Targeting NF-κB pathway for the therapy of diseases:mechanism and clinical study
作者机构：Department of Rheumatology and ImmunologyNational Clinical Research Center for GeriatricsState Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengduChina Immunobiology and Transplant Science CenterHouston Methodist HospitalHoustonTX 77030USA
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2020年第5卷第1期
页 面：749-771页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the Ministry of Science and Technology of China(the National Key Research and Development Program 2016YFA0502203,2019YFA0110201,and 2019YFA0110203) the National Natural Science Foundation of China(91740111,81871232,and 31870881),1.3.5 Project of disciplines of excellence and National Clinical Research Center for Geriatrics(Z2020001),West China Hospital,Sichuan University
主 题：diseases homeostasis inflammation
摘 要：NF-κB pathway consists of canonical and non-canonical *** canonical NF-κB is activated by various stimuli,transducing a quick but transient transcriptional activity,to regulate the expression of various proinflammatory genes and also serve as the critical mediator for inflammatory ***,the activation of the non-canonical NF-κB pathway occurs through a handful of TNF receptor superfamily *** the activation of this pathway involves protein synthesis,the kinetics of non-canonical NF-κB activation is slow but persistent,in concordance with its biological functions in the development of immune cell and lymphoid organ,immune homeostasis and immune *** activation of the canonical and non-canonical NF-κB pathway is tightly controlled,highlighting the vital roles of ubiquitination in these *** studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers,and NF-κB has been long proposed as the potential target for therapy of *** review attempts to summarize our current knowledge and updates on the mechanisms of NF-κB pathway regulation and the potential therapeutic application of inhibition of NF-κB signaling in cancer and inflammatory diseases.
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