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Nano-sized stationary phase packings retained by single-particle frit for microchip liquid chromatography

Chinese Chemical Letters 2024年第4期35卷 486-489页

作者： Wangyan Hu Ke Li Xiangnan dou Ning Li Xiayan Wang Center Excellence for Environmental Safety and Biological Effects Beijing Key Laboratory for Green Catalysis and SeparationDepartment of ChemistryBeijing University of TechnologyBeijing 100124China Center for Environmental Metrology National Institute of MetrologyBeijing 100029China

Modern chromatography is increasingly focused on miniaturization and integration. Compared to conventional liquid chromatography, microfluidic chip liquid chromatography(microchip-LC) has the potential due to its zero-dead volume connection and ease of integration. Nano-sized packings have the potential to significantly enhance separation performance in microchip-LC. However, their application has been hindered by packing difficulties. This study presents a method for packing nano-sized silica particles into a microchannel as the stationary phase. The microchip-LC packed column was prepared by combining the weir and the porous silica single-particle as frit to retain the packing particles. A surface tensionbased single-particle picking technique was established to insert porous single-particle frit into glass microchannels. Additionally, we developed a slurry packing method that utilizes air pressure to inject nano-sized packing into the microchannel. Pressure-driven chromatographic separation was performed using this nano-packed column integrated into a glass microchip. The mixture of four PAHs was successfully separated within just 8 min using a 5 mm separation channel length, achieving high theoretical plates(10~6plates/m). Overall, these findings demonstrate the potential of utilizing nano-sized packings for enhancing chromatographic performance in microchip systems.

关键词： Nano-size packing Single-particle frit Packed column Microchip LC Chromatographic separation

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Large Deviations for a Critical Galton-Watson Branching Process

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Acta Mathematicae Applicatae Sinica 2024年

作者： dou-dou LI Wan-lin SHI Mei ZHANG College of Statistics and Data Science Faculty of Science Beijing University of Technology Laboratory of Mathematics and Complex Systems (Ministry of Education) School of Mathematical SciencesBeijing Normal University Department of Mathematics and Physics North China Electric Power University

In this paper, a critical Galton-Watson branching process{Zn}is considered. Large deviation rates of SZn:=∑i=1ZnXiare obtained, where{Xi, i≥1}is a sequence of independent and identically distributed random variables and X1is in the domain of attraction of an α-stable law with α∈(0, 2). One shall see that the convergence rate is determined by the tail index of X1and the variance of Z1. Our results can be compared with those ones of the supercritical case.

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Exploring Trade-offs in Thermal Interface Materials:The Impact of Polymer-Filler Interfaces on Thermal Conductivity and Thixotropy

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Chinese Journal of Polymer Science 2024年第7期42卷 916-925,I0006页

作者： Bin Zhang Zheng-Li dou Yong-Zheng Zhang Qiang Fu Kai Wu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China

Effective thermal transport across solid-solid interfaces which is essential in thermal interface materials(TIMs),necessitates both optimal thixotropy and high thermal *** role of filler surface modification,a fundamental aspect of TIM fabrication,in the influence of these properties is not fully *** study employs the use of a silane coupling agent(SCA)to modify alumina,integrating experimental approaches with molecular dynamics simulations,to elucidate the interface effects on thixotropy and thermal conductivity in polydimethylsiloxane(PDMS)-based *** findings reveal that the variations of SCAs modify both interface binding energy and transition layer *** interface binding energy restricts macromolecular segmental relaxation near the interface,hindering desirable thixotropy and bond line *** the contrary,the thickness of the transition layer at the interface positively influences thermal conductivity,facilitating the transport of phonons between the polymer and ***,selecting an optimal SCA allows a balance between traditionally conflicting goals of high thermal conductivity and minimal bond line thickness,achieving an impressively low interface thermal resistance of just 2.45-4.29 K·mm^(2)·W^(-1)at275.8 kPa.

