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物理学科核心素养下的深度学习--以“磁现象磁场”教学为例

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物理教学 2022年第9期44卷 38-41,7页

作者：李建锋潘威熊华陈耿炎深圳市龙岗区龙城天成学校广东518172 深圳市龙岗区教育科学研究院广东518172 深圳市龙岗区华南师范大学附属平湖学校广东518115

在全面深化课程改革的趋势下,深度学习已成为教学研究的焦点,被视为落实学生核心素养的重要途径。本文以“磁现象磁场”市级公开课为例:创设情境,实验探究,聚焦科学观念;类比推理,深度互动,显化科学思维;优化实验,科学论证,助力科学探究... 详细信息

在全面深化课程改革的趋势下,深度学习已成为教学研究的焦点,被视为落实学生核心素养的重要途径。本文以“磁现象磁场”市级公开课为例:创设情境,实验探究,聚焦科学观念;类比推理,深度互动,显化科学思维;优化实验,科学论证,助力科学探究;追本溯源,学以致用,培养科学态度。

关键词：深度学习物理核心素养实验探究

Genetic Analysis and Mapping of TWH Gene in Rice Twisted Hull Mutant

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Rice science 2009年第1期16卷 79-82页

作者： LI Jin-bo XIA Ming-yuan WAN Bing-liang DU Xue-shu ZHA Zhong-ping Yu Da-zhao QI hua-xiong Food Crops Research Institute Hubei Academy of Agricultural Sciences Wuhan 430064 China Plant Protection and Soil and Fertilizer Research Institute Hubei Academy of Agricultural Sciences Wuhan 430064 China

A mutant with twisted hulls was found in a breeding population of rice （Oryza sativa L.）. The mutant shows less grain weight and inferior grain quality in addition to twisted hulls. Genetic analysis indicated that the phenotype of mutant was controlled by a single recessive gene （temporarily designated as TW（H）. To map the TWH gene, an F2 population was generated by crossing the twh mutant to R725, an indica rice variety with normal hulls. For bulked segregant analysis, the bulk of mutant plants was prepared by mixing equal amount of plant tissue from 10 twisted-hull plants and the bulk of normal plants was obtained by pooling equal amount tissue of 10 normal-hull plants. Two hundred and seven pairs of simple sequence repeat （SSR） primers, which are distributed on 12 rice chromosomes, were used for polymorphism analysis of the parents and the two bulks. The TWH locus was initially mapped close to the SSR marker RM526 on chromosome 2. Therefore, further mapping was performed using 50 pairs of SSR primers around the marker RM526. The TWH was delimited between the SSR markers RM14128 and RM208 on the long arm of chromosome 2 at the genetic distances of 1.4 cM and 2.7 cM, respectively. These results provide the foundation for further fine mapping, cloning and functional analysis of the TWH gene.

关键词： rice twisted-hull mutant genetic analysis gene mapping

Hepatic amyloidosis in a patient with chronic liver failure:A case report

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World Journal of Clinical Cases 2024年第19期12卷 3918-3924页

作者： Yan Chen Jing Peng Yao Wang Li-hua Xiao Fang Liu Yin-Bin Wei xiong-Fei Wu Lu-Wen Wang Department of Infectious Diseases Hanchuan People's HospitalHanchuan 431699Hubei ProvinceChina Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

BACKGROUND Amyloidosis is a rare disorder that can be classified into various types,and the most common type is the systemic light chain *** prognosis of this disease is extremely *** general,amyloidosis mainly affects the kidneys and heart and manifests as abnormal proliferation of clonal plasma *** in which the liver is the primary organ affected by amyloidosis,as in this report,are less common in clinical *** SUMMARY A 62-year-old man was admitted with persistent liver dysfunction of unknown cause and poor treatment *** condition persisted,and he developed chronic liver failure,with severe cholestasis in the later stage that was gradually accompanied by renal ***,he was diagnosed with hepatic amyloidosis through liver biopsy and pathological *** Hepatic amyloidosis rarely occurs in the clinic,and liver biopsy and pathological examination can assist in the accurate and effective diagnosis of this condition.

