检索结果-南通市图书馆

组蛋白去乙酰化酶抑制剂MS-275诱导骨髓瘤细胞株U266凋亡过程中Survivin的表达

在线全文

学校读者我要写书评

暂无评论

癌症 2009年第5期28卷 466-471页

作者：马健赵名于晓妉王志红解放军总医院第一附属医院血液科北京100037 军事医学科学院基础医学研究所北京100850

背景与目的:组蛋白去乙酰化酶抑制剂(histone deacetylase inhibitors,HDACi)是一类具有抗肿瘤活性的新型药物,主要通过诱导细胞凋亡发挥作用。本实验研究HDACi(MS-275)对人骨髓瘤细胞系U266细胞增殖和凋亡的影响及其与Survivin表达的... 详细信息

背景与目的:组蛋白去乙酰化酶抑制剂(histone deacetylase inhibitors,HDACi)是一类具有抗肿瘤活性的新型药物,主要通过诱导细胞凋亡发挥作用。本实验研究HDACi(MS-275)对人骨髓瘤细胞系U266细胞增殖和凋亡的影响及其与Survivin表达的关系。方法:将不同浓度的MS-275作用于U266细胞不同时间后,用台盼蓝拒染法观察药物对细胞活力的影响;通过瑞氏-姬姆萨染色观察药物作用后细胞形态学的变化;用流式细胞仪分析细胞周期;用Western blot检测Survivin、P21和Cdk4等的蛋白表达,以及凋亡信号通路中Caspase-3活化及蛋白聚ADP核糖聚合酶[poly(ADP-ribose)polymerase,PARP]的裂解情况。结果:MS-275呈时间和剂量依赖性抑制U266细胞增殖,阻断细胞周期于G0/G1期。MS-275作用U266细胞48h时的IC50为1.39μmol/L;2μmol/L的MS-275作用U266细胞24h后,G0/G1期细胞占66.39%,36h后G0/G1期细胞占89.80%。瑞氏-姬姆萨染色显示细胞形态发生明显变化。Western blot检测结果显示,MS-275作用U266细胞后,Survivin和Cdk4表达下降,P21表达增加,Caspase3被裂解活化,其底物蛋白PARP发生剪切。结论:MS-275抑制人多发性骨髓瘤细胞系U266增殖并诱导细胞凋亡,可能与下调Survivin蛋白的表达有关。

关键词：组蛋白去乙酰化酶抑制剂 MS-275 人骨髓瘤 U266细胞 Survivin 细胞凋亡

“One stone, two birds”: Salt template enabling porosity engineering and single metal atom coordinating toward high-performance zinc-ion capacitors

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 637-645页

作者： Chunliu Zhu Huanyu Liang Ping Li Chenglong Qiu Jingyi Wu Jingwei Chen Weiqian Tian Yue Zhu zhi Li Huanlei wang School of Materials Science and Engineering Ocean University of China Department of Chemical and Materials Engineering University of Alberta

Zinc-ion hybrid capacitors （ZIHCs） have received increasing attention as energy storage devices owing to their low cost,high safety,and environmental ***,their progress has been hampered by low energy and power density,as well as unsatisfactory long-cycle stability,mainly due to the lack of suitable electrode *** this context,we have developed manganese single atoms implanted in nitrogen-doped porous carbon nanosheets （MnSAs/NCNs） using a metal salt template method as cathodes for *** metal salt serves a dual purpose in the synthesis process:It facilitates the uniform dispersion of Mn atoms within the carbon matrix and acts as an activating agent to create the porous *** applied in ZIHCs,the MnSAs/NCNs electrode demonstrates exceptional performance,including a high capacity of 203 m Ah g-1,an energy density of 138 Wh kg-1at 68 W kg-1,and excellent cycle stability with 91%retention over 10,000 *** calculations indicate that the introduced Mn atoms modulate the local charge distribution of carbon materials,thereby improving the electrochemical *** work demonstrates the significant potential of carbon materials with metal atoms in zinc-ion hybrid capacitors,not only in enhancing electrochemical performance but also in providing new insights and methods for developing high-performance energy storage devices.

