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World Journal of Gastrointestinal Surgery 2022年第7期14卷 706-713页

作者： Xu-Xia He mei-Xing sun Ke Lv Jian Cao Sheng-Yu Zhang Jing-Nan Li Department of Gastroenterology Peking Union Medical College HospitalBeijing 10000China Department of Ultrasound Peking Union Medical College HospitalBeijing 10000China Department of Radiology Peking Union Medical College HospitalBeijing 10000China

BACKGROUND Giant simple hepatic cysts causing intrahepatic duct dilatation and obstructive jaundice are uncommon.A variety of measures with different clinical efficacies and invasiveness have been *** management,such as percutaneous aspiration and sclerotherapy,is often *** SUMMARY The case is a 39-year-old female with a 5-mo history of cutaneous and scleral icterus,loss of appetite,and dark *** tests showed jaundice and liver function *** revealed a giant simple hepatic cyst obstructing the intrahepatic bile ducts.A combination of percutaneous catheter aspiration and lauromacrogol sclerotherapy was successfully performed and the effects were satisfactory with the size of cyst decreasing from 13.7 cm×13.1 cm to 3.0 cm×3.0 *** literature review presented the challenges of managing giant simple hepatic cysts that cause obstructive jaundice and compared the safety and efficacy of a combination of percutaneous aspiration and lauromacrogol sclerotherapy with other management *** Giant simple hepatic cysts can cause obstructive jaundice,and a combination of percutaneous catheter aspiration and sclerotherapy with lauromacrogol are suggested to treat such cases.

关键词： Simple hepatic cyst Obstructive jaundice Aspiration Sclerotherapy Lauromacrogol Case report

基于Aspen EDR的管壳式换热器工艺选型设计教学实践

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广州化工 2024年第7期52卷 204-207页

作者：晋梅刘红姣安良吴宇琼宋姣华邹琳玲江汉大学湖北武汉430056

管壳式换热器工艺选型设计是化工过程中设备设计的重要环节之一。为了避免手工计算中繁琐的计算和复杂的校核问题,以无相变的乙醇冷却器为例,探讨Aspen EDR软件在管壳式换热器工艺选型设计中的实践应用。通过Aspen EDR软件的教学示范,... 详细信息

管壳式换热器工艺选型设计是化工过程中设备设计的重要环节之一。为了避免手工计算中繁琐的计算和复杂的校核问题,以无相变的乙醇冷却器为例,探讨Aspen EDR软件在管壳式换热器工艺选型设计中的实践应用。通过Aspen EDR软件的教学示范,激发学生学习积极性和主动性,提升学生运用理论知识分析和解决复杂化学工程问题的能力,强化专业软件应用能力。

关键词： Aspen EDR软件管壳式换热器工艺选型设计教学实践

DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer

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World Journal of Gastroenterology 2014年第25期20卷 8201-8208页

作者： Xue-Yuan Cao hong-Xi Ma Yan-hong Shang mei-Shan Jin Fei Kong Zhi-Fang Jia Dong-Hui Cao Yin-Ping Wang Jian Suo Jing Jiang Department of Gastric and Colorectal Surgery First Hospital of Jilin University Division of Pathology First Hospital of Jilin University Department of Oncology Affiliated Hospital of Hebei University Division of Clinical Epidemiology First Hospital of Jilin University

AIM: To explore the alteration of DNA methyltransferase expression in gastric cancer and to assess its prognostic value.

