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Sequence Variations in the Bovine IGF-I and IGFBP3 Genes and Their Association with Growth and Development Traits in Chinese Beef Cattle

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Agricultural Sciences in China 2009年第6期8卷 717-722页

作者： GAO Xue SHI Ming-yan XU Xiu-rong LI Jun-ya REN hong-yan XU Shang-zhong Institute of Animal Science Chinese Academy of Agricultural Sciences Beijing 100193 P.R.China Life Science Department Luoyang Normal College Luoyang 471022 P.R.China College of Animal Science Northwest A＆F University Yangling 712100 P.R. China

The objective of this study was to determine the genotype effects of the bovine insulin-like growth factor Ⅰ （IGF-Ⅰ） and its binding protein 3 （IGFBP3） genes on growth and development traits in beef cows, including 130 Chinese Simmental, 42 Nanyang, and 47 Luxi Yellow cattle. Sequence variations in the bovine IGF-Ⅰ and IGFBP3 genes were investigated by single strand conformation polymorphism （SSCP）. SSCPs were detected in 6 fragments, which is the 5＇-flanking region, the 2nd exon, the 5th exon, and the 5th intron of the IGF-1 gene, and the 2nd exon, the 3rd exon of the 1GFBP3 gene. Two polymorphisms, an A-to-G transition in the 2rid exon of the IGF-Ⅰ gene and a T-to-C transition in the 2rid exon of IGFBP3 gene were detected in 3 breeds. The allele frequencies of 2 polymorphisms were 0.0411 （A）, 0.9589 （B）, and 0.7237 （A）, 0.2763 （B）, respectively. These 2 loci were analyzed to associate with body weight, height at withers, body length, heart girth, rump width, and beef production index （BPI） at 0, 6, 12, 24, and 36-month old. The IGFBP3 locus was shown to be associated with rump width, heart girth at 24-month and 36-month. Animals with BB genotype had higher rump width （24.86 ± 0.47） cm at 24-month and （27.50 ± 0.63） em at 36-month. The heart girth was highest for the individuals with BB genotype （171.33 ± 1.84） cm and higher than those with AB genotype （166.68 ± 1.13） cm （P〈 0.05） at 36-month.

关键词： beef cattle IGF-1 gene 1GFBP3 gene growth and development traits PCR-SSCP

Introgression of lac6/tl1/du13 improves the palatability of japonica rice

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The Crop Journal 2024年第4期12卷 1259-1265页

作者： Yong yang Tao Zhang Yuliang Shi yan Lu Qianfeng Li Xiaolei Fan Lichun Huang Lu Chen Xuetang Song Qing Liu Changquan Zhang Qiaoquan Liu Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education Agricultural College of Yangzhou UniversityYangzhou 225009JiangsuChina Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops/Jiangsu Key Laboratory of Crop Genetics and Physiology Yangzhou UniversityYangzhou 225009JiangsuChina Jiang Su(Wu Jin)Rice Research Institute Changzhou 213175JiangsuChina

Amylose content(AC)is a crucial determinant of the eating and cooking quality(ECQ)of rice,with low AC varieties exhibiting a softer texture and greater stickiness-attributes that enhance palatability and are desirable in specific culinary *** harness these traits,significant efforts have been made to manipulate AC to improve rice *** research utilized the MutMap+approach to identify LAC6/TL1,a gene that is an allele of Du13,responsible for low ***6 encodes a C2H2 zinc finger protein,which specifically increases the splicing efficiency of the Wxb allele without affecting the Wxa *** studies of LAC6 revealed that its proper integration could rectify the undesirable AC phenotype,whereas mutations within this gene led to reduced AC and were associated with shorter grain length and decreased thousand-grain *** these drawbacks,such mutations positively impact rice palatability,presenting a trade-off between grain size and eating *** address the challenges posed by the reduced grain weight associated with LAC6 mutations,we developed a specific molecular marker for LAC6,which has been effectively used in breeding programs to select lac6/tl1/du13 homozygous individuals with larger grain *** findings demonstrate that the“small grain”trait associated with lac6/tl1/du13 can be effectively mitigated through combined phenotype-based and marker-assisted *** study highlights the potential of lac6/tl1/du13 as a valuable gene for breeding novel,high-quality soft rice varieties through targeted breeding strategies.

