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Brucea javanica oil emulsion improves the effect of radiotherapy on esophageal cancer cells by inhibiting cyclin D1-CDK4/6 axis

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World Journal of Gastroenterology 2019年第20期25卷 2463-2472页

作者： Zhong-hua Qiu Wei-Wei zhang hong-hua zhang Gui-hua Jiao Department of Neurology Liangshan County People's HospitalJining272600Shandong ProvinceChina Department of Neurology Liangshan County People's HospitalJining272600Shandong ProvinceChina

BACKGROUND Esophageal cancer is one of the most common cancers around the world, and it has high incidence and mortality rates. The conventional therapy for esophageal cancer is radiotherapy, although its effect is highly limited by the resistance of esophageal cancer cells. Thus, strong radiosensitizers can be very crucial during radiotherapy against esophageal cancer. Brucea javanica oil emulsion (BJOE) is a widely used drug against various cancers, such as liver, colon, and ovarian cancer. However, its anti-cancer effect and mechanism and the use of BJOE as a radiosensitizer have not been explored in esophageal cancer. AIM To evaluate the anti-cancer effect and mechanism of BJOE and explore the potential use of BJOE as a radiosensitizer during radiotherapy. METHODS The inhibitory effect of BJOE and its enhancement function with radiation on cell viability were examined with the calculated half-maximal effective concentration and half-maximal lethal concentration. The influence of BJOE on cell migration and invasion were measured with EC109 and JAR cells by wound-healing and transwell assay. Clonogenesis and apoptotic rate, which was measured by Hoechst staining, were investigated to confirm its enhancement function with radiation. To investigate the molecular pathway underlying the effect of BJOE, the expressions of several apoptosis- and cycle-related proteins was detected by western *** lines more than normal cell lines, and it markedly reduced migration and invasion in esophageal cancer cells (EC109 and JAR). Moreover, it promoted cell apoptosis and enhanced the effect of radiotherapy against esophageal cancerous cells. In the viability test, the values of half-maximal effective concentration and half-maximal lethal concentration were reduced. Compared to the control, only around 1/5 colonies formed when using BJOE and radiation together in the clonogenic assay. The apoptotic rate in EC109 was obviously promoted when BJOE was added during radiotherap

关键词： Esophageal cancer Brucea javanica oil emulsion Radiosensitizer Apoptosis Cyclin D1-CDK4/6 axis

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Taxonomic Distinctness of Macrofauna as an Ecological Indicator in Laizhou Bay and Adjacent Waters

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Journal of Ocean University of China 2010年第4期9卷 350-358页

作者： ZHOU hong hua Er zhang Zhinan College of Marine Life Sciences Ocean University of China Qingdao 266003 P. R. China

In this paper, we assessed the ecological and biodiversity status in the Bohai Sea through a quantitative survey on mac-rofaunal community at 25 stations in Laizhou Bay and adjacent waters in the autumn of *** tested the robustness and effectiveness of taxonomic distinctness as an ecological indictor by analyzing its correlation with species richness and natural environmental variables and by analyzing other ecological indicators (Shannon-Wiener H' and W statistics from Abundance Biomass Comparison curve).Results so obtained indicated that the benthic environment of the study waters in general is not under major impact of anthropogenic disturbance, but some stations in Laizhou Bay and along the coast of the Shandong Peninsula and even in the central Bohai Sea might be moderately disturbed and showed signs of ecological *** taxonomic distinctness measures △+ and Λ+ were independent of sampling effort and natural environment factors and were compliant to other ecological *** application of the taxonomic distinctness indicator to assess marine biodiversity and ecosystem health on a larger regional scale with historical data seems promising.

关键词： Taxonomic distinctness macrofauna ecological indicator biodiversity Laizhou Bay Bohai Sea

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Spectrofluorimetric Determination of Magnesium (Ⅱ) with 7-(8-Hydroxy-3, 6-Disulfonaphthylazo)-8-Hydroxyquinoline-5-Sulfonic Acid

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Wuhan University Journal of Natural Sciences 2001年第4期6卷 831-835页

作者： zhang Xian, Wang hong, zhang hua shan College of Chemisitry and Molecular Science, Wuhan University, Wuhan 430072, China Wuhan University College of Chemistry and Molecular Science Wuhan China (GRID:grid.49470.3e) (ISNI:***)

A new fluorescent reagent, 7 (8 hydroxy 3, 6 disulfonaphthylazo) 8 hydroxyquinoline 5 sulfonic acid (HDNHQ) for the determination of magnesium has been developed. It reacted with magnesium to form a 1∶1 fluorescent complex with λ ex / λ em =356/495 nm immediately at room temperature in ammonia ammonium chloride buffer (pH 10.7). A linear relationship was obtained in the magnesium concentration range of 0 160 ng·mL -1 with the detection limit of 0.04 ng·mL -1 . The proposed method was simple, rapid and sensitive. It has been successfully applied to the determination of trace magnesium in blood serum with recoveries of 103.75% and 98.16%, respectively.