关键词： Thermal interface material Surface modification Thermal conductivity Thixotropy Interface thermal resistance

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由自组装构筑蛋白酶响应性近红外/磁共振双显影微球

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高分子学报 2018年第8期28卷 1127-1140页

作者：郭和泽宋晟戴婷婷李圣利窦红静上海交通大学材料科学与工程学院金属基复合材料国家重点实验室上海200240 上海交通大学医学院附属第九人民医院上海市组织工程重点实验室上海200011

由分子侧链上修饰近红外荧光分子的聚赖氨酸及表面聚丙烯酸修饰的磁共振显影磁性纳米颗粒为组装单元,采用自组装法构筑了在近红外、磁共振双重显影中均具有蛋白酶响应性的纳米尺度自组装微球.微球形成的组装驱动力为聚赖氨酸侧链氨基与... 详细信息

由分子侧链上修饰近红外荧光分子的聚赖氨酸及表面聚丙烯酸修饰的磁共振显影磁性纳米颗粒为组装单元,采用自组装法构筑了在近红外、磁共振双重显影中均具有蛋白酶响应性的纳米尺度自组装微球.微球形成的组装驱动力为聚赖氨酸侧链氨基与磁性纳米颗粒表面羧基在水相中的静电相互作用,两类组装前驱体在静电力作用下组装为纳米尺度团聚体,再通过戊二醛对氨基的适度交联来构筑胰蛋白酶响应的双显影复合微球.该复合微球处于自组装聚集状态时,微球内近红外荧光分子间的距离减小从而发生荧光共振能量转移,导致荧光分子的自淬灭;而在胰蛋白酶活化后的解组装状态,微球内聚赖氨酸重复单元间的酰胺键被胰蛋白酶切断,荧光分子间距扩大,共振能量转移现象消失,从而导致复合微球在胰蛋白酶存在下释放荧光,荧光释放强度/淬灭强度的比值最高可达18.此外,自组装微球的磁共振显影同样具有胰蛋白酶敏感性,这与组装—解组装过程导致微球内磁性纳米颗粒的局部浓度及聚集状态发生变化有关.细胞和动物实验研究表明,复合微球呈现低细胞毒性,并可特异性地对胰蛋白酶阳性的细胞和组织进行近红外/磁共振双显影,在胰蛋白酶的生物影像学检测中具有潜在的应用前景.

关键词：聚赖氨酸蛋白酶响应性磁性纳米颗粒自组装近红外荧光/磁共振双显影

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Cyclic Dinucleotide Self-Assembled Nanoparticles as a Carrier-Free Delivery Platform for STING-Mediated Cancer Immunotherapy

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CCS Chemistry 2024年第1期6卷 177-195页

作者： Lang Zhao Shao-Hua Zhuo Tian-Yang Wang Jun-Jun Wu jing-Yun Su Wen-Hao Li Bo-dou Zhang Yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 Beijing Institute for Brain Disorders Beijing 100069 Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084

Cyclic dinucleotides(CDNs)are natural agonists of the stimulator of interferon genes(STING),which is an attractive immunotherapy ***,CDNs and their derivatives are being investigated ***,the poor bioavailability of exogenous CDNs has limited their application in *** nanocarriers are widely used for cytosolic delivery of CDNs,their loading capacity is insufficient,and their complicated composition and purification process raises bio-compatibility ***,we report a super-simplified CDN self-assembly strategy for carrier-free delivery of *** the presence of excess K^(+),CDNs form oligomers which further self-assemble with divalent metal ions(such as Mn^(2+))to form nanoparticles(NPs)in aqueous *** demonstrate that the self-assembled CDN NPs promote cellular uptake of CDNs and enhance tumor immunogenicity by remodeling the tumor microenvironment,inducing immunogenic tumor cell death and increasing tumorinfiltrating lymphocytes,which is conducive to the generation of tumor neoantigen-specific T-cell *** also demonstrate that the use of CDN NPs alone or in combination with immune checkpoint blockades inhibits tumor growth,highlighting the fact that CDN NPs are a potent platform for cancer immunotherapy.

