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High performance inkjet-printed QLEDs with 18.3% EQE: improving interfacial contact by novel halogen-free binary solvent system

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Nano Research 2021年第11期14卷 4125-4131页

作者： Ming Chen Liming Xie Changting wei Yuan-qiu-Qiang yi Xiaolian Chen Jian Yang Jinyong Zhuang Fushan Li Wenming su Zheng Cui Printable Electronics Research Center Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou215123China Guangdong Juhua Printed Display Technol Company Ltd. Guangzhou510700China Institute of Optoelectronic Technology Fuzhou UniversityFuzhou350002China

Poly[(9,9-dioctylfluorenyl-2,7-diyl)-alt(4,4′-(N-(4-butylphenyl))](TFB),one of the most popular and widely used hole-transport layer(HTL)materials,has been successfully applied in high performance spin-coated quantum dots-based light-emitting diodes(QLEDs)due to its suitable energy level and high ***,there are still many challenging issues in inkjet-printed QLED devices when using TFB as *** normally suffers from the interlayer mixing and erosion,and low surface energy against the good film ***,a novel environment-friendly binary solvent system was established for formulating quantum dot(QD)inks,which is based on mixing halogen-free alkane solvents of decalin and *** optimum volume ratio for the mixture of decalin and n-tridecane was found to be 7:3,at which a stable ink jetting flow and coffee-ring free QD films could be *** research the influence of substrate surface on the formation of inkjet-printed QD films,TFB was annealed at different temperatures,and the optimum annealing temperature was found to enable high quality inkjet-printed QD ***-printed red QLED was ultimately manufactured.A maximum 18.3%of external quantum efficiency(EQE)was achieved,reaching 93%of the spin-coated QLED,which is the best reported high efficiency inkjet-printed red QLEDs to *** addition,the inkjet-printed QLED achieved similar T75 operational lifetime(27 h)as compared to the spin-coated reference QLED(28 h)at 2,000 cd·m−*** work demonstrated that the novel orthogonal halogen-free alkane co-solvents can improve the interfacial contact and facilitate high-performance inkjet printing QLEDs with high EQE and stability.

关键词： quantum dots quantum dots light-emitting diodes(QLEDs) inkjet printing halogen-free inks contact interface

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Human transcription factor genes involved in neuronal development tend to have high GC content and CpG elements in the proximal promoter region

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Journal of Genetics and Genomics 2011年第4期38卷 157-163页

作者： Yue-Sheng Long Jia-Ming Qin Tao su Qi-hua Zhao Yong-Hong yi wei-Ping Liao Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Institute of Neuroscience and The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260China

Transcription factors（TFs）play critical roles in the development of the nervous system,but the transcriptional regulatory mechanisms of these genes are poorly *** we analyzed 5-kb of the 5＇ flanking genomic DNA sequences of 41 TF genes involved in neuronal *** results showed that the TF genes tend to have higher GC contents in the proximal region and most of the TF genes have at least one proximal GC-rich（GC content60%）promoter with a CpG *** promoter distribution analysis showed that the GC-poor promoters were sporadically distributed within the 5-kb flanking genomic sequence（FGS）;however,more than half（37 of 70）of the GC-rich promoters were located in the proximal region between nucleotides—1 and—*** assays showed that partial GC-rich promoters increased gene expression in SH-SY5Y cells and that CpG methylation repressed the promoter *** study suggests a potential general mechanism for regulation of TF expression.

关键词： Transcription factor Promoter GC content CpG island DNA methylation

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Immunohistochemical investigation of voltage-gated potassium channel-interacting protein 1 in normal rat brain and Pentylenettrazole-induced seizures

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Neuroscience Bulletin 2006年第4期22卷 195-203页

作者： Tao su Ai-hua LUO Wen-Dong CONG wei-Wen suN wei-yi DENG Qi-hua ZHAO Zhuo-hua ZHANG wei-Ping LIAO Institute of Neuroscience and The Second Affiliated Hospital Guangzhou Medical College Guangzhou 510260 China Center for Neuroscience and Aging the Burnham Institute University of California CA92037 San Diego USA

