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Enhancement of Mechanical Properties of Natural Rubber with Maleic Anhydride Grafted Liquid Polybutadiene Functionalized Graphene Oxide

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Chinese Journal of Polymer Science 2015年第7期33卷 1058-1068页

作者： Long-mei Wu 廖双泉 Sheng-jun Zhang Xiao-ying Bai Xue hou College of Agriculture Hainan University College of Materials and Chemical Engineering Hainan University

An effective procedure has been developed to synthesize the functionalized graphene oxide grafted by maleic anhydride grafted liquid polybutadiene（MLPB-GO）. Fourier transform spectroscopy and X-ray photoelectron spectroscopy indicate the successful functionalization of GO. The NR/MLPB-GO composites were then prepared by the co-coagulation process. The results show that the mechanical properties of NR/MLPB-GO composites are obviously superior to those of NR/GO composites and neat NR. Compared with neat NR, the tensile strength, modulus at 300% strain and tear strength of NR composite containing 2.12 phr MLPB-GO are significantly increased by 40.5%, 109.1% and 85.0%, respectively. Dynamic mechanical analysis results show that 84% increase in storage modulus and 2.9 K enhancement in the glass transition temperature of the composite have been achieved with the incorporation of 2.12 phr MLPB-GO into NR. The good dispersion of GO and the strong interface interaction in the composites are responsible for the unprecedented reinforcing efficiency of MLPB-GO towards NR.

关键词： Enhancement Maleic anhydride-grafted liquid polybutadiene Graphene oxide Composites Mechanical properties

Transcriptome wide association studies: general framework and methods

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Quantitative Biology 2021年第2期9卷 141-150页

作者： Yuhan Xie Nayang shan Hongyu Zhao Lin hou Department of Biostatistics School of Public HealthYale UniversityNew HavenCT 06510USA Center for Statistical Science Tsinghua UniversityBeijing 100084China Department of Industrial Engineering Tsinghua UniversityBeijing 100084China MOE Key Laboratory of Bioinformatics School of Life SciencesTsinghua UniversityBeijing 100084China

Background:Genome-wide association studies(GWAS)have succeeded in identifying tens of thousands of genetic variants associated with complex human traits during the past decade,however,they are still hampered by limited statistical power and difficulties in biological *** the recent progress in expression quantitative trait loci(eQTL)studies,transcriptome-wide association studies(TWAS)provide a framework to test for gene-trait associations by integrating information from GWAS and eQTL ***:In this review,we will introduce the general framework of TWAS,the relevant resources,and the computational *** of the original TWAS methods will also be ***,we will briefly introduce methods that are closely related to TWAS,including MR-based methods and colocalization *** and difference between these approaches will be ***:Finally,we will summarize strengths,limitations,and potential directions for TWAS.

关键词： TWAS gene imputation gene-trait association test eQTL studies GWAS

Antitumor activity of nervosine Ⅶ,and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells

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Chinese Journal of Natural Medicines 2020年第2期18卷 81-89页

作者： HUANG Shuai ZHAO Shuang-mei shan Lian-Hai Zhou Xian-Li School of Life Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

Nervosine Ⅶ is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis *** is first study to investigate the antitumor activity of nervosine Ⅶ in vitro,and the results indicated that nervosine Ⅶ induced autophagy and apoptosis in HCT116 human colorectal cancer *** studies showed that nervosine Ⅶ-induced apoptosis was associated with the intrinsic pathway by the activation of caspase-9,-3 *** induced by nervosine Ⅶ was characteristic with the regulation of autophagic markers including the increase of LC3-Ⅱ and beclin 1 proteins,and the decrease of p62 *** Ⅶ simultaneously induced autophagy and apoptosis by activated MAPKs signaling pathway including JNK,ERK1/2 and p38,suppressing the p53 signaling pathway.

关键词： Liparis nervosa Pyrrolizidine alkaloids NervosineⅦ Autophagy Apoptosis HCT116 cells

Strategies to overcome drug resistance using SHP2 inhibitors

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3908-3924页

作者： Meng Liu shan Gao Reham M.Elhassan Xuben hou Hao Fang School of Pharmaceutical Sciences Cheeloo College of MedicineShandong UniversityJinan 250012China

Encoded by PTPN11,the SHP2(Src homology-2 domain-containing protein tyrosine phosphatase-2)is widely recognized as a carcinogenic *** a promising anti-cancer drug target,SHP2 regulates many signaling pathways such as RAS-RAF-ERK,PI3 K-AKT and ***,SHP2 plays a significant role in regulating immune cell function in the tumor ***,five SHP2 allosteric inhibitors have been recruited in clinical studies for the treatment of *** recently,studies have proved the therapeutic potential of SHP2 inhibitor in overcoming drug resistance of kinase inhibitors and programmed cell death-1(PD-1)***,we review the structure,function and small molecular inhibitors of SHP2,and highlight recent progress in overcoming drug resistance using SHP2 *** hope this review would facilitate the future clinical development of SHP2 inhibitors.

