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Clinical significance of the expression of isoform 165 vascular endothelial growth factor mRNA in noncancerous liver remnants of patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第2期11卷 187-192页

作者： I-ShyanSheen Kuo-ShyangJeng Shou-ChuanShih Chih-RoaKao Wen-HsingChang horng-yuanwang Po-ChuanWang Tsang-EnWang Li-RungShyung Chih-ZenChen MedicalDepartment MackayMemorialHospitalTaipeiTaiwanChina LiverResearchUnit DivisionofHepatogastroenterologyChangGungMemorialHospitalTaipeiTaiwanChina DepartmentofSurgery MackayMemorialHospitalTaipeiTaiwanChina//MackayJuniorSchoolofNursingTaipeiTaiwanChina

AIM: To investigate the prognostic role of isoform 165 vascular endothelial growth factor messenger RNA (VEGF165 mRNA)in noncancerous liver tissues from patients with primary hepatocellular carcinoma (HCC).METHODS: Using a reverse-transcription polymerase chain reaction (RT-PCR)-based assay, VEGF mRNA was determined prospectively in noncancerous liver tissues from 60 consecutive patients with HCC undergoing curative resection. We categorized the patients with VEGF165 mRNA over 0.500 in noncancerous liver tissues as group A, and those below 0.500 as group ***: Among the isoforms of VEGF mRNA by multivariate analysis, a higher level of VEGF165 mRNA in noncancerous liver tissue correlated significantly with a higher risk of HCC recurrence (P = 0.039) and recurrence-related mortality (P= 0.048), but VEGF121 did not. The other significant predictors of recurrence consisted of vascular permeation (P = 0.022),daughter nodules (P = 0.033), cellular dedifferentiation (P = 0.033), an absent or incomplete capsule (P = 0.037).A significant variable of recurrence-related mortality was Vascular permeation (P= 0.012). As to the clinical manifestations of 16 patients who developed recurrence,the recurrent tumor number over 2, recurrent extent over two-liver segments, and the median survival after recurrence,all significantly correlated with group A patients (P = 0.043,0.043, and 0.048, respectively). However, the presence of extrahepatic metastasis was not (P＞0.05). The difference in recurrence after treatment between the two groups had no statistical significance (P＞0.05).CONCLUSION: The higher expression of isoform VEGF165mRNA in noncancerous liver remnant of patients with HCC may be a significant biological indicator of the invasiveness of postoperative recurrence.

关键词： Hepatocellular carcinoma VEGF protein Messenger RNA

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Do the expressions of gap junction gene connexin messenger RNA in noncancerous liver remnants of patients with hepatocellular carcinoma correlate with postoperative recurrences?

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World Journal of Gastroenterology 2005年第2期11卷 171-175页

作者： I-ShyanSheen Kuo-ShyangJeng Shou-ChuanShih Chin-RoaKao Po-ChuanWang Chih-ZenChen Wen-HsingChang horng-yuanwang Li-RungShyung DepartmentsofInternalMedicine MackayMemorialHospitalTaipeiTaiwanChina DivisionofHepatogastroenterology ChangGungMemorialHospitalTaipeiTaiwanChina DepartmentsofSurgery MackayMemorialHospitalTaipeiTaiwanChina//MackayMedicineNursingandManagementCollegeTaipeiTaiwanChina

