检索结果-南通市图书馆

Journal of Clinical and Nursing Research 2024年第4期8卷 122-127页

作者： hongyan zhu Jingzhou Maternal and Child Health Center Jingzhou 434020Hubei ProvinceChina

Objective: To study the application effect of flexible nursing in patients with postpartum urinary retention and its effect on lactation. Methods: A total of 200 cases of postpartum urinary retention patients admitted between January 2021 and January 2022 were selected and randomly grouped into two groups, a control group (conventional nursing) and an observation group (flexible nursing), of 100 cases each. The time of onset of lactation, the lactation volume score, urinary indicators, the amount of post-partum hemorrhage, and the quality of life score of the two groups were compared. Results: The observation group’s lactation initiation time (21.41 ± 1.52) h and lactation volume score (2.11 ± 0.52) were better than that of the control group (P < 0.05). The observation group’s first urination time (2.11 ± 0.51) min was lower than the control group, while the urinary retention completely relieved time (33.12 ± 8.61) h, and first urinary volume (262.17 ± 52.41) mL was higher than that of the control group (P < 0.05). The amount of postpartum hemorrhage in the observation group (151.21 ± 22.12) mL was less than that in the control group (P < 0.05). The scores of somatic functioning (86.25 ± 2.20), psychological functioning (91.56 ± 1.45), social functioning (89.25 ± 2.45), and material life (89.75 ± 1.45) of the observation group were higher than those of the control group after nursing (P < 0.05). Conclusion: Flexible nursing care in patients with postpartum urinary retention exhibited significant nursing effects and lactation function was effectively improved.

关键词： Flexible nursing Postpartum urinary retention Lactation

Application of the rotating-convection paradigm for tropical cyclones to interpreting medicanes:An example

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tropical Cyclone Research and Review 2022年第3期11卷 131-145页

作者： Gerard Kilroy hongyan zhu Minhee Chang Roger K.Smith Meteorological Institute Ludwig-Maximilians UniversityMunichGermany Research Science and InnovationBureau of MeteorologyMelbourneAustralia School of Earth and Environmental Sciences Seoul National UniversitySeoulSouth Korea

The rotating-convection paradigm for tropical cyclone behaviour is shown to provide an attractive and consistent framework for interpreting the dynamics of formation and intensification of at least some medicanes.The ideas are illustrated by a case study of the medicane that formed over the eastern Mediterranean in mid-December 2020.This case study is based on analyses of data from the European Centre for Medium Range Weather Forecasts(ECMWF),imagery from the European geostationary meteorological satellite,Meteosat Second Generation,and output from a convection permitting numerical simulation of the event using the United Kingdom(UK)Met Office regional model with the RAL2 physics configuration.Limitations of the currently widely accepted interpretation of medicanes in terms of the so-called Wind-Induced Surface Heat Exchange(WISHE)intensification mechanism are discussed.

关键词： Tropical cyclone Hurricane Typhoon Deep convection Medicane

A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第3期21卷 299-312页

作者： Zhilin Li Hao Cai Zhiqian Li Long Ren Xuelei Ma hongyan zhu Qiyong Gong Hu Zhang Zhongwei Gu Kui Luo Laboratory of Stem Cell Biology Department of RadiologyHuaxi MR Research Centner(HMRRC)Department of BiotherapyCancer CenterNational Clinical Research Center for GeriatricsFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China Amgen Bioprocessing Centre Keck Graduate InstituteClaremontCA91711USA Functional and Molecular Imaging Key Laboratory of Sichuan Province And Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu610041China