关键词： DNA methyltransferase Prognosis Gastric cancer Expression Helicobacter pylori

基于研究性教学和以学生为中心的课程教学探索——以“香料香精品控学”课程为例

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教育教学论坛 2024年第7期 133-136页

作者：崔冰孙亚楠贾宏昉宋朝鹏河南农业大学烟草学院河南郑州450046

随着教学改革的不断深入,研究性教学和以学生为中心的教学法已经成为课程教学的重要手段。以“香料香精品控学”课程为例,探讨了研究性教学和以学生为中心的教学法在该课程中的应用。具体包括课程前置阅读、研究性学习、课程报告、课程... 详细信息

随着教学改革的不断深入,研究性教学和以学生为中心的教学法已经成为课程教学的重要手段。以“香料香精品控学”课程为例,探讨了研究性教学和以学生为中心的教学法在该课程中的应用。具体包括课程前置阅读、研究性学习、课程报告、课程展示等方面的实施,以及以学生为导向的课程设计。同时也分析了香料香精技术与工程专业的培养目标和培养标准与研究性教学和以学生为中心的教学法之间的联系。最后提出了研究性教学和以学生为中心教学法的应用效果评估和未来教学改革的方向和探索。

关键词：研究性教学学生为中心教学法课程教学应用

Diagnostic role of transient elastography in patients with autoimmune liver diseases:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第39期29卷 5503-5525页

作者： hong Chen Yue Shen Sheng-Di Wu Qin Zhu Cheng-Zhao Weng Jun Zhang mei-Xia Wang Wei Jiang Department of Gastroenterology and Hepatology Zhongshan Hospital(Xiamen)Fudan UniversityXiamen 361015Fujian ProvinceChina Department of Gastroenterology and Hepatology Zhongshan Hospital of Fudan UniversityShanghai 200032China Shanghai Institute of Liver Diseases Fudan University Shanghai Medical CollegeShanghai 200032China

BACKGROUND Noninvasive methods have been developed to detect fibrosis in many liver diseases due to the limits of liver ***,previous studies have focused primarily on chronic viral hepatitis and nonalcoholic fatty liver *** diagnostic value of transient elastography for autoimmune liver diseases(AILDs)is worth *** To compare the diagnostic accuracy of imaging techniques with serum biomarkers of fibrosis in *** The PubMed,Cochrane Library and EMBASE databases were *** evaluating the efficacy of noninvasive methods in the diagnosis of AILDs[autoimmune hepatitis(AIH),primary biliary cholangitis(PBC)and primary sclerosing cholangitis(PSC)]were *** summary area under the receiver operating characteristic curve(AUROC),diagnostic odds ratio,sensitivity and specificity were used to assess the accuracy of these noninvasive methods for staging *** A total of 60 articles were included in this study,and the number of patients with AIH,PBC and PSC was 1594,3126 and 501,*** summary AUROC of transient elastography in the diagnosis of significant fibrosis,advanced fibrosis and cirrhosis in patients with AIH were 0.84,0.88 and 0.90,respectively,while those in patients with PBC were 0.93,0.93 and 0.91,*** AUROC of cirrhosis for patients with PSC was ***,other noninvasive indices(aspartate aminotransferase to platelet ratio index,aspartate aminotransferase/alanine aminotransferase ratio,fibrosis-4 index)had corresponding AUROCs less than *** Transient elastography exerts better diagnostic accuracy in AILD patients,especially in PBC *** appropriate cutoff values for staging advanced fibrosis and cirrhosis ranged from 9.6 to 10.7 and 14.4 to 16.9 KPa for PBC patients.

关键词： Liver stiffness Serum parameter Liver fibrosis Noninvasive diagnosis Transient elastography Autoimmune liver disease

益肾解毒化瘀方治疗慢性肾脏病合并动脉粥样硬化临床观察

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山西中医 2024年第9期40卷 19-21页

作者：万鸣宏陈美雪蓝小琴于清志吴晓芸浙江省平湖市中医院平湖314200

目的:观察益肾解毒化瘀方对慢性肾脏病3~4期合并动脉粥样硬化患者的临床疗效。方法:选取符合纳入标准的脾肾气虚兼血瘀型慢性肾脏病3~4期合并动脉粥样硬化患者60例,随机分为两组各30例。对照组采用慢性肾脏病一体化治疗,治疗组在对照组... 详细信息

