuronally differentiated SH-SY5Y *** addition,etoposide induced p53 phosphorylation and H2AX foci formation in proliferating SH-SY5Y cells but failed to do so in differentiated SH-SY5Y ***,while inhibition of ATM in undifferentiated SH-SY5Y cells partially protected them from etoposide-induced apoptosis,the same treatment had no effect on cell viability in differentiated SH-SY5Y *** results suggest that DNA damage or defective response to DNA damage is not the cause of neuronal cell death in human *** contrast,we discovered that Akt phosphorylation was inhibited when ATM activity was suppressed in differentiated SH-SY5Y ***,inhibition of ATM induced apoptosis following serum starvation in neuronally differentiated SH-SY5Y cells but could not trigger apoptosis under the same conditions in undifferentiated proliferating SH-SY5Y *** results demonstrate that ATM mediates the Akt signaling and promotes cell survival in neuron-like human SH-SY5Y cells,suggesting that impaired activation of Akt is the reason for neuronal degeneration in human A-T.

关键词：神经元样细胞 DNA损伤细胞增殖 ATM Akt SH-SY5Y细胞人类有丝分裂

Characteristics of metal flow in cold extrusion under electric-hydraulic chattering

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Journal of Iron and Steel Research International 2017年第2期24卷 138-146页

作者： Zhi-heng Wang Wei-tao Zhan Xiao-xiao Hong Guan-jun Bao qing-hua yang Key Laboratory of E&M Zhejiang University of Technology Hangzhou 310032 Zhejiang China

An experimental setup for cold extrusion process with electric-hydraulic chattering was developed and its working principle was introduced. The finite element （FE） model for a kind of cup part （material： 20Cr） was built by using the software Deform-3D. FE simulation experiments with and without electric-hydraulic chattering were carried out to analyze the velocity fields and the metal grid flow lines. The extrusion ex- periments of the cup part were also performed under different conditions. The difference of metal flow lines with and without electric-hydraulic chattering was discussed via a scanning electron microscope （SEM） and the Keyence super-depth three-dimensional microscopic system. The results showed that with the electric-hydraulic chattering, the velocity of material flow increases, whereas deformation resistance decreases. Electric hydraulic chattering results in easy metal flow, small bending degree of metal flow lines, slender and dense metal grains, and thereby an improved quality of the deformed parts.

关键词： Cold extrusion Electric-hydraulic chattering Finite element analysis Material flow

Accuracy of axial length measurements from immersion B-scan ultrasonography in highly myopic eyes

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 441-445页

作者： qing-hua yang Bing Chen Guang-hua Peng Zhao-Hui Li Yi-Fei huang Department of Ophthalmology Chinese PLA General Hospital

AIM:To evaluate the accuracy of axial length(AL)measurements obtained from immersion B-scan ultrasonography(immersion B-scan)for intraocular lens(IOL)power calculation in patients with high myopia and ***:Immersion B-scan,contact A-scan ultrasonography(contact A-scan),and the IOLMaster were used to preoperatively measure the AL in 102 eyes from 102 patients who underwent phacoemulsification and IOL *** were divided into two groups according to the AL:one containing patients with22 mm≤AL<26 mm(group A)and the other containing patients with AL≥26 mm(group B).The mean error(ME)was calculated from the difference between the AL measurement methods predicted refractive error and the actual postoperative refractive ***:Ingroup A,ALs measured byimmersion Bscan(23.48±1.15)didn’t differ significantly from those measured by the IOLMaster(23.52±1.17)or from those by contact A-scan(23.38±1.20).In the same group,the standard deviation(SD)of the mean error(ME)of immersion B-scan(-0.090±0.397 D)didn’t differ significantly from those of IOLMaster(-0.095±0.411 D)and contact A-scan(-0.099±0.425 D).In group B,ALs measured by immersion B-scan(27.97±2.21 mm)didn’t differ significantly from those of the IOLMaster(27.86±2.18 mm),but longer than those measured by Contact A-scan(27.75±2.23 mm,P=0.009).In the same group,the standard deviation(SD)of the mean error(ME)of immersion B-scan(-0.635±0.157 D)didn’t differ significantly from those of the IOLMaster(-0.679±0.359 D),but differed significantly from those of contact A-scan(-0.953±1.713 D,P=0.028).CONCLUSION:ImmersionB-scanexhibitsmeasurement accuracy comparable to that of the IOLMaster,and is thus a good alternative in measuring AL in eyes with high myopia when the IOLMaster can’t be used,and it is more accurate than the contact A-scan.