关键词： SHP2 inhibitor Allosteric inhibitor Anti-cancer Drug resistance

Effects of substituting chemical fertilizers with manure on rice yield and soil labile nitrogen in paddy fields of China: A meta-analysis

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Pedosphere 2023年第1期33卷 172-184页

作者： Qiong hou Yuemin NI shan HUANG Ting ZUO Jian WANG Wuzhong NI College of Environmental and Resource Sciences Zhejiang UniversityZhejiang Provincial Key Laboratory of Agricultural Resources and EnvironmentHangzhou 310058China Agricultural Experimental Station Zhejiang UniversityHangzhou 310058China

Substituting chemical fertilizers with manure is an important method for efficient nutrient management in rice cropping systems of *** nitrogen(N)is the most active component of the soil N pool and plays an essential role in soil ***,the effects of manure substitution on soil labile N in rice cropping systems and their relationships with soil properties,fertilization practices,and climatic conditions remain unclear and should be systematically ***,we investigated rice grain yield and four types of soil labile N that have been widely reported,including available nitrogen(AN),ammonium nitrogen(NH_(4)^(+)-N),nitrate nitrogen(NO_(3)^(−)-N),and microbial biomass nitrogen(MBN).We reviewed 187 published articles and performed a meta-analysis to quantify the effects of manure substitution on yield and soil labile *** results showed that manure substitution increased AN,MBN,NH+4-N,and NO−3-N by 11.3%,38.5%,5.9%,and 8.1%,*** substitution significantly increased the yield by 1.4%–5.9%,but full substitution significantly decreased the yield by 2.9%.The positive effects of manure substitution on yield and AN were stronger with long-term *** differences in responses varied across specific manure types,N application rates,soil properties,and climatic *** conclusion,manure substitution can increase soil labile N and is regarded as an efficient strategy for improving soil N fertility and a recommended measure for applying both chemical and organic fertilizers in rice *** study provides evidence of the effects of manure substitution on yield enhancement by increasing soil labile N.

关键词： available nitrogen climatic factors fertilization practices manure substitution microbial biomass nitrogen soil properties

Preliminary Study on Raw Materials Exploitation at Donggutuo Site,Nihewan Basin,North China

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人类学学报 2002年第S1期21卷 53-66页

作者： PEI Shu-wen hou Ya-mei Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SiciencesBeijing 100044China

The present study examines material quarrying, utilization, and exploitation strategy with respect to availability, quality and distribution at Donggutuo, a Lower Pleistocene archeological site in the Nihewan Basin of North China. Through identification of the bedrocks in the vicinity, the analysis reveals that raw materials available at the Donggutuo site are mainly chert, dolomicrite, siliceous dolomite, siliceous limestone, tectonic breccia, quartzite and intermediate lava. Related documents and a geological survey of the area demonstrate that the chert was quarried from dolomite within the Gaoyuzhuang Formation of the Mesoproterozoic Changcheng Group, and the quartzite from the Yousuopu Formation of the Archeozoic Qianxi Group, as well as from Jurassic volcanic lava. Fractures formed by tectonic movements of the Yanshan Stage and the Himalaya Stage made it convenient to quarry these materials. It is observed that fragmentary rock pieces were directly collected and quarried from local fracture belts and that this became the principal strategy of raw material exploitation adopted by the Donggutuo toolmakers. In general, raw materials were not efficiently used, and many of them could have been reduced, retouched and used again. Some suggestions are also proposed to improve the understanding of earlyhumans’ tool complex in the Nihewan Basin.

