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Not to be and how not to be:the questions of Tregs controlled by RIPK1

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Cellular & Molecular Immunology 2024年第2期21卷 205-206页

作者： Zhengcai Peng huiyuan Zhang hongbo hu Center for Immunology and Hematology Department of Biotherapy and Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China Chongqing International Institute for Immunology Chongqing401338China

Millions of cells undergo daily cell death,a process essential for maintaining physiological homeostasis and *** forms of cell death,such as apoptosis,necroptosis,ferroptosis and pyroptosis,have been extensively studied for their distinct biological functions[1,2].Generally,programmed cell death,like apoptosis,is considered physiological and results in little to no inflammatory response.

关键词： death homeostasis pathogenesis

Targeting NF-κB pathway for the therapy of diseases:mechanism and clinical study

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Signal Transduction and Targeted Therapy 2020年第1期5卷 749-771页

作者： hui Yu Liangbin Lin Zhiqiang Zhang huiyuan Zhang hongbo hu Department of Rheumatology and Immunology National Clinical Research Center for GeriatricsState Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengduChina Immunobiology and Transplant Science Center Houston Methodist HospitalHoustonTX 77030USA

NF-κB pathway consists of canonical and non-canonical *** canonical NF-κB is activated by various stimuli,transducing a quick but transient transcriptional activity,to regulate the expression of various proinflammatory genes and also serve as the critical mediator for inflammatory ***,the activation of the non-canonical NF-κB pathway occurs through a handful of TNF receptor superfamily *** the activation of this pathway involves protein synthesis,the kinetics of non-canonical NF-κB activation is slow but persistent,in concordance with its biological functions in the development of immune cell and lymphoid organ,immune homeostasis and immune *** activation of the canonical and non-canonical NF-κB pathway is tightly controlled,highlighting the vital roles of ubiquitination in these *** studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers,and NF-κB has been long proposed as the potential target for therapy of *** review attempts to summarize our current knowledge and updates on the mechanisms of NF-κB pathway regulation and the potential therapeutic application of inhibition of NF-κB signaling in cancer and inflammatory diseases.

关键词： diseases homeostasis inflammation

Measuring observability by generalized information theoretic quantities

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控制理论与应用（英文版） 2008年第3期6卷 233-238页

作者： Badong CHEN Jinchun hu hongbo LI Zengqi SUN State Key Laboratory of Intelligent Technology and Systems Tsinghua University Beijing 100084 China

A normalized measure is established to provide the quantitative information about the degree of observability for the discrete-time, stochastically autonomous system. This measure is based on the generalized information theoretic quantities （generalized entropy, mutual information） of the system state and the observations, where the system state can be a discrete or a continuous random vector. Some important properties are presented. For the linear case, the explicit formula for the degree of observability is derived, and the equivalence between the proposed measure and the traditional rank condition is proved. The curves for the degree of observability are depicted in a simple example.

关键词： Stochastic system Observability Information theory

Experimental research on rotating detonation with liquid hypergolic propellants

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Chinese Journal of Aeronautics 2018年第12期31卷 2199-2205页

作者： Shuaijie XUE Hongjun LIU Lixin ZHOU Weidong YANG hongbo hu Yu YAN Science and Technology on Liquid Rocket Engine Laboratory Xi'an Aerospace Propulsion Institute

This paper describes experimental research into the initiation and propagation of rotating detonation for liquid Nitrogen TetrOxide(NTO) and liquid MonoMethylHydrazine(MMH).An annular rocket-type combustor without nozzle was designed to investigate detonation combustion. The propellants were injected through unlike impingement injectors. The combustion flame fronts and pressure waves were detected using optical diagnostics and dynamic pressure sensors,respectively. The propagation of rotating detonation was established spontaneously by increasing the mass flow rate of propellants. The velocity of propagation of the flame fronts and pressure waves was nearly equal and reaches supersonic speed. Two different detonation combustion patterns are present, single wave mode and double waves mode. And in double waves mode, the two detonation waves are always counter-rotating. The possibility of rotating detonation initiation in a combustor with nozzle was also checked. Stable rotating detonation can be initialized and sustained at similar operating conditions.

关键词： Hypergolic Initiation Liquid propellant Nozzle Rotating detonation

Green Synthesis of Calcium Carbonate Uniform Microspheres Using Vegetables

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Chinese Journal of Chemistry 2012年第2期30卷 445-448页

作者： Chen,Long Bao,Zuben Pan,Jian Xu,Weibing Zhang,Heping hu,hongbo hu,Jichao Zhou,Lili Post-Doetoral Scientific Research Workstation Huangshan NOVEL Co.LtdHuangshanAnhui 245061China Department of Chemistry Huangshan UniversityHuangshanAnhui 245041China Mobile Post-Doctoral Center School of Materials Science and EngineeringHefei University of TechnologyHefeiAnhui 230009China

We report a novel strategy for the green synthesis of calcium carbonate （CaCO3） microspheres by using four vegetables： potato, cucumber, aubergine, and carrot. The products were characterized by scanning electron microscopy, X-ray powder diffractometry and/or Fourier transform infrared spectroscopy. The results show that the spherical calcite crystals are obtained in the presence of potato, cucumber and aubergine extracts, while uniform vaterite and calcite mixed microspheres are produced with the extracts of carrot. The possible formation mechanism of the CaCO3 microspheres by using vegetables is also discussed, suggesting that the biomolecules especially proteins may induce and control the nucleation and growth of CaCO3 crystals. CaCO3 is an important biomineral and inorganic material. Uniform particles have numerous important applications in many areas. Therefore, this study is very significant not only for expanding the scope of crystal engineering, but also for biomineralization research and green synthesis of functional inorganic materials.

