Comparisons of voided urine cytology, nuclear matrix protein-22 and bladder tumor associated antigen tests for bladder cancer of geriatric male patients in Taiwan, China

作     者：Ke-Hung Tsui Shao-Ming Chen Ta-Ming Wang Horng-Heng Juang Chien-Lun Chen Guang-Huan Sun Phei-Lang Chang 

作者机构：Department of Nursing Chang Gung lnstitute of Technology Kwei Shan Taoyuan 333 Taiwan China Department of Urology Taipei City Hospital Heping Campus Taipei 100 Taiwan China Department of Geriatric Urology Chang Gung Bioinformatics Center Chang Gung Memorial Hospital Kwei ShanTaoYuan 333 Taiwan China Department of Anatomy College of Medicine Chang Gung University Taoyuan 332 Taiwan China Division of Urology Department of Surgery Tri-Service General Hospital National Defense Medical Center Taibei 114Taiwan China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2007年第9卷第5期

页      面：711-715页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The authors would like to thank the Chang Gug Memorial Hospital(Contract No.CMRPG1006) for financially supporting this research 

主　　题：bladder neoplasm cytology bladder tumor associated antigen nuclear matrix protein 22 

摘      要：Aim： To compare the results of bladder tumor associated antigen （BTA TRAK）, nuclear matrix protein 22 （NMP 22） and voided urine cytology （VUC） in detecting bladder cancer. Methods： A total of 135 elderly male and 50 healthy volunteers enrolled in this study were classified into three groups： （i） 93 patients with bladder cancer; （ii） 42 patients with urinary benign conditions; and （iii） 50 healthy volunteers. BTA TRAK and NMP 22 kits were used to detect bladder cancer. Voided urine cytology was used to compare the sensitivity and specificity of the screening tests. Results： The sensitivity and specificity of cytology, BTA TRAK and NMP 22 were 24% and 97%, 51% and 73%, 78% and 73%, respectively. The level of NMP 22 increased with tumor grading. The BTA TRAK kit has the lowest sensitivity among the screening tests. The NMP 22 with the best sensitivity can be an adjunct to cytology for evaluating bladder cancer. Conclusion： The NMP 22 test has a better correlation with the grading of the bladder cancer than BTA TRAK. As cytology units are typically not available in hospitals or in outpatient clinics, NMP 22 might be a promising tool for screening bladder cancer.