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肉羊体外胚胎生产技术规模化应用中品种的影响

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畜牧兽医学报 2024年第6期55卷 2451-2459页

作者：陈莹陈大勇乌日嘎仇春娟范利宏包梅荣岳媛梁红艳张家新田见晖安磊汪立芹农业农村部草食家畜遗传育种与繁殖重点实验室乌鲁木齐830011 中国农业大学北京100193 内蒙古赛诺种羊科技有限公司乌兰察布011800 内蒙古农业大学呼和浩特010018

旨在分析品种因素对OPU-IVEP商业化快繁效率的影响。本研究以经品种鉴定的健康8月龄至3周岁黑头萨福克、黑头杜泊、德克赛尔肉用种母羊为试验供体,在内蒙古赛诺种羊科技有限公司,采用OPU技术获取卵母细胞并进行体外胚胎工厂化生产或经... 详细信息

旨在分析品种因素对OPU-IVEP商业化快繁效率的影响。本研究以经品种鉴定的健康8月龄至3周岁黑头萨福克、黑头杜泊、德克赛尔肉用种母羊为试验供体,在内蒙古赛诺种羊科技有限公司,采用OPU技术获取卵母细胞并进行体外胚胎工厂化生产或经腹腔镜输精和手术冲胚获得体内胚胎,进行胚胎移植,记录卵母细胞回收、胚胎发育以及移植妊娠的相关数据,进行统计分析。比较不同品种在体外胚胎规模化生产中卵母细胞回收效率、卵母细胞体外受精和胚胎发育能力、胚胎移植妊娠和产羔效率等方面的差异;同时,还比较了不同品种体内、外胚胎生产技术的应用效果。结果表明:1)3个品种间卵母细胞回收率差异极显著(P0.05),但德克赛尔羊的囊胚发育率极显著高于其他两个品种(P0.05),且各品种内,体内胚胎和体外胚胎移植的平均受胎率和产羔率均无显著差异(P>0.05)。综上所述,在工厂化、规模化应用绵羊体外胚胎生产技术过程中,不同品种间卵泡发育、回收卵母细胞数、囊胚发育率等存在差异,平均卵泡数和平均回收卵母细胞最少的德克塞尔羊的囊胚发育率最高;移植后受胎和产羔情况在不同品种间无显著差异,体内胚胎和体外胚胎单次生产获得的后代数也无显著差异,但OPU-IVEP的供体利用率远大于MOET。

关键词：品种肉羊体外胚胎生产胚胎移植规模化应用

Fluorouracil-based preoperative chemoradiotherapy with or without oxaliplatin for stage Ⅱ/Ⅲ rectal cancer:a 3-year follow-up study

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Chinese Journal of Cancer Research 2015年第6期27卷 588-596页

作者： Dexin Jiao Rui Zhang Zhiqiang Gong Fang Liu yue Chen Qinrui Yu Liping Sun hongyan Duan Shendong Zhu Fei Liu Jian Wang Jianhui Jia Department of Radiotherapy Liaoning Cancer Hospital&Institute Department of Colorectal Surgery Liaoning Cancer Hospital&Institute

