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Impact of the professional exposure on the spermatic parameters and the results of ICSI at Tunisian unfertile couples

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Advances in Reproductive Sciences 2014年第1期2卷 24-31页

作者： Habib ben Ali Monia Zaouali Fatma Atig Iheb Bougmiza Souhir Mehri houda ben frej Faten Tabka Ali Saad Mounir Ajina Laboratoire de Cytogénétique Génétique Moléculaire et Biologie de la Reproduction Humaines CHU Farhat Hached de Sousse Sousse Tunisie Laboratoire de Physiologie et des Explorations Fonctionnelles Faculté de Médecine de Sousse Sousse Tunisie Service de Médecine Communautaire Faculté de Médecine de Sousse Sousse Tunisie Service de Médecine de Travail CHU Farhat Hached de Sousse Sousse Tunisie Unité de Médecine de la Reproduction CHU Farhat Hached de Sousse Sousse Tunisie

Introduction: The association of the professional exposure to the decline of the male reproductive function had been the subject of several studies but without arriving to one envisagement undeniable of its existence. The ICSI, technique of reference in severe male infertilities, is visavis unexplained failures whose environmental and professional exposure could be about its cause partly. In this work, we tried to highlight an association between certain factors of professional exposure and the deterioration of the spermatic parameters, then to evaluate the effect of such factors on the result of the ICSI. Materials and Methods: It is about a study of the exposed type—no exposed, realized through collaboration between the Unit of Medicine of the Reproduction and the Service of Medicine of Work of the CHU Farhat Hached of Sousse. This study was based on a questionnaire of which part of the items was collected medical files of the patients raising the general characteristics, the profile of exposure as well as the spermatic parameters and the biological assessment of ICSI. Results: Significant associations between the deterioration of sperm and the professional risk factors such as the exposure to the formaldehydes (p = 0.01) and heat (p = 0.001) were noted. The exposure to formaldehydes was associated at the higher risk of oli gozoospermy, of asthenozoospermy with a significant reduction in mobility (p = 0.05), whereas the talks with cement had a risk higher of teratozoospermy. In addition an exposure to heat was associated at the high risk of oligoteratozoospermy. The total rate of pregnancies after ICSI among 220 patients of our series was of 14.47%. The ICSI balance showed a reduction in total fertility rate (76.6% exposed vs 75.3% no exposed). Conclusion: In spite of the limited number of the patients, this study had shown a correlation between certain professional exposures of origin and the deterioration of sperm. They are preliminary results which encourage co

关键词： Male Sterility Professional Exposure Spermogramm ICSI

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A New Sliding Function for Discrete Predictive Sliding Mode Control of Time Delay Systems

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International Journal of Automation and computing 2013年第4期10卷 288-295页

作者： Abdennebi Nizar ben Mansour houda Nouri Ahmed Said Numerical Control of Industrial Processes National Engineering School of Gabes University of Gabes

The control of time delay systems is still an open area for research. This paper proposes an enhanced model predictive discrete-time sliding mode control with a new sliding function for a linear system with state delay. Firstly, a new sliding function including a present value and a past value of the state, called dynamic surface, is designed by means of linear matrix inequalities （LMIs）. Then, using this dynamic function and the rolling optimization method in the predictive control strategy, a discrete predictive sliding mode controller is synthesized. This new strategy is proposed to eliminate the undesirable effect of the delay term in the closed loop system. Also, the designed control strategy is more robust, and has a chattering reduction property and a faster convergence of the system s state. Finally, a numerical example is given to illustrate the effectiveness of the proposed control.

关键词： State time delay systems discrete sliding mode control model predictive control dynamic sliding function linear matrix inequalities (LMIs) chattering.

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Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia

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World Journal of Gastroenterology 2010年第4期16卷 479-483页

作者： Imen Sfar Walid ben Aleya Leila Mouelhi houda Aouadi Thouraya ben Rhomdhane Mouna Makhlouf Salwa Ayed-Jendoubi houda Gargaoui Taoufik Najjar Taieb ben Abdallah Khaled Ayed Yousr Gorgi Laboratory of Immunology Charles Nicolle HospitalTunis 1006Tunisia Department of Gastroenterology Charles Nicolle HospitalTunis 1006Tunisia