目的:观察益肾解毒化瘀方对慢性肾脏病3~4期合并动脉粥样硬化患者的临床疗效。方法:选取符合纳入标准的脾肾气虚兼血瘀型慢性肾脏病3~4期合并动脉粥样硬化患者60例,随机分为两组各30例。对照组采用慢性肾脏病一体化治疗,治疗组在对照组基础上加用益肾解毒化瘀方。治疗12周后比较两组临床疗效。结果:治疗组临床总有效率为90.0%,明显高于对照组的76.7%(P﹤0.05);治疗后,治疗组Scr、BUN、Ccr、LDL-C、TG、RDW、CRP、UA、IMT水平改善程度均优于对照组(P﹤0.05),治疗组斑块面积、总证候积分均优于对照组(P﹤0.05)。结论:益肾解毒化瘀方治疗脾肾气虚兼血瘀型慢性肾脏病3~4期合并动脉粥样硬化患者可以有效改善患者肾功能及临床症状,降低RDW水平。

关键词：慢性肾脏病动脉粥样硬化益肾解毒化瘀方中医药疗法

Cell transplantation therapies for spinal cord injury focusing on bone marrow mesenchymal stem cells:Advances and challenges

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World Journal of Stem Cells 2023年第5期15卷 385-399页

作者： Li-Yi Huang Xin sun hong-Xia Pan Lu Wang Cheng-Qi He Quan Wei Rehabilitation Medicine Center and Institute of Rehabilitation Medicine West China Hospital/West China School of MedicineSichuan UniversityChengdu 610044Sichuan ProvinceChina

Spinal cord injury(SCI)is a devastating condition with complex pathological mechanisms that lead to sensory,motor,and autonomic dysfunction below the site of *** date,no effective therapy is available for the treatment of ***,bone marrow-derived mesenchymal stem cells(BMMSCs)have been considered to be the most promising source for cellular therapies following *** objective of the present review is to summarize the most recent insights into the cellular and molecular mechanism using BMMSC therapy to treat *** this work,we review the specific mechanism of BMMSCs in SCI repair mainly from the following aspects:Neuroprotection,axon sprouting and/or regeneration,myelin regeneration,inhibitory microenvironments,glial scar formation,immunomodulation,and ***,we summarize the latest evidence on the application of BMMSCs in clinical trials and further discuss the challenges and future directions for stem cell therapy in SCI models.

关键词： Spinal cord injury Bone marrow derived mesenchymal stem cells Neuroprotection Axon Myelin Inhibitory microenvironment

重复经颅磁刺激对精神分裂症患者快感缺失和吸烟的影响

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中国药物依赖性杂志 2024年第4期33卷 343-347页

作者：孙萍杨慧婷潘宇鸿牛伟盼杨皓大庆市第三医院黑龙江大庆市163000 哈尔滨精神专科白渔泡医院哈尔滨150000

目的观察重复经颅磁刺激(rTMS)对精神分裂症患者快感缺失和吸烟的影响以及两者的改善是否存在一定相关性。方法选取2022年8月至2023年6月哈尔滨某精神专科医院住院的74例男性精神分裂症患者为研究对象,随机分为研究组及对照组,每组37例... 详细信息

目的观察重复经颅磁刺激(rTMS)对精神分裂症患者快感缺失和吸烟的影响以及两者的改善是否存在一定相关性。方法选取2022年8月至2023年6月哈尔滨某精神专科医院住院的74例男性精神分裂症患者为研究对象,随机分为研究组及对照组,每组37例。两组在接受常规治疗的基础上,分别给予rTMS刺激和伪刺激,每天1次,每周5天,连续4周共20次治疗。采用中文版修订躯体快感缺失量表(RPAS-C)、尼古丁依赖量表(FTND)于治疗前、治疗4周结束时、治疗结束8周后进行评估,并记录近1周的日均吸烟量。结果重复测量方差分析显示:各变量组间效应、时间效应、交互效应显著,差异均有统计学意义(均P0.05)。结论rTMS能有效改善精神分裂症的患者快感缺失、减少其尼古丁依赖水平及吸烟量,且其快感缺失的改善程度与吸烟量、尼古丁依赖水平降低程度存在一定相关性。

