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Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第2期30卷 152-162页

作者： YANG Ying QU Jin-yu GUO hua ZHOU Hai-ying RUAN Xia PENG Ying-chun SHEN Xue-fang XIONG Jin WANG Yi-li School of Clinical Medicine Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine the First Affliated Hospital of Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu(610041)China Department of Neurology the First Affiliated Hospital of Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic neural pathways to relieve colitis and somatic referred pain,and explore the underlying ***:Rats were treated with 5% dextran sodium sulfate(DSS) solution for 7 days to establish a colitis *** rats were randomly divided into the control and model groups according to a random number table(n=6).According to the Research on Rat Acupoint Atlas",sensitized acupoints and non-sensitized acupoints were *** were randomly divided into the control,model,Zusanli-EA(ST 36),Dachangshu-EA(BL 25),and Xinshu(BL 15) groups(n=6),as well as the control,model,EA,and EA+GR113808(a 5-HT inhibitor)groups(n=6).The rats in the control group received no *** was administered on 2 days after modeling using the stimulation pavameters:1 mA,2 Hz,for 30 min,with sparse and dense waves,for 14 consecutive ***113808 was injected into the tail vein at 5 mg/kg before EA for 10 min for 7 consecutive *** sensitivity was assessed with von Frey *** weight and disease activity index(DAI) scores of rats were *** and eosin staining was performed to observe colon *** was analyzed by immunofluorescence *** staining was performed to detect 5-HT and substance P(SP) *** calcitonin gene-related peptide(CGRP) in skin tissue and tyrosine hydroxylase(TH) protein levels in DRG were detected by Western *** levels of hyaluronic acid(HA),bradykinin(BK),prostaglandin I2(PGI2) in skin tissue,5-HT,tryptophan hydroxylase 1(TPH1),serotonin transporters(SERT),5-HT 3 receptor(5-HT3R),and 5-HT 4 receptor(5-HT4R) in colon tissue were measured by enzyme-linked immunosorbent assay(ELISA).Results:BL 25 and ST 36 acupoints were determined as sensitized acupoints,and BL 1

关键词： electroacupuncture sensitized acupoints sympathetic-sensory coupling 5-hydroxytryptamine neurogenic inflammation somaticreferredpain

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精品课程《机械零部件造型与测绘》的实施与思考

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武汉职业技术学院学报 2009年第6期8卷 61-63,71页

作者：华红芳无锡职业技术学院机械系江苏无锡214121

本文论述了精品课程《机械零部件造型与测绘》的实施情况及取得成效,就该课程建设中情境化教学实训室的创建、课程资源的优化以及师资队伍的建设等提出了建议及今后的努力方向。

关键词：机械零部件造型与测绘学习情境情境化教学实训室

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《机械制图》项目教学课程的开发及教材编写

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无锡职业技术学院学报 2008年第6期7卷 3-5页

作者：华红芳无锡职业技术学院机械技术学院江苏无锡214121

本着以能力为本位,就业为导向的职业教育理念,以机制类专业《机械制图》教学为载体,紧扣机械行业背景,选取机械设备中的典型零部件为案例,采用项目任务驱动教学进程,重新构建课程框架体系,开发相应教材。教材编写格式新颖,信息量大,知... 详细信息

本着以能力为本位,就业为导向的职业教育理念,以机制类专业《机械制图》教学为载体,紧扣机械行业背景,选取机械设备中的典型零部件为案例,采用项目任务驱动教学进程,重新构建课程框架体系,开发相应教材。教材编写格式新颖,信息量大,知识实用性强,力求突出职业能力培养。

关键词：项目教学项目任务机械零部件课程框架体系典型案例职业能力

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大长径比整体硬质合金深孔钻头的切削性能分析

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中国制造业信息化（学术版） 2009年第8期38卷 51-52,57页

作者：华红芳无锡职业技术学院机械技术学院江苏无锡214121

讲述了深孔钻削的优点及局限性,着重分析了带有XD技术的大长径比整体硬质合金麻花深孔钻的特点,通过性能分析及相关比较解析了深孔钻头高效加工的优点及合理的钻削步骤。

关键词：长径比深孔钻削 XD技术高效

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CPL-active hybrid copper(Ⅰ)halides enabled by cation inclusion with chiral crown-ether

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Science China Chemistry 2024年第10期67卷 3283-3290页