关键词： axial length measurement immersion ultrasonography high myopia

PVP/PAN-derived porous carbon fiber for zinc-ion hybrid supercapacitors

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Rare Metals 2024年第7期43卷 3066-3073页

作者： Shu-hua yang Wen-qing Fu Yan-Wei Cui Bing-Qiang Cao Materials Center for Energy and Photoelectrochemical Conversion School of Material Science and EngineeringUniversity of JinanJinan 250022China

Porous carbon fibers are promising cathodes for zinc-ion hybrid supercapacitors(ZHSs)owing to their abundant active sites,great conductivity,and stable physical and chemical ***,designing a proper preparation technique to regulate the microstructure of carbon fibers still remains a great ***,a poly vinylpyrrolidone/po-lyacry lonitrile(PVP/PAN)-derived porous carbon fiber is developed via the PVP/PAN blend electrospinning and hydrothermal selective PVP removal *** hydrothermal selective PVP removal strategy can effectively avoid a cross-linking between PVP and PAN during the traditional stabilization at air *** PVP/PAN-derived porous carbon fiber,the sufficient micropores provide abundant space for the Zn^(2+)storage,whereas the proper mesopores contribute to the fast ion *** hierarchical porous structures endow ZHSs with high specific capacity and high-rate *** ZHS assembled with the optimal PVP/PAN-derived porous carbon fiber(PVP-PANC-0.8)displays an outstanding specific capacity of 208 mAh·g^(-1),high rate capability(49.5%)from 0.5 to 5 A·g^(-1),and 72.25%capacity retention after 10,000 cycles at 0.5 A·g^(-1).

关键词： Zinc-ion hybrid supercapacitors Porous carbon fibers Hierarchical porous structures Electrospinning

Evaluation of immersion 20 MHz B-scan ultrasonography in observing lens in the alkali burn eyes

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International Journal of Ophthalmology(English edition) 2014年第4期7卷 632-637页

作者： qing-hua yang Bing Chen Li-Qiang Wang Guang-hua Peng Zhao-Hui Li Yi-Fei huang Department of Ophthalmology Chinese People's Liberation Army General Hospital

·AIM: To evaluate the accuracy of 20 MHz immersion Bscan ultrasonography in observing lens and to investigate the value of this noninvasive preoperative diagnosis method in alkali burn eyes.·METHODS: It was a comparative study. Fifty-six cases(56 eyes) of alkali burn eyes were examined by ultrasound biomicroscopy(UBM) and immersion 20 MHz B-scan ultrasonography from June 2011 to April 2013,the images were analyzed, and the ultrasonographic diagnosis compared with the operation results.·RESULTS: In 56 alkali burn eyes examined by UBM, the lens were not detected in 16 eyes; the IOL could be detected in 2 eyes; the anterior lens capsule surface or/and the front lens could be detected in 18 eyes, and lens opacification in 3 eyes of them; suspected abnormal lens were detected in the other 20 eyes. In all the same eyes examined by immersion 20 MHz B-scan ultrasonography,the lens were not detected in 16 eyes; the IOL could be detected in 2 eyes; 24 abnormal lens(opacity, lens expansion, shrinkage) and 14 normal lens were *** with the intraoperative findings, the diagnostic accordance rate of the immersion 20 MHz B-scan appearance of lens was 100%(56/56), which was significantly higher than examined by UBM 57.14%(32/56)(χ2=30.55, P =0.0000).·CONCLUSION: Immersion 20 MHz B-scan ultrasonography can observe the lens accurately in alkali burn eyes. It has important clinical value to combine with UBM in eyes of alkali burn.

关键词： immersion B-scan ultrasonography alkali burn ultrasound biomicroscopy

Comprehensive Surgical Approaches to Management of Various Facial Nevi

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Chinese Medical Sciences Journal 2009年第2期24卷 127-129页

作者： Xiao-gen Hu Hai-huan Ma Yan-yong Zhao qing-hua yang Department of Plastic Surgery China-Japan Friendship Hospital Chinese Health Ministry Beijing 100029 China Department of Ear Plastic and Reconstructive Surgery Plastic Surgery Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100041 China

Objective To investigate the effects of the flexible surgical approaches on therapeutic and cosmetic outcomes of facial *** From August 2002 to January 2008,16 cases with facial nevi had been treated in our wards with the selected *** approaches including serial excision or one-time radical excision,free skin graft,and expanded flap were adopted in accordance with the individual size and location of the facial *** All cases experienced complete excision and had satisfactory cosmetic appearance in the *** The flexible surgical measures help to minimize the risk of malignant transformation and achieve good cosmetic results.