AIM: To investigate whether the changes of gap junction gene connexin messenger RNA in the noncancerous liver tissue of patients with hepatocellular carcinoma (HCC) could play a significant role in its postresection ***: Seventy-nine consecutive patients having undergone curative resection for HCC entered this *** a reverse-transcription polymerase chain reaction (RT-PCR)-based assay, connexin (Cx) 26, connexin (Cx)32 and connexin (Cx) 43 mRNAs were determined prospectively in noncancerous liver tissues from these 79 patients and in the liver tissues from 15 controls. The correlations between connexin mRNA expression and the clinicopathological variables and outcomes (tumor recurrence and recurrence related mortality) were ***: Compared with liver tissues of control patients,the expression of Cx 32 mRNA in noncancerous liver tissues was significantly lower (mean: 0.715 vscontrol 1.225,P＜0.01), whereas the decreased Cx 26 mRNA (mean:0.700 vs of control 1.205,P＞0.05) and increased Cx 43 mRNA (mean: 0.241 vscontrol 0.100, P＞0.05) had no statistical significance. We defined the value of Cx 32 mRNA or Cx 26mRNA below 0.800 as a lower value. By multivariate analysis for noncancerous livers, a lower value of Cx 32 mRNA correlated significantly with a risk of HCC recurrence and recurrence-related mortality. The lower value of Cx 26 mRNA did not correlate with recurrence and mortality. The increased value of Cx43 mRNA also did not correlate with postoperative recurrence and recurrence-related mortality. By multivariate analysis, other significant predictors of HCC recurrence included vascular permeation, cellular dedifferentiation, and less encaps-ulation. The other significant parameter of recurrence related mortality was vascular ***: The decreased expression of Cx 32 mRNA in noncancerous liver tissues plays a significant role in the prediction of postoperative recurrence of HCC.

关键词： Hepatocellular carcinoma Gap junctions Connexins Local neoplasm recurrences

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Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma:A prospective study

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World Journal of Gastroenterology 2004年第5期10卷 643-648页

作者： Kuo-ShyangJeng I-ShyanSheen Yi-ChingWang Shu-LingGu Chien-MingChu Shou-ChuanShih Po-Chuanwang Wen-HsingChang horng-yuanwang DepartmentofSurgery MackayMemorialHospitalTaipeiTaiwan.China LiverResearchUnit ChangGungMemorialHospitalTaipeiTaiwanChina MedicalResearch MackayMemorialHospitalTaipeiTaiwanChina DepartmentofInternalMedicine MackayMemorialHospitalTaipeiTaiwanChina

AIM:To investigate the prognostic value of vascular endothelial growth factor messenger RNA (VEGF mRNA) in the peripheral blood (PB) of patients with hepatocellular carcinoma (HCC) undergoing curative ***:Using a reverse-transcription polymerase chain reaction (RT-PCR)-based assay, VEGF mRNA in the PB was determined prospectively in 50 controls and in 50 consecutive patients undergoing curative resection for ***:Among the isoforms of VEGF mRNA, VEGF165 and VEGF121 were expressed. By multivariate analysis, a higher level of VEGF165 in preoperative PB correlated with a risk of HCC recurrence with borderline significance (P=0.050)and significantly with recurrence-related mortality (P=0.048);while VEGF121 did not. Other significant predictors of HCC recurrence included cellular dedifferentiation (P=0.033),an absent or incomplete capsule (P=0.020), vascular permeation (P=0.018), and daughter nodules (P=0.006).The other significant parameter of recurrence related mortality was cellular dedifferentiation (P=0.053). The level of circulating VEGF mRNA, however, did not significantly correlate with tumor size, cellular differentiation, capsule,daughter nodules, vascular permeation, necrosis and hemorrhage of ***: The preoperative level of circulating VEGF mRNA, especially isoform VEGF165, plays a significant role in the prediction of postoperative recurrence of HCC.

关键词：肝细胞癌 RNA信使血管内皮生长因子外科治疗 RT-PCR 血管内皮细胞

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Is the vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma of prognostic value after resection?

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World Journal of Gastroenterology 2004年第5期10卷 676-681页

作者： Kuo-ShyangJeng I-ShyanSheen Yi-ChingWang Shu-LingGu Chien-MingChu Shou-ChuanShih Po-ChuanWang Wen-HsingChang horng-yuanwang DepartmentofSurgery MackayMemorialHospitalTaipeiTaiwanChina LiverResearchUnit ChangGungMemorialHospitalTaipeiTaiwanChina MedicalResearch MackayMemorialHospitalMackayJuniorSchoolofNursingTaipeiTaiwanChina DepartmentofInternalMedicine MackayMemorialHospitalTaipeiTaiwanChina