关键词： cyclic dinucleotide STING carrierfree delivery tumor immunogenicity cancer immunotherapy

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Values of macular ganglion cell-inner plexiform layer and 10-2 visual field measurements in detecting and evaluating glaucoma

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 852-860页

作者： Hai-Jian Hu Ping Li Bin Tong Yu-Lian Pang hong-dou Luo Fei-Fei Wang Chan Xiong Yu-Lin Yu Hai He Xu Zhang Affiliated Eye Hospital of Nanchang University Jiangxi Research Institute of Ophthalmology and Visual ScienceJiangxi Clinical Research Center for Ophthalmic DiseaseJiangxi Branch of National Clinical Research Center for Ocular DiseasesNanchang 330006Jiangxi ProvinceChina Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital) Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430015Hubei ProvinceChina

AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced ***:Totally 127 eyes from 89 participants(36 eyes of 19 healthy participants,45 eyes of 31 early glaucoma patients and 46 eyes of 39 advanced glaucoma patients)were *** relationships between the optical coherence tomography(OCT)-derived parameters and VF sensitivity were *** with early glaucoma were divided into eyes with or without central 10°of the VF damages(CVFDs),and the diagnostic performances of OCT-derived parameters were ***:In early glaucoma,the mGCIPLT was significantly correlated with 10-2 VF pattern standard deviation(PSD;with average mGCIPLT:β=-0.046,95%CI,-0.067 to-0.024,P<0.001).In advanced glaucoma,the mGCIPLT was related to the 24-2 VF mean deviation(MD;with average mGCIPLT:β=0.397,95%CI,0.199 to 0.595,P<0.001),10-2 VF MD(with average mGCIPLT:β=0.762,95%CI,0.485 to 1.038,P<0.001)and 24-2 VF PSD(with average mGCIPLT:β=0.244,95%CI,0.124 to 0.364,P<0.001).Except for the minimum and superotemporal mGCIPLT,the decrease of mGCIPLT in early glaucomatous eyes with CVFDs was more severe than that of early glaucomatous eyes without *** area under the curve(AUC)of the average mGCIPLT(AUC=0.949,95%CI,0.868 to 0.982)was greater than that of the average circumpapillary retinal nerve fiber layer thickness(cpRNFLT;AUC=0.827,95%CI,0.674 to 0.918)and rim area(AUC=0.799,95%CI,0.610 to 0.907)in early glaucomatous eyes with CVFDs versus normal ***:The 10-2 VF and mGCIPLT parameters are complementary to 24-2 VF,cpRNFLT and ONH parameters,especially in detecting early glaucoma with CVFDs and evaluating the severity of advanced glaucoma in group level.

关键词： 10-2 visual field ganglion cell-inner plexiform layer retinal nerve fiber layer thickness glaucoma

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Lithium-Ion Charged Polymer Channels Flattening Lithium Metal Anode

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Nano-Micro Letters 2024年第4期16卷 379-393页

作者： Haofan Duan Yu You Gang Wang Xiangze Ou Jin Wen Qiao Huang Pengbo Lyu Yaru Liang Qingyu Li Jianyu Huang Yun‑Xiao Wang Hua‑Kun Liu Shi Xue dou Wei‑hong Lai Hunan Provincial Key Laboratory of Thin Film Materials and Devices School of Material Sciences and EngineeringXiangtan UniversityXiangtan 411105People’s Republic of China Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemical and Pharmaceutical ScienceGuangxi Normal UniversityGuilin 541004People’s Republic of China Institute for Superconducting and Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongInnovation CampusSquires WayNorth WollongongNSW 2500Australia Institute of Energy Materials Science University of Shanghai for Science and TechnologyShanghai 200093People’s Republic of China