Background： Fluorouracil-based preoperative chemoradiotherapy has become the standard treatment for stage Ⅱ/Ⅲ rectal cancer. In order to improve the overall survival （OS） and disease-flee survival （DFS）, we added oxaliplatin to the standard treatment, and compared the effectiveness of these two treatment patterns. Methods： A total of 206 patients enrolled in the prospective study had histologically confirmed rectal cancer of clinical stage Ⅱ/Ⅲ during July 2007 to July 2010. They were randomized into the experimental group received oxaliplatin and capecitabine in combination with radiotherapy, and the control group received capecitabine in combination with radiotherapy. All patients received surgery in 6-10 weeks after chemoradiotherapy and adjuvant chemotherapy with mFOLFOX6. The primary endpoints were DFS and OS, and the secondary endpoints included toxicity, compliance, and histopathological response. Results： The 3-year OS in the experimental group and the control group was 90.29% vs. 86.41% （P〉0.05）, and the 3-year DFS was 80.58% vs. 69.90% （P〉0.05）. The pathological complete remission （pCR） rates were 23.30% and 19.42%, respectively （P=0.497）. The 3-year local recurrence rates were 4.85% vs. 5.83% （P=0.694）, and the 3-year distant metastasis rates were 16.50% and 28.16%, respectively （P=0.045）. There were no significant differences in most grade 3-4 toxicities between two groups, however, grade 3-4 diarrhea occurred in 16.50% （17/103） of the experimental group, compared with 6.80% （7/103） of the control group （P=0.030）. Also, the total grade 3-4 acute toxicity showed a significant difference （10.68% vs. 21.36%, P=0.037）. Conclusions： The experimental treatment did not lead significantly improved OS and DFS, and thus longer follow-up is warranted for our patient cohort. Adding oxaliplatin to capecitabine-based preoperative chemoradiotherapy can significantly reduce metastasis, but has only minimal impact on local recurrence. Although grade 3-4 toxicity rate incr

关键词： Oxaliplatin capecitabine preoperative chemoradiotherapy rectal adenocarcinoma

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桑枝和蚕沙的基础成分测定及堆肥试验

蚕学通讯 2024年第1期44卷 28-34页

作者：赵珮高琴琼朱红艳宋长贵吴均黄越王晓静王梅重庆市蚕业科学技术研究院重庆400700

桑枝和蚕沙是蚕桑生产的大宗副产物,用其制作堆肥是资源化利用和无害化处理的有效途径。测定结果表明,桑枝条的木质化程度越高,枝条的碳氮比(C/N)也越高;混入残余桑叶碎片和叶梗的蚕沙与蚕粪比较,其C/N显著降低。堆肥试验设置1号堆(100... 详细信息

桑枝和蚕沙是蚕桑生产的大宗副产物,用其制作堆肥是资源化利用和无害化处理的有效途径。测定结果表明,桑枝条的木质化程度越高,枝条的碳氮比(C/N)也越高;混入残余桑叶碎片和叶梗的蚕沙与蚕粪比较,其C/N显著降低。堆肥试验设置1号堆(100%桑枝)、2号堆(20%蚕沙+80%桑枝)、3号堆(100%蚕沙)3个处理组,测定各组堆肥腐熟过程中的物质变化及腐熟后的堆肥品质,结果显示:堆肥过程中各堆体的高温(≥50℃)持续天数由长到短依次为1号堆、2号堆、3号堆;堆肥的前60 d是堆体中各种养分物质含量变化最为剧烈的时期。各处理组堆体腐熟后,有机质含量由高到低依次为1号堆、2号堆、3号堆,有效氮、磷、钾及速效总养分含量由高到低依次为3号堆、2号堆、1号堆。综上认为:堆肥需要根据原料的组成合理调节氮源用量;2号处理组堆肥的品质最优,即在桑枝堆体中添加一定量的蚕沙,既可保证较高的有机质含量,又可提高堆肥的速效肥力。

关键词：桑枝蚕沙碳氮比堆肥有机质速效肥力

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基于络病理论探讨胰腺癌炎癌转化的防治

现代中医临床 2024年第2期31卷 69-72页

作者：李越吕红艳梁天宇王郅宜张若宣贾智李泉旺北京中医药大学北京100029 鄂尔多斯市中医医院北京中医药大学东方医院

胰腺癌又称“癌中之王”,其起病隐匿,难以早期诊断,发展迅速,预后极差。络病学主要研究络病的发病特点、病机变化、辨证论治等内容,络病理论体系从《黄帝内经》首次论述络脉及络病,到现代医家的深入研究,形成了基于络病学对肿瘤的认知... 详细信息