AIM:To study whether vascular endothelial growth factor messenger RNA (VEGF mRNA) in the hepatocellular carcinoma (HCC) tissues obtained after curative resection has a prognostic ***: Using a reverse-transcription polymerase chain reaction (RT-PCR)-based assay, VEGF mRNA was determined prospectively in liver tissues of 50 controls and in HCC tissues of 50 consecutive patients undergoing curative resection for ***: Among the isoforms of VEGF mRNA, VEGF165 and VEGF121 were expressed. By multivariate analysis, a higher level of VEGF165 in HCC tissue correlated with a significant risk of HCC recurrence (P=0.038) and significantly with recurrencerelated mortality (P=0.045); while VEGF121 did not. Other significant predictors of HCC recurrence included cellular dedifferentiation (P=0.033), an absent or incomplete capsule(P=0.020), vascular permeation (P=0.018), and daughter nodules (P=0.006). The other significant variables of recurrence related mortality consisted of vascular permeation (P=0.045),and cellular dedifferentiation (P=0.053). The level of VEGF mRNA in HCC tissues, however, did not significantly correlate with tumor size, cellular differentiation, capsule, daughter nodules,vascular permeation, necrosis and hemorrhage of ***: The expression of VEGF mRNA, especially isoform VEGF165,in HCC tissues, may play a significant and independant role in the prediction of postoperative recurrence of HCC.

关键词：血管内皮生长因子 RNA信使肝细胞癌肿瘤切除术术前评估 RT-PCR

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Does surgical resection of hepatocellular carcinoma accelerate cancer dissemination?

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World Journal of Gastroenterology 2004年第1期10卷 31-36页

作者： I-ShyanSheen Kuo-ShyangJeng Shou-ChuanShih Po-ChuanWang Wen-HsiungChang horng-yuanwang Li-RungShyung Shee-ChanLin Chin-RoaKao Yi-ChunTsai Tsu-YenWu DivisionsofHepatogastroenterology ChangGungMemorialHospitalTaipeiTaiwanChina DepartmentsofSurgery MackayMemorialHospitalTaipeiTaiwanChina DepartmentofIntemalMedicine MackayMemorialHospitalTaipeiTaiwanChina MedicalResearch MackayMemorialHospitalTaipeiTaiwanChina

AIM: This study was to investigate whether surgery could increase cancer dissemination and postoperative recurrence in patients with hepatocellular carcinoma (HCC) by detection of human α-fetoprotein messenger RNA (hAFP mRNA), hAFP mRNA in the peripheral blood of patients with HCC has been considered as a surrogate marker for circulating tumor cells. METHODS: Eighty-one consecutive patients who underwent curative resection for HCC entered this prospective cohort study. We examined hAFP mRNA from the peripheral blood obtained preoperatively, perioperatively, and postoperatively to correlate the prognosis after curative resections from HCC patients and from the control subjects. Detection of hAFP mRNA by reverse transcriptase and polymerase chain reaction amplification (RT-PCR) was performed with primers specifically. The relations between the clinical variables (age,sex, associated liver cirrhosis, hepatitis B virus infection,hepatitis C virus infection, serum α-fetoprotein and ChildPugh class), the histological variables (size, capsule, vascular permeation, grade of differentiation, and daughter nodules),hAFP mRNA in peripheral blood of 3 different sessions, and postoperative course (recurrence, and recurrence related death) were analysed. RESULTS: No hAFP mRNA was detected in control group subjects. Twenty-two (27%), 24 (30%) and 19 (23%) of 81 HCC patients had hAFP mRNA positivity in the preoperative,perioperative and postoperative peripheral blood. The preoperative presence did not influence the risk of HCC recurrence (55% vs 41%, P=0.280). In contrast, patients with postoperative presence had a significantly higher recurrence (90% vs31%, P<0.001; odds ratio 19.2; 95% confidence interval: 4.0-91.7). In the multivariate analysis by COX proportional hazards model, postoperative positivity had a significant influence on recurrence (P=0.067) and recurrence related mortality (P=-0.017). Whereas, the perioperative positivity of hAFP mRNA did not increase HCC recurrence

