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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo ma Wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

DSC and NMR Study on the Inclusion Complex of Lappaconitine with b-Cyclodextrin

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Chinese Chemical Letters 2002年第3期13卷 227-230页

作者： Kai Jun LIAO Xiao hua YAN dong Yun ZHAO Xue Yi ma Department of Chemistry National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000

The inclusion complex of lappaconitine (Lap) with b-cyclodextrin (b-CD) has been studied by the differential scanning calorimetry (DSC) and 1H-NMR, 2D-NMR spectroscopy. The structure of the complex has been deduced.

关键词： Aconitum delphinium lappaconitine b-cyclodextrin inclusion complex DSC NMR.

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Synthesis and surface modification of cobalt nanoparticles and electromagnetic property of Co/PPy nanocomposites

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Rare Metals 2015年第4期34卷 223-228页

作者： Hai-Cheng Wang Zhi-Ran Yan Ling Deng hua dong Yi-He Jia Ning ma Jun He Guang-hua Yu School of materials Science and Engineering University of Science and Technology Beijing Institute of Functional materials Central Iron & Steel Research Institute

In this work, cobalt nanoparticles were syn- thesized by chemical reduction procedure. After the hydrophilic functionalization, Co/polypyrrole （PPy） nanocomposites were prepared by in situ polymerization of pyrrole in aqueous dispersion of Co nanoparticles. The Co/ PPy nanocomposites show good electromagnetic properties with both magnetic loss and dielectric loss to electromag- netic wave. The electromagnetic wave absorbing band- width （reflection loss 〈-10 dB） for Co/PPy （20 wt%） is above 5.5 GHz at a thickness of 2 mm, and with a maximum reflection loss （around -20.02 dB） at 14.77 GHz. This magnetic nanoparticles/conducting polymer nanocomposites are great potential candidates for electromagnetic wave absorbent, because of their wide-absorbing frequency, strong absorption, good compatibility, low density, and controllable absorbing properties.

关键词： Cobalt nanoparticles Synthesis Surface modification Nanocomposites Electromagnetic property

Advances in Uniform Polymer Microspheres and Microcapsules:Preparation and Biomedical Applications

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Chinese Journal of Chemistry 2020年第9期38卷 911-923页

作者： Guanghui ma hua Yue State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of ScienceBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

What is the most favorite and *** developed in your research group?We clarified the,mechanism for obtaining uniform microspheres and microcapsules in 0/W,W/0 and double emulsion systems,which enabled us to develop the technique to a universal technique,successfully,preparing various uniform particles including,hydrophobic,hydrophilic and composite functional particles,and leading to the original systematic studies on biomedical applications including"Synthetic Vaccine".

关键词： composite preparing favorite

Vicinal Na^(+) as structure guardians of atomically dispersed Ru catalysts in hydrogenation reactions

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Science China Chemistry 2020年第11期63卷 1584-1585页

作者： Chunyang dong Ding ma Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering and College of Engineeringand BIC-ESATPeking UniversityBeijing 100871China

Owing to the distinctive structural and electronic properties,atomically dispersed metal catalysts have raised tremendous attentions in the last ten years[1,2].Generally,isolated metal atoms or clusters that dispersed across oxide supports(e.g.,Al2O3,TiO2,CeO2)are stabilized through the coordination with supported O atoms,forming electron-deficient metal cations(Mδ+-O)at interfaces[3].However,in many cases,such metal-support interactions may not strong enough to maintain their structure uniformity under harsh reductive conditions,and the resultant reduction/aggregation of metal atoms/clusters often attenuated the activity of catalysts[4,5].

关键词： dispersed structure atomic

Testing and modeling of frozen clay-concrete interface behavior based on large-scale shear tests

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Advances in Climate Change Research 2021年第1期12卷 83-94页

作者： HE Peng-Fei MU Yan-Hu ma Wei huaNG Yong-Ting dong Jian-hua State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China School of Science Lanzhou University of TechnologyLanzhou730050China University of Chinese Academy of Sciences Beijing100049China Key Laboratory of Disaster Prevention and Mitigation in Civil Engineering of Gansu Province Lanzhou University of TechnologyLanzhou730050China