Objective To explore the possible role of voltage-gated potassium channel-interacting protein 1 (KChIP1) in the pathogenesis of epilepsy. Methods Sprague Dawley female adult rats were treated with pentylenettrazole (PTZ) to develop acute and chronic epilepsy models. The approximate coronal sections of normal and epilepsy rat brain were processed for immunohistochemistry. Double-labeling confocal microscopy was used to determine the coexistence of KChIP1 and gamma-aminobutyric acid (GABA). Results KChIP1 was expressed abundantly throughout adult rat brain. KChIP1 is highly co-localize with GABA transmitter in hippocampus and cerebral cortex. In the acute PTZ-induced convulsive rats, the number of KChIP1-postive cells was significantly increased especially in the regions of CA1 and CA3 (P < 0.05); whereas the chronic PTZ-induced convulsive rats were found no changes. The number of GABA-labeled and co-labeled neurons in the hippocampus appeared to have no significant alteration responding to the epilepsy-genesis treatments. Conclusion KChIP1 might be involved in the PTZ-induced epileptogenesis process as a regulator to neuronal excitability through influencing the properties of potassium channels. KChIP1 is preferentially expressed in GABAergic neurons, but its changes did not couple with GABA in the epileptic models.

关键词： KChIP1 PTZ epilepsy seizure GABA immunohistochemistry

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Construction of Salmonella Pullorum ghost by co-expression of lysis gene E and the antimicrobial peptide SMAP29 and evaluation of its immune efficacy in specific-pathogen-free chicks

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Journal of Integrative Agriculture 2018年第1期17卷 197-209页

作者： TIAN qiu-feng ZHOU wei SI wei yi Fei hua Xin YUE Min CHEN Li-ping LIU Si-guo YU Shen-ye Division of Bacterial Diseases State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150069 P.R. China Heilongjiang Bayi Agricultural University Daqing 163319 P.R. China College of Animal Sciences Zhejiang University Hangzhou 310058 P.R. China

In this study, a safety enhanced Salmonella Pullorum （S. Pullorum） ghost was constructed using an antimicrobial peptide gene, and evaluated for its potential as a Pullorum disease （PD） vaccine candidate. The antimicrobial peptide SMAP29 was co-expressed with lysis gene E to generate S. Pullorum ghosts. No viable bacteria were detectable either in the fermentation culture after induction of gene E- and SMAP29-mediated lysis for 24 h or in the lyophilized ghost products. Specific-pathogen- free （SPF） chicks were intraperitoneally immunized with ghosts at day 7 of age and no mortality, clinical symptoms or signs of PD such as anorexia, depression and diarrhea were observed. On challenge with a virulent S. Pullorum strain at 4 wk post-immunization, a comparatively higher level of protection was observed in the S. Pullorum ghost immunized chickens with a minimum of pathological lesions and bacterial loads compared to the birds in inactivated vaccine groups. In addition, immunization with the S. Pullorum ghosts induced a potent systemic IgG response and was associated with significantly increased levels of cytokine IFN-y and IL-4 and relative percentages of CD4＋ and CD8＋ T lymphocytes. Our results indicate that SMAP29 can be employed as a new secondary lethal protein to enhance the safety of bacterial ghosts, and to prepare a non-living bacterial vaccine candidate that can prevent PD in chickens.

关键词： Salmonella Pullorum bacterial ghost antimicrobial peptide immune response immune protection

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Dynamic alteration of telomerase expression and its diagnostic significance in liver or peripheral blood for hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第31期12卷 4966-4972页

作者： Deng-Fu Yao wei Wu Min Yao Li-wei qiu Xin-hua Wu Xiao-Qin su Li Zou Deng-Bing Yao Xian-Yong Meng Research Center of Clinical Molecular Biology Affiliated Hospital Nantong University Nantong 226001 Jiangsu Province China Nanjing University Nanjing 210008 Jiangsu Province China Center of Oncology Affiliated Hospital of Nantong University Nantong 226001 Jiangsu Province China Institute of Neurosciences Nantong University Nantong 226001 Jiangsu Province China Department of Gastroenterology Affiliated Hospital Nantong University Nantong 226001 Jiangsu Province China