关键词：肝细胞癌肿瘤切除术肿瘤转移 RT-PCR 肝动脉灌注化疗栓塞

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Antibody switch AIDed by pyruvate

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Life Metabolism 2024年第2期3卷 1-2页

作者： Haoming Luan Tiffany horng School of Life Sciences and Technology ShanghaiTech UniversityShanghai 201210China

Metabolism is mobilized to meet the biosynthetic,bioenergetic,and regulatory demands of immune cell *** nothing is known about the metabolic basis of antibody class switch in B cells.A recent study published in Nature Communications through a joint effort by Chen Lab(metabolism biology)and Liu Lab(B cell biology)from Tsinghua University reveals that the monocarboxylate carrier MCT1(monocarboxylate transporter 1)promotes pyruvate oxidation and histone acetylation to support class switch recombination(CSR),the process by which B cells make antibodies of different isotypes with unique effector functions.

关键词： functions. activation Almost

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Urban rail transit disruption management: Research progress and future directions

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Frontiers of Engineering Management 2024年第1期11卷 79-91页

作者： Lebing WANG Jian Gang JIN Lijun SUN Der-horng LEE School of Naval Architecture Ocean&Civil Engineeringand State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering McGill UniversityMontrealQuebec H3A 0C3Canada ZJU-UIUC Institute Zhejiang UniversityHaining 314400China

Urban rail transit (URT) disruptions present considerable challenges due to several factors: i) a high probability of occurrence, arising from facility failures, disasters, and vandalism;ii) substantial negative effects, notably the delay of numerous passengers;iii) an escalating frequency, attributable to the gradual aging of facilities;and iv) severe penalties, including substantial fines for abnormal operation. This article systematically reviews URT disruption management literature from the past decade, categorizing it into pre-disruption and post-disruption measures. The pre-disruption research focuses on reducing the effects of disruptions through network analysis, passenger behavior analysis, resource allocation for protection and backup, and enhancing system resilience. Conversely, post-disruption research concentrates on restoring normal operations through train rescheduling and bus bridging services. The review reveals that while post-disruption strategies are thoroughly explored, pre-disruption research is predominantly analytical, with a scarcity of practical pre-emptive solutions. Moreover, future research should focus more on increasing the interchangeability of transport modes, reinforcing redundancy relationships between URT lines, and innovating post-disruption strategies.

关键词： urban rail transit disruption management resilient network train rescheduling bus bridging services

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Unknown DDoS Attack Detection with Fuzzy C-Means Clustering and Spatial Location Constraint Prototype Loss

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Computers, Materials & Continua 2024年第2期78卷 2181-2205页

作者： Thanh-Lam Nguyen HaoKao Thanh-Tuan Nguyen Mong-Fong horng Chin-Shiuh Shieh Department of Electronic Engineering National Kaohsiung University of Science and TechnologyKaohsiung807618Taiwan Department of Electronic and Automation Engineering Nha Trang UniversityNha Trang650000Vietnam

Since its inception,the Internet has been rapidly *** the advancement of science and technology and the explosive growth of the population,the demand for the Internet has been on the *** applications in education,healthcare,entertainment,science,and more are being increasingly deployed based on the ***,malicious threats on the internet are on the rise as *** Denial of Service(DDoS)attacks are among the most common and dangerous threats on the internet *** scale and complexity of DDoS attacks are constantly *** Detection Systems(IDS)have been deployed and have demonstrated their effectiveness in defense against those *** addition,the research of Machine Learning(ML)and Deep Learning(DL)in IDS has gained effective results and significant ***,one of the challenges when applying ML and DL techniques in intrusion detection is the identification of unknown *** attacks,which are not encountered during the system’s training,can lead to misclassification with significant *** this research,we focused on addressing the issue of Unknown Attack Detection,combining two methods:Spatial Location Constraint Prototype Loss(SLCPL)and Fuzzy C-Means(FCM).With the proposed method,we achieved promising results compared to traditional *** proposed method demonstrates a very high accuracy of up to 99.8%with a low false positive rate for known attacks on the Intrusion Detection Evaluation Dataset(CICIDS2017)***,the accuracy is also very high,reaching 99.7%,and the precision goes up to 99.9%for unknown DDoS attacks on the DDoS Evaluation Dataset(CICDDoS2019)*** success of the proposed method is due to the combination of SLCPL,an advanced Open-Set Recognition(OSR)technique,and FCM,a traditional yet highly applicable clustering *** has yielded a novel method in the field of unknown attack *** further expands the trend of applying DL and M