关键词： Hydroxy 3 6 disulfonaphthylazo) 8 hydroxyquinoline 5 sulfonic acid magnesium spectrofluorimetry blood serum

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Risk Assessment of Nitrogen Discharge from a Coastal Watershed

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Pedosphere 2007年第4期17卷 467-474页

作者： CHEN Neng-Wang hong hua-Sheng zhang Luo-Ping CAO Wen-Zhi State Key Laboratory of Marine Environmental Science Environmental Science Research Center Xiamen University Xiamen 361005 （China）.

Probabilistic risk assessment （PRA） uses probability theory to quantify the probability of occurrence of an event. In this study, PRA was conducted for the discharge of excess nitrogen （N） from an agricultural （Jiulong River） watershed in Southeast China. Using fault tree analysis, a type of PRA, the probability of occurrence of excess N discharge into the river during a runoff event was evaluated both qualitatively and quantitatively. Land use maps, soil maps, fertilizer use records, and expert opinions were used to determine probabilities of individual events within the fault tree and to calculate the overall probability of excess N discharge during a runoff event. Qualitative analysis showed that the risk of excess N discharge was mainly related to crop and livestock practices in the watershed. Proper management of tillage, fertilizer, and manure was necessary to control N releases. Quantitative assessment results indicated that alternative practices including reduction of fertilization, installation of vegetative strip buffer around the pig farms, and installation of more riparian buffers along the Jiulong River could reduce the likelihood of N discharge through runoff.

关键词： N discharge probabilistic risk assessment runoff watershed

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Optimized cardiac resynchronization therapy in patients with congestive heart failure

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Chinese Medical Journal 2007年第7期120卷 605-607页

作者： NIU hong-xia hua Wei zhang Shu SUN Xin CHEN Ke-ping WANG Fang-zheng CHEN Xin Center of Arrhythmia Diagnosis and Treatment Fuwai Hospital and Cardiovascular Institute Chinese Academy and Medical Sciences ＆ Peking Union Medical College Beijing 100037 China

Heart failure was a major and increasing public health problem, with an almost ＂epidemic＂ increase in the number of patients. Despite recent advances in pharmacotherapy, the prognosis remains poor. Cardiac resynchronization therapy （CRT）, by pacing right and left ventricles, has been proved to improve symptoms and reduce mortality for heart failure patients with cardiac dyssynchrony, However, 20% to 30% of patients did not respond to CRT. The good cardiac synchronicity before CRT and the remaining atrioventficular, inter- and intra-ventricular dyssynchrony after CRT may explain the non-response. New echocardiographic techniques, and in particular tissue Doppler imaging （TDI） analysis, has been proved to be a helpful tool in evaluating cardiac dyssynchrony, as well as in assessing the degree of cardiac resynchronization after biventricular device implantation. So, in this study, we optimized the pacing parameters to determine whether echo-guided optimizing of AV/VV delays would enhance the effect of CRT on cardiac function and synchronicity.

关键词： heart failure dysynchrony cardiac resynchronization therapy atrioventricular delay interventricular delay tissue Doppler imaging

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Synthesis of Novel Fluorescence reagents and Their Application in Determination of Thiol Compounds

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有机化学 2003年第Z1期23卷 265-265页

作者： LIANG Shu-Cai WANG hong zhang hua-Shan HU Xian-Ming Colloge of Pharmacy Wuhan University Wuhan 430072 Colloge of Chemistry Wuhan University Wuhan 430072 Colloge of Chemistry Wuhan University Wuhan 430072 Colloge of Pharmacy Wuhan University Wuhan 430072

　　The identification and determination of thiol compounds is essential both for the clinical diagnosis and the con trol of diseases because alteration of their concentrations in biological systems are somehow respon... 详细信息

关键词： myocardial infarction clinical diagnosis biological systems determination of

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船舶振荡运动仿真

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上海交通大学学报 2001年第10期35卷 1566-1569页

作者：江红赵忠华张炎华上海交通大学信息检测技术及仪器系上海200030

为节约昂贵的海上试验费用 ,以 6个自由度中最关键的横摇运动为例说明了仿真计算过程 .在由船模试验得到船舶响应幅值算子 (RAO)的基础上 ,采用 ITTC单参数标准波谱计算船舶的运动幅值谱 ,然后采用线性迭加法得到船舶振荡运动的时域序... 详细信息

为节约昂贵的海上试验费用 ,以 6个自由度中最关键的横摇运动为例说明了仿真计算过程 .在由船模试验得到船舶响应幅值算子 (RAO)的基础上 ,采用 ITTC单参数标准波谱计算船舶的运动幅值谱 ,然后采用线性迭加法得到船舶振荡运动的时域序列 .仿真信号序列的频谱与实船采集的横摇运动数据的频谱具有相似性 ,对频率区间细分可以提高仿真结果的精度 .

