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Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes

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World Journal of Diabetes 2024年第6期15卷 1263-1271页

作者： Xiang-Yu Gao Chen-Xia Zhou hong-mei li Min Cheng Da Chen Zi-Yi li Bo Feng Jun Song Department of Endocrinology East HospitalTongji University School of MedicineShanghai 200120China Department of Endocrinology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Immunization Program Huangdao District Center for Disease Prevention and ControlQingdao 266400Shandong ProvinceChina

BACKGROUND Cognitive dysfunction is the main manifestation of central *** cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive *** is closely related to neurological abnormalities,while often disregarded in clinical *** in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(T2DM).AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c(HbA1c)*** A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East *** participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(linical data were collected and measured,including age,height,weight,neck/waist/hip circumferences,blood pressure,comorbidities,duration of DM,and biochemical ***,neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance *** The HbA1c level was significantly associated with urinary microalbumin(mALB),triglyceride,low-density lipoprotein cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/Cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(P<0.05),whereas HOMA-βwas negatively correlated with the HbA1c level(P<0.05).Ordered multiple logistic regression analysis showed that NAA/Cho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P<0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P<0.05),and HOMA-IR(OR:1.107,95%CI:1.031-

关键词： Type 2 diabetes mellitus Hemoglobin A1c Proton magnetic resonance spectroscopy Neurotransmitters Central neuropathy

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Schistosomiasis transmission in Zimbabwe:Modelling based on machine learning

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Infectious Disease Modelling 2024年第4期9卷 1081-1094页

作者： hong-mei li Jin-Xin Zheng Nicholas Midzi Masceline Jenipher Mutsaka-Makuvaza Shan Lv Shang Xia Ying-jun Qian Ning Xiao Robert Berguist Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghai200025China National Institute of Health Research Ministry of Health and Child CareHarareZimbabwe University of Rwanda College of Medicine and Health SciencesSchool of Medicine and PharmacyDepartment of Microbiology and ParasitologyRwanda Ingerod 407 SE-45494BrastadSweden

Zimbabwe,located in Southern Africa,faces a significant public health challenge due to *** investigated this issue with emphasis on risk prediction of schistosomiasis for the entire *** this end,we reviewed available data on schistosomiasis in Zimbabwe from a literature search covering the 1980-2022 period considering the potential impact of 26 environmental and socioeconomic variables obtained from public *** studied the population requiring praziquantel with regard to whether or not mass drug administration(MDA)had been regularly *** machinelearning algorithms were tested for their ability to predict the prevalence of schistosomiasis in Zimbabwe based on the mean absolute error(MAE),the root mean squared error(RMSE)and the coefficient of determination(R2).The findings revealed different roles of the 26 factors with respect to transmission and there were particular variations between Schistosoma haematobium and *** *** found that the top-five correlation factors,such as the past(rather than current)time,unsettled MDA implementation,constrained economy,high rainfall during the warmest season,and high annual precipitation were closely associated with higher *** prevalence,while lower elevation,high rainfall during the warmest season,steeper slope,past(rather than current)time,and higher minimum temperature in the coldest month were rather related to higher *** *** random forest(RF)algorithm was considered as the formal best model construction method,with MAE=0.108;RMSE=0.143;and R^(2)=0.517 for ***,and with the corresponding figures for *** being 0.053;0.082;and *** on this optimal model,the current total schistosomiasis prevalence in Zimbabwe under MDA implementation was 19.8%,with that of *** at 13.8% and that of *** at 7.1%,requiring annual MDA based on a population of 3,003,*** MDA,the current total schistosomiasis prevalence would

关键词： Machine-learning Transmission risk model Schistosomiasis Zimbabwe

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Application of prostate resectoscope in the treatment of massive rectal bleeding after transrectal prostate puncture

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World Journal of Clinical Cases 2024年第18期12卷 3438-3443页

作者： hong-mei li Fa-Ying Yang Song Tu Peng Yan Jun Qian Jia-Xi Yao Department of Urology Hexi University Affiliated Zhangye People’s HospitalHexi UniversityZhangye 734000Gansu ProvinceChina Department of General Surgery II Hexi UniversityZhangye 734000Gansu ProvinceChina