关键词： Rice Dull endosperm Amylose content Wx Breeding

The beneficial effects of Tartary buckwheat (Fagopyrum tataricum Gaertn.) on diet-induced obesity in mice are related to the modulation of gut microbiota composition

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Food Science and Human Wellness 2023年第4期12卷 1323-1330页

作者： Yiming Zhou Haoyu Lu Shen Zhao Beibei yan hong Wang Xiaoli Zhou Ying Xiao School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai 201418China University Think Tank of Shanghai Municipality Institute of Beautiful China and Ecological CivilizationShanghai 201418China

The gut is home to a large number of intestinal microbiota that play an important role in the metabolism and immune system of the host.A growing body of evidence suggests that a high-fat diet is closely associated with many metabolic disorders,including fatty liver and type 2 *** to reports,Tartary buckwheat extract has a positive effect on intestinal microbiota in *** effects of Tartary buckwheat on biochemical indexes and intestinal microflora in mice were *** buckwheat protein(FGP),Tartary buckwheat resistant starch(FGS)and Tartary buckwheat flour(FGF)alleviated organ damage in mice and lowered the atherosclerotic index(AI)in ***,principal coordinate analysis(PCoA)showed that intestinal bacterial structure of FGF were separated apparently from other *** Firmicutes/Bacteroidetes(F/B)value of the high-fat(HF)-FGF group was significantly lower than that of the HF-FGP and HF-FGS *** significantly increases the abundance of beneficial bacteria such as Bifidobacterium,while decreasing the abundance of lipopolysaccharide(LPS)-producing *** of blood lipid metabolism parameters and analysis of the intestinal microbiota suggested that FGF can be more effective than FGP and FGS to reduce the effects of a high-fat diet in mice,restoring the blood parameters to values similar of those in mice fed a low-fat *** may be used to prevent or treat blood lipid metabolism disorders and intestinal microbiota disorders in mice fed a high-fat diet.

关键词： Tartary buckwheat High-fat diet Biochemical parameters Gut microbiota Lipid metabolism

A rare case of severe toxic optic neuropathy induced by formaldehyde vapor under working in mushroom cultivation room

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1993-1996页

作者： Min Gong yan-Nian Hui hong-Jun Du Department of Ophthalmology Eye Institute of PLAXijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

Citation:Gong M,Hui YN,Du HJ.A rare case of severe toxic optic neuropathy induced by formaldehyde vapor under working in mushroom cultivation *** J Ophthalmol 2021;14(12):1993-1996 Dear Editor,We are writing this letter to present a rare case of severe toxic optic neuropathy induced by formaldehyde(FA)vapor under working in mushroom cultivation *** such circumstance exists popularly in rural China,this case warns us to pay more attention to avoid similar cases.A 49-year-old male complained of bilateral vision loss after continuous working for 11h in an air-tight greenhouse filled with FA vapor on 03/15/*** after work,the patient felt weakness,dizziness,and *** of asking for medical consultation,he went home to *** next day,the patient was found to be in a coma with dyspnea and was taken to the local hospital by his *** blood pressure waved around 70-80/50-65 mm Hg,and then maintained at 100/80 mm Hg by *** was diagnosed with acute FA poisoning,pulmonary edema,metabolic acidosis,respiratory alkalosis,and hypotension and was given symptomatic relief and supportive measures.

