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Manganese antagonizes iron blocking mitochondrial aconitase expression in human prostate carcinoma cells

Asian Journal of Andrology 2006年第3期8卷 307-315,387页

作者： Ke-Hung Tsui Phei-Lang Chang horng-heng juang Department of Urology Chang Gung Molecular Image CenterChang Gung Memorial Hospital Department of Urology Chang Gung Memorial Hospital Chang Gung Molecular Image Center Chang Gung Memorial Hospital Department of AnatomyChang Gung UniversityKwei-Shan.Tao-Yuan 333TaiwanChina

Aim:To investigate the possible role of manganese in the regulation of mitochondrial aconitase(mACON)activity human prostate carcinoma cell line PC-3 ***:The mACON enzymatic activities of human prostate carcinoma cell line PC-3 cells were determined using a reduced nicotinamide adenine dmucleotide-coupled assay. Immunoblot and transient gene expression assays were used to study gene expression of the *** putative response element for gene expression was identified using reporter assays with site-directed mutagenesis and electro- phoretic mobility-shift ***:In vitro study revealed that manganese chloride(MnCl2)treatment for 16h inhibited the enzymatic activity of mACON,which induced the inhibition of citrate utility and cell proliferation of PC- 3 *** results from transient gene expression assays showed that MnCl_2,treatment upregulated gene translation by approximately 5-fold through the iron response element pathway,immunoblot and reporter assays showed that MnCl_2 treatments inhibited protein and gene expression of *** effect was reversed by co- treatment with fenic ammonium *** reporter assays with site-directed mutagenesis and electrophoretic mobility-shift assays suggested that a putative metal response element in the promoter of the mACON gene was involved in the regulation of MnCl_2 on the gene expression of ***:These findings suggest that manganese acts as an antagonist of iron,disrupting the enzymatic activity and gene expression of mACON and citrate metabolism in the prostate.

关键词： citrate adenosine triphosphate proliferation PC-3 metal response element prostate carcinoma cell line

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Comparisons of voided urine cytology, nuclear matrix protein-22 and bladder tumor associated antigen tests for bladder cancer of geriatric male patients in Taiwan, China

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Asian Journal of Andrology 2007年第5期9卷 711-715页

作者： Ke-Hung Tsui Shao-Ming Chen Ta-Ming Wang horng-heng juang Chien-Lun Chen Guang-Huan Sun Phei-Lang Chang Department of Nursing Chang Gung lnstitute of Technology Kwei Shan Taoyuan 333 Taiwan China Department of Urology Taipei City Hospital Heping Campus Taipei 100 Taiwan China Department of Geriatric Urology Chang Gung Bioinformatics Center Chang Gung Memorial Hospital Kwei ShanTaoYuan 333 Taiwan China Department of Anatomy College of Medicine Chang Gung University Taoyuan 332 Taiwan China Division of Urology Department of Surgery Tri-Service General Hospital National Defense Medical Center Taibei 114Taiwan China

Aim： To compare the results of bladder tumor associated antigen （BTA TRAK）, nuclear matrix protein 22 （NMP 22） and voided urine cytology （VUC） in detecting bladder cancer. Methods： A total of 135 elderly male and 50 healthy volunteers enrolled in this study were classified into three groups：（i） 93 patients with bladder cancer; （ii） 42 patients with urinary benign conditions; and （iii） 50 healthy volunteers. BTA TRAK and NMP 22 kits were used to detect bladder cancer. Voided urine cytology was used to compare the sensitivity and specificity of the screening tests. Results： The sensitivity and specificity of cytology, BTA TRAK and NMP 22 were 24% and 97%, 51% and 73%, 78% and 73%, respectively. The level of NMP 22 increased with tumor grading. The BTA TRAK kit has the lowest sensitivity among the screening tests. The NMP 22 with the best sensitivity can be an adjunct to cytology for evaluating bladder cancer. Conclusion： The NMP 22 test has a better correlation with the grading of the bladder cancer than BTA TRAK. As cytology units are typically not available in hospitals or in outpatient clinics, NMP 22 might be a promising tool for screening bladder cancer.