关键词： Hepatic amyloidosis Rare disease Chronic liver failure Liver biopsy Pathological examination Case report

北京市老年人医养结合的难点与对策:机构的视角

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中国医学伦理学 2024年第2期37卷 204-209页

作者：谢广宽熊冰雪程洁杨华北京大学医学人文学院北京100191 北京大学统战部北京100871 北京大学统计室北京100871 南阳市人社局河南南阳473000

中国老年群体在全国人口中的比例越来越大,如何通过医养结合真正做到老有所养、病有所医,是当前亟须解决的重要难题。以北京市为例,分析了北京市医养结合的发展形势,通过对北京三种主要的医养结合模式进行实地调研,从组织机构的视角总... 详细信息

中国老年群体在全国人口中的比例越来越大,如何通过医养结合真正做到老有所养、病有所医,是当前亟须解决的重要难题。以北京市为例,分析了北京市医养结合的发展形势,通过对北京三种主要的医养结合模式进行实地调研,从组织机构的视角总结不同模式面临的困难和挑战,建议进一步统筹协调京津冀医养结合政策,加快长期照护险落地,加强养老人才队伍的专业化建设,强化对养老机构的标准化建设和监管,大力发展科技养老、智慧养老。

关键词：老龄化医养结合养老机构

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日本数字货币发展策略及启示

国际经济合作 2024年第3期 38-49,92页

作者：宋爽熊爱宗华佳丽中国社会科学院世界经济与政治研究所中国社会科学院大学国际政治经济学院

日本是全球数字货币交易和使用最活跃的国家之一,在私人数字货币、央行数字货币和数字货币国际合作三方面制定了系统的发展策略。从政策目标看,日本的国内数字货币政策强调发展,国际数字货币政策意在安全,而国际上追求安全也是为国内发... 详细信息

日本是全球数字货币交易和使用最活跃的国家之一,在私人数字货币、央行数字货币和数字货币国际合作三方面制定了系统的发展策略。从政策目标看,日本的国内数字货币政策强调发展,国际数字货币政策意在安全,而国际上追求安全也是为国内发展提供保障。从政策内容看,为促进国家经济发展,日本在国内采取了重私人数字货币、慎央行数字货币的策略;为保障国家经济安全,日本在国际上积极推动发达国家之间的央行数字货币合作,以弥补国内央行数字货币发展的制约。在政策协调方面,日本在本国领先的私人数字货币领域采取国内国际互补性策略,在本国慎重的央行数字货币领域采取国内国际替代性策略。参考日本数字货币发展策略,中国在发展数字货币时可考虑充分调动国内私营部门的创新作用,促进国际央行数字货币治理的公平性和包容性,加强国内国际数字货币之间的政策协调。

关键词：加密资产稳定币央行数字货币发展与安全金融安全

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农村剩余劳动力转移与教育投资主体多元化

特区经济 2006年第8期211卷 141-143页

作者：姬雄华延安大学经济管理学院西北农林科技大学经济管理学院陕西杨凌712100

现阶段我国面临农村剩余劳动力转移的巨大压力,而农村教育水平低是制约农村剩余劳动力转移的根本性原因。在农村教育投资机制中,政府、企业与农户均呈现出投资不力状况,建立多元化的农村教育投资新机制,鼓励多方投资农村教育,提高农民素... 详细信息

现阶段我国面临农村剩余劳动力转移的巨大压力,而农村教育水平低是制约农村剩余劳动力转移的根本性原因。在农村教育投资机制中,政府、企业与农户均呈现出投资不力状况,建立多元化的农村教育投资新机制,鼓励多方投资农村教育,提高农民素质,实现农村剩余劳动力的转移。

关键词：农村剩余劳动力转移教育多元化投资

珠江口盆地白云凹陷中新统珠江组潮流改造的砂质海底扇沉积

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地球科学 2024年第1期49卷 71-83页

作者：王家豪庞雄王华柳保军陈鑫鑫中国地质大学构造与油气资源教育部重点实验室湖北武汉430074 中国地质大学资源学院湖北武汉430074 中海石油(中国)有限公司深圳分公司广东深圳510240

近年来,浅海扇和底流改造作用的较多发现对深水扇术语、鲍马序列等传统认识带来了挑战,有待进一步研究.珠江口盆地白云凹陷是我国海底扇油气勘探的重要场所之一,中新统珠江组SQ21层序(层序底界年龄21 Ma)是该凹陷砂质海底扇发育和油气... 详细信息

