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Toward Systems Understanding of Leaf Senescence： An Integrated Multi-Omics Perspective on Leaf Senescence Research

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Molecular Plant 2016年第6期9卷 813-825页

作者： Jeongsik kim Hye Ryun Woo hong Gil nam Center for Plant Aging Research Institute for Basic Science (IBS) Daegu 42988 Republic of Korea Department of New Biology DGIST Daegu 42988 Republic of Korea

Leaf senescence is a complex but tightly regulated developmental process involving a coordinated sequence of multiple molecular events, which ultimately leads to death of the leaf. Efforts to understand the mechanistic principles underlying leaf senescence have been largely made by transcriptomic, proteomic, and metabolomic studies over the past decade. This review focuses on recent milestones in leaf senes- cence research obtained using multi-omics technologies, as well as future endeavors toward systems understanding of leaf senescence processes. In particular, we discuss recent advances in understanding molecular events during leaf senescence through genome-wide transcriptome analyses in Arabidopsis. We also describe comparative transcriptome analyses used to unveil the commonality and diversity of regulatory mechanisms governing leaf senescence in the plant kingdom. Finally, we provide current illustrations of epigenomic, proteomic, and metabolomic landscapes of leaf senescence. We envisage that integration of multi-omics leaf senescence data will enable us to address unresolved questions regarding leaf senescence, including determining the molecular principles that coordinate concurrent and ordered changes in biological events during leaf senescence.

关键词： leaf senescence transcriptomics epigenomics proteomics metabolomics multi-omics

An edible green algae polysaccharide CRVP from Caulerpa racemosa var. peltate induced apoptosis of liver cancer cells Hepa1-6 by regulating glutathione metabolism

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Food Science and Human Wellness 2024年

作者： Xuewei Xia Heying Zhou Rongxin Zhang Xiaoyong Zhang Baojun Xu Io nam Wong Riming Huang Guangdong Provincial Key Laboratory of Food Quality and Safety， College of Food Science， South China Agricultural University Department of Pharmacy， Guangdong Second Provincial General Hospital Department of Colorectal Surgery， Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Joint Laboratory of Guangdong Province and hong Kong Region on Marine Bioresource Conservation and Exploitation， College of Marine Sciences， South China Agricultural University Food Science and Technology Program， BNU-HKBU United International College Faculty of Medicine， Macau University of Science and Technology

Algal polysaccharides are an essential active substance in food nutrition and even pharmaceutical activity research due to wide sources， low toxicity， and no side effects. In our previous research， we identified the chemical structure and studied the immunomodulatory mechanism of the polysaccharide CRVP from edible green algae Caulerpa racemosa var. peltata. In this study， we further investigated the cytotoxicity and potential mechanism of CRVP against Hepa1-6 cells. Metabolomics analysis showed that CRVP might affect glutathione metabolism-related pathways. CRVP significantly up-regulated oxidized glutathione （GSSG） and down-regulated reduced glutathione （GSH） in Hepa1-6 cells， increasing the ratio of GSSG to GSH and intracellular reactive oxygen species. The potential anti-liver cancer mechanism is that CRVP may affect redox homeostasis and lead to apoptosis by inhibiting glutathione reductase or System Xc-. Based on the known immunomodulatory mechanism of CRVP， this study can provide a material basis for adjuvant therapeutic nutritional agents with immune-enhancing anti-cancer activity.

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Duo Property on the Monoid of Regular Elements

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Algebra Colloquium 2022年第2期29卷 203-216页

作者： Chan Yong hong hong Kee kim nam Kyun kim Tai Keun Kwak Yang Lee Department of Mathematics Kyung Hee UniversitySeoul 02447Korea Department of Mathematics and RINS Gyeongsang National University Jinju 52828Korea School of Basic Sciences Hanbat National UniversityDaejeon 34158Korea Department of Mathematics Daejin UniversityPocheon 11159Korea Department of Mathematics Yanbian UniversityYanjiJilin 133002China Instituteof Basic Science Daejin UniversityPocheon 11159Korea

We study the right duo property on regular elements,and we say that rings with this property are right *** is first shown that the right duo property is preserved by right quotient rings when the given rings are right *** prove that thepolynomial ring over a ring R is right DR if and only if R is *** is also proved that for a prime number p,the group ring KG of a finite p-group G over a field K of characteristic p is right DR if and only if it is right duo,and that there exists a group ring KG that is neither DR nor duo when G is not a p-group.