AIM:To assess the possible association between PTPN22(R620W) gene polymorphism and inflammatory bowel disease(IBD).METHODS:One hundred and sixty-four patients with IBD 105 Crohn's disease(CD) and 59 ulcerative colitis(UC) and 100 healthy controls were *** of the PTPN22 gene 1858C→T polymorphism was performed by restriction fragment length polymorphism-polymerase chain reaction with Rsa Ⅰ ***:The genotypic and allelic frequencies of(R620W) PTPN22 gene polymorphism reveal a significant association of the PTPN22 620-W allele with IBD,compared to the healthy control group(OR:17.81,95% CI:4.18-21.86,P = 0.00001).Nevertheless,nodifference in this polymorphism was found between CD and UC *** significant association was found between the frequencies of genotypes of the PTPN22 gene with either the clinical features such as sex,age,age at disease onset,and extent of colitis,or the production of serological markers(anti-Saccharomyces cerevisiae antibody in CD and perinuclear anti-neutrophil cytoplasmic antibody in UC).CONCLUSION:These observations confirm the association of IBD susceptibility with the PTPN22 1858T(620-W) allele in Tunisian patients.

关键词： Inflammatory bowel disease PTPN22 Genetic polymorphism Genetic susceptibility

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Prevention of H2O2 Induced Oxidative Damages of Rat Testis by Thymus algeriensis

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Biomedical and Environmental Sciences 2016年第4期29卷 275-285页

作者： Fatma Guesmi Hamida Beghalem Amit K Tyagi Manel ben Ali Ramla ben Mouhoub houda Bellamine Ahmed Landoulsi Laboratory of Biochemistry and Molecular Biology Faculty of Sciences of Bizerte Zarzouma Bizerte 7021 Tunisia Cytokine Research Laboratory Department of Experimental Therapeutics The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA Laboratory of Biomonitoring of the Environment (LRO1/ES14) Faculty of Sciences of Bizerte Zarzouma Bizerte 7021 Tunisia Service of Anatomo-Pathology of Menzel Bourguiba Bizerte 7050 Tunisia

Objective We evaluate the effects of Thymus algeriensis （TEO） against hydrogen peroxide （H202） toxicity on body and testis weight, testis sperm count, testis lipid peroxidation, and antioxidant enzyme activities in rats. Methods Rats were treated with low （LD） and high dose （HD） of H202 （0.1 and 1 mmol/L） in the presence or absence of TEO （150 mg/kg）. Results The results exhibited a significant decrease in body weight and testis weight, in total sperm number decrease （P〈0.05）, sperm motility and percentage of sperm viability, leading to complete arrest, in sperm flagellar beat frequency by the gavage of 1 mmol/L H202 compared to controls. The administration of H2O2 resulted in a significant reduction in testis GSH, GPx, CAT, SOD, and GST activity and significant increase （P〈0.05） in MDA concentration compared with the untreated control animals. TEO pre-treatment protected testis from the H2O2 generated oxidative stress. These results were confirmed by histological architecture examinations. Conclusion H2O2 has the ability to alter the sperm function, characteristics and development of testis. However, TEO is an efficient natural agent, which can prevent the testis from H2O2-induced oxidative damage in rats.

关键词： Testis Hydrogen peroxide TEO Antioxidants Infertility

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A Comparative Study of Different Drying Processes for a Deformable Saturated Porous Medium

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Fluid Dynamics & Materials Processing 2023年第6期19卷 1339-1348页

作者： Nour El houda ben Mustaphaa Ibtissem Boumnijel M.El-Ganaoui Daoued Mihoubi Laboratory of Wind Energy Management and Waste Energy Recovery Research and Technology Center of EnergyHammam-LifTunisia Laboratory of Studies and Research on Wood Material(LERMAB) University of LorraineLongwyFrance National Engineering School of Monastir University of MonastirMonastirTunisia

Drying of a deformable saturated porous medium based on convective tempering is a novel method that can enhance energy efficiency and the quality of the dried product *** this experimental investigation,the performances of this specific technique are compared with those of a standard stationary drying process in terms of deformation,drying kinetics,moisture redistribution,and energy *** particular,the response of a deformable saturated porous medium(Kaolin)is *** results are critically discussed pointing out advantages and drawbacks.