AIM： To investigate the dynamic alteration of telomerase expression during development of hepatocellular carcinoma （HCC） and its diagnostic implications in liver tissues or peripheral blood mononuclear cells for HCC. METHODS： Dynamic expressions of liver telomerase during malignant transformation of hepatocytes were observed in Sprague-Dawly （SD） rats fed with 0.05% of 2-fluoenyacetamide （2-FAA）. Total RNA and telomerase were extracted from rat or human liver tissues. The telomerase activities in livers and in circulating blood were detected by a telomeric repeat amplification protocol-enzyme-linked immunosorbent assay （TRAP- ELISA）, and its diagnostic value was investigated in patients with benign or malignant liver diseases. REsuLTS： The hepatoma model displayed the dynamic expression of hepatic telomerase during HCC development. The telomerase activities were consistent with liver total RNA levels （r = 0.83, P 〈 0.01） at the stages of degeneration, precancerosis, and cancerization of hepatocytes. In HCC patients, the telomerase levels in HCC tissues were significantly higher than in their adjacent non-cancerous tissues, but liver total RNA levels were lower in the former than in the latter. Although the circulating telomerase of HCC patients was abnormally expressed among patients with chronic liver diseases, the telomerase activity was a non-specific marker for HCC diagnosis, because the incidence was 15.7% in normal control, 25% in chronic hepatitis, 45.9% in liver cirrhosis, and 85.2% in HCC, respectively when absorbance value of telomerase activity was more than 0.2. If the value was over 0.6, the incidence was 60% in HCC group and 0% in any of the others （P 〈 0.01） except in two cases with liver cirrhosis. However, the combination of circulating telomerase with serum alpha-fetoprotein level could increase the positive rate and the accuracy （92.6%, 125 of 135） of HCC diagnosis. CONCLUSION： The overexpression of telomerase is associated with HCC development, a

关键词： Hepatocellular carcinoma Telomerase Peripheral blood mononuclear cells Telomeric repeat amplification protocol

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Advances in electrical impedance tomography-based brain imaging

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Military Medical Research 2022年第6期9卷 705-726页

作者： Xi-Yang Ke wei Hou Qi huang Xue Hou Xue-ying Bao wei-Xuan Kong Cheng-Xiang Li Yu-Qi qiu Si-yi Hu Li-hua Dong Department of Radiation Oncology and Therapy the First Hospital of Jilin UniversityChangchun 130021China Jilin Provincial Key Laboratory of Radiation Oncology and Therapy the First Hospital of Jilin UniversityChangchun 130021China NHC Key Laboratory of Radiobiology School of Public HealthJilin UniversityChangchun 130021China CAS Key Laboratory of Bio-Medical Diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163JiangsuChina

Novel advances in the field of brain imaging have enabled the unprecedented clinical application of various imaging modalities to facilitate disease diagnosis and treatment. Electrical impedance tomography(EIT) is a functional imaging technique that measures the transfer impedances between electrodes on the body surface to estimate the spatial distribution of electrical properties of tissues. EIT offers many advantages over other neuroimaging technologies,which has led to its potential clinical use. This qualitative review provides an overview of the basic principles,algorithms, and system composition of EIT. Recent advances in the field of EIT are discussed in the context of epilepsy,stroke, brain injuries and edema, and other brain diseases. Further, we summarize factors limiting the development of brain EIT and highlight prospects for the field. In epilepsy imaging, there have been advances in EIT imaging depth,from cortical to subcortical regions. In stroke research, a bedside EIT stroke monitoring system has been developed for clinical practice, and data support the role of EIT in multi-modal imaging for diagnosing stroke. Additionally, EIT has been applied to monitor the changes in brain water content associated with cerebral edema, enabling the early identification of brain edema and the evaluation of mannitol dehydration. However, anatomically realistic geometry,inhomogeneity, cranium completeness, anisotropy and skull type, etc., must be considered to improve the accuracy of EIT modeling. Thus, the further establishment of EIT as a mature and routine diagnostic technique will necessitate the accumulation of more supporting evidence.

关键词： Electrical impedance tomography(EIT) Brain diseases Tissue impedance Microelectrode array

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Effects of Land Cover on Soil Organic Carbon Stock in a Karst Landscape with Discontinuous Soil Distribution

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Journal of Mountain Science 2014年第3期11卷 774-781页

作者： CHEN Xiang-bi ZHENG hua ZHANG wei HE Xun-yang LI Lei WU Jin-shui huaNG Dao-you su yi-rong Key Laboratory of Agro-ecological Processes in subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences huanjiang Observation and Research Station for Karst Eco-systems Guangxi Institute of subtropical Crops