关键词： rare formaldehyde maintained

Development of a novel critical nitrogen concentration-cumulative transpiration curve for optimizing nitrogen management under varying irrigation conditions in winter wheat

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The Crop Journal 2024年第4期12卷 1242-1251页

作者： Tianyang Ye Yu Zhang Jingyan Xuan Xintian Wang yang Li Junhao Xu Liujun Xiao Leilei Liu Liang Tang Weixing Cao Bing Liu yan Zhu National Engineering and Technology Center for Information Agriculture Engineering Research Center of Smart AgricultureMinistry of EducationKey Laboratory for Crop System Analysis and Decision MakingMinistry of AgricultureJiangsu Key Laboratory for Information AgricultureJiangsu Collaborative Innovation Center for Modern Crop ProductionNanjing Agricultural UniversityNanjing 210095JiangsuChina Institute of Remote Sensing and Digital Agriculture Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina

Accurate nitrogen(N)nutrition diagnosis is essential for improving N use efficiency in crop *** widely used critical N(Nc)dilution curve traditionally depends solely on agronomic variables,neglecting crop water *** three-year field experiments with winter wheat,encompassing two irrigation levels(rainfed and irrigation at jointing and anthesis)and three N levels(0,180,and 270 kg ha1),this study aims to establish a novel approach for determining the Nc dilution curve based on crop cumulative transpiration(T),providing a comprehensive analysis of the interaction between N and water *** Nc curves derived from both crop dry matter(DM)and T demonstrated N concentration dilution under different conditions with different *** equation Nc=6.43T0.24 established a consistent relationship across varying irrigation *** test results indicated that the nitrogen nutrition index(NNI),calculated from this curve,effectively identifies and quantifies the two sources of N deficiency:insufficient N supply in the soil and insufficient soil water concentration leading to decreased N availability for root ***,the NNI calculated from the Nc-DM and Nc-T curves exhibited a strong negative correlation with accumulated N deficit(Nand)and a positive correlation with relative grain yield(RGY).The NNI derived from the Nc-T curve outperformed the NNI derived from the Nc-DM curve concerning its relationship with Nand and RGY,as indicated by larger R2 values and smaller *** novel Nc curve based on T serves as an effective diagnostic tool for assessing winter wheat N status,predicting grain yield,and optimizing N fertilizer management across varying irrigation *** findings would provide new insights and methods to improve the simulations of water-N interaction relationship in crop growth models.

关键词： Crop dry matter Crop cumulative transpiration Bayesian statistical model Critical nitrogen dilution curve Nitrogen nutrition index

快速康复理念下剖宫产术后多模式镇痛的研究进展

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中国疼痛医学杂志 2024年第7期30卷 529-533页

作者：丁维思张红张冉冯艺刘国莉赵婉璐安海燕北京大学人民医院麻醉科北京100044 北京大学人民医院妇产科北京100044

为了减少产妇术后疼痛、促进产妇术后快速恢复以及保障婴儿健康,剖宫产术后的镇痛方案一直在不断完善。其中多模式镇痛是剖宫产术后快速康复(enhanced recovery after cesarean,ERAC)的重要组成部分,做好剖宫产术后的多模式镇痛是十分... 详细信息

为了减少产妇术后疼痛、促进产妇术后快速恢复以及保障婴儿健康,剖宫产术后的镇痛方案一直在不断完善。其中多模式镇痛是剖宫产术后快速康复(enhanced recovery after cesarean,ERAC)的重要组成部分,做好剖宫产术后的多模式镇痛是十分必要的。为尽量减少阿片类药物的不良反应,非阿片类药物与区域阻滞的应用逐渐增多,多模式镇痛方案也在逐步完善。然而,到目前为止,关于剖宫产术后的多模式镇痛方案仍存在争议,尚无最佳方案出现。本文总结了目前剖宫产术后的多模式镇痛方案,并为多模式镇痛方案的发展提供思路。

关键词：剖宫产术多模式镇痛术后康复阿片类药物疼痛

The Variability of the Narrow-line Seyfert 1 Galaxies from the Pan-STARRS's View

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Research in Astronomy and Astrophysics 2022年第1期22卷 148-155页