BACKGROUND Ultrasound-guided prostate biopsy is a reliable diagnostic procedure for prostate cancer diagnosis with minimal procedure-related ***,complications,such as massive rectal bleeding may occur after the *** hypothesized that using a transrectal resectoscope could help treat massive rectal bleeding after transrectal prostate *** To identify a simple and effective treatment for massive rectal bleeding after transrectal prostate *** Patients requiring treatment for massive rectal bleeding after transrectal prostate punctures were included.A SIMAI resectoscope was inserted through the *** electrocoagulation was performed for superficial bleeding *** of the rectal mucosa or surface muscle layer was removed to expose deep bleeding points,followed by *** electric cutting ring was used to compress and stop the bleeding for jet-like points before *** fluid color in the drainage tube was monitored postoperatively for continuous *** Eight patients were included from 2012 to *** of the patients with massive rectal bleeding after the transrectal prostate punctures improved with conventional conservative and blood transfusion *** patients had an inferior artery embolism,and digital subtraction angiography was *** patients received emergency transanal prostate resection,which immediately stopped the *** days after the procedure,the patients had recovered and were *** Using a transanal prostate resection instrument is a simple,safe,and effective method for treating massive rectal bleeding after transrectal prostate punctures.

关键词： Electrocoagulation Hemostasis Transanal prostate resection instrumentation Prostate puncture

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Absorption interferometer of two-sided cavity

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Chinese Physics B 2021年第5期30卷 373-377页

作者： Miao-Di Guo hong-mei li School of Sciences Xi'an Technological UniversityXi'an 710021China College of Electronic Science and Engineering Jilin UniversityChangchun 130012China

We propose a scheme in which an arbitrary incidence can be made perfectly reflected/transmitted with a phase *** analyze the variation of intracavity field as well as output field with closed-loop phaseφ_(1) of the control fields and relative phaseφ_(2)of the probe *** two phases,medium absorption and light interference can be controlled so that photon escape from the cavity can be manipulated,thus an intensity switching based on phase modulation can be *** the condition for perfect transmitter or reflector is *** based on the transmission/reflection analysis,the total absorption of this system can be *** our scheme can be used as an absorption interferometer to explore the optical absorption in some complicated *** state delay of the output light intensity,which is dependent onφ1 orφ2,can be applied in the realization of quantum phase gate and subtle wave *** based on this scheme,we implement the state transfer between perfect transmitter/reflector and non-perfect coherent photon absorber via relative-phase modulation.

关键词： cavity quantum electrodynamics(QED) optical switching quantum interference

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Boundary states for entanglement robustness under dephasing and bit flip channels

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Chinese Physics B 2019年第10期28卷 257-262页

作者： hong-mei li Miao-Di Guo Rui Zhang Xue-mei Su College of Physics Jilin University

We investigate the robustness of entanglement for a multiqubit system under dephasing and bit flip channels. We exhibit the difference between the entanglement evolution of the two forms of special states, which are locally unitarily equivalent to each other and therefore possess precisely the same entanglement properties, and demonstrate that the difference increases with the number of qubits n. Moreover, those two forms of states are either the most robust genuine entangled states or the most fragile ones, which confirm that local unitary(LU) operations can greatly enhance the entanglement robustness of n-qubit states.

关键词： entanglement decoherence robustness local unitary equivalence

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DNA Repair Gene Polymorphisms in the Nucleotide Excision Repair Pathway and Lung Cancer Risk: A Meta-analysis

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Chinese Journal of Cancer Research 2011年第2期23卷 79-91页

作者： Chao-rong mei Meng Luo hong-mei li Wen-jun Deng Qing-hua Zhou Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Tianjin Lung Cancer Institute Tianjin Medical University General Hospital Tianjin 300052 China West China Hospital Sichuan University Chengdu 610041 China Cancer Center the Affiliated Hospital Qingdao University Medical College Qingdao 266003 China