关键词： right DR ring right duo ring quotient ring (skew)polynomial ring group ring

Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

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Asian Journal of Urology 2024年第3期11卷 450-459页

作者： Jung Ki Jo Seong Il Seo MinYong Kang Jinsoo Chung Cheol Kwak Sung-Hoo hong Cheryn Song Jae Young Park Chang Wook Jeong Seok Hwan Choi Sung Han kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(TKI)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progression-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TKIeTKI”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with TKIs,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosinekinase inhibitor Metastaticrenalcell carcinoma Overall survival Progression-free survival

Effect of nanoclay on properties of porous PVdF membranes

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 141-147页

作者： Hae-Young HWANG Deuk-Ju kim Hyung-Jun kim Young-Taik hong Sang-Yong nam School of Materials Science and Engineering Engineering Research Institute i-Cube Center Gyeongsang National University Fuel Cell Research Center Korea Institute of Science and Technology Seoul 136-791 Korea Energy Material Research Center Korea Research Institute of Chemical Technology Daejeon 305-600 Korea

The main requirements for battery separators are high porosity which can serve pathways of lithium ion and space for gel electrolytes to impregnate in a membrane and mechanical strength to allow easy handling for battery assembly. Generally, it appears the trade-off relationship between the porosity and mechanical strength of the membrane. PVdF composite membranes containing nano-size clays were used to improve the mechanical strength of the membrane without affecting the membrane porosity. The composite membranes were prepared by phase inversion method controlling the membrane preparation conditions such as retention time. The resultant membranes show increased mechanical properties with similar membrane porosity around 80 % compared to the pristine PVdF membrane. Incorporation of nonoclay can be considered as an effective method to improve the mechanica! strength in porous membrane supports, especially in a separator.

关键词： Li-ion battery separator poly(vinylidene fluoride) nanocomposite

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Deduction of a meteorological phenology indicator from reconstructed MODIS LST imagery

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Journal of Forestry Research 2020年第6期31卷 2205-2216页

作者： Chi hong Lim Song Hie Jung nam Shin kim Chang Seok Lee Department of Bio and Environmnetal Technology Graduate SchoolSeoul Women’s UniversitySeoul Republic of Korea Research Team on Ecological and Natural Map National Institute of EcologySeocheon Choongnam Republic of Korea Department of Bio and Environmnetal Technology Seoul Women’s UniversitySeoul Republic of Korea

Phenology is a valuable attribute of vegetation to assess the biological impacts from climate change.A challenge of phenological research is to obtain information on both high temporal resolution and fine spatial scale ***,we constructed an air temperature map based on temporal merging and spatial interpolation algorithms to overcome the cloud-related problem from the MODIS LST ***,we derived the accumulated growing degree days(AGDD)from the constructed mean air temperature map to use as a meteorological ***,we verified the indicator with the seasonal mean air temperature and the green-up date of a Quercus mongolica forest determined from the field-based *** AGDD threshold for each *** forest when the first leaf has unfolded was detected from the EXG trajectory extracted from digital camera images.A comparison between meteorological and MODIS-derived AGDD showed good agreement between *** was also high consistency between DoYs extracted from AGDD and EVI based on curvature K for *** forests of 30 sampling sites throughout South *** results prove that microclimatic factors such as elevation,waterbody,and land-use intensity were faithfully reflected in the reconstructed ***,the results of this study could be applied effectively in areas where microclimatic variation is very severe and for monitoring phenology of undergrowth,which is difficult to detect from reflectance imaging.