关键词： bladder neoplasm cytology bladder tumor associated antigen nuclear matrix protein 22

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Liquefaction susceptibility and deformation characteristics of saturated coral sandy soils subjected to cyclic loadings-a critical review

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 261-296页

作者： Chen Guoxing Qin You Ma Weijia Liang Ke Wu Qi C.Hsein juang Institute of Geotechnical Engineering Nanjing Tech UniversityNanjing 210009China Civil Engineering and Earthquake Disaster Prevention Center of Jiangsu Province Nanjing 210009China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 210016China Glenn Department of Civil Engineering Clemson UniversityClemsonSC 29634USA

Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical *** to the unique marine depositional environment of coral sandy soils,the engineering characteristics and responses of these soils subjected to monotonic and cyclic loadings have been a subject of intense interest among the geotechnical and earthquake engineering *** paper critically reviews the progress of experimental investigations on the undrained behavior of coral sandy soils under monotonic and cyclic loadings over the last three *** focus of coverage includes the contractive-dilative behavior,the pattern of excess pore-water pressure(EPWP)generation and the liquefaction mechanism and liquefaction resistance,the small-strain shear modulus and strain-dependent shear modulus and damping,the cyclic softening feature,and the anisotropic characteristics of undrained responses of saturated coral sandy *** particular,the advances made in the past decades are reviewed from the following aspects:(1)the characterization of factors that impact the mechanism and patterns of EPWP build-up;(2)the identification of liquefaction triggering in terms of the apparent viscosity and the average flow coefficient;(3)the establishment of the invariable form of strain-based,stress-based,or energy-based EPWP ratio formulas and the unique relationship between the new proxy of liquefaction resistance and the number of cycles required to reach liquefaction;(4)the establishment of the invariable form of the predictive formulas of small strain modulus and strain-dependent shear modulus;and(5)the investigation on the effects of stress-induced anisotropy on liquefaction susceptibility and dynamic deformation *** gained through the critical review of these advances in the past decades offer a perspective for future research to further resolve the fundamental issues concerning the liquefaction mechanism and responses of coral sandy sites subjecte

关键词： liquefaction susceptibility dynamic deformation characteristics coral sandy soil cyclic loading review and prospect

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High-rate electrochemical H_(2)O_(2) production over multimetallic atom catalysts under acidic–neutral conditions

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Carbon Energy 2024年第1期6卷 44-62页

作者： Yueyu Tong Jiaxin Liu Bing-Jian Su Jenh-Yih juang Feng Hou Lichang Yin Shi Xue Dou Ji Liang Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education School of Materials Science and EngineeringTianjin UniversityTianjinChina Institute for Superconducting and Electronic Materials University of WollongongInnovation CampusNorth WollongongNew South WalesAustralia Department of Electrophysics National Chiao Tung UniversityHsinchuTaiwanChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyangLiaoningChina Institute of Energy Materials Science University of Shanghai for Science and TechnologyShanghaiChina

Hydrogen peroxide(H_(2)O_(2))production by the electrochemical 2-electron oxygen reduction reaction(2e−ORR)is a promising alternative to the energy-intensive anthraquinone process,and single-atom electrocatalysts show the unique capability of high selectivity toward 2e−ORR against the 4e−*** extremely low surface density of the single-atom sites and the inflexibility in manipulating their geometric/electronic configurations,however,compromise the H_(2)O_(2) yield and impede further performance ***,we construct a family of multiatom catalysts(MACs),on which two or three single atoms are closely coordinated to form high-density active sites that are versatile in their atomic configurations for optimal adsorption of essential*OOH *** them,the Cox–Ni MAC presents excellent electrocatalytic performance for 2e−ORR,in terms of its exceptionally high H_(2)O_(2) yield in acidic electrolytes(28.96 mol L^(−1) gcat.^(−1) h^(−1))and high selectivity under acidic to neutral conditions in a wide potential region(>80%,0–0.7 V).Operando X-ray absorption and density functional theory analyses jointly unveil its unique trimetallic Co2NiN8 configuration,which efficiently induces an appropriate Ni–d orbital filling and modulates the*OOH adsorption,together boosting the electrocatalytic 2e−ORR *** work thus provides a new MAC strategy for tuning the geometric/electronic structure of active sites for 2e−ORR and other potential electrochemical processes.