作者： Peng Fan Li-Xuan Cai Xiao-fang Duan Fan Yin Chen-Chen Li Zhong-hua Deng Xiao-Zhen Li Qing-Fu Sun College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Strait Institute of Flexible Electronics(Future Technologies) Fujian Key Laboratory of Flexible ElectronicsFujian Normal University and Strait Laboratory of Flexible ElectronicsFuzhou 350117China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian College University of Chinese Academy of SciencesFuzhou 350002China

Chiral hybrid metal halides with high photoluminescence quantum yield(PLQY)and superior dissymmetry factor(g_(lum))are promising candidates for circularly polarized luminescence(CPL)emitting ***,it is a great challenge to achieve both high g_(lum)and large ***,we report a new supramolecular strategy to fabricate chiral hybrid Cu(Ⅰ)-halides with nearunity quantum yields and intense CPL *** dissymmetry factor can be dramatically modulated by tuning the hostguest *** to the chirality and variable conformations of the host-guest complexes,a series of chiral[G@L^(R/S)]_(2)Cu_(4)I_(6)have been *** incorporation of different cations within the chiral L^(R/S)hosts leads to variations of packing modes along the c-axis and different extent of distortions in the[Cu_(4)I_(6)]_(2)-*** them,[H_(3)O@L^(R/S)]+cations are stacked based on Van der Waals interactions and hierarchically self-assemble into a right/left-handed helix in[H_(3)O@L^(R/S)]_(2)Cu_(4)I_(6),which results in a high g_(lum)of-7×10^(-3)and a large PLQY of 96.92%.Notably,[G@L^(R/S)]_(2)Cu_(4)I_(6)shows promising applications in single-component white light emitting diodes(WLEDs),exhibiting a maximum dissymmetry factor of-1.2×10^(-3).The effective host-guest complexation and oriented hierarchical self-assembly provide an effective strategy for the development of high-performance CPL materials.

关键词： host-guest interaction circularly polarized luminescence copper iodide cluster hierarchical self-assembly chirality

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浅谈CAD建筑图纸的绘制

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装备制造技术 2008年第12期 191-193页

作者：华红芳无锡职业技术学院机械技术学院江苏无锡214121

根据教学经验,讲述了在AutoCAD绘图软件下准确、清晰、高效地绘制建筑图纸的一些绘图经验和方法。

关键词： AutoCAD 建筑图准确清晰高效

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《机械制图》教学资源库的开发与制作

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荆楚理工学院学报 2009年第5期24卷 69-72页

作者：华红芳无锡职业技术学院机械技术学院江苏无锡214121

文章阐述了《机械制图》教学资源库建立的目的、制作思路、制作内容及本课程资源库的特点,并就资源库素材格式的选取展开了分析探讨。

关键词：机械制图教学资源库网络教学平台积件

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Babao Dan Inhibits Gastric Cancer Progression in vivo Through Multiple Signaling Pathways

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 14-21页

作者： Hai-Xia Shang Yi fang Bin Guan Jian-hua Guan Jun Peng Jin-Yan Zhao Jiu-Mao Lin Institute of Oncology of Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhouFujianChina Key Laboratory of Integrative Medicine of Fujian Province University Fujian University of Traditional Chinese MedicineFuzhouFujianChina Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese MedicineFuzhouFujianChina Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhouFujianChina Xiamen Traditional Chinese Medicine Co. Ltd.XiamenFujianChina

Objective:The aim of this study was to explore the effects of Babao dan(BBD),a traditional Chinese medicine,on gastric cancer(GC)progression in *** and Methods:A subcutaneous xenograft mouse model of GC was established using MGC80-3 *** terminal deoxynucleotidyl transferase-mediated dUTP:2'-deoxyuridine 5'-triphosphate-biotin nick-end labeling method was adopted to detect cell apoptosis in *** expression levels of proteins associated with proliferation,apoptosis,and angiogenesis were measured by immunohistochemical staining or western blotting(WB).The activation and protein levels of p-c-Jun N-terminal kinase(JNK),p-p38,p-extracellular-regulated kinase 1/2,p-nuclear factor-κB(NF-κB),and p-STAT3 were examined by Bio-plex and ***:BBD significantly inhibited tumor growth in GC mouse models with no adverse effect on body weight or organ *** was also found that BBD significantly suppressed the proliferation of GC tumor cells,induced the apoptosis of tumor cells,and inhibited angiogenesis through inactivating with mitogen-activated protein kinase,NF-κB,and STAT3 ***:BBD exerts suppressive effects on GC tumor growth by regulating multiple pathways in vivo,which may provide a novel treatment option for GC therapy.