胰腺癌又称“癌中之王”,其起病隐匿,难以早期诊断,发展迅速,预后极差。络病学主要研究络病的发病特点、病机变化、辨证论治等内容,络病理论体系从《黄帝内经》首次论述络脉及络病,到现代医家的深入研究,形成了基于络病学对肿瘤的认知。探索炎癌转化的关键节点,及早干预,是实现胰腺癌早防、早治的重要手段。胰络是胰腺癌炎癌转化关键病位,伏阳是胰腺癌炎癌转化关键病机。胰腺癌炎癌转化是“气病—血病—毒生”的三阶段病理变化。基于络病理论防治胰腺癌炎癌转化,主要包括扶正通络、理气通络、化痰通络、逐瘀通络、解毒通络和解郁通络等治法。

关键词：络病学胰腺癌炎癌转化伏阳

Bending behavior of double-row stabilizing piles with constructional time delay

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第8期13卷 596-609页

作者： Yang YU yue-quan SHANG Hong-yue SUN College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310058China Department of Ocean Science and Engineering Zhejiang UniversityHangzhou 310058China

The bending behavior of double-row stabilizing plies is associated with the constructional time delay(CTD),which can be defined as the time interval between the installations of the front stabilizing pile and the rear stabilizing *** paper investigates the effect of CTD on the bending moments of double-row stabilizing piles and a method for determining the optimal CTD is *** stabilizing pile is modeled as a cantilever pile embedded in the Winkler elastic foundation.A triangular distributed earth pressure is assumed on the pile segment in the sliding *** front stabilizing pile and the rear stabilizing pile are connected by a beam with pinned *** analytical solutions of bending moments on the front and the rear stabilizing piles are derived and the accuracy of bending moment solutions is validated by comparing the tensile strain measured from the hongyan landslide project,Taizhou,Zhejiang,*** is concluded that CTD has a significant influence on the bending moments of double-row stabilizing *** optimal CTD can be obtained when the maximum tensile stress in the front stabilizing pile is equal to that in the rear stabilizing pile,which is 1.4 months for the hongyan landslide project.

关键词： Subgrade reaction Landslide Stabilizing pile Constructional time delay (CTD) Bending moment

Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients

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Neuroscience Bulletin 2016年第6期32卷 547-549页

作者： Weifeng Mi Feihu Liu Yongqiao Liu Bo Du Weidong Xiao Lingzhi Li Lan Huang Tianlan Lu Jia He Le Shi Weihua yue hongyan Zhang Peking University Sixth Hospital Peking University Instituteof Mental Health Key Laboratory of Mental Health Ministry of Health (Peking University) National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) Beijing 100191 China The Mental Health Center of Xi'an Xi'an 710061 China The Sixth People's Hospital of Hebei Province Baoding 07100 China The People's Hospital of Hubei Province Wuhan 430060China National Institute on Drug Dependence and Beijing KeyLaboratory of Drug Dependence Peking UniversityBeijing 100191 China Department of Pharmacology School of Basic Medical Sciences Peking University Health Science CenterBeijing 100191 China

Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are abundant [ 1, 2], and ABCB1 is a well-conserved gene, there is increasing evi- dence that its polymorphisms affect substrate specificity [3]. A previous study reported that the synonymous single nucleotide polymorphism （SNP） C3435T （rs1045642） affects the timing of co-translational folding and insertionof P-gp into the membrane,

关键词： PANSS Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients

FISS GAN:A Generative Adversarial Network for Foggy Image Semantic Segmentation

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IEEE/CAA Journal of Automatica Sinica 2021年第8期8卷 1428-1439页

作者： Kunhua Liu Zihao Ye hongyan Guo Dongpu Cao Long Chen Fei-yue Wang School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China State Key Laboratory of Automotive Simulation and Control and the Department of Control Science and Engineering Jilin University(Campus Nanling)Changchun 130025China Mechanical and Mechatronics Engineering Department at the University of Waterloo 200 University Avenue West WaterlooON N2L 3G1Canada State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 Institute of Systems Engineering Macao University of Science and TechnologyMacao 999078China

Because pixel values of foggy images are irregularly higher than those of images captured in normal weather(clear images),it is difficult to extract and express their *** method has previously been developed to directly explore the relationship between foggy images and semantic segmentation *** investigated this relationship and propose a generative adversarial network(GAN)for foggy image semantic segmentation(FISS GAN),which contains two parts:an edge GAN and a semantic segmentation *** edge GAN is designed to generate edge information from foggy images to provide auxiliary information to the semantic segmentation *** semantic segmentation GAN is designed to extract and express the texture of foggy images and generate semantic segmentation *** on foggy cityscapes datasets and foggy driving datasets indicated that FISS GAN achieved state-of-the-art performance.