关键词： Convective drying tempering convective drying energy consumption Kaolin

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Implantable port thrombosis in cancer patients: a monocentric experience

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Cancer Biology & Medicine 2016年第3期13卷 384-388页

作者： Manel Dridi Nesrine Mejri Soumaya Labidi Mehdi Afrit houda El benna Khaoula ben Miled Hamouda Boussen Medical Oncology Department Abderrahmen Mami Hospital Radiology Department Abderrahmen Mami Hospital

Objective: Implantable port thrombosis(IPT) in cancer patients is a relatively rare but severe complication. Several factors are reportedly associated with the occurrence of thrombosis. We aimed to describe the prevalence and the anatomoclinical features of IPT observed in cancer patients who were treated in a medical oncology department in ***: A total of 600 cancer patients who had port implantation from January 2013 to December 2015 were retrospectively identified. Cases with symptomatic/incidental IPT(radiologically confirmed) were further identified. Epidemiological and anatomoclinical features were collected from patient records and the department ***: We observed that 33 of the 600 patients had IPT; thus, the prevalence was 5.5%. The median age was 57 years, and the gender ratio was 0.43. Overweight or obesity was observed in 73% of the patients. IPT occurred mainly in patients with breast(36.4%) and colorectal(33.3%) cancers, which were mostly nonmetastatic(79%). At least one identified classical thromboembolic risk factor was found in 13 patients(smoking in 9, tamoxifen in 2). IPT was symptomatic in 93% of the cases, occurring within an average time of 56 days. Implantable ports were removed because of infection in 2 cases and nonfunctionality in 3 cases. IPT treatment was based on low-molecular-weight heparins(94%) and antivitamin K(6%) for an average of 130 days. Four patients had post-therapy complications: one thrombosis recurrence and three ***: IPT cases in the 600 patients were observed to occur in obese nonmetastatic cancer patients within the first 3 months after IP implantation.

关键词： Implantable port cancer patients thrombosis

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Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD

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World Journal of Gastroenterology 2009年第29期15卷 3643-3648页

作者： Walid ben Aleya Imen Sfar Leila Mouelhi houda Aouadi Mouna Makhlouf Salwa Ayed-Jendoubi Samira Matri Azza Filali Taoufik Najjar Taeib ben Abdallah Khaled Ayed Yousr Gorgi Laboratory of Immunology EPS Charles Nicolle 1006 Bab Saadoun Tunis 1006 Tunisia Department of Gastroenterology EPS Charles Nicolle Tunis 1006 Tunisia Department of Gastroenterology La Rabta Tunis 1006 Tunisia

AIM： To detect a possible association between the polymorphism of the （-670 A/G） Fas/Apol gene promoter and susceptibility to Crohn＇s disease （CD） and ulcerative colitis （UC） in the Tunisian population. METHODS： The （-670 A/G） Fas polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS： Significantly lower frequencies of the Fas -670 A allele and A/A homozygous individuals were observed in CD and UC patients when compared with controls. Analysis of （-670 A/G） Fas polymorphism with respect to sex in CD and UC showed a significant difference in A/A genotypes between female patients and controls （P corrected = 0.004 ＂in CD patients＂ and P corrected = 0.02 ＂in UC patients＂, respectively）. Analysis also showed a statistically significant association between genotype AA of the （-670 A/G） polymorphism and the ileum localization of the lesions （P corrected = 0.048） and between genotype GG and the colon localization （P corrected = 0.009）. The analysis of IBD patients according to clinical behavior revealed no difference. CONCLUSION： Fas-670 polymorphism was associated with the development of CD and UC in the Tunisian population.

关键词： Fas/Apol Gene polymorphisms Inflammatory bowel disease Crohn's disease Ulcerative colitis

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Complete pathologic response after chemoradiotherapy in a patient with rectal squamous cell carcinoma： a case report

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Cancer Biology & Medicine 2017年第4期14卷 414-417页

作者： Zaied Sonia Daldoul Amira Bhiri Hanene Ammar Nouha Khechine Wiem Toumi Omar Abbes Ibtissem ben Salem Amina Njima Manel Mhabrech houda Department of Medical Oncology Fattouma Bourguiba University Hospital of Monastir Monastir 5000 Tunisia Department of Surgery Fattouma Bourguiba University Hospital of Monastir Monastir 5000 Tunisia Department of Radiology El Omrane University Hospital of Monastir Monastir 5000 Tunisia Department of Pathological Anatomy Fattouma Bourguiba University Hospital of Monastir Monastir 5000 Tunisia

Squamous cell carcinoma(SCC)of the rectum is a rare disease.A 59-year-old man presented with SCC of the middle rectum located 10 cm from the *** stage of the tumor was revealed to be T3N+*** patient received a combined treatment with cisplatin and fluorouracil in concomitance with external radiation *** then underwent an anterior resection of the *** postoperative histopathological findings classified the tumor as yp T0N0 with cancer-free margins and lymph *** of SCC remains very challenging,and the acquisition of more consistent data is needed.