关键词： Zinc ion hybrid capacitors Cathodes Carbon materials Heteroatoms Single atoms

全域旅游视阈下海洋渔业与滨海旅游业互动发展研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

山东大学学报（哲学社会科学版） 2017年第4期 135-143页

作者：张红智王波韩立民中国海洋大学管理学院工商管理博士后流动站中国海洋大学管理学院

在全域旅游发展理念下,滨海旅游业加深了与其他产业的互动发展关系,推动了区域经济的发展。基于滨海旅游业与海洋渔业在资源投入的空间、功能的复合叠加特征,采用皮尔斯曼相关系数与VAR模型研究了滨海旅游业与海洋渔业之间的经济关系。... 详细信息

在全域旅游发展理念下,滨海旅游业加深了与其他产业的互动发展关系,推动了区域经济的发展。基于滨海旅游业与海洋渔业在资源投入的空间、功能的复合叠加特征,采用皮尔斯曼相关系数与VAR模型研究了滨海旅游业与海洋渔业之间的经济关系。结果显示:海洋渔业与滨海旅游业的皮尔斯曼相关系数为0.982,具有较强的产业关联性;海洋渔业与滨海旅游业存在长期稳定的均衡关系且现阶段滨海旅游的壮大不会危及海洋渔业的发展,反而海洋渔业对滨海旅游业具有较大影响,但长期来看,滨海旅游业与海洋渔业的相互影响将趋于平稳。最后,从产业转型升级、产业融合与绿色发展等方面提出了相关建议与措施。

关键词：全域旅游海洋渔业滨海旅游业产业融合 VAR模型

A low redox potential and long life organic anode material for sodium-ion batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： zhi Li Yang Wei Kang Zhou Xin Huang Xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

白细胞介素-18、趋化因子配体2在血管性认知损害患者中的表达意义及诊断效能分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国现代医学杂志 2022年第1期32卷 75-80页

作者：王志红李雪莲王剑梅韶关学院医学院临床医学系广东韶关512026 粤北人民医院神经内科广东韶关512000 韶关学院医学院附属医院内科广东韶关512026

目的探讨白细胞介素-18(IL-18)、趋化因子配体2(CCL2)在血管性认知损害(VCI)患者中的表达意义及对VCI的诊断效能。方法选取粤北人民医院和韶关学院医学院附属医院2019年1月—2020年4月收治的脑小血管病患者140例,根据其是否发生VCI分成... 详细信息

目的探讨白细胞介素-18(IL-18)、趋化因子配体2(CCL2)在血管性认知损害(VCI)患者中的表达意义及对VCI的诊断效能。方法选取粤北人民医院和韶关学院医学院附属医院2019年1月—2020年4月收治的脑小血管病患者140例,根据其是否发生VCI分成VCI组(n=76)和非VCI组(n=64)。采用蒙特利尔认知评价量表(MoCA)评价两组患者的认知功能。采用酶联免疫吸附试验(ELISA)检测患者血清IL-18、CCL2水平。Pearson法分析MoCA总分与血清IL-18、CCL2的相关性。绘制受试者工作特征(ROC)曲线分析血清IL-18、CCL2对VCI的诊断效能。结果VCI组视空间与执行能力、命名、记忆、注意、语言、抽象、延迟回忆及总分低于非VCI组(P<0.05)。VCI组血清IL-18、CCL2水平高于非VCI组(P<0.05)。MoCA总分与血清IL-18水平(r=-0.828,P=0.000)、CCL2水平(r=-0.738,P=0.000)均呈负相关。血清IL-18水平诊断VCI的曲线下面积(AUC)为0.772(95%CI:0.692,0.852),敏感性为72.40%(95%CI:0.715,0.858),特异性为73.40%(95%CI:0.698,0.897);血清CCL2水平诊断VCI的AUC为0.722(95%CI:0.636,0.808),敏感性为70.30%(95%CI:0.619,0.840),特异性为74.20%(95%CI:0.644,0.868)。结论脑小血管病后VCI发生率较高,且VCI患者的血清IL-18、CCL2水平升高,两者对VCI有一定诊断价值,可作为筛查该病的重要指标。

关键词：血管性认知损害趋化因子配体2 白细胞介素-18 认知功能相关性

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

在线全文

学校读者我要写书评

暂无评论

Tungsten 2025年第1期7卷 195-213页

作者： zhi-Peng Zhu Dian Jia William Yi wang Jun-Lei Yin Xing-Yu Gao Shu-Feng Yang Hai-Feng Song Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

