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A Macaca mulatta model of fulminant hepatic failure

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World Journal of Gastroenterology 2012年第5期18卷 435-444页

作者： Ping Zhou Jie xia Gang Guo Zi-Xing Huang Qiang Lu li li hong-xia li Yu-Jun Shi hong Bu Department of Pathology West ChinaHospital Sichuan University Chengdu 610041 Sichuan Prov-ince China Key Labo-ratory of Transplant Engineering and Immunology Ministryof Health West China Hospital Sichuan University Chengdu610041 Sichuan Province China Department of Radiology West China HospitalSichuan University Chengdu 610041 Sichuan Province China Department of Ultrasound West China Hospital Si-chuan University Chengdu 610041 Sichuan Province China National Chengdu Center for Safety Evalua-tion of Drugs West China Hospital Sichuan University Chengdu610041 Sichuan Province China

AIM:To establish an appropriate primate model of fulminant hepatic failure (FHF).METHODS:We have,for the first time,established a large animal model of FHF in Macaca mulatta by intraperitoneal infusion of amatoxin and *** features,biochemical indexes,histopathology and iconography were examined to dynamically investigate the progress and outcome of the animal ***:Our results showed that the enzymes and serum bilirubin were markedly increased and the enzyme-bilirubin segregation emerged 36 h after toxin *** activity was significantly *** deteriorated parenchymal abnormality was detected by magnetic resonance imaging (MRI) and ultrasonography at 48 *** liver biopsy showed marked hepatocyte steatosis and massive parenchymal necrosis at 36 h and 49 h,*** autopsy showed typical yellow atrophy of the *** encephalopathy of the models was also confirmed by hepatic coma,MRI and pathological changes of cerebral *** lethal effects of the extrahepatic organ dysfunction were ruled out by their biochemical indices,imaging and ***:We have established an appropriate large primate model of FHF,which is closely similar to clinic cases,and can be used for investigation of the mechanism of FHF and for evaluation of potential medical therapies.

关键词： Fulminant hepatic failure Macaca mulatta Biochemistry Imaging Pathology

Thermodynamic simulation of the effect of slag chemistry on the corrosion behavior of alumina–chromia refractory

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International Journal of Minerals,Metallurgy and Materials 2016年第12期23卷 1458-1465页

作者： Shi-xian Zhao Bin-li Cai hong-gang Sun Gang Wang hong-xia li xiao-yan Song State Key Laboratory of Advanced Refractories Sinosteel Luoyang Institute of Refractories Research Co. Ltd. School of Materials Science and Engineering Beijing University of Technology

The corrosion behavior of alumina-chromia refractory against two kinds of industrial slags （coal slag and iron smelting slag） at 1550℃ was investigated via thermodynamic simulations. In the proposed simulation model, the initial slag first attacks the matrix and surface aggregates and subsequently attacks the inner aggregates. The simulation results indicate that the slag chemistry strongly affects the phase formation and corrosion behavior of the refractory brick. Greater amounts of alumina were dissolved and spinel solid phases formed when the brick interacted with iron smelting slag. These phenomena, as well as the calculated lower viscosity, may lead to much deeper penetration than that exhibited by coal slag and to more severe corrosion compared to that induced by coal slag. The thermodynamic calculations well match the experimental observations, demonstrating the efficiency of the proposed simulation model for evaluating the corrosion behavior of alumina-chromia refractory.

关键词： thermodynamic analysis simulation corrosion spinel alumina chromia refractories

Nucleation and crystallization of tailing-based glass-ceramics by microwave heating

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International Journal of Minerals,Metallurgy and Materials 2015年第12期22卷 1342-1349页

作者： Bao-wei li hong-xia li Xue-feng Zhang xiao-lin Jia Zhi-chao Sun School of Materials and Engineering Inner Mongolia University of Technology Key Laboratory of Integrated Exploitation of Bayan Obo Multi-metal Resources Inner Mongolia University of Science and Technology School of Mathematics Physics and Biological Engineering Inner Mongolia University of Science and Technology School of Material Science and Engineering Zhengzhou University

The effect of microwave radiation on the nucleation and crystallization of tailing-based glass-ceramics was investigated using a 2.45 GHz multimode microwave cavity. Tailing-based glass samples were prepared fi＇om Shandong gold tailings and Guyang iron tailings utilizing a conventional glass melting technique. For comparison, the tailing-based glass samples were crystallized using two different heat-treatment methods： conventional heating and hybrid microwave heating. The nucleation and crystallization temperatures were determined by performing a differential thermal analysis of the quenched tailing-based glass. The prepared glass-ceramic samples were further characterized by Fourier transform infrared spectroscopy, X-ray diffraction, Raman spectroscopy, thermal expansion coefficient measurements, and scanning electron microscopy. The results demonstrated that hybrid microwave heating could be successfully used to crystallize the tailing-based glass, reduce the processing time, and decrease the crystallization temperature. Furthermore, the results indicated that the nucleation and crystallization mechanism of the hybrid microwave heating process slightly differs fi＇om that of the conventional heating process.