关键词： hydrogen peroxide production multiatom catalysts operando X-ray adsorption spectrum reaction mechanism tendency structure-property relation

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Electrochemical decolorization of dye wastewater by surface-activated boron-doped nanocrystalline diamond electrode

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Journal of Environmental Sciences 2016年第7期28卷 100-107页

作者： Chienhung Chen Ervin Nurhayati Yaju juang Chihpin Huang Institute of Environmental Engineering National Chiao Tung University Material and Chemical Research Laboratories Industrial Technology Research Institute

Complex organics contained in dye wastewater are difficult to degrade and often require electrochemical advanced oxidation processes（EAOPs） to treat it. Surface activation of the electrode used in such treatment is an important factor determining the success of the *** performance of boron-doped nanocrystalline diamond（BD-NCD） film electrode for decolorization of Acid Yellow（AY-36） azo dye with respect to the surface activation by electrochemical polarization was studied. Anodic polarization found to be more suitable as electrode pretreatment compared to cathodic one. After anodic polarization, the originally H-terminated surface of BD-NCD was changed into O-terminated, making it more *** to the oxidation of surface functional groups and some portion of sp2 carbon in the BD-NCD film during anodic polarization, the electrode was successfully being activated showing lower background current, wider potential window and considerably less surface activity compared to the non-polarized one. Consequently, electrooxidation（EO） capability of the anodically-polarized BD-NCD to degrade AY-36 dye was significantly enhanced, capable of nearly total decolorization and chemical oxygen demand（COD） removal even after several times of re-using. The BD-NCD film electrode favored acidic condition for the dye degradation; and the presence of chloride ion in the solution was found to be more advantageous than sulfate active species.

关键词： Boron-doped NCD Surface activation Electrochemical polarization Electrooxidation Azo dye Acid Yellow(AY-36)

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Secure and Efficient Mutual Authentication Scheme for NFC Mobile Devices

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Journal of Electronic Science and Technology 2017年第3期15卷 240-245页

作者： You-Han Tung Wen-Shenq juang Department of Information Management National Kaohsiung First University of Science and Technology Kaohsiung 824

As the technology of mobile devices spreads fast,the price of mobile devices is getting *** of the people have mobile devices,and these devices have the technology of near field communication（NFC）.With the long time development and research,the mobile devices use NFC technology on the payment and authentication applications,and replace the smartcard,the access control card,and the credit card by using the card emulation *** helps the development of NFC *** recent years,more and more users begin using NFC technology on mobile payment and *** researches have proposed the related NFC authentication protocols,but their schemes are still lack of some security properties and functions,which are necessary for NFC authentication *** this paper,we propose a secure and efficient NFC authentication scheme between two NFC devices by the help of the authentication server that provides mutual authentication.

关键词： Index Terms--Authentication protocol informationsecurity mutual authentication near fieldcommunication (NFC)

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Static and Dynamic Integrated Analysis Scheme for Android Malware

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Journal of Electronic Science and Technology 2017年第3期15卷 246-250页

作者： Chun-Hao Yung Wen-Shenq juang Department of Information Management National Kaohsiung First University of Science and Technology Kaohsiung 824

The Android platform is the most popular mobile operating *** the increase of the number of Android users,a lot of security issues have *** order to detect the malicious behaviors for the installed Android Apps,in this paper,we propose an Android malware detecting scheme by integrating static and dynamic analysis *** use Androguard and Droid Box to extract the features,and then remove the irrelevant *** we employ the support vector machine（SVM） to classify the Android malware and *** the result of our proposed scheme,the proposed integrated static and dynamic analysis scheme with SVM can effectively detect the Android malware.

