Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients

作     者：Weifeng Mi Feihu Liu Yongqiao Liu Bo Du Weidong Xiao Lingzhi Li Lan Huang Tianlan Lu Jia He Le Shi Weihua Yue Hongyan Zhang 无

作者机构：Peking University Sixth Hospital Peking University Instituteof Mental Health Key Laboratory of Mental Health Ministry of Health (Peking University) National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) Beijing 100191 China The Mental Health Center of Xi'an Xi'an 710061 China The Sixth People's Hospital of Hebei ProvinceBaoding 07100 China The People's Hospital of Hubei Province Wuhan 430060China National Institute on Drug Dependence and Beijing KeyLaboratory of Drug Dependence Peking UniversityBeijing 100191 China Department of Pharmacology School of Basic Medical Sciences Peking University Health Science CenterBeijing 100191 China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2016年第32卷第6期

页      面：547-549页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the project of Science Fund for Creative Research Groups of the National Natural Science Foundation of China(81221002) Rational Medication Application Patterns of Schizophrenia(BMU20140430) of Peking University Health Science Center 

主　　题：PANSS Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients 

摘      要：Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are abundant [ 1, 2], and ABCB1 is a well-conserved gene, there is increasing evi- dence that its polymorphisms affect substrate specificity [3]. A previous study reported that the synonymous single nucleotide polymorphism （SNP） C3435T （rs1045642） affects the timing of co-translational folding and insertionof P-gp into the membrane,