To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody in immunosup-pressive cancers like triple-negative breast cancer(TNBC),induction of immunogenic cell death(ICD)at tumor sites can increase the antigenicity and adjuvanticity to activate the immune microenvironment so that tumors become sensitive to the intervention of immune checkpoint inhibitors.Herein,a self-amplified biomimetic nanosystem,mEHGZ,was constructed by encapsulation of epirubicin(EPI),glucose oxidase(Gox)and hemin in ZIF-8 nanoparticles and coating of the nanoparticles with calreticulin(CRT)over-expressed tumor cell mem-brane.EPI acts as an ICD inducer,Gox and hemin medicate the cascade generation of reactive oxygen species(ROS)to strengthen the ICD effect,and CRT-rich membrane as“eat me”signal promote presentation of the released antigens by dendritic cells(DCs)to invoke the tumor-immunity cycle.The biomimetic delivery system displays an amplified ICD effect via Gox oxidation,hydroxyl radical generation and glutathione(GSH)depletion.The induced potent ICD effect promotes DCs maturation and cytotoxic T lymphocytes(CTLs)infiltration,reversing an immunosuppressive tumor microenvironment to an immunoresponsive one.Treatment with the nanosystem in combination with anti-PD-L1 antibody results in distinctive inhibition of tumor growth and lung metastasis,supporting that a potent ICD effect can significantly boost the therapeutic efficacy of the anti-PD-L1 antibody.This self-amplified biomimetic nanoplatform offers a promising means of raising the response rate of immune checkpoint inhibitors.

关键词： Cell membrane Biomimetic nanosystem Immunogenic cell death Immunotherapy anti-PD-L1 antibody

Epigenetic Regulation of a Powdery Mildew Resistance Gene in Medicago truncatula

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2013年第6期6卷 2000-2003页

作者： Shengming Yang Fang Tang Eveline Teixeira Caixeta hongyan zhu Department of Plant and Soil Sciences University of KentuckyLexingtonKY 40546USA Instituto de Biotecnologia Aplicada a Agropecuária Universidade Federal de VicosaVicosaMGBrazil

Dear Editor, Medicago truncatula is a model legume that is conge- neric with alfalfa （Medicago sativa）, a forage crop of global importance. Over the last decade, tremendous genetic and genomic tools have been developed for this model system, which has greatly facilitated the study of various aspects of legume genomics and biology. From an applied perspective, genomic information gained from M. truncatula is particu- larly useful for genetic improvement of cultivated alfalfa, a crop that is not amenable to genetic analysis because of its allogamous and autotetraploid nature （Yang et al., 2008）. For instance, M. truncatula can be used to clone the orthologs of many economically important genes in alfalfa,

关键词： Anti powdery mildew gene Alfalfa Genetic regulation

Aqueous-phase catalytic hydrogenation of furfural to cyclopentanol over Cu-Mg-Al hydrotalcites derived catalysts:Model reaction for upgrading of bio-oil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2014年第1期23卷 91-96页

作者： Minghao Zhou Zuo Zeng hongyan zhu Guomin Xiao Rui Xiao School of Chemistry and Chemical Engineering Southeast University Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education Southeast University

A series of Cu-Mg-Al hydrotalcites derived oxides with a(Cu+Mg)/Al mole ratio of 3 and varied Cu/Mg mole ratio(from 0.07 to 0.30) were prepared by co-precipitation and calcination methods, then they were introduced to the hydrogenation of furfural in aqueous-phase. Effects of Cu/Mg mole ratio, reaction temperature, initial hydrogen pressure, reaction time and catalyst amount on the conversion rate of furfural as well as the selectivity toward desired product cyclopentanol were systematically investigated. The conversion of furfural over calcined hydrotalcite catalyst with a Cu/Mg mole ratio of 0.2 was up to 98.5% when the reaction was carried out under 140 ?C and the initial hydrogen pressure of 4 MPa for 10 h, while the selectivity toward cyclopentanol was up to 94.8%. The catalysts were characterized by XRD and SEM. XRD diffraction of all the samples showed characteristic pattern of hydrotalcite with varied peak intensity as a result of different Cu content. The catalytic activity was improved gradually with the increase of Cu component in the hydrotalcite.