关键词： glass-ceramics ore tailings microwave heating crystallization nucleation

Analysis of temporal and spatial distribution characteristics of ammonium chloride smoke particles in confined spaces

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Defence Technology（防务技术） 2022年第7期18卷 1269-1280页

作者： Chen-youshi Xu Bing-ting Zha Jia-qian Bao He Zhang hong-xia li ZNDY of Ministerial Key Laboratory Nanjing University of Science and TechnologyJiangsuNanjing210094China

In response to the demand for short-range detection of anti-smoke environment interference by laser fuzes,this study proposes a smoke environment simulation of non-uniform continuous point source diffusion and investigates an experimental laboratory smoke environment using an ammonium chloride smoke *** particle size distribution,composition,and mass flow distribution of the smoke were *** on a discrete phase model and a kεturbulence model,a numerical simulation was developed to model the smoke generation and diffusion processes of the smoke agent in a confined *** temporal and spatial distribution characteristics of the smoke mass concentration,velocity,and temperature in the space after smoke generation were analyzed,and the motion law governing the smoke diffusion throughout the entire space was *** with the experimental verification of the smoke environment laboratory,the results showed that the smoke plume changed from fan-shaped to umbrella-shaped during smoke generation,and then continued to spread ***,the mass concentration of smoke in the space decreased from the middle outward;the changes in temperature and velocity were small and *** the diffusion stage(after 900 s),the mass concentration of smoke above 0.8 m was relatively uniform across an area of smoke that was 12 m *** concentration decreased over time,following a consistent decreasing trend,and the attenuation was negligible in a very short ***,this system was suitable for conducting experimental research on laser fuzes in a smoke *** to the stability of the equipment and facilities,the setup could reproduce the same experimental smoke environment by artificially controlling the smoke emission of the smoke ***,this work provides a theoretical reference for subsequent research efforts regarding the construction of uniform smoke environments and evaluating laser transmission characteristics in smoky envir

关键词： Laser fuze Smoke environment Temporal distribution Spatial distribution Confined space Smoke agent

Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

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World Journal of Clinical Cases 2024年第5期12卷 951-965页

作者： Wen-Ting An Yu-xia Hao hong-xia li Xing-Kang Wu Department of Pharmacy Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina Department of Oncology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is a major risk factor for chronic gastritis,affecting approximately half of the global *** eradication is a popular treatment method for ***-positive chronic gastritis,but its mecha-nism remains *** metabolomics has been used to elucidate the mechanisms of gastric disease ***,no clinical study has been conducted on urinary metabolomics of chronic *** To elucidate the urinary metabolic profiles during *** eradication in patients with chronic *** We applied LC–MS-based metabolomics and network pharmacology to in-vestigate the relationships between urinary metabolites and ***-positive chronic gastritis via a clinical follow-up *** Our study revealed the different urinary metabolic profiles of ***-positive chronic gastritis before and after *** *** metabolites regulated by *** eradication therapy include cis-aconitic acid,isocitric acid,citric acid,L-tyrosine,L-phenylalanine,L-tryptophan,and hippuric acid,which were involved in four metabolic pathways:(1)Phenylalanine metabolism;(2)phenylalanine,tyrosine,and tryptophan biosynthesis;(3)citrate cycle;and(4)glyoxylate and dicarboxylate *** metabolomics and network pharmacology revealed that MPO,COMT,TPO,TH,EPX,CMA1,DDC,TPH1,and LPO were the key proteins involved in the biological progress of *** eradication in chronic *** Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of ***-positive chronic gastritis patients.

关键词： LC-MS metabolomics chronic gastritis Helicobacter pylori urinary metabolites

Efficient synthesis of 4(3H)-quinazolinones using a soluble polymeric support

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Chinese Chemical Letters 2008年第5期19卷 505-508页

作者： Chang Xie hong xia li Ming Guo liu Ming Wu Ding Key Laboratory of Pesticide ＆ Chemical Biology of Ministry of Education Central China Normal University Wuhan 430079 China

4（3H）-Quinazolinones have been synthesized from poly（ethylene glycol）（PEG） supported aza-Wittig reaction. 2-Dialkylamino- 4（3H）-quinazolinones 6 were synthesized efficiently by reaction of secondary amine with PEG-supported carbodiimides 4, which were obtained from aza-Wittig reaction of PEG-supported iminophosphoranes 3 with isocyanates.

关键词： 4(3H)-Quinazolinone Poly(ethylene glycol) supported Aza-Wittig reaction Carbodiimide Iminophosphorane

Malignant peripheral nerve sheath tumor with hemophilic syndrome and bone marrow fibrosis:A rare case report

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World Journal of Clinical Cases 2023年第31期11卷 7673-7679页

作者： Hui li li Wang Ying-hong Wu Gang Chen hong-xia li li-Fen Fan Min Gu Cai-hong Jiang Department of Medical Oncology Ordos Central HospitalOrdos 017000Inner Mongolia Autonomous RegionChina Department of Pathology Ordos Central HospitalOrdos 017000Inner Mongolia Autonomous RegionChina Department of Neurology Baogang HospitalBaotou 014010Inner Mongolia Autonomous Region 014010China Department of Pharmacy Ordos Central HospitalOrdos 017000Inner Mongolia Autonomous RegionChina Department of Orthopedics Ordos Central HospitalOrdos 017000Inner Mongolia Autonomous RegionChina