Objective： A number of studies have reported the association of ＂XPA＂, ＂XPC＂, ＂XPD/ERCC2＂ gene polymorphisms with lung cancer risk. However, the results were conflict. To clarify the impact of polymorphisms of ＂XPA＂, ＂XPC＂, ＂XPD/ERCC2＂, on lung cancer risk, a meta-analysis was performed in this study. Methods： The electronic databases PubMed and Embase were retrieved for studies included in this meta-analysis by ＂XPA＂, ＂XPC＂, ＂XPD/ERCC2＂, ＂lung＂, ＂cancer/neoplasm/tumor/carcinoma＂, ＂polymorphism＂（An upper date limit of October, 31, 2009）. A meta-analysis was performed to evaluate the relationship among XPA, XPC and XPD polymorphism and lung cancer risks. Results： A total of 31 publications retrieved from Pubmed and Embase included in this study. XPC A939C CC genotype increased lung cancer risk in total population （recessive genetic model： OR=1.23, 95% CI：1.05-1.44; homozygote comparison： OR=1.21,95%CI：1.02-1.43and CC vs. CA contrast： OR=1.25,95%CI：1.06-1.48）, except in Asians. XPD A751C, 751C allele and CC genotype also increased lung cancer risk in total population and in Caucasians （recessive genetic model： Total population： OR=1.20, 95%CI：1.07-1.35）. No significant correlation was found between XPD A751C and lung cancer risk in Asians and African Americans. XPD G312A AA genotype increased lung cancer risk in total population, in Asians and Caucasians（recessive genetic model： Total population： OR=1.20, 95%CI： 1.06-1.36）. No significant association was found between XPA G23A, XPC C499T, XPD C156A and lung cancer risk. Conclusion： Our results suggest that the polymorphisms in XPC and XPD involve in lung cancer risks. XPA polymorphisms is less related to lung cancer risk.

关键词： Nucleotide excision repair Polymorphism Lung cancer Meta-analysis

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A new aryltetrahydronaphthalene lignan from Epimedium brevicornum

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Chinese Chemical Letters 2011年第1期22卷 85-87页

作者： Hai Zhou li Guo Jun Luo hong mei li Xiao Lei li Rong Tao li The college of life Science and Technology Kunming University of Science and Technology Kunming 650224 China

A new aryltetrahydronaphthalene lignan, （＋）-cycloolivil formaldehyde condensate （1）, was isolated from the whole plants of Epimedium brevicornum （Berberidaceae）. Its structure was elucidated on the basis of MS,... 详细信息

关键词： Epimedium brevicornum lignan Cycloolivil formaldehyde condensate

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The chemical constituents from Schisandra propinqua var. intermedia

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Chinese Chemical Letters 2008年第12期19卷 1450-1452页

作者： hong mei li Wei Guang Wang Xiao Nian li Yong Zhao Rong Tao li Han Dong Sun The College of life Science and Technology Kunming University of Science and Technology Kunming 650224 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

A new cinnamic acid monoterpenoid ester, intermedin C （1）, was isolated from the aerial parts of Schisandra propinqua var. interthedia. The structure of 1 was elucidated by spectroscopic methods including extensive ... 详细信息

关键词： Schisandra propinqua Monoterpenoid Intermedin C

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Schisanlactone G,a new 3,4-seco-lanostane triterpenoid from Schisandra sphenanthera

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Chinese Chemical Letters 2009年第5期20卷 601-603页

作者： Rong Ren Guo Jun Luo hong mei li Zhao Yuan Wu Hai Zhou li Rong Tao li The College of life Science and Technology Kunming University of Science and Technology Kunming 650224 PR China

A new 3,4-seco-lanostane triterpenoid, schisanlactone G （1）, was isolated from the fruits of Schisandra sphenanthera. Its structure was established on the basis of extensive spectroscopic analysis.

关键词： Schisandra sphenanthera Triterpenoid Schisanlactone G

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Lanthanide Thiolate Complexes： Novel Initiators for Ring-opening Polymerization of ε-Caprolactone

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Chinese Journal of Chemistry 2005年第11期23卷 1541-1544页

作者： SUN, hong-mei li, Huan-Rong YAO, Chang-Sheng YAO, Ying-Ming SHENG, hong-Ting SHEN, Qi The Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical Engineering Suzhou University Suzhou 215006 China

The ring-opening polymerization （ROP） of ε-caprolactone （ε-CL） using lanthanide thiolate complexes [（CH3CsH4）2Sm（μ-SPh）（THF）]2 （1） and Sm（SPh）3（HMPA）3 （2） as initiators has been investigated for the first time. Both of 1 and 2 were found to be highly efficient initiators for the ROP of ε-CL. The poly（ε-caprolactone）（PCL） with molecular weight Mn up to 1.97 ×10^5 and relatively narrow molecular weight distributions （1.20〈MW/Mn〈 2.00） have been obtained in high yield in the temperature range of 35-65℃. According to the polymer yield, 2 showed much higher activity than 1. However, the number-average molecular weight of PCL obtained with 2 was much lower than with 1. The possible polymerization mechanism of the ε-CL polymerization has been proposed based on the results of the end group analysis of the ε-CL oligomer.

关键词： ring-opening polymedzation samarium thiolate complex catalysis ε-caprolactone

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