关键词： hydrotalcite hydrogenation furfural cyclopentanol cyclopentanone bio-oil upgrading

Identification of natural compounds targeting Annexin A2 with an anti-cancer effect

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2018年第6期9卷 568-579页

作者： Yu-Shi Wang He Li Yang Li hongyan zhu Ying-Hua Jin Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education College of Life Science Jilin University Changchun 130012 China

Annexin A2, a multifunctional tumor associated protein, promotes nuclear factor-kappa B （NF-κB） activation by interacting with NF-κB p50 subunit and facilitating its nuclear translocation. Here we demonstrated that two ginsenosides Rg5 （G-Rg5） and Rkl （G-Rkl）, with similar structure, directly bound to Annexin A2 by molecular docking and cellular thermal shift assay. Both Rg5 and Rkl inhibited the interaction between Annexin A2 and NF-κB p50 subunit, their translocation to nuclear and NF-κB activation. Inhibition of NF-κB by these two gin- senosides decreased the expression of inhibitor of apoptosis proteins （lAPs）, leading to caspase activation and apoptosis. Over expression of K302A Annexin A2, a mutant version of Annexin A2, which fails to interact with G-Rg5 and G-Rkl, effectively reduced the NF-κB inhibitory effect and apoptosis induced by G-Rg5 and G-Rkl. In addition, the knockdown of Annexin A2 largely enhanced NF-κB activation and apoptosis induced by the two molecules, indicating that the effects of G-Rg5 and G-Rkl on NF-κB were mainly mediated by Annexin A2. Taken together, this study for the first time demon- strated that G-Rg5 and G-Rkl inhibit tumor cell growth by targeting Annexin A2 and NF-κB pathway, and G-Rg5 and G-Rkl might be promising natural compounds for targeted cancer therapy.

关键词： Annexin A2 G-Rg5 G-Rkl HCC NF-κB

Influence of Voids on the Tensile Performance of Carbon/epoxy Fabric Laminates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2011年第1期27卷 69-73页

作者： hongyan zhu Baochang Wu Dihong Li Dongxing Zhang Yuyong Chen School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Harbin Aircraft Industry Co. Ltd.Harbin 150060China

This paper aims at investigating the effect of voids on the tensile properties of [（±45）4/（0,90）/（±45）2] S and [（±45）/0 4/（±45）（0,90）] S composites.Specimens with void contents in the range of 0.4% to 9.0% were fabricated from carbon/epoxy fabric.The void content was determined by ultrasonic attenuation and optical image analysis,and microscopic inspection was also used to analyze the shape and size of the voids.The influence of voids on the tensile strength and modulus of both stacking sequence is compared in terms of the size and the shape of the voids.The effect of voids on the initiation and propagation of tensile failure of both stacking sequence composite was investigated.

关键词： Composite Void Tensile strength

颈动脉斑块超声联合临床特征预测冠状动脉重度狭窄

在线全文

学校读者我要写书评

暂无评论

中国超声医学杂志 2024年第1期40卷 20-22页

作者：朱鸿燕宗珍高枫杭州师范大学附属医院超声科

目的探讨颈动脉斑块超声联合临床特征预测冠状动脉重度狭窄的效能。方法选取428例经冠状动脉造影证实重度与非重度狭窄的患者，比较两组差异，以多因素Logistic回归分析来确定独立预测因素，绘制受试者工作特征(ROC)曲线，通过曲线下... 详细信息

目的探讨颈动脉斑块超声联合临床特征预测冠状动脉重度狭窄的效能。方法选取428例经冠状动脉造影证实重度与非重度狭窄的患者，比较两组差异，以多因素Logistic回归分析来确定独立预测因素，绘制受试者工作特征(ROC)曲线，通过曲线下面积(AUC)来评估不同模型的预测性能。结果性别、血脂异常、吸烟、颈动脉内中膜厚度(CIMT)、多发斑块、最大斑块高度(MPH)和最大斑块长度(max-CPL)均有统计学意义(P<0.05)。多因素Logistic回归分析发现血脂异常、吸烟、MPH≥2.3 mm、CIMT≥1 mm、多发斑块是独立预测因素。血脂异常和多发斑块对冠状动脉重度狭窄的预测值相对较低，AUC均为0.59;MPH、CIMT的预测值较高，AUC均为0.62;超声联合临床特征的AUC最高，为0.74。结论颈动脉斑块超声及临床特征两者联合模型预测冠状动脉重度狭窄效能更高。