关键词： facial nevi treatment surgical technique

Predictors of outcomes of endoscopic balloon dilatation in strictures after esophageal atresia repair: A retrospective study

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World Journal of Gastroenterology 2020年第10期26卷 1080-1087页

作者： Dong-Ling Dai Chen-Xi Zhang Yi-Gui Zou qing-hua yang Yu Zou Fei-Qiu Wen Department of Gastroenterology Shenzhen Children’s Hospital

BACKGROUND Endoscopic balloon dilatation (EBD) has become the first line of therapy for benign esophageal strictures (ESs);however,there are few publications about the predictive factors for the outcomes of this *** To assess the predictive factors for the outcomes of EBD treatment for strictures after esophageal atresia (EA) *** Children with anastomotic ES after thoracoscopic esophageal atresia repair treated by EBD from January 2012 to December 2016 were *** procedures were performed under tracheal intubation and intravenous anesthesia using a three-grade controlled radial expansion balloon with *** were recorded and predictors of the outcomes were *** A total of 64 patients were included in this *** rates of response,complications,and recurrence were 96.77%,8.06%,and 2.33%,*** number of dilatation sessions and complications were significantly higher in patients with a smaller stricture diameter (P=0.013 and 0.023,respectively) and with more than one stricture (P=0.014 and 0.004,respectively).The length of the stricture was significantly associated with complications of EBD (P=0.001).A longer interval between surgery and the first dilatation was related to more sessions and a poorer response (P=0.017 and 0.024,respectively).CONCLUSION The diameter,length,and number of strictures are the most important predictive factors for the clinical outcomes of endoscopic balloon dilatation in pediatric *** interval between surgery and the first EBD is another factor affectingresponse and the number of sessions of dilatation.

关键词： Children Endoscopic balloon dilatation Esophageal stricture Outcome Predictor

Distribution of wetlands and salt lakes in the Yadong region of Tibet based on remote sensing, and their geo-climatic environmental changes

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China Geology 2022年第4期5卷 637-648页

作者： Ang Sun qing-hua yang Zhi Liu hua Chen Lei Han Shou-min Jiang Yue-yue Meng Yu Bian Yong-peng yang China Aero Geophysical Survey and Remote Sensing Center for Natural Resources China Geological SurveyBeijing 100083China Sichuan Geological Survey Institute Chengdu 610036China

Based on the 16 scenes GF-1 satellite multi-spectral remote sensing images,through the adoption of data processing methods including orthorectification,geometric rectification,data fusion and image mosaic,integrated with field surveys,the remote sensing interpretation signs for the inland wetland types have been built,and the remote sensing survey of inland wetlands in Yadong region has been initiated,with six types of inland wetlands recognized in Yadong region,namely permanent rivers,seasonal rivers,lakes,salt lakes,alpine meadows,and inundated *** spatial distribution characteristics and the spreading rules of these wetlands have also been *** on full understanding of the overall characteristics of the inland wetlands in the Yadong region,using the three phases of TM images acquired in 1989,2003 and 2008 as well as the PMS2 data gathered by GF-1 in 2014,and the wide-range data(WFV3)gathered by GF-1 in *** to the typical salt lakes,a long-time salt lakes transition study was carried *** results show that the typical salt lakes in Yadong have been shrinking in the past three *** average annual shrinkage of Duoqing Co(Co means lake in Tibetan)was stronger than that of Gala Co,which are respective 87.30 hectares(usually short as ha;1 ha equals to 0.01 km^(2))/a and 24.20 ha/a;the shrinkage degree of Gala Co was higher than that of Duoqing Co,shrank by 59.27% and 35.73% *** on the remote sensing survey results and an integrated analysis of the predecessors’researchers,the reason for the shrinkage of the salt lakes is more inclined to geological *** process is manifested by a series of extensional faults at the bottom of the lake basin generated from tectonic activities,providing fluid infiltration channels,and inducing the eventual leakage of lake water to the lower *** result provides an important instance for understanding the evolution characteristics of wetlands and salt lakes in specific environ

关键词： Yadong Wetlands Salt lakes Duoqing Co Gala Co Geological survey engineering Tibet Plateau

Layered coordination polymer with two-dimensional covalent bismuth-organic networks:Semiconductor and lithium ion storage

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Nano Research 2024年第3期17卷 2181-2185页

作者： Mu-qing Li Yulin Cao Lei Qin hua Cheng Weimin yang Zhouguang Lu School of Materials Science and Environmental Engineering Shenzhen Polytechnic UniversityShenzhen 518055China Industrial Training Center Shenzhen Polytechnic UniversityShenzhen 518055China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

Single crystals of a bismuth-based coordination polymer(CP)with carboxyl-thiol ligands,[Bi(C_(8)H_(2)O_(4)S_(2))(C2H8N)]n(Bi-DSBDC-DMA,DMBDC=2,5-disulfur-1,4-dicarboxylate,DMA=dimethylamine),have been successfully synthesized.X-ray diffraction analysis reveals that Bi-DSBDC-DMA possesses a layered structure,with two-dimensional(2D)Bi-DSBDC networks alternating with layers composed of dimethylamine *** material demonstrates semiconducting properties,featuring an optical bandgap of 2.2 eV and an electrical conductivity of 2×10^(-8) S/***,electrodes based on this material exhibit a capacity of 250 mAh/g after 200 cycles for lithium-ion storage.

关键词： bismuth layer coordination polymer(CP) semiconductor lithium ion storage