关键词： Raw materials Donggutuo Lower Pleistocene

掺杂磷烯二维纳米材料对草甘膦吸附机理的研究

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原子与分子物理学报 2025年第4期42卷 58-64页

作者：王群周乃武单正莉覃庆雨刘钰佳王梅梅青刚孙玉希绵阳师范学院生命科学与技术学院绵阳621006 绵阳师范学院化学与化学工程学院绵阳621000 绵阳师范学院光致功能材料重点实验室绵阳621006 曲阜师范大学生命有机分析重点实验室曲阜273165 北京市食品风味化学重点实验室北京100048

草甘膦是世界上普遍使用的除草剂之一,被广泛使用在农田和非农田杂草的防治.由于草甘膦类除草剂的大范围应用,其对动植物的危害性逐渐受到人们的关注.磷烯二维纳米材料与草甘膦之间相互作用机理的研究对草甘膦的检测及去除具有重大的意... 详细信息

草甘膦是世界上普遍使用的除草剂之一,被广泛使用在农田和非农田杂草的防治.由于草甘膦类除草剂的大范围应用,其对动植物的危害性逐渐受到人们的关注.磷烯二维纳米材料与草甘膦之间相互作用机理的研究对草甘膦的检测及去除具有重大的意义.本研究将采用基于密度泛函理论方法考察本征及Al,Ca,Ti及Fe金属原子掺杂的磷烯对草甘膦的吸附,通过吸附能,差分电荷密度,布居电荷分析本征及金属原子掺杂磷烯对草甘膦的吸附机制,从分子和原子水平上研究它们之间的详细机理.研究结果有望为掺杂磷烯材料在草甘膦吸附方面的应用提供有意义的理论参考.

关键词：磷烯掺杂磷烯草甘膦密度泛函理论

Effect of surface modification of activated carbon on its adsorption capacity for NH_3

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Journal of China University of Mining and Technology 2008年第2期18卷 261-265,274页

作者： shan Xiao-mei ZHU Shu-quan ZHANG Wen-hui School of Chemical and Environmental Engineering China University of Mining ＆ Technology Beijing 100083 China Beijing Research Institute of Coal Chemistry Beijing 100013 China

To investigate the effects of carbon surface characteristics on NH3 adsorption,coal-based and coconut shell activated carbons were modified by treatment with *** surface properties of the carbons were characterized by low temperature nitrogen sorption,by Boehm's titrations and by XPS ***3 adsorption isotherms of the original and the modified carbons were *** results show that the carbons were oxidized by HNO3 and(NH4)2S2O8,and that there was an increase in oxygen containing functional groups on the ***,the pore-size distribution of the coal-based carbons was changed after KMnO4 *** was found that the NH3 adsorption capacity of the modified carbons was enhanced and that the most pronounced enhancement results from(NH4)2S2O8 *** our experimental conditions,the capacity is positively cor- rected to the number of surface functional groups containing oxygen,and to the number of ***,an empirical model of the relationship between NH3 adsorption and multiple factors on the carbon surface was fit using a complex regression method.

关键词： activated carbon surface modification ammonia adsorption

Low Resource Chinese Geological Text Named Entity Recognition Based on Prompt Learning

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Journal of Earth Science 2024年第3期35卷 1035-1043页

作者： Hang He Chao Ma shan Ye Wenqiang Tang Yuxuan Zhou Zhen Yu Jiaxin Yi Li hou Mingcai hou State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Institute of Sedimentary GeologyCollege of Computer Science and Cyber SecurityChengdu University of TechnologyChengdu 610059China Key Laboratory of Deep-Time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu 610059China School of Information Engineering China University of Geosciences(Beijing)Beijing 100083China

Geological reports are a significant accomplishment for geologists involved in geological investigations and scientific research as they contain rich data and textual *** the rapid development of science and technology,a large number of textual reports have accumulated in the field of ***,many non-hot topics and non-English speaking regions are neglected in mainstream geoscience databases for geological information mining,making it more challenging for some researchers to extract necessary information from these *** Language Processing(NLP)has obvious advantages in processing large amounts of textual *** objective of this paper is to identify geological named entities from Chinese geological texts using NLP *** propose the RoBERTa-Prompt-Tuning-NER method,which leverages the concept of Prompt Learning and requires only a small amount of annotated data to train superior models for recognizing geological named entities in low-resource dataset *** RoBERTa layer captures context-based information and longer-distance dependencies through dynamic word ***,we conducted experiments on the constructed Geological Named Entity Recognition(GNER)*** experimental results show that the proposed model achieves the highest F1 score of 80.64%among the four baseline algorithms,demonstrating the reliability and robustness of using the model for Named Entity Recognition of geological texts.

关键词： Prompt Learning Named Entity Recognition(NER) low resource geological text text information mining big data geology.