关键词： Index Terms--Android dynamic analysis malware,static analysis support vector machine

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Regional characterization of vs30 with hybrid geotechnical and geological data

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Underground Space 2023年第4期11卷 218-231页

作者： Wenxin Liu C.Hsein juang Yanjv Peng Guoxing Chen College of Civil Engineering and Architecture Zhejiang Sci-Tech UniversityHangzhou 310018China Glenn Department of Civil Engineering Clemson UniversitySC 29634USA National Institute of Natural Hazards Ministry of Emergency ManagementBeijing 100085China Institute of Geotechnical Engineering Nanjing Tech UniversityNanjing 210009China

Regional characterization of soil properties requires not only geostatistical models considering the spatial variability of soil properties but also methods that account for various sources of heterogeneous *** paper presents a multi-conditional random field approach to characterize the regional characteristics of the average shear-wave velocity in the top 30 meters of subsoil(vs30)based on hybrid geotechnical and geological *** workflow for integrating multiple sources of soil properties information in a random field model for regional vs30 mapping is developed.A detailed two-dimensional(2D)synthetic digital soil field is generated to assess and verify this *** the generated synthetic field,parametric studies on the investigation plans,the value of Markov Bayes coefficient B,element size,and a predefined grid of secondary data are *** on whether to incorporate secondary data for vs30 mapping and the determination of coefficient B are provided.

关键词： Shear wave velocity Random field model Uncertainty Vs30 mapping

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Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line

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Acta Pharmacologica Sinica 2007年第8期28卷 1231-1235页

作者： Te-jen Lai Sheng-feng HSU Te-mao li horng-chaung HSU juang-geng lIn Chin-jung HSU Ming-chih CHOU Meng-chih LEE Shun-fa yang Yi-chin FONG Institute of Medicine Chung Shah Medical University~3Department of PsychiatryChung Shan Medical University HospitalTaiwanChina Gruduate Institute of Acupuncture Science China Medical UniversityTaiwanChina Department of Orthopaedic Surgery China Medical University HospitalTaiwanChina Institute of Medicine Chung Shah Medical University School of Chinese Medicine China Medical UniversityTaiwanChina

Aim:Chondrosarcoma is a malignant primary bone tumor that responds poorly toboth chemotherapy and radiation *** aim of the present study was toinvestigate the effect of alendronate,a bisphosphonate,on the invasion andmigration of human chondrosarcoma cells(JJ012).Methods:JJ012 cells weretreated with alendronate of various concentrations up to 100μmol/L for a speci-fied period,and then gelatin zymography and matrigel invasion assay was per-formed to study the effects of alendronate on matrix metalloproteinase(MMP)-2activity and the invasion ability of JJ012 cells,***:Our datashowed that alendronate exerted a dose-and time-dependent inhibitory effect onthe invasion and migration of JJ012 ***,gelatin zymography andRT-PCR showed that alendronate treatment decreased the activity and mRNAlevels of MMP-2 in a concentration-dependent ***:Our find-ings suggest that alendronate may reduce MMP-2 secretion at the transcriptionaland translational levels,and inhibit the invasion of chondrosarcoma ***,alendronate may be a potential candidate for the systemic therapy of chondro-sarcomas,as well as other malignant diseases.

关键词： alendronate" bisphosphonate chondrosarcoma matrix metalloproteinase-2 invasion migration

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Affective computing study of attention recognition for the 3D guide system

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CAAI Transactions on Intelligence Technology 2020年第4期5卷 260-267页

作者： Li-Hong juang Ming-Ni Wu Cian-Huei Lin School of Electrical Engineering and Automation Xiamen University of TechnologyNo.600Ligong RoadJimeiXiamen 361024People’s Republic of China

The eye-tracking has been widely used in multiple discipline studies in recent ***,most of the studies focused on the analysis for static images or text but less for highly interactive operation *** addition,the affective computing rose and development in recent years have changed completely the design of thinking pattern for the human-computer ***,this study hopes to integrate the affective computing into the 3D guide system which was developed for the real campus through the eye-tracking *** analysing user’s gaze position and recognising attention emotion are according to the interest region which is stetted into the environment,and shows the feedback content corresponds to the area and the *** the most intuitive gaze analysis,the operation burden can be reduced and the user’s interactive experience can be improved to achieve intuitive and user-friendly *** results can also apply for medical therapy on human attention training.

关键词： computing interactive computer

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