The shear behavior of the frozen soil-structure interface is important for accurately predicting the interface responses of structures adopted in the cold *** purpose of this study is to experimentally and theoretically investigate the shear behavior of frozen clay-concrete interface under engineering conditions.A large-scale direct shear apparatus with a temperature-controlled shear box is used to test the interface *** specimens consisting of a cement concrete block and frozen soil with initial water content ranging between 14.6%and 24.6%were prepared at different conditions of temperatures(15.4 to-9.8℃),shear rates(0.03-0.9 mm min^(-1)),and normal stresses(50-200 *** is found that the peak shear strength is linear developing with increasing of normal stress,initial water content,and *** increased from 67.7 to 133.3 kPa as the initial water content increased from 14.9%to 24.6%at temperature of-6.8 to-6.6℃,and it increased from 51.2 to 80.6 kPa with temperature decreasing from 15.4 to-9.8℃at initial water content of 14.6%-14.9%,furthermore it has a power law relationship with shear *** final vertical displacement increases with the decreasing temperature,and increasing initial water ***,it is slight or could be ignored at lower shear rates(e.g.0.03 mm min^(-1) and 0.15 mm min^(-1))and it is-0.25 mm and-0.28 mm at shear rate of 0.3 mm min^(-1) and 0.9 mm min^(-1),*** addition,the evolution of vertical displacement also varies with test condition,the growth rate at beginning increases with increasing initial water content and decreasing temperature or ice content,which is because of the ice film effects the particle ***,a disturbed state concept model combined with linear and nonlinear characteristics is developed to describe the interface shear *** disturbance D reflects the interface mechanical response and responds differently trend for different test conditions,increasing faster with i

关键词： Shear strength Frozen clay-concrete interface Disturbed state concept Constitutive model

Synthesis of novel copolymer:Poly(p-dioxanone-co-L-phenylalanine)

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Chinese Chemical Letters 2013年第5期24卷 392-396页

作者： Bing Wang Chi ma Zuo-Chun Xiong Cheng-dong Xiong Quan-hua Zhou dong-Liang Chen Chengdu Institute of Organic Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Sichuan Staff University of Science and Technology

In order to expand the application of poly（p-dioxanone） or PPDO in biomedical area,a series of novel copolymers were synthesized successfully by one-step,melted copolymerization of p-dioxanone（PDO） and L-phenylalanine N-carboxyanhydride（L-Phe-NCA） *** the in-feed molar ratio of L-PheNCA /PDO equal to 1/20,the conversions of the two kinds of monomers were calculated from 1H NMR. The average molecular weight and polydispersity of the copolymer increase with the increasing reaction time and catalyst ***,the conversions of the two kinds of monomers did not change with the reaction conditions.A three-step mechanism is presented and proved by high resolution 1H NMR and IR spectrums.

关键词： Copolymer p-Dioxanone L-Phenylalanine Mechanism

Evaluation of Ambient Light Display for High Information Capacity

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Journal of Beijing Institute of Technology 2018年第4期27卷 637-644页

作者： hua ma Suzhou Art and Design Technology Institute Suzhou 215000China

Ambient light display presents peripheral information unobtrusively,and it can be context aware and aesthetically enhance specific ***,since the abstract characteristic of light,people should attentively keep agood balance between unobtrusiveness and effectiveness,when designing an ambient light ***,in the condition of high information capacity,ambient light display need a mechanism to portray information *** this paper,a framework with an overlay mechanism is evaluated for high information *** on the framework,two ambient light displays are designed to support the evaluation *** evaluation questions are related with three aspects including information understanding,transition and encoding,special output *** the perception level,interpretation level and experience level,the process of evaluation is *** results indicate that the framework with the overlay mechanism can effectively support varied and specific communicating *** transitions and information encoding benefit from the proper mapping of states and notification levels in the framework.

关键词： evaluation ambient display light information capacity

Heterointerface engineering of Ru/RuS_(2) on N/S-doped hollow mesoporous carbon for promoting alkaline hydrogen evolution

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Chinese Chemical Letters 2023年第7期34卷 373-378页

作者： Ning Wang dong-dong ma Sheng-hua Zhou Meng-Ke Hu Xiaofang Li Xin-Tao Wu Qi-Long Zhu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences(CAS)Fuzhou 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of Chin1 Fuzhou 350108China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China University of Chinese Academy of Sciences Beijing 100049China

Alkaline hydrogen evolution reaction (HER) suffers from a sluggish kinetic,which requires the elaborate catalytic interface and micro-nanoscale architecture engineering of the electrocatalysts to accelerate the water dissociation and hydrogen ***,the heterointerface engineering was proposed for promoting the alkaline HER by constructing the highly exposed Ru/RuS_(2) heterostructures homogeneously distributed on hollow N/S-doped carbon microspheres (Ru/RuS_(2)@h-NSC).Benefited from the synergistic effect of heterointerfacial Ru/RuS_(2),the high accessibility of the active sites on both inner and outer surface of mesoporous shells and the efficient mass transport,Ru/RuS_(2)@h-NSC affords a remarkable catalytic performance with an overpotential of 26 mV@10 ma/cm^(2) for alkaline HER,outperforming most of the state-of-the-art *** applying Ru/RuS_(2)@h-NSC and its oxidized derivate for the overall alkaline water splitting,the required cell voltage is much lower than that of the commercial Pt/C||RuO_(2)pair to achieve the same current *** study may allow us to guide the design of micro-nanoreactors with optimal catalytic interfaces for promising electrocatalytic applications.

关键词： Hydrogen evolution reaction Heterostructures N/S-doped carbon Hollow mesoporous microspheres Ru nanoparticles