作者： hong-Tao Wang yan-Ping Su Xue Ge Yong-Yun Chen Xiao-Ling Yu School of Science Langfang Normal UniversityLangfang065000China School of Life Science Langfang Normal UniversityLangfang065000China School of Physics and Electronic Engineering Jiangsu Second Normal UniversityNanjingJiangsu 211200China The College of Physics and Electronic Engineering Qujing Normal UniversityQujing655011China School of Astronomy and Space Science Nanjing UniversityNanjing210093China

By means of the data sets from the Pan-STARRS1 survey, we have systematically examined the relationship between the variability characteristics and the physical parameters of the largest NLS1 galaxy sample up to *** results are summarized as follows:(1). We find significant anti-correlations between variability amplitude and absolute magnitude in g, r, i, z and y bands, which are consistent with the results in previous works.(2) The correlations between the variability amplitude in optical band and many physical parameters(e.g., λL(5100 A),black hole mass, Eddington ratio, R;and R;) are investigated. The results show the variability amplitude is significantly anti-correlated with L(5100 A), MBH, Eddington ratio and R_(4570), but positively correlated with R;.The relation could be explained by the simple standard accretion disk model.(3) We further investigate the relationship between optical variability and radio luminosity/radio-loudness. The results present weak positive correlation in g and r bands, but insignificant correlation in i, z and y bands. The large error of the approximate fraction of the host galaxy in i, z and y bands may lead to insignificant correlations.

关键词： catalogs galaxies:photometry galaxies:Seyfert

BET in hematologic tumors:Immunity,pathogenesis,clinical trials and drug combinations

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Genes & Diseases 2023年第6期10卷 2306-2319页

作者： Tao Ma yan Chen Zhi-Gang Yi yan-hong Li Jun Bai Li-Juan Li Lian-Sheng Zhang Department of Hematology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Department of Hematology Lanzhou University Second HospitalLanzhouGansu 730000China

The bromodomain and extra-terminal(BET)proteins act as“readers”for lysine acetylation and facilitate the recruitment of transcriptional elongation *** protein is associated with transcriptional elongation of genes such as c-MYC and BCL-2,and is involved in the regulation of cell cycle and ***,BET inhibitors(BETi)have regulatory effects on immune checkpoints,immune cells,and cytokine *** role of BET proteins and BETi in a variety of tumors has been *** paper reviews the recent research progress of BET and BETi in hematologic tumors(mainly leukemia,lymphoma and multiple myeloma)from cellular level studies,animal studies,clinical trials,drug combination,*** has a promising future in hematologic tumors,and future research directions may focus on the combination with other drugs to improve the efficacy.

关键词： BET BRD4 Clinical trials Hematologic tumors Immunity MYC

Measuring solar irradiance profiles in the Arctic sea ice using fiber optic spectrometry via inclined holes

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Acta Oceanologica Sinica 2021年第3期40卷 134-141页

作者： Zexia Qiu Hangzhou Wang Tao Li hong Song Yuanqian Wu Tingting yan Ying Chen Ocean College Zhejiang UniversityZhoushan 316021China Key Laboratory of Physical Oceanography Ocean University of ChinaQingdao 266100China Zhejiang Heli Electrical Engineering Co. Ltd.Taizhou 317000China

An irradiance profile measurement approach and profiling system were developed to measure the solar irradiance profile of the Arctic sea ice using fiber optic *** approach involved using a miniature spectrometer to sense light signals collected and transmitted from a fiber *** fiber probe was small,and could thus move freely in inclined bore holes drilled in sea ice with its optical entrance pointing *** input-output relationship of the system was analyzed and *** factors that determined the system output were analyzed.A correctional system output approach was proposed to correct the influence of these factors,and to obtain the solar irradiance profile based on the measurements outputted by this *** overall performance of the system was examined in two ice floes in the Arctic during the 9th Chinese National Arctic Research *** measured solar irradiance profiles were in good agreement with those obtained using other commercially available oceanographic *** derived apparent optical properties of sea ice were comparable to those of similar sea ice measured by other optical instruments.

关键词： solar irradiance profile sea ice fiber optic spectrometry inclined hole