Land cover type is critical for soil organic carbon （SOC） stocks in territorial ecosystems. However, impacts of land cover on SOC stocks in a karst landscape are not fully understood due to discontinuous soil distribution. In this study, considering soil distribution, SOC content and density were investigated along positive successional stages （cropland, plantation, grassland, scrubland, secondary forest, and primary forest） to determine the effects of land cover type on SOC stocks in a subtropical karst area. The proportion of continuous soil on the ground surface under different land cover types ranged between 0.0% and 79.8%. As land cover types changed across the positive successional stages, SOC content in both the 0-20 cm and 20-50 cm soil layers increased significantly. SOC density （SOCD） within O-lOO cm soil depth ranged from 1.45 to 8.72 kg m^-2, and increased from secondary forest to primary forest, plantation, grassland, scrubland, and cropland, due to discontinuous soil distribution. Discontinuous soil distribution had a negative effect on 8OC stocks, highlighting the necessity for accurate determination of soil distribution in karst areas. Generally, ecological restoration had positive impacts on SOC accumulation in karst areas, but this is a slow process. In the short term, the conversion of croplandto grassland was found to be the most efficient way for SOC sequestration.

关键词： Soil organic carbon (SOC) Karst area Discontinuous soil distribution Land cover type Carbon sequestration potential

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Trivalent Ni oxidation controlled through regulating lithium content to minimize perovskite interfacial recombination

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Rare Metals 2022年第1期41卷 96-105页

作者： Jin-Jin Zhao Xiao su Zhou Mi ying Zhang Yan-Jun Hu hua-Jun Guo yi-Nan Jiao Yu-Xia Zhang Yan Shi wei-Zhong Hao Jing-wei Wu yi Wang Cun-Fa Gao Guo-Zhong Cao School of Materials Science and Engineering School of Mechanical EngineeringShijiazhuang Tiedao UniversityShijiazhuang 050043China School of Materials Science and Engineering Hebei Key Laboratory of Material Near Net Forming TechnologyHebei University of Science and TechnologyShijiazhuang 050018China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Materials Science and Engineering University of WashingtonSeattleWA 98195-2120USA

Organic–inorganic hybrid perovskite solar cells,one of the most promising photovoltaic devices,have made great progress in their efficiency and preparation *** this study,uniform,highly conductive Li_(n)NiO_(x)(0≤n... 详细信息

关键词： Lithium ions Ni^(3+) Oxidized defect Photocurrent Perovskite solar cells

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CETP polymorphism confer genetic contribution to centenarians of Hainan,south of China

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 851-855页

作者： Yun-Xia Zhang Ya su Li Tang Ze-Xing Yang Dai-Feng Zhou yi-Min qiu Wang-wei Cai Department of Biochemistry and Molecular Biology Hainan Medical College Hainan Cadre Sanatorium Geriatric Hospital of Hainan Department of Reproduction and Genetics the First Affiliated Hospital of Kunming Medical University

Objective:In this paper,we will discuss if the CETP polymorphism contributes to the centenarians in Hainan ***:We tested the Taq IB and I405 V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package(Version 19.0).Results:Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with Psuch as B1B1-II(Psults implied that allele B1B1 and VV,as well as the combination B1B1-II,B1B1-IV,B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan,south of China.

关键词： Centenarians Polymorphisms of CETP Genetic contribution

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Characteristic Optimization of 1.3 μm High-Speed MQW InGaAsP-AIGaInAs Lasers

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Chinese Physics Letters 2012年第6期29卷 141-144页

作者： MAO yi-wei WANG Yao CHEN Yang-hua XUE Zheng-Qun LIN Qi DUAN Yan-Min su Hui Fujian Institute Of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350002

We investigate 1.3μm multi quantum-well (MQW) lasers with InGaAsP (well) and InGaAIAs (barrier) on InP for high speed application,compared to the typical structures of In GaAsP (well)-InGaAsP (barrier)/InP and InGaAlAs (well)-InGaAlAs (barrier)/InP with the same quaternary in the well and *** calculate the characteristics of band offset and gain of InGaAsP-AlGaInAs quantum wells ( Q Ws).The advances of the new Q W design are mainly rooted in the large ratio between conduction-band and valence-band offsets (△Ec:△Ev =7:1),higher than the typical value of 4:6 in InGaAsP-InGaAsP and 7:3 in InGaAlAs-InGaAlAs for 1.3μm *** to the 1ow confinement energy of holes,non-uniformity of carrier distribution over multi-InGaAsP-AlGaInAs QWs is significantly *** enhancement of high-speed performance of InGaAsP-AlGaInAs MQW lasers is investigated in terms of turn-on oscillation.

关键词： InGaAsP GaAsP barrier

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