Diagnostic role of transient elastography in patients with autoimmune liver diseases:A systematic review and meta-analysis

作     者：Hong Chen Yue Shen Sheng-Di Wu Qin Zhu Cheng-Zhao Weng Jun Zhang Mei-Xia Wang Wei Jiang 

作者机构：Department of Gastroenterology and HepatologyZhongshan Hospital(Xiamen)Fudan UniversityXiamen 361015Fujian ProvinceChina Department of Gastroenterology and HepatologyZhongshan Hospital of Fudan UniversityShanghai 200032China Shanghai Institute of Liver DiseasesFudan University Shanghai Medical CollegeShanghai 200032China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))

年 卷 期：2023年第29卷第39期

页      面：5503-5525页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Natural Science and Technology Major Project of Fujian Province,No.2021D033 Natural Science Foundation of Shanghai,No.20ZR1410900 Medical Innovation Project of Fujian Province,No.2022CXB020 National Science and Technology Major Project,No.2017ZX 10203202-003-002 

主　　题：Liver stiffness Serum parameter Liver fibrosis Noninvasive diagnosis Transient elastography Autoimmune liver disease 

摘      要：BACKGROUND Noninvasive methods have been developed to detect fibrosis in many liver diseases due to the limits of liver ***,previous studies have focused primarily on chronic viral hepatitis and nonalcoholic fatty liver *** diagnostic value of transient elastography for autoimmune liver diseases(AILDs)is worth *** To compare the diagnostic accuracy of imaging techniques with serum biomarkers of fibrosis in *** The PubMed,Cochrane Library and EMBASE databases were *** evaluating the efficacy of noninvasive methods in the diagnosis of AILDs[autoimmune hepatitis(AIH),primary biliary cholangitis(PBC)and primary sclerosing cholangitis(PSC)]were *** summary area under the receiver operating characteristic curve(AUROC),diagnostic odds ratio,sensitivity and specificity were used to assess the accuracy of these noninvasive methods for staging *** A total of 60 articles were included in this study,and the number of patients with AIH,PBC and PSC was 1594,3126 and 501,*** summary AUROC of transient elastography in the diagnosis of significant fibrosis,advanced fibrosis and cirrhosis in patients with AIH were 0.84,0.88 and 0.90,respectively,while those in patients with PBC were 0.93,0.93 and 0.91,*** AUROC of cirrhosis for patients with PSC was ***,other noninvasive indices(aspartate aminotransferase to platelet ratio index,aspartate aminotransferase/alanine aminotransferase ratio,fibrosis-4 index)had corresponding AUROCs less than *** Transient elastography exerts better diagnostic accuracy in AILD patients,especially in PBC *** appropriate cutoff values for staging advanced fibrosis and cirrhosis ranged from 9.6 to 10.7 and 14.4 to 16.9 KPa for PBC patients.