关键词： calcium carbonate crystal growth microsphere vegetable X-ray diffraction

The Evaluation Characteristics of Type B Aortic Intramural Hematoma and Ten Years Treatment Outcomes

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World Journal of Cardiovascular Diseases 2021年第1期11卷 58-68页

作者： Jinguo Zhu hongbo hu Department of Cardiothoracic Surgery The Second Affiliated Hospital of Shantou University Medical College Shantou China Department of Cardiothoracic Surgery The People’s Hospital of Sanya Sanya China Department of Cardiothoracic Surgery Liuzhou Municipal Liutie Central Hospital Liuzhou China

Background: Type B aortic intramural hematoma (IMH-B) is recognized as a subset of aortic dissection. The evolution of uncomplicated IMH-B is very difficult to predict. How and when to deal with this disease is unclear. The present study constructed two models to explore this problem. One is the morphology evolution model, which explored the risk factors and predictors for the IMH-B patients. Another is the predictive model confirmed the predictors and the time for invasive treatment of uncomplicated IMH-B patients. Objective: To explore the evolution predictors and detect the time for invasive treatment of uncomplicated IMH-B patients. Methods: Themorphology evolution model demonstrated that all 81 patients were diagnosis with CTA images. The initial and follow-up data were retrospectively studied. The evolution data were collection and measurement from initial and follow-up CTA images data. The predictive model showed that predictors of progression were detected with cox regression analysis. Results: All 81IMH-B patients were followed-up ranged from 1.2 to 36 months (median, 22 months). 26 patients accepted invasive treatment (24 underwent TEVAR and 2 underwent Surgery)

Distinct roles of the IRE1αarm and PERK arm of unfolded protein response in arachidonic acid-induced ferroptosis in hepatocytes

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Food Innovation and Advances 2023年第3期2卷 184-192页

作者： Han Zhang Kai Han Shutao Yin Lihong Fan hongbo hu Chong Zhao College of Food Science and Nutritional Engineering China Agricultural UniversityNo 17Qinghua East RoadHaidian DistrictBeijing 10083China College of Veterinary Medicine China Agricultural UniversityNo 2Yuanmingyuan West RoadHaidian DistrictBeijing 100193China

Ferroptosis is a distinct form of cell death that is driven by iron-dependent phospholipid *** fatty acids(PUFAs),particularly arachidonic acid(AA)and adrenal acid(AdA),are most prone to lipid peroxidation,which induces ferroptosis and affects the function of cell *** this study,we discovered that AA induces ferritinophagy in hepatocytes,a selective form of autophagy that degrades ferritin,triggering unstable iron ***,AA enhances cellular uptake of bound iron by up-regulating transferrin receptor 1(TfR1).Additionally,AA induces endoplasmic reticulum stress(ER stress)and simultaneously activates two of its branches,pancreatic ER kinase(PERK)and inositol-requiring enzyme 1(IRE1).Notably,PERK and IRE1 appear to play distinct roles in inducing *** of PERK reduced the AA-induced increase of Fe^(2+)by alleviating ferritinophagy,while inhibition of IRE1 further exacerbated ferroptosis by activating ***,there seems to be an interaction between the signaling pathways of ER stress,and inhibition of IRE1 exacerbates AA-induced ferritinophagy by further activating the PERK signaling pathway,thereby exacerbating the extent of cell ***,our findings suggest that iron overload is involved in AA-induced hepatocyte ferroptosis and that this process is regulated by ER stress-mediated *** study suggests potential therapeutic strategies for treating liver diseases related to lipid metabolism disorders by intervening in the ferroptosis process.

关键词： peroxidation metabolism unstable

Survival and maintenance of regulatory T cells require the kinase TAK1

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Cellular & Molecular Immunology 2015年第5期12卷 572-579页

作者： Jae-Hoon Chang hongbo hu Shao-Cong Sun Department of Immunology The University of Texas MD Anderson Cancer Center 7455 Fannin Street Box 902 Houston TX 77030 USA Center for Inflammation and Cancer The University of Texas MD Anderson Cancer Center 7455 Fannin Street Box 902 Houston TX 77030 USA The University of Texas Graduate School of Biomedical Sciences at Houston Houston TX 77030 USA College of Pharmacy Yeungnam University Gyeongsan 712- 749 Republic of Korea

Regulatory T （Treg） cells play a central role in regulating peripheral immune tolerance and preventing autoimmunity. Despite the extensive studies on the development of Treg cells, the molecular mechanisms that maintain the population of committed Treg cells remain poorly understood. We show here that Treg-conditional ablation of the kinase TAK1 reduced the number of Treg cells in the peripheral lymphoid organs, causing abnormal activation of conventional T cells and autoimmune symptoms. Using an inducible gene knockout approach, we further demonstrate that TAK1 is crucial for the survival of Treg cells. Expression of a constitutively active IKB kinase partially restored the level of Treg cells in the TAKITreg-KO mice. These results suggest a crucial role for TAK1 for maintaining the survival of committed Treg cells under physiololzical conditions.

关键词： regulatory T cells autoimmunity TAK1 IKK Foxp3

Non-canonical NF-kB in Immune Response

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Non-canonical NF-kB in Immune Response