关键词： Climate change Digital camera Growing degree days MODIS Phenology Quercus mongolica

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On extensions of matrix rings with skew Hochschild 2-cocycles

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Frontiers of Mathematics in China 2016年第4期11卷 869-900页

作者： Chan Yong hong nam Kyun kim Tai Keun KWAK Yang LEE Department of Mathematics and Research Institute for Basic Sciences Kyung Hee University Seoul 02447 Korea School of Basic Sciences Hanbat National University Daejeon 34158 Korea Department of Mathematics Daejin University Pocheon 11159 Korea Department of Mathematics Pusan National University Pusan 46241 Korea

We study structures of endomorphisms and introduce a skew Hochschild 2-cocycles related to Hochschild 2-cocycle. We moreover define skew Hochschild extensions equipped with skew Hochschild 2-cocycles, and then we examine uniquely clean, Abelian, directly finite, symmetric, and reversible ring properties of skew Hochschild extensions and related ring systems. The results obtained here provide various kinds of examples of such rings. Especially, we give an answer negatively to the question of H. Lin and C. Xi for the corresponding Hochschild extensions of reversible （or semicommutative） rings. Finally, we establish three kinds of Hochschild extensions with Hochschild 2-cocycles and skew Hochschild 2-cocycles.

关键词： Skew Hochschild extensions matrix rings skew triangular matrix rings (uniquely) clean rings symmetric rings

Preparation and Characterization of Porous PVdF-HFP/clay Nanocomposite Membranes

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Journal of Materials Science & Technology 2010年第7期26卷 633-638页

作者： Mi Jin Koh Hae Young Hwang Deuk Ju kim Hyeng Jun kim Young Taik hong Sang Yong nam School of Materials Science and Engineering Engineering Research Institutei-Cube CenterGyeongsang National UniversityJinjuKorea Fuel Cell Research Center Korea Institute of Science and TechnologySeoul 136-791Korea Energy Material Research Center Korea Research Institute of Chemical TechnologyDaejeon 305-600Korea

Polyvinylidene fluoride-hexafluoropropylene （PVdF-HFP） / clay nanocomposite membranes were prepared by phase inversion method through controlling retention time to apply for a lithium ion secondary batteries. Increased membrane porosity with macrovoids was observed at increasing retention time. Partially intercalated structures of PVdF-HFP/clay nanocomposite membranes were confirmed by X-ray diffraction （XRD） analysis. PVdF-HFP membranes containing various kind of clay showed the increase of membrane modulus compared to the pristine PVdF-HFP membrane.

关键词： PVdF-HFP Porosity Mechanical properties Clay Separator

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The protective effects of Panax notoginseng in the treatment of inflammatory bowel disease:in silico and in vivo studies

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Traditional Medicine Research 2024年第11期9卷 38-50页

作者： Jie-Wei Wang Guan-Hua Yue hong-Mei Xue Qiu-Ran Ding Guo-Yu Ding Hyonil kim Hui-Yun Zhang Yang-Guang Hao Department of Genetics College of Life SciencesNortheast Forestry UniversityHarbin 150040China Department of Basic Medical Shenyang Medical CollegeShenyang 110034China Department of Children’s Emergency Medicine Women’s and Children’s Hospital Affiliated to Qingdao UniversityQingdao 266000China.

Background:Panax notoginseng(PNE)is a prominent traditional Chinese medicine with extensive beneficial effects on the immune ***,the precise mechanism of PNE in treating inflammatory bowel disease(IBD)remains ***:We first used an extensive metabolomics approach utilizing UPLC-ESI-Q TRAP-MS/MS to identify the metabolite components of PNE aqueous ***,the mechanism of PNE in treating IBD was investigated through in silico analysis including RNA-seq analysis,Network pharmacology and Molecular *** a Drosophila toxin-induced intestinal inflammation model was employed to investigate ***:A total of 1,543 metabolites of PNE aqueous extract were characterized using UPLC-ESI-Q TRAP-MS/*** silico analyses showed that 97 IBD hub targets were targeted by 21 PNE *** Encyclopedia of Genes and Genomes results indicated that PNE may play an anti-IBD role through the Mitogen-activated protein kinase(MAPK)signaling pathway and other immune-related signaling ***,11 top hits compounds of PNE show a good affinity binding to IBD *** experimental results demonstrated that PNE can effectively improve the survival rate of adult Drosophila while also inhibit the excessive proliferation and differentiation of intestinal stem cells induced by sodium dodecyl ***,PNE notably lower the epithelial cell mortality,the accumulation of reactive oxygen species and the activation of oxidative stress-associated jun-Nterminal kinase(JNK)***:Our data suggests that PNE aqueous extract has a significant protective impact on the intestinal homeostasis of *** findings establish a basis for utilizing PNE in clinical investigations and managing IBD.

关键词： Panax notoginseng inflammatory bowel disease Drosophila intestinal homeostasis JNK pathway