BACKGROUND Malignant schwannoma is a rare tumor in the peripheral nervous system,accounting for approximately 5%to 10%of systemic soft tissue ***,malignant schwannoma occurring in the broad ligament of the uterus with hemophilic syndrome and bone marrow fibrosis is extremely rare in clinical ***,we report the first case of an patient diagnosed with malignant peripheral nerve sheath tumor(MPNST)of the broad ligament of the uterus with hemophilic syndrome and bone marrow fibrosis,and share our reference clinical diagnosis and treatment *** SUMMARY A patient was diagnosed with MPNST of the uterus harboring hemophilic syndrome and bone marrow *** received combination,and repeated imaging revealed further encountered rare complications(hemophilia syndrome and bone marrow fibrosis)after two cycles of ***,combined treatment with pazopanib,gemcitabine,and dacarbazine was ***,the patient succumbed to death at hospital after two *** This report firstly provided reference clinical practice for a patient with MPNST of the uterus harboring hemophilic syndrome and bone marrow *** case raises a reminder about the tolerance and safety of combination therapy,especially in young women.

关键词： Malignant peripheral nerve sheath tumor Hemophilic syndrome Bone marrow fibrosis Case report

Corrosion resistance of BN-ZrO_(2)ceramics with different additives by molten steel

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Journal of Iron and Steel Research International 2022年第7期29卷 1101-1109页

作者： Fan Qian Hua-long li Wen-gang Yang Hai-rong Guo Guo-qi liu hong-xia li Bei-yue Ma State Key Laboratory of Advanced Refractories Sinosteel Luoyang Institute of Refractories Research Co.Ltd.Luoyang 471039HenanChina Institute of Research of Iron and Steel ShasteelZhangjiagang 215625JiangsuChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

BN–ZrO_(2)ceramics with different additives such as SiC,Al_(2)O_(3) and MgAl_(2)O_(4) were fabricated by hot pressing sintering process to study sintering properties and corrosion resistance by the rotary immersion molten steel *** results showed that SiC,Al_(2)O_(3) and MgAl_(2)O_(4) can improve the sintering properties of BN–ZrO_(2)ceramics;especially,the introduction of SiC can significantly improve the hardness of the material;thus,the above compounds will help to improve the wear resistance of BN–ZrO_(2)*** exposed oxide layer is in contact with molten steel and forms liquid phase after BN oxidation and B_(2)O_(3) volatilization,additives can significantly affect the properties of liquid phase,and m-ZrO_(2)grains are sintered and grown by dissolution–precipitation mechanism by liquid ***,Al_(2)O_(3) and MgAl_(2)O_(4) are more conducive to the formation of working layer with solid skeleton,which determines the corrosion resistance of BN–ZrO_(2)ceramics.

关键词： Thin strip continuous casting Side-dam Hot-pressing sintering BN–ZrO_(2)ceramic

A novel large animal model of recurrent migraine established by repeated administration of inflammatory soup into the dura mater of the rhesus monkey

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Neural Regeneration Research 2019年第1期14卷 100-106页

作者： Ning Chen Wei Su Shu-Hui Cui Jian Guo Jia-Chuan Duan hong-xia li li He Department of Neurology West China Hospital Sichuan University Department of Science & Technology West China Hospital Sichuan University National Chengdu Center for Safety Evaluation of Traditional Chinese Medicine West China Hospital Sichuan University

Several animal models of migraine have been established, and those based on trigeminovascular system activation are widely accepted. How- ever, most of these models have been established on lower animals, such as rodents, and involve only a single administration of a noxious stimulus. In this study, an inflammatory soup （10 μL）, consisting of prostaglandin E2 （0.2 mM）, serotonin （2 mM）, bradykinin （2 raM） and histamine （2 raM）, was injected into the dura mater of conscious rhesus monkeys through an indwelling catheter. The infusion started on day 8 and was repeated every 3 days, for a total of six administrations, to induce neurogenic inflammation. We performed behavioral assessments and measured the expression of the oncogene c-fos, neuronal nitric oxide synthase （nNOS） and calcitonin gene related peptide （CGRP） ill the trigeminal system and in multiple brain regions involved in pain processing by immunohistochemical staining. Compared with monkeys in the control group, three of the four animals in the inflammatory soup group displayed decreased motor behaviors, and two showed increased ipsilateral nose and mouth secretions during the stimulus period. Higher expression levels of c-fos, nNOS and CGRP were found in various brain areas of experimental animals compared with controls, including the trigeminal nucleus caudalis, thalamus, hypothalamus, midbrain, pons and other areas involved in pain perception. These results suggest that repeated inflammatory soup stimulation of the dura activates the trigeminovascular system and produces migraine-like pathological changes and abnormal behaviors in conscious rhesus monkeys.

关键词： nerve regeneration migraine rhesus monkey neurogenic inflammation cellular oncogene fos neuronal nitric oxide synthase calcitonin gene related peptide trigeminal system behavior immunohistochemistry neural regeneration