The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite *** this issue will be key to achieving high-performance lithium metal batteries(LMBs).Herein,we construct a lithium nitrate(LiNO_(3))-implanted electroactiveβphase polyvinylidene fluoride-co-hexafluoropropylene(PVDF-HFP)crystalline polymorph layer(PHL).The electronegatively charged polymer chains attain lithium ions on the surface to form lithium-ion charged *** channels act as reservoirs to sustainably release Li ions to recompense the ionic flux of electrolytes,decreasing the growth of lithium *** stretched molecular channels can also accelerate the transport of Li *** combined effects enable a high Coulombic efficiency of 97.0%for 250 cycles in lithium(Li)||copper(Cu)cell and a stable symmetric plating/stripping behavior over 2000 h at 3 mA cm^(-2)with ultrahigh Li utilization of 50%.Furthermore,the full cell coupled with PHL-Cu@Li anode and Li Fe PO_(4) cathode exhibits long-term cycle stability with high-capacity retention of 95.9%after 900 ***,the full cell paired with LiNi_(0.87)Co_(0.1)Mn_(0.03)O_(2)maintains a discharge capacity of 170.0 mAh g^(-1)with a capacity retention of 84.3%after 100 cycles even under harsh condition of ultralow N/P ratio of *** facile strategy will widen the potential application of LiNO_(3)in ester-based electrolyte for practical high-voltage LMBs.

关键词： Polymer ionic channel Li metal batteries Artificial protective layer Uniform Li deposition Electrochemical performances

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Natural variations of HvSRN1 modulate the spike rachis node number in barley

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Plant Communications 2024年第1期5卷 148-163页

作者： Chaofeng Fan Dongdong Xu Chunchao Wang Zhaoyan Chen Tingyu dou Dandan Qin Aikui Guo Meng Zhao honghong Pei Mengwei Zhao Renxu Zhang Ke Wang jing Zhang Zhongfu Ni Ganggang Guo Key Laboratory of Grain Crop Genetic Resources Evaluation and Utilization(MARA) The National Key Facility for Crop Gene Resources and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural Sciences(ICS-CAAS)Beijing 100081China Hainan Yazhou Bay Seed Laboratory Sanya 572025China Institute of Industrial Crops Shandong Academy of Agricultural SciencesJinan 250100China Key Laboratory of Crop Heterosis and Utilization Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100193China Key Laboratory for Crop Molecular Breeding of Ministry of Agriculture and Rural Affairs Institute of Food CropsHubei Academy of Agricultural SciencesWuhan 430064China

Grain number,one of the major determinants of yield in Triticeae crops,is largely determined by spikelet number and spike rachis node number(SRN).Here,we identified three quantitative trait loci(QTLs)for SRN using 145 recombinant inbred lines derived from a barley R90/1815D ***1,the major-effect QTL,was mapped to chromosome 2H and explained up to 38.77%of SRN ***-based cloning revealed that qSRN1 encodes the RAWUL domain-containing protein *** analysis revealed that two key SNPs in the HvSRN1 promoter region(-2 kb upstream of the transcription start site)affect the transcript level of HvSRN1 and contribute to variation in *** to its orthologous proteins OsLAX2 and ZmBA2,HvSRN1 showed protein–protein interactions with HvLAX1,suggesting that the LAX2–LAX1 model for spike morphology regulation may be conserved in Poaceae ***-Cas9-induced HvSRN1 mutants showed reduced SRN but increased grain size and weight,demonstrating a trade-off *** results shed light on the role of HvSRN1 variation in regulating the balance between grain number and weight in barley.

关键词： barley fine-mapping grain number kernel weight

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Nano friction behaviour between magnetic materials and copper considering the inter-diffusion effect

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Friction 2024年第7期12卷 1532-1547页

作者： Zilin LI Lisha dou Shiyu YANG Huajiang OUYANG Qichen ZHU Xiaoyang CHEN Xin JIA Shuaiwei dou Xiaolong CUI Yudong ZHANG jingjiang QIU Guochen QI Bangbang NIE Pan LIU Ronghan WEI School of Mechanics and Safety Engineering Zhengzhou UniversityZhengzhou 450001China Engineering Technology Research Center of Henan Province for MEMS Manufacturing and Application Zhengzhou UniversityZhengzhou 450001China Institute of Intelligent Sensing Zhengzhou UniversityZhengzhou 450001China School of Engineering University of LiverpoolLiverpool L693GHUK School of Cyber Science and Engineering&Hanwei Institute of Internet of Things Zhengzhou UniversityZhengzhou 450001China