关键词：颈动脉斑块临床特征冠状动脉重度狭窄预测

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

文化产业赋能乡村振兴探究

学术交流 2024年第4期 119-135页

作者：朱红艳孔少华南楠中央民族大学经济学院北京100000 中央财经大学文化与传媒学院北京100000 石河子大学经济与管理学院新疆石河子832000

“民族要复兴,乡村必振兴”,乡村振兴事关人民共同富裕和中华民族伟大复兴,文化产业赋能乡村振兴的时代特征和破解之道离不开其基本内涵、发展脉络与理论支撑。文化产业从赋能城市复兴再到赋能乡村振兴,这是历史发展的必然规律。作为绿... 详细信息

“民族要复兴,乡村必振兴”,乡村振兴事关人民共同富裕和中华民族伟大复兴,文化产业赋能乡村振兴的时代特征和破解之道离不开其基本内涵、发展脉络与理论支撑。文化产业从赋能城市复兴再到赋能乡村振兴,这是历史发展的必然规律。作为绿色低碳和延展性产业,文化产业可以从赋能产业兴旺、生态宜居、乡风文明、治理有效、生活富裕五大方面促进乡村振兴:通过发挥经济效益,促进资源产业化、优化产业结构和催生新业态赋能产业兴旺;通过发挥生态效益,加强环境保护、传承文化资源和改善人居环境赋能生态宜居;通过发挥文化效益,促进乡土文化回归、提高乡村居民文化自信和加强农牧民思想道德建设赋能乡风文明;通过发挥政治效益和文化效益,促进乡村善治、提升组织凝聚力、加强民族团结赋能治理有效;通过发挥经济效益和社会效益,促进物质生活富裕、精神生活富裕、兴边富边赋能生活富裕。就推进路径而言,相关利益主体要在文化资源挖掘、人才队伍建设、数字技术助力、体制机制构建、文明乡风涵养等方面下功夫。

关键词：文化产业乡村振兴赋能

围产期全程针对性营养指导对初产妇分娩的影响

在线全文

学校读者我要写书评

暂无评论

中国计划生育学杂志 2024年第6期32卷 1360-1363页

作者：朱红燕朱桃燕中国人民解放军联勤保障部队第904医院无锡214000

目的:探讨围产期全程针对性营养指导对初产妇分娩的影响。方法:纳入2020年4月-2023年6月本院收治初产妇103例,随机数字表法分为对照组(51例)和观察组(52例),两组均常规围产期产科护理,观察组同时实施围产期全程针对性营养指导干预,干预... 详细信息

目的:探讨围产期全程针对性营养指导对初产妇分娩的影响。方法:纳入2020年4月-2023年6月本院收治初产妇103例,随机数字表法分为对照组(51例)和观察组(52例),两组均常规围产期产科护理,观察组同时实施围产期全程针对性营养指导干预,干预过程中对照组和观察组各脱落1例,观察各组总产程、产后2h出血量、自然分娩、产妇并发症、新生儿并发症、分娩时产妇疼痛程度(VAS评分)、产后3d产妇爱丁堡产后抑郁量表(EPDS)评分与康纳-戴维森弹性量表(CD-RISC)评分、孕妇营养情况及产妇干预满意率。结果:观察组产妇总产程(431.49±24.19 min)短于对照组(508.18±22.17 min),产后2h出血量(123±10 ml)少于对照组(204±11 ml),自然分娩率(80.4%)高于对照组(60.0%),产妇并发症率(0)、新生儿并发症率(3.9%)均低于对照组(8.0%、16.0%);分娩时观察组VAS评分(4.85±0.94分)低于对照组(6.23±0.56分),产后3d的EPDS评分(7.29±0.69分)与CD-RISC评分(81.27±4.27分)均优于对照组(9.13±0.77分、77.62±2.65分),孕妇营养不良发生率(0)低于对照组(8.0%),产妇干预满意率(94.1%)高于对照组(78.0%)(均P<0.05)。结论:围产期全程针对性营养指导可较好改善初产妇营养状况,降低营养不良发生率,缩短总产程、减少产后出血,减轻了分娩疼痛,提高自然分娩率,降低并发症发生,产妇产后心理状态好、满意度高。

关键词：初产妇围产期全程针对性营养指导并发症疼痛满意率