Synthesis of novel copolymer:Poly(p-dioxanone-co-L-phenylalanine)

作     者：Bing Wang Chi Ma Zuo-Chun Xiong Cheng-Dong Xiong Quan-Hua Zhou Dong-Liang Chen 

作者机构：Chengdu Institute of Organic ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences Sichuan Staff University of Science and Technology 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2013年第24卷第5期

页      面：392-396页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：supported financially by the "Western Light" joint researcher program of Chinese Academy of Science 

主　　题：Copolymer p-Dioxanone L-Phenylalanine Mechanism 

摘      要：In order to expand the application of poly（p-dioxanone） or PPDO in biomedical area,a series of novel copolymers were synthesized successfully by one-step,melted copolymerization of p-dioxanone（PDO） and L-phenylalanine N-carboxyanhydride（L-Phe-NCA） *** the in-feed molar ratio of L-PheNCA /PDO equal to 1/20,the conversions of the two kinds of monomers were calculated from 1H NMR. The average molecular weight and polydispersity of the copolymer increase with the increasing reaction time and catalyst ***,the conversions of the two kinds of monomers did not change with the reaction conditions.A three-step mechanism is presented and proved by high resolution 1H NMR and IR spectrums.