AFP阳性或阴性的肠道肝样腺癌的病理及临床特征

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界华人消化杂志 2016年第33期24卷 4519-4525页

作者：王志宏顾立萍宋锦文徐红兰州军区兰州总医院放射介入病区甘肃省兰州市730050 甘肃省中医药研究院甘肃省兰州市730050 西京医院病理科陕西省西安市710032

目的探讨甲胎蛋白(?-fetoprotein,AFP)阳性或阴性的肠道肝样腺癌(hepatoid adenocarcinoma,HAC)的病理特征、诊断治疗及预后.方法收集2010-01/2016-07就诊于西京医院并经病理科确诊为肠道HAC的病例3例,观察记录患者临床相关症状,用电化... 详细信息

目的探讨甲胎蛋白(?-fetoprotein,AFP)阳性或阴性的肠道肝样腺癌(hepatoid adenocarcinoma,HAC)的病理特征、诊断治疗及预后.方法收集2010-01/2016-07就诊于西京医院并经病理科确诊为肠道HAC的病例3例,观察记录患者临床相关症状,用电化学发光方法检测血清内肿瘤标志物,影像科检查肝及肺转移情况,手术后标本行常规病理及免疫组织化学验查染色,观察分析病理特征,随访预后并进行回顾性分析.结果术前患者血清学AFP检查,1例呈高浓度阳性,并发生肝转移,1例为阴性,1例未查.3例患者均行肠癌根治术,病理学特征为可见到肝细胞样和腺样两种分化,肝细胞样分化区瘤胞浆内可见嗜酸性玻璃样小体,免疫表型为AFP和/或Hepatocyte阳性.术后临床病理分期为3期2例、4期1例,淋巴结转移2例,均可见或经免疫组织化学染色提示脉管、神经侵犯.患者术后随访时间为2-16 mo,1例死亡,2例生存.结论HAC患者临床症状无特异性,具有特征性的病理学特征和免疫表型,需与肝细胞癌及卵黄囊瘤相鉴别.依靠血清学诊断肠道HAC不可行,但其可能预测肿瘤的生物学行为及转移、复发情况,AFP阴性的患者预后可能要比阳性的好.

关键词：肠道甲胎蛋白肝样腺癌病理特征临床特征预后

GSH在DSS诱导的小鼠实验性肠炎中的作用

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界华人消化杂志 2005年第12期13卷 1400-1403页

作者：张静韩英纪欣王志红李虹义郑力中国人民解放军总医院军医进修学院北京市100853 北京军区总医院消化内科北京市100700

目的:探讨硫酸葡聚糖钠(dextransodiumsulphate,DSS)诱导的小鼠肠炎模型病变结肠组织的谷胱甘肽(GSH)变化及其与病变组织分泌的Th1/Th2型细胞因子IFN-γ,IL-4及黏膜损伤的关系.方法:实验组小鼠(n=10)给予含50g/LDSS的蒸馏水自由饮用7d... 详细信息

目的:探讨硫酸葡聚糖钠(dextransodiumsulphate,DSS)诱导的小鼠肠炎模型病变结肠组织的谷胱甘肽(GSH)变化及其与病变组织分泌的Th1/Th2型细胞因子IFN-γ,IL-4及黏膜损伤的关系.方法:实验组小鼠(n=10)给予含50g/LDSS的蒸馏水自由饮用7d之后处死,分离出的病变结肠一部分评价其病理学改变并用GSH1抗体做免疫组化,另一部分结肠培养后检测其IL-4、IFN-γ的表达.对照组小鼠(n=10)给予蒸馏水自由饮用7d之后处死.结果:DSS诱导实验性肠炎小鼠口服50g/L的DSS溶液7d出现体重减轻、腹泻、血便等急性肠炎的表现.病理学切片HE染色发现小鼠病变结肠腺体结构紊乱,黏膜和黏膜下单核细胞和多核细胞浸润.DSS组病变肠段组织GSH表达较对照组明显减少(2±0.6vs3.14±1.0,t=3.95,P=0.010.05).结论:DSS诱导的实验性肠炎小鼠病变结肠组织GSH的减少与病变结肠组织分泌的细胞因子IL-4增加、IFN—γ下降以及黏膜损伤相关.

关键词： GSH DSS 诱导小鼠实验性肠炎硫酸葡聚糖钠谷胱甘肽