Copper,permalloy,cobalt,and silicon are the materials that have been widely utilised in magnetic *** the size of interest is down to the nanoscale,the inter-diffusion between certain materials becomes *** paper studies the nanoscale friction characteristics between frictional pairs with and without inter-diffusion properties through the atomic force *** distinct evolution features of nanoscale friction force when inter-diffusion is involved are discovered experimentally,which is also confirmed through theoretical ***,through the thin film deposition method,four pairs of contact materials(Cu–Ni_(81)Fe_(19),Si–Ni_(81)Fe_(19),Cu–Co,Cu–Si)are designed for friction tests,in which diffusion occurs at the interface of Cu–Ni_(81)Fe_(19)***,the effects of sliding velocity and loading force on the nano friction of each pair are *** is found that regardless of the diffusion phenomenon:(1)the adhesion force values exhibit a notable correlation to the values of the friction force;(2)the friction force in all four material pairs consistently increases with the growth of the normal loading force,although the growth rate may *** terms of the sliding velocity effect,the friction forces of immiscible materials(Si–Ni_(81)Fe_(19),Cu–Co,and Cu–Si)are found to increase with the increasing sliding ***,the friction force of Cu–Ni_(81)Fe_(19),decreases with the increasing sliding ***,a compositive friction model considering both the velocity and the normal force effect was proposed,which shows good agreement with the experimental results and explains the nano friction behaviour of both miscible and immiscible metals.

关键词： atomic force microscope friction force normal load sliding velocity

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Predicted Climate Change will Increase Landslide Risk in Hanjiang River Basin,China

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Journal of Earth Science 2024年第4期35卷 1334-1354页

作者： Xinggang Tang Lingjian Wang Huiyong Wang Yingdan Yuan dou Huang Jinchi Zhang Co-Innovation Center for Sustainable Forestry in Southern China Jiangsu Province Key Laboratory of Soil and Water Conservation and Ecological RestorationNanjing Forestry UniversityNanjing210037China Jiangsu Key Laboratory of Crop Genetics and Physiology College of Horticulture and Plant ProtectionYangzhou UniversityYangzhou225009China College of Forestry Nanjing Forestry UniversityNanjing210037China

Landslides are widespread geomorphological phenomena with complex mechanisms that have caused extensive causalities and property damage *** scale and frequency of landslides are presently increasing owing to the warming effects of climate change,which further increases the associated safety *** this study,the relationship between historical landslides and environmental variables in the Hanjiang River Basin was determined and an optimized model was used to constrain the relative contribution of variables and best spatial response *** optimal MaxEnt model was used to predict the current distribution of landslides and influence of future rainfall changes on the landslide *** results indicate that environmental variables in the study area statistically correlate with landslide events over the past 20 *** MaxEnt model evaluation was applied to landslide hazards in the Hanjiang River Basin based on current climate change *** results indicate that 25.9%of the study area is classified as a high-risk *** main environmental variables that affect the distribution of landslides include altitude,slope,normalized difference vegetation index,annual precipitation,distance from rivers,and distance from roads,with a cumulative contribution rate of approximately 90%.The annual rainfall in the Hanjiang River Basin will continue to increase under future climate warming *** rainfall will further increase the extent of high-and medium-risk areas in the basin,especially when following the RCP8.5 climate prediction,which is expected to increase the high-risk area by 10.7%by ***,high landslide risk areas in the basin will migrate to high-altitude areas in the future,which poses new challenges for the prevention and control of landslide *** study demonstrates the usefulness of the MaxEnt model as a tool for landslide susceptibility prediction in the Hanjiang River Basin caused by global warming and yi

关键词： Hanjiang River Basin climate change environmental factor landslide susceptibility assessment MaxEnt model

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