关键词： Squamous cell carcinoma rectal neoplasm surgery colonoscopy

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Natural evolution of hepatitis C virus infection in hemodialysis Tunisian patients and CTLA-4 SNP's

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World Journal of Gastroenterology 2015年第35期21卷 10150-10158页

作者： Leila Ksiaa Cheikhrouhou Yousr Lakhoua-Gorgi Imen Sfar Salwa Jendoubi-Ayed houda Aouadi Mouna Makhlouf Khaled Ayed Taieb ben Abdallah Immunology Research Laboratory of Kidney Transplantation and Immunopathology Laboratoire de Recherche Laboratory of Immunology Charles Nicolle Hospital

AIM: To analyze the polymorphisms of CTLA-4 gene involved in the response against hepatitis C virus(HCV) ***: We recruited 500 hemodialysed patients from several hemodialysis centers, all HCV-antibody positive, spread over different regions of Tunisia, as part of a national survey in 2008 conducted in the laboratory of immunology at the Charles Nicolle hospital Tunisia, classified into two groups G1(PCR+) and G2(PCR-) according to the presence or absence of viral RNA. Of these patients, 307 were followed prospectively on a viral molecular level over a period from 2002 to 2008, divided into two groups based on the persistence and viral clearance. PCR-RFLP was performed for the analysis of SNPs(+49) A/G and(+6230) G/A CTLA-4 for these 500 patients and 358 healthy ***: Analysis of clinical and virological charac-teristics of our cohort suggests a nosocomial infection in our hemodialysed patients with transfusion history as a primary risk factor and a predominance of genotype 1b. The haplotype analysis revealed an increase of frequencies of GG(+49)/(CT60) CTLA-4 in the entire patients group compared to controls(P = 0.0036 and OR = 1.42; 95%CI: 1.12-1.79, respectively). This haplotype is therefore associated with susceptibility to HCV infection. CONCLUSION: Our study suggests a possible role of CTLA-4 polymorphisms in the outcome of HCV infection in the Tunisian hemodialysed population.

关键词： Hepatitis C virus Hemodialysis Natural evolution C

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Cytokine and apoptosis gene polymorphisms influence the outcome of hepatitis C virus infection

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Hepatobiliary & Pancreatic Diseases International 2011年第3期10卷 280-288页

作者： Leila Ksiaa Cheikhrouhou Imen Sfar Hajer Aounallah-Skhiri houda Aouadi Salwa Jendoubi-Ayed Taieb ben Abdallah Khaled Ayed Yousr Lakhoua-Gorgi Immunology Research Laboratory of Kidney Transplantation and Immunopathology (Laboratoire de Recherche:LR03SP01) Charles Nicolle Hospital National Health Institute

BACKGROUND:Hepatitis C virus (HCV) infection is thought to be chronic and the factors leading to viral clearance or persistence are poorly *** study was undertaken to investigate the possibility of a significant relationship between the spontaneous clearance or the persistence of hepatitis C virus (HCV) infection and cytokine and apoptosis gene polymorphisms in Tunisian patients on ***:Polymorphisms of the genes IL-1 (-889 IL-1α,-511 and +3954 IL-1β,IL-1Ra),IL-18 (-137 and-607),IL-12 (-1188) and Apo1/Fas (-670) were determined by PCR-RFLP,PCR-SSP and PCR-VNTR in 100 healthy blood donors and 100 patients infected with HCV and undergoing *** patients were classified into two groups:G1 consisted of 76 active chronic hepatitis patients (positive for HCV RNA) and G2 consisted of 24 hemodialysed patients who spontaneously eliminated the virus (negative for HCV RNA).RESULTS:The frequency of genotype association [-137GC/-607CA] IL-18 was higher in G2 (41.7%) than in G1 (15.8%) (P=0.008;OR=0.26;95% CI,0.10-0.73).We also found a higher frequency of the AA genotype of the Apo1/Fas gene in G2 (41.6%) than in G1 (17.5%) (P=0.026;OR=3.49;95% CI,1.13-10.69).Adjustment for known covariate factors (age,gender and genotype) confirmed these univariate findings and revealed that the genotype association GC-CA of the (-137 and-607) IL-18 gene and the AA genotype of the Apo1/Fas gene were associated with the clearance of HCV (P=0.041 and 0.017,respectively).CONCLUSION:The two genotypes GC-CA of the (-137 and-607) IL-18 polymorphism and the AA genotype of the Apo1/Fas gene influence the outcome of HCV infection in Tunisian patients on hemodialysis.

关键词： hepatitis C virus spontaneous clearance cytokine gene polymorphisms Apo1/Fas gene polymorphisms

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