近年来,浅海扇和底流改造作用的较多发现对深水扇术语、鲍马序列等传统认识带来了挑战,有待进一步研究.珠江口盆地白云凹陷是我国海底扇油气勘探的重要场所之一,中新统珠江组SQ21层序(层序底界年龄21 Ma)是该凹陷砂质海底扇发育和油气发现的主力层位.采取岩心观察与测井相、地震反射结构、地震地貌分析相结合,揭示了该层序下降期体系域和低位体系域发育为数众多的海底扇,由重力流水道、天然堤和席状朵叶体构成,在地震属性图上分别表现为均方根振幅高值条带和朵状形态.上陆坡带重力流水道由块状-递变层理中-细砂岩、波状层理粉-细砂岩组成,具有正旋回、箱型-钟型测井相、水道充填地震相等识别标志.其中,波状层理粉-细砂岩夹较多泥岩纹层,局部表现为单粘土层和双粘土层构造,且富含潜穴、生物扰动构造和菱铁质结核,指示该时期海平面大幅下降直至陆架坡折以下,上陆坡带逐渐演化为浅海环境,导致研究区砂质海底扇发育及其重力流水道沉积在上陆坡带遭受明显的潮流改造.地震地貌分析方法的应用,保证了潮流改造型海底扇沉积相的准确识别.此外,本文的研究还表明,鲍马序列可以是底流改造成因;“深水扇”术语并非广泛适用.

关键词：中新统海底扇底流改造作用重力流鲍马序列珠江口盆地白云凹陷沉积学

Effect of heparin on apoptosis in human nasopharyngeal carcinoma CNE2 cells

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Cell Research 2001年第4期11卷 311-315页

作者： LI HONG LIANG , KAI HE YE , HAI WEI ZHANG , YING RU LUO , XIAN DA REN, AI hua xiong, RUI SITU Department of Pharmacology ,Pharmacy College, Department of Pathology Medical College, Jinan University, Guangzhou 510632, China Department of Pharmacology Pharmacy College Jinan University Guangzhou China Department of Pathology Medical College Jinan University Guangzhou China

In order to study the mechanism of the effect of heparin on apoptosis in carcinoma cells, the nasopha- ryngeal carcinoma cell line CNE2 was used to identify the effect of heparin on apoptosis associated with the expression of c-myc,bax, bcl-2 proteins by use of Hoechst 33258 staining, terminal deoxynucleotidyl transferasemediated dUTP nick-end labeling (TUNEL), agarose gel electrophoresis, and flow cytometry, as well as Western blot analysis. The results showed that heparin induced apoptosis of cNE2 cens including the morphologic changes such as reduction in the volume, and the nuclear chromatin condensation, as well as the 'ladder pattern' revealed by agarose gel electrophoresis of DNA in a concentration-dependent manner. The number of TUNEL-positive cells was dramatically increased to 33.6+1.2% from 2.8+0.3% by treat- ment with heparin in different concentrations (10~40 kU/L). The apoptotic index was increased to 32.5% from 3.5% by detecting SubG1 peaks on flow cytometry. Western blot analysis showed that levels of bcl-2, bax and c-myc were significantly overexpressed by treatment with the increase of heparin concentrations. These results suggest that heparin induces apoptosis of CNE2 cells, which may be regulated by differential expression of apoptosis-related genes.

关键词： Heparin agarose gel electrophoresis flow cytometry apoptosis protein kinase C(PKC)

Biomedical polymers: synthesis, properties, and applications

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Science China Chemistry 2022年第6期65卷 1010-1075页

作者： Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-hua xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan UniversityWuhan430072China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology) Ministry of EducationBeijing Laboratory of Biomedical MaterialsCollege of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing100029China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationCollege of ChemistryNankai UniversityTianjin300071China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Jinhua Institute of Zhejiang University Jinhua321299China Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou311215China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai200438China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nano-scienceNational Center for Nanoscience and Technology(NCNST)Beijing100190China School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou510006China Institute of Functional Nano and So

Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

关键词： biomedical polymer nanomedicine cancer therapy drug delivery bioimaging and biosensing tissue engineering regenerative medicine cytotoxicity biocompatibility