关键词： Babao dan gastric cancer multiple signaling pathways proliferation traditional Chinese medicine

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Airfoil friction drag reduction based on grid-type and super-dense array plasma actuators

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Plasma Science and Technology 2024年第2期26卷 94-103页

作者：方子淇宗豪华吴云梁华苏志 School of Aerospace Engineering Xi'an Jiaotong UniversityXi'an 710049People's Republic of China School of Mechanical Engineering Xi'an Jiaotong UniversityXi'an 710049People's Republic of China National Key Lab of Aerospace Power System and Plasma Technology Air Force Engineering UniversityXi'an 710038People's Republic of China

To improve the cruise flight performance of aircraft, two new configurations of plasma actuators(grid-type and super-dense array) were investigated to reduce the turbulent skin friction drag of a low-speed airfoil. The induced jet characteristics of the two actuators in quiescent air were diagnosed with high-speed particle image velocimetry(PIV), and their drag reduction efficiencies were examined under different operating conditions in a wind tunnel. The results showed that the grid-type plasma actuator was capable of producing a wall-normal jet array(peak magnitude: 1.07 m/s) similar to that generated in a micro-blowing technique, while the superdense array plasma actuator created a wavy wall-parallel jet(magnitude: 0.94 m/s) due to the discrete spanwise electrostatic forces. Under a comparable electrical power consumption level,the super-dense array plasma actuator array significantly outperformed the grid-type configuration,reducing the total airfoil friction drag by approximately 22% at a free-stream velocity of 20 m/*** magnitude of drag reduction was proportional to the dimensionless jet velocity ratio(r), and a threshold r = 0.014 existed under which little impact on airfoil drag could be discerned.

关键词： plasma actuator flow control drag reduction airfoil

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Risk stratification in gastric cancer lung metastasis: Utilizing an overall survival nomogram and comparing it with previous staging

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 357-381页

作者： Zhi-Ren Chen Mei-fang Yang Zhi-Yuan Xie Pei-An Wang Liang Zhang Ze-hua huang Yao Luo Department of Science and Education Xuzhou Medical UniversityXuzhou Clinical CollegeXuzhou 221000Jiangsu ProvinceChina Department of Neurology Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Neurology Clinical LaboratoryGastrointestinal SurgeryCentral Hospital of XuzhouCentral Hospital of XuzhouXuzhou 221000Jiangsu ProvinceChina Department of Public Health Xuzhou Central HospitalXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology Xuzhou Centre HospitalXuzhou 221000Jiangsu ProvinceChina Department of Public Health Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is prevalent and aggressive,especially when patients have distant lung metastases,which often places patients into advanced *** identifying prognostic variables for lung metastasis in GC patients,it may be po-ssible to construct a good prediction model for both overall survival(OS)and the cumulative incidence prediction(CIP)plot of the *** To investigate the predictors of GC with lung metastasis(GCLM)to produce nomograms for OS and generate CIP by using cancer-specific survival(CSS)*** Data from January 2000 to December 2020 involving 1652 patients with GCLM were obtained from the Surveillance,epidemiology,and end results program *** major observational endpoint was OS;hence,patients were se-parated into training and validation *** analysis determined va-rious *** and multivariate Cox analyses validated the independent predictive *** distinction and calibration were performed with the time-dependent area under the curve(AUC)and calibration *** evaluate the accuracy and clinical usefulness of the nomograms,decision curve analysis(DCA)was *** clinical utility of the novel prognostic model was compared to that of the 7th edition of the American Joint Committee on Cancer(AJCC)staging system by utilizing Net Reclassification Improvement(NRI)and Integrated Discrimination Improvement(IDI).Finally,the OS prognostic model and Cox-AJCC risk stratification model modified for the AJCC system were *** For the purpose of creating the OS nomogram,a CIP plot based on CSS was *** multivariate regression analysis identified eleven significant prognostic factors(P0),time-de-pendent ROC curve(training/v

关键词： Gastric cancer Lung metastasis Nomograms Surveillance Epidemiology Surveillance epidemiology and end results program database Overall survival Prognosis

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