关键词： Edge GAN foggy images foggy image semantic segmentation GAN semantic segmentation

Knowing and doing of residents’ reading in rural areas in China: A survey of the current situation in the ethnic minority regions along the Nenjiang River

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Journal of Library Science in China 2015年 253-254页

作者： Hong WANG Jingyan yue hongyan YANG Changqing WANG 不详

Concerning the problem of the lack of reading for the residents in Chinese rural areas,the existing studies mainly focus on developing rural reading facilities and improving the service models in ***,the problems,which arise from the fundamental characteristics of the rural residents(predominately farmers),have not been sufficiently *** paper reports on a research study,which aims to address these problems through a survey of 51

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基于宏基因组二代测序的ICU感染性疾病患者病原体分布

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福建医科大学学报 2024年第1期58卷 44-51页

作者：吴越卓惠长杨火保陈存荣尤彦菁李红艳王庆林峰福建医科大学附属第一医院重症医学科福州350005 福建医科大学附属第一医院滨海院区国家区域医疗中心重症医学科福州350212 福建省立医院重症医学二科福州350001 福建医科大学附属协和医院重症医学科福州350001 中国人民解放军联勤保障部队第九〇〇医院呼吸与危重症医学科福州350001 福建中医药大学附属人民医院呼吸科福州350004 福建中医药大学附属第三人民医院呼吸科福州350108 福建医科大学附属福州市第一医院重症医学科福州350009

目的基于宏基因组二代测序(mNGS)数据,分析重症监护室(ICU)感染性疾病患者的病原体分布情况,为临床抗感染治疗提供依据。方法回顾性分析7所综合性三甲医院ICU感染性疾病标本的mNGS报告结果,探讨ICU病原体分布情况。结果收集1083份感染... 详细信息

目的基于宏基因组二代测序(mNGS)数据,分析重症监护室(ICU)感染性疾病患者的病原体分布情况,为临床抗感染治疗提供依据。方法回顾性分析7所综合性三甲医院ICU感染性疾病标本的mNGS报告结果,探讨ICU病原体分布情况。结果收集1083份感染性疾病标本的mNGS报告,总体检出率为85.50%。病原体种类172种,病原体例数1334例,检出的细菌的种类和数量最多,其次为病毒。革兰阴性菌例数(60.29%)较革兰阳性菌(39.71%)多,检出数前3位的革兰阴性菌为肺炎克雷伯菌(114例,22.75%)、鲍曼不动杆菌(78例,15.57%)和铜绿假单胞菌(66例,13.17%);革兰阳性菌为屎肠球菌(68例,20.61%)、纹带棒状杆菌(46例,13.94%)和金黄色葡萄球菌(31例,9.39%)。检出数前3位的真菌为白色念珠菌(79例,40.51%)、耶氏肺孢子菌(32例,16.41%)和近平滑念珠菌(16例,8.21%)。DNA病毒为主要的检出病毒,检出数前3位为巨细胞病毒(71例,27.52%)、人疱疹病毒1型(62例,24.03%)和EB病毒(57例,22.09%);RNA病毒中检出数前3位为HpgV病毒(13例,43.33%)、人冠状病毒229E型(4例,13.33%)、鼻病毒(3例,10.00%)和人冠状病毒HKU1型(3例,10.00%)。在不典型病原体中,鹦鹉热衣原体检出率最高(11例,55.00%)。结论革兰阴性菌是ICU感染性疾病患者的主要病原体,其次为病毒。动态监测ICU病原体分布情况有助于制定合理有效的抗感染治疗策略。

关键词：宏基因组二代测序重症监护室病原体分布