关键词：船舶波谱响应幅值算子仿真振荡运动

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Deciphering Water Oxidation Catalysts: The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： An, Li Li, Jianyi Sun, Yuanmiao Zhu, Jiamin Seow, Justin Zhu Yeow zhang, hong zhang, Nan Xi, Pinxian Xu, Zhichuan J. Yan, Chun-hua Lanzhou Univ Frontiers Sci Ctr Rare Isotopes Key Lab Nonferrous Met Chem & Resources Utilizat G State Key Lab Appl Organ ChemColl Chem & Chem Eng Lanzhou 730000 Peoples R China Nanyang Technol Univ Sch Mat Sci & Engn Singapore 639798 Singapore Chinese Acad Sci Fac Mat Sci & Energy Engn Shenzhen Inst Adv Technol Inst Technol Carbon Neutral Shenzhen 518055 Peoples R China Yunnan Univ Natl Ctr Int Res Photoelect & Energy Mat Electron Microscopy Ctr Sch Mat & EnergyKey Lab Electromagnet Mat & Devic Kunming 650091 Peoples R China Baotou Res Inst Rare Earths State Key Lab Baiyunobo Rare Earth Resource Res & Baotou 014030 Peoples R China Peking Univ Beijing Natl Lab Mol Sci State Key Lab Rare Earth Mat Chem & Applicat PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Chem Beijing 100871 Peoples R China

Demonstrate that the key factor to determine the activity of reconstructed surfaces is the surface chemistry, instead of reconstruction degree using the popular perovskite LaNi1-xFexO3 oxides as model *** content can influence both the surface reconstruction degree, the activation degree, and the activity of reconstructed *** oxygen evolution reaction activity of reconstructed catalysts is primarily governed by the chemistry of the reconstructed surface species. Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution reaction. The surface reconstruction has been widely observed in perovskite catalysts, and the reconstruction degree has been often correlated with the activity enhancement. Here, a systematic study on the roles of Fe substitution in activation of perovskite LaNiO3 is reported. The substituting Fe content influences both current change tendency and surface reconstruction degree. LaNi0.9Fe0.1O3 is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi1-xFexO3 (x = 0.00, 0.10, 0.25, 0.50, 0.75, 1.00) series. The reconstructed LaNi0.9Fe0.1O3 shows a higher intrinsic activity than most reported NiFe-based catalysts. Besides, density functional theory calculations reveal that Fe substitution can lower the O 2p level, which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term stability. Furthermore, it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction degree. The effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface reconstruction. This finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

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ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期 272-283页

作者： Yuwei hua Yizhi zhang Zhenming Guo Shan Bian Yong zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

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关节镜手术治疗稳定型内侧半月板ramp损伤的前瞻性随机对照研究

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中华外科杂志 2017年第3期55卷 161-165页

作者：刘心冯华洪雷张辉北京积水潭医院运动医学中心 100035

目的探讨稳定型内侧半月板ramp损伤是否需要手术缝合修补.方法前瞻性收集2008年8月至2012年4月北京积水潭医院运动医学中心收治的91例经关节镜手术证实为稳定型ramp损伤的患者资料,全部患者接受前交叉韧带（ACL）重建手术（自体腘绳... 详细信息

目的探讨稳定型内侧半月板ramp损伤是否需要手术缝合修补.方法前瞻性收集2008年8月至2012年4月北京积水潭医院运动医学中心收治的91例经关节镜手术证实为稳定型ramp损伤的患者资料,全部患者接受前交叉韧带（ACL）重建手术（自体腘绳肌腱移植）,术后采用MRI评估ramp损伤愈合状况,采用KT1000测量评估ACL稳定性,主观功能评估采用国际膝关节评分委员会（IKDC）评分及Lysholm膝关节功能评分.计量资料的比较采用t检验,计数资料的比较采用x2检验.结果 73例（80％）患者获得随访,随访时间24 ～ 72个月,平均（38.9±16.1）个月,缝合组40例,对照组33例.两组患者在年龄（t=0.458,P＞0.05）、性别（x2 =0.222,P＞0.05）、受伤至手术时间（t=0.643,P＞0.05）和合并损伤（x2=0.658,P＞0.05）方面差异均无统计学意义.随访时MRI显示缝合组愈合率为97.5％（39/40）,完全愈合率为95.0％（38/40）,部分愈合率与不愈合率均为2.5％（1/40）;对照组愈合率为93.9％（31/33）,完全愈合率为87.8％（29/33）,部分愈合率与不愈合率均为6.1％（2/33）,两组间差异无统计学意义（x2=0.446,P＞0.05）;术后膝关节稳定性差异无统计学意义（t=-0.510,P＞0.05）;ramp损伤完全愈合者其ACL稳定性明显优于部分愈合或不愈合者（x2=11.919,P＜0.01）;两组间术后Lysholm评分和IKDC评分差异均无统计学意义（t=-0.166,P＞0.05;t=0.032,P＞0.05）.结论稳定型内侧半月板ramp损伤是否手术缝合与术后早期愈合率及主、客观疗效无关,ramp损伤愈合率与ACL稳定性有显著相关.

关键词：内侧半月板损伤关节镜手术愈合率前交叉韧带重建

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