关键词：精神分裂症重复经颅磁刺激吸烟尼古丁依赖快感缺失

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苦味受体T2Rs在不同疾病中的研究进展

中国中药杂志 2024年第16期49卷 4347-4358页

作者：李紫微吴志瑰张舟张伟杰夏紫微钟卫红裴建国黄潇付小梅刘婧江西中医药大学药学院江西南昌330004 范崔生全国名中医传承工作室江西南昌330006

苦味作为动物最重要的生理感觉之一,其识别过程主要由苦味受体介导完成。近年来发现该受体不仅在舌头味蕾细胞上表达,而且在呼吸系统、心血管系统、消化系统、生殖系统和神经系统中均有表达,同时也参与调控多种基本生理过程,现作为治疗... 详细信息

苦味作为动物最重要的生理感觉之一,其识别过程主要由苦味受体介导完成。近年来发现该受体不仅在舌头味蕾细胞上表达,而且在呼吸系统、心血管系统、消化系统、生殖系统和神经系统中均有表达,同时也参与调控多种基本生理过程,现作为治疗各类疾病的重要靶点之一。该文对苦味受体的结构、分类、分布及其信号转导通路与不同疾病的关系、苦味受体激动剂等方面进行综述,以期为苦味受体的科学研究提供依据。

关键词：苦味受体苦味受体激动剂通路

Modified viscocanalostomy in the Chinese population with open angle glaucoma: a 10-year follow-up results

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 429-435页

作者： Ya Liang hong sun Jie Shuai Kai Xu Fang-Fang Ji Sucijanti Zhi-Lan Yuan Department of Ophthalmology the First Affiliated Hospital of Nanjing Medical University Department of Ophthalmology Eye & ENT Hospital of Fudan University

AIM: To study the long-term efficacy and safety of modified viscocanalostomy in Chinese people with open angle glaucoma(OAG).METHODS: This retrospective study included a total of 100 eyes from 100 Chinese patients with medically uncontrolled OAG. All the patients underwent modified viscocanalostomy with injection of viscoelastic material in the surgically created ostia of Schlemm's canal(SC). The modifications included peeling of the inner wall of SC and the juxtacanalicular meshwork, use of mitomycin C, and loosely suturing the superficial scleral flap. Intraocular pressure(IOP), visual acuity, number of medications, laser goniopuncture data and complications were recorded. The definition of complete(qualified) success was an IOP equal to or lower than 21, 18, 16 mm Hg without(with or without) anti-glaucoma medications. RESULTS: The mean IOP was 33.5±9.9 mm Hg before surgery, 15.2±3.6 mm Hg(mean IOP reduction of 51%) at 5 y after surgery, and 15.6±2.8 mm Hg(mean IOP reduction of 49.9%) at 10 y after surgery(P<0.001). The number of anti-glaucoma medications dropped from 2.39±0.5 preoperatively to 0.47±0.8 at 5 y and 0.67±0.8 at 10 y postoperatively(P<0.001). The follow-up period was 104.5±37.0 mo. The qualified success rate for an IOP of 21, 18 or 16 mm Hg or less was 84% [95% confidence interval(CI): 0.80-0.88], 73%(95%CI: 0.68-0.78), and 59%(95%CI: 0.52-0.66) after 5 y, and 80%(95%CI: 0.76-0.84), 69%(95%CI: 0.64-0.74), 51%(95%CI: 0.44-0.58) after 10 y, respectively. There was a relationship between age, preoperative IOP and success rate(P<0.01, P<0.05). A total of 31 eyes(31.3%)in 31 patients underwent laser goniopuncture, decreasing the IOP from 22.9±4.3 mm Hg to 16.3±2.5 mm Hg(P<0.01). Neither blebitis nor endophthalmitis ***: Modified viscocanalostomy could be performed to lower IOP, decrease multiple anti-glaucoma drops use as well. It's a safe procedure with less complications over 10 y in Chinese individuals with OAG.

关键词： non-penetrating glaucoma surgery viscocanalostomy Schlemm’s canal open angle glaucoma laser goniopuncture