关键词： Cybersecurity DDoS unknown attack detection machine learning deep learning incremental learning convolutional neural networks(CNN) open-set recognition(OSR) spatial location constraint prototype loss fuzzy c-means CICIDS2017 CICDDoS2019

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中国武术“内摶外搏”的历史本质发微——基于明中后期武术古籍的考论

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北京体育大学学报 2024年第8期47卷 142-156页

作者：蒋德龙蒋愿望衡阳师范学院体育科学学院湖南衡阳421007 鄂尔多斯应用技术学院教务处内蒙古鄂尔多斯017000

从传统小学、文献学、武术史学角度,深化对中国武术的历史本质的探讨和认知。论证以明中后期武术古籍刻本、抄本的原件或影印件为中心,以明朝首辅大臣沈一贯《■者张松溪传》之“■”的考证为切入点,将“■”归置于中国武术发展史当中,... 详细信息

从传统小学、文献学、武术史学角度,深化对中国武术的历史本质的探讨和认知。论证以明中后期武术古籍刻本、抄本的原件或影印件为中心,以明朝首辅大臣沈一贯《■者张松溪传》之“■”的考证为切入点,将“■”归置于中国武术发展史当中,纵贯前后、对比分析,得出结论:1)《■者张松溪传》之“■”是古代繁体“摶”(tuán)的异体字,简体为“抟”,是流行于明中后期的武学概念,体现出了静气、凝聚、凭借这几层独特含义,显现为“修习者气质的‘静省’、招势的‘转圆’、内在精气神锻炼及‘摶穴’秘技修炼”等内容。2)“摶”的武学内涵在明朝万历时期凸显,且融入到了中国武术界官方和民间的各个层面;中国武术历史进程在这一时期升华到了内在超越性的摶(术以至道),形成了“内摶外搏”的本质特征。3)“摶”的武学内质在武术发展历程中薪火相传,以“推手”之名延续至今;讨论中国武术的发展,不应只围绕“技击之争”,需要把握其“内摶外搏”的历史本质,回归到“搏摶相合”的修炼路径上。

关键词：摶搏中国武术张松溪

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乙型肝炎核心抗体在特殊人群中的应用进展

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中华临床感染病杂志 2024年第3期17卷 235-240页

作者：洪泽华邱源旺南京医科大学无锡医学中心无锡214023

乙型肝炎核心抗体(抗-HBc)在慢性乙型肝炎(CHB)患者的病程分期、肝脏炎症及纤维化预测、抗病毒疗效预测及停药后病毒再激活预测等方面广泛应用。但近年来研究发现, 抗-HBc阳性对合并其他病毒感染(如 HCV、HDV和HIV)、恶性肿瘤、自身免... 详细信息

乙型肝炎核心抗体(抗-HBc)在慢性乙型肝炎(CHB)患者的病程分期、肝脏炎症及纤维化预测、抗病毒疗效预测及停药后病毒再激活预测等方面广泛应用。但近年来研究发现, 抗-HBc阳性对合并其他病毒感染(如 HCV、HDV和HIV)、恶性肿瘤、自身免疫性肝病、代谢相关脂肪性肝病、风湿性疾病等患者的疾病进展及预后存在相互影响。本文就抗-HBc在这些特殊人群中的应用及研究进展进行了综述, 为此类患者病情评估和临床治疗提供依据。

关键词：乙型肝炎丙型肝炎乙型肝炎核心抗体人类免疫缺陷病毒乙型肝炎病毒再激活

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