Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD
Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD作者机构：Laboratory of Immunology EPS Charles Nicolle 1006 Bab Saadoun Tunis 1006 Tunisia Department of Gastroenterology EPS Charles Nicolle Tunis 1006 Tunisia Department of Gastroenterology La Rabta Tunis 1006 Tunisia
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2009年第15卷第29期
页 面：3643-3648页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by Laboratory of Immunology EPS Charles Nicolle Tunis Tunisia
主 题：Fas/Apol Gene polymorphisms Inflammatory bowel disease Crohn's disease Ulcerative colitis
摘 要：AIM： To detect a possible association between the polymorphism of the （-670 A/G） Fas/Apol gene promoter and susceptibility to Crohn＇s disease （CD） and ulcerative colitis （UC） in the Tunisian population. METHODS： The （-670 A/G） Fas polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS： Significantly lower frequencies of the Fas -670 A allele and A/A homozygous individuals were observed in CD and UC patients when compared with controls. Analysis of （-670 A/G） Fas polymorphism with respect to sex in CD and UC showed a significant difference in A/A genotypes between female patients and controls （P corrected = 0.004 ＂in CD patients＂ and P corrected = 0.02 ＂in UC patients＂, respectively）. Analysis also showed a statistically significant association between genotype AA of the （-670 A/G） polymorphism and the ileum localization of the lesions （P corrected = 0.048） and between genotype GG and the colon localization （P corrected = 0.009）. The analysis of IBD patients according to clinical behavior revealed no difference. CONCLUSION： Fas-670 polymorphism was associated